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Protein

Tensin-4

Gene

Tns4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton May promote apoptosis, via its cleavage by caspase-3. Cytoplasm, cytoskeleton.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-MMU-8875513. MET interacts with TNS proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-4
Gene namesi
Name:Tns4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144377. Tns4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14By similarityAdd BLAST14
ChainiPRO_000024821415 – 696Tensin-4Add BLAST682

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230PhosphoserineBy similarity1

Post-translational modificationi

Proteolytically cleaved by caspase-3 during apoptosis.By similarity
Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BZ33.
PaxDbiQ8BZ33.
PeptideAtlasiQ8BZ33.
PRIDEiQ8BZ33.

PTM databases

iPTMnetiQ8BZ33.
PhosphoSitePlusiQ8BZ33.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017607.
CleanExiMM_TNS4.
GenevisibleiQ8BZ33. MM.

Interactioni

Subunit structurei

Binds to actin filaments and interacts with phosphotyrosine-containing proteins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017751.

Structurei

3D structure databases

ProteinModelPortaliQ8BZ33.
SMRiQ8BZ33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini429 – 536SH2PROSITE-ProRule annotationAdd BLAST108
Domaini528 – 695Phosphatase tensin-typeAdd BLAST168

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi174 – 299Ser-richAdd BLAST126

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, Signal

Phylogenomic databases

eggNOGiENOG410IUIK. Eukaryota.
ENOG41125SH. LUCA.
GeneTreeiENSGT00760000119113.
HOGENOMiHOG000230981.
HOVERGENiHBG080039.
InParanoidiQ8BZ33.
KOiK18080.
OMAiLNQMILE.
OrthoDBiEOG091G0G8Y.
TreeFamiTF315996.

Family and domain databases

CDDicd01213. PTB_tensin. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR033929. Tensin_PTB.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BZ33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSLLAGGH MVSLTPCEES RMALHPTPSP GLPALCPYYT TESWGTQPLM
60 70 80 90 100
APTLRKGSSD RLQQAQQAEA RAHCLLQGPG EQASGASQDL ESCIDFSLEA
110 120 130 140 150
LNQMILEIDP TFQLLPSGTA GPQAESTNSI MSRNKKEEPE ALDIKYIEVT
160 170 180 190 200
STRSRYLDGP QRCSSPCATP PFGSPRSGSL FLSRDIPRET RSSSNESLIF
210 220 230 240 250
SGNQGRGPSP LTPSSLSNAI PCRESRTSGS PLATPPGWEK GLRAPQRGSR
260 270 280 290 300
VSILSASPVS DVSYVFGSNQ SLPHSSLSSY PSSSRSLGSP ASSSSSLHSL
310 320 330 340 350
DRGSQCGRPS DAQAPSNPIL GMGQPQAVQS TPVAKEQASS CPASVTNSMA
360 370 380 390 400
DIPIVLINGS PEPQSPPAQR TPGHQDSVQS RVTSPSHLCQ AIKSPSKTLP
410 420 430 440 450
DVPLPASPDG PAKDMQPTMK FVMDTSKYWF KPSITREQAI NLLRTEKPGA
460 470 480 490 500
FVIRDSSSYR GSFGLALKVQ ETSASAPNRP GEDSSDLIRH FLIESSAKGV
510 520 530 540 550
HLKGADEEPY FGSLSSFVCQ HSIMALALPC KLTIPQKELG GAEPASDSPT
560 570 580 590 600
HGQTSCLKIS AGCHTLYLSS VSVETLSGAL AVQKAISVTL ERDVLPTPTV
610 620 630 640 650
VHFKVTEQGI TLTDVQRKVF FRRHYPLSAL RFCGMDPEQR KWQKYCKPSR
660 670 680 690
IFGFVAKSQT EPQENVCHLF AEYDAVQPAS QVISLVTALL QDTERM
Length:696
Mass (Da):74,622
Last modified:July 27, 2011 - v2
Checksum:iE2EB3F1D4DBFD079
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268S → I in BAC29598 (PubMed:16141072).Curated1
Sequence conflicti490H → D in BAE41928 (PubMed:16141072).Curated1
Sequence conflicti507E → K in BAE41928 (PubMed:16141072).Curated1
Sequence conflicti589T → I in AAH55820 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591366 Genomic DNA. Translation: CAM26976.1.
CH466556 Genomic DNA. Translation: EDL16179.1.
AK036834 mRNA. Translation: BAC29598.1.
AK170638 mRNA. Translation: BAE41928.1.
BC055820 mRNA. Translation: AAH55820.1.
CCDSiCCDS25372.1.
RefSeqiNP_766152.2. NM_172564.3.
UniGeneiMm.262067.

Genome annotation databases

EnsembliENSMUST00000017751; ENSMUSP00000017751; ENSMUSG00000017607.
GeneIDi217169.
KEGGimmu:217169.
UCSCiuc007lig.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591366 Genomic DNA. Translation: CAM26976.1.
CH466556 Genomic DNA. Translation: EDL16179.1.
AK036834 mRNA. Translation: BAC29598.1.
AK170638 mRNA. Translation: BAE41928.1.
BC055820 mRNA. Translation: AAH55820.1.
CCDSiCCDS25372.1.
RefSeqiNP_766152.2. NM_172564.3.
UniGeneiMm.262067.

3D structure databases

ProteinModelPortaliQ8BZ33.
SMRiQ8BZ33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017751.

PTM databases

iPTMnetiQ8BZ33.
PhosphoSitePlusiQ8BZ33.

Proteomic databases

MaxQBiQ8BZ33.
PaxDbiQ8BZ33.
PeptideAtlasiQ8BZ33.
PRIDEiQ8BZ33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017751; ENSMUSP00000017751; ENSMUSG00000017607.
GeneIDi217169.
KEGGimmu:217169.
UCSCiuc007lig.2. mouse.

Organism-specific databases

CTDi84951.
MGIiMGI:2144377. Tns4.

Phylogenomic databases

eggNOGiENOG410IUIK. Eukaryota.
ENOG41125SH. LUCA.
GeneTreeiENSGT00760000119113.
HOGENOMiHOG000230981.
HOVERGENiHBG080039.
InParanoidiQ8BZ33.
KOiK18080.
OMAiLNQMILE.
OrthoDBiEOG091G0G8Y.
TreeFamiTF315996.

Enzyme and pathway databases

ReactomeiR-MMU-8875513. MET interacts with TNS proteins.

Miscellaneous databases

PROiQ8BZ33.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017607.
CleanExiMM_TNS4.
GenevisibleiQ8BZ33. MM.

Family and domain databases

CDDicd01213. PTB_tensin. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR033929. Tensin_PTB.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTENS4_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ33
Secondary accession number(s): A2A552, Q3TCM8, Q7TNR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.