ID   ANKK1_MOUSE             Reviewed;         745 AA.
AC   Q8BZ25;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 53.
DE   RecName: Full=Ankyrin repeat and protein kinase domain-containing protein 1;
DE            EC=2.7.11.1;
GN   Name=Ankk1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Vagina;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family.
CC   -!- SIMILARITY: Contains 11 ANK repeats.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AK036872; BAC29613.1; -; mRNA.
DR   IPI; IPI00313677; -.
DR   RefSeq; NP_766510.1; -.
DR   UniGene; Mm.119994; -.
DR   HSSP; Q60778; 1OY3.
DR   PhosphoSite; Q8BZ25; -.
DR   PRIDE; Q8BZ25; -.
DR   Ensembl; ENSMUSG00000032257; Mus musculus.
DR   GeneID; 244859; -.
DR   KEGG; mmu:244859; -.
