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Protein

Putative Polycomb group protein ASXL2

Gene

Asxl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1332 – 1369PHD-type; atypicalAdd BLAST38

GO - Molecular functioni

GO - Biological processi

  • adult heart development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • heart development Source: MGI
  • heart morphogenesis Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of bone mineralization involved in bone maturation Source: MGI
  • positive regulation of fat cell differentiation Source: UniProtKB
  • positive regulation of histone H3-K27 trimethylation Source: MGI
  • positive regulation of osteoclast differentiation Source: MGI
  • positive regulation of peroxisome proliferator activated receptor signaling pathway Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Polycomb group protein ASXL2
Alternative name(s):
Additional sex combs-like protein 2
Gene namesi
Name:Asxl2
Synonyms:Kiaa1685
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1922552. Asxl2.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003138271 – 1370Putative Polycomb group protein ASXL2Add BLAST1370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei150PhosphoserineBy similarity1
Modified residuei477PhosphoserineBy similarity1
Modified residuei524PhosphoserineBy similarity1
Modified residuei553PhosphoserineBy similarity1
Modified residuei590PhosphoserineBy similarity1
Modified residuei594Asymmetric dimethylarginineCombined sources1
Modified residuei601PhosphoserineBy similarity1
Modified residuei1121PhosphoserineCombined sources1
Modified residuei1254PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BZ32.
PaxDbiQ8BZ32.
PRIDEiQ8BZ32.

PTM databases

iPTMnetiQ8BZ32.
PhosphoSitePlusiQ8BZ32.

Expressioni

Gene expression databases

CleanExiMM_ASXL2.

Interactioni

Subunit structurei

Interacts with PPARA and PPARG.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217375. 3 interactors.
STRINGi10090.ENSMUSP00000106846.

Structurei

3D structure databases

ProteinModelPortaliQ8BZ32.
SMRiQ8BZ32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi178 – 182Nuclear localization signalSequence analysis5
Motifi258 – 262LXXLL motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi95 – 166Ser-richAdd BLAST72
Compositional biasi176 – 179Poly-Gln4
Compositional biasi258 – 262Poly-Leu5
Compositional biasi607 – 637Ala-richAdd BLAST31
Compositional biasi640 – 692Gly-richAdd BLAST53

Domaini

Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which may be required for an association with nuclear receptors.By similarity

Sequence similaritiesi

Belongs to the Asx family.Curated
Contains 1 PHD-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1332 – 1369PHD-type; atypicalAdd BLAST38

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIF3. Eukaryota.
ENOG4111F3G. LUCA.
HOGENOMiHOG000168836.
HOVERGENiHBG106941.
InParanoidiQ8BZ32.
KOiK11471.

Family and domain databases

InterProiIPR026905. ASX-like_PHD.
IPR024811. ASX/ASX-like.
IPR028020. ASXH.
IPR024817. ASXL2.
IPR007759. HB1/Asxl_HTH.
[Graphical view]
PANTHERiPTHR13578. PTHR13578. 2 hits.
PTHR13578:SF11. PTHR13578:SF11. 2 hits.
PfamiPF13919. ASXH. 1 hit.
PF05066. HARE-HTH. 1 hit.
PF13922. PHD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZ32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREKGRRKKG RTWAEAAKTV LEKYPNTPMS HKEILQVIQR EGLKEIRSGT
60 70 80 90 100
SPLACLNAML HTNSRGEEGI FYKVPGRMGV YTLKKDVPDG VKELSECSEE
110 120 130 140 150
SSDGQSDSHS SDNSSSSDGG SNKEGRKSRW KRKVSSRLSH PPSPPSGCPS
160 170 180 190 200
PTIPASKVIS PSQKHSKKAL KQALKQQQQK KKQQQCRPSM SISNQHLSLK
210 220 230 240 250
TVKAASDSVP AKPGQMKRTK CADIDVETPD SILVNTNLRA LINKHTFSVL
260 270 280 290 300
PGDCQQRLLL LLPEVDRQVG PDGLMKLNGS ALNNEFFTSA AQGWKERLSE
310 320 330 340 350
GEFTPEMQVR IRQEIEKEKK VELWKEQFFE NYYGQSSGLS LEDSQKLTAS
360 370 380 390 400
SSDPKAKKTP AEQPKSILPS EASPVRIVPV VPQSECKEEA VQIPSPSQKE
410 420 430 440 450
ENQDEARPDS KSPEPVLASA SNTNELITMK PIKSPKDEGL LEQKPVACAE
460 470 480 490 500
QESEKENHVT TTSRNNKSEN QEALAISPSK SKNAGLQKPI IKPVAEASPL
510 520 530 540 550
NPDMKMPPAT VTDQIQESLK RKSSLTDEEA TSSWEKRPRI TENRQHQQPF
560 570 580 590 600
QVSPQPFLNR GDRVQVRKVP PLKIPVSRIS PMLFSTSQVS PRARFPISIT
610 620 630 640 650
SPYRTGARTL ADIKAKAQLV EAQKAAAAAA AAAAAAASVG GTIPGPGPGG
660 670 680 690 700
GQSPREGGER KIAGGGSAGS DPVSTNGKGP TLELAGTGSR GGTRELLPCG
710 720 730 740 750
PQPETNMPGQ AQPPGISGAQ LQQTSSVPTG LASSGACTSV PLPAHIEISN
760 770 780 790 800
SEKPNLHKAT ATAASPCHLQ DPRSCRLEKA LSPTGPPLIS GASTVYFVAD
810 820 830 840 850
GTVEPKAGSN KNAPKPSALA KTTAPAPLDM TSSPVTTASL EKLPVPQISG
860 870 880 890 900
TATSTGSAPS SSTLPAASSL KTPGTSANMN GPISRTSSSI PANNPLVTQL
910 920 930 940 950
LQGKDVPLEQ ILPKPLTKIE MKTVPLTTKE EKGIGIFPGI SVMESSSREE
960 970 980 990 1000
VNGRQAHLAI PQLGKPLQSK QLSQVPRPVF TAKDRKDPCI DTHQYREGLS
1010 1020 1030 1040 1050
KTTQDQLFQT LIQRAQRQSV LSFVPPSQFN FAHSGFHLED ISTSQKFMLG
1060 1070 1080 1090 1100
FAGRRTSKPA MAGHYLLNIS TYGRGTENIK RTHSVNPDDR FCLSSPTEAL
1110 1120 1130 1140 1150
RMGHADYKNT TGEISSKEDE SDEDRVGDEQ EPISVKEEPW ASQSSGRHPH
1160 1170 1180 1190 1200
HGEASSTNDC LASKNGKTEA PVSEQTTLGQ ENYIFSRGQA SDEKSLPRDF
1210 1220 1230 1240 1250
IPAAHKQMTH AVRGKTVCSS PELFNSTALS LPADSPTHQP LLLPPLQTPK
1260 1270 1280 1290 1300
LYGSPTQIGP SYRGMINVST SSDMDHNSAI PGSQVSSNVG DVMSFSVTVT
1310 1320 1330 1340 1350
TIPASQAMNP SSHGQTIPVQ TFPDDNSIED TPSKCYCRLK AMIMCKGCGA
1360 1370
FCHDDCIGPS KLCVSCLVVR
Length:1,370
Mass (Da):147,107
Last modified:March 1, 2003 - v1
Checksum:i5E93DCF61F64861B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti564V → S in BAE36927 (PubMed:16141072).Curated1
Sequence conflicti621E → K in BAE36927 (PubMed:16141072).Curated1
Sequence conflicti621E → K in BAC65822 (PubMed:12693553).Curated1
Sequence conflicti627A → P in BAE36927 (PubMed:16141072).Curated1
Sequence conflicti646P → L in BAC65822 (PubMed:12693553).Curated1
Sequence conflicti686G → V in BAE36927 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036839 mRNA. Translation: BAC29602.1.
AK162455 mRNA. Translation: BAE36927.1.
AK122540 mRNA. Translation: BAC65822.1.
CCDSiCCDS36395.2.
RefSeqiNP_001257917.1. NM_001270988.1.
NP_766009.2. NM_172421.5.
UniGeneiMm.120475.

Genome annotation databases

GeneIDi75302.
KEGGimmu:75302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036839 mRNA. Translation: BAC29602.1.
AK162455 mRNA. Translation: BAE36927.1.
AK122540 mRNA. Translation: BAC65822.1.
CCDSiCCDS36395.2.
RefSeqiNP_001257917.1. NM_001270988.1.
NP_766009.2. NM_172421.5.
UniGeneiMm.120475.

3D structure databases

ProteinModelPortaliQ8BZ32.
SMRiQ8BZ32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217375. 3 interactors.
STRINGi10090.ENSMUSP00000106846.

PTM databases

iPTMnetiQ8BZ32.
PhosphoSitePlusiQ8BZ32.

Proteomic databases

MaxQBiQ8BZ32.
PaxDbiQ8BZ32.
PRIDEiQ8BZ32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi75302.
KEGGimmu:75302.

Organism-specific databases

CTDi55252.
MGIiMGI:1922552. Asxl2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IIF3. Eukaryota.
ENOG4111F3G. LUCA.
HOGENOMiHOG000168836.
HOVERGENiHBG106941.
InParanoidiQ8BZ32.
KOiK11471.

Miscellaneous databases

ChiTaRSiAsxl2. mouse.
PROiQ8BZ32.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ASXL2.

Family and domain databases

InterProiIPR026905. ASX-like_PHD.
IPR024811. ASX/ASX-like.
IPR028020. ASXH.
IPR024817. ASXL2.
IPR007759. HB1/Asxl_HTH.
[Graphical view]
PANTHERiPTHR13578. PTHR13578. 2 hits.
PTHR13578:SF11. PTHR13578:SF11. 2 hits.
PfamiPF13919. ASXH. 1 hit.
PF05066. HARE-HTH. 1 hit.
PF13922. PHD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASXL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ32
Secondary accession number(s): Q3TRU9, Q80TA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.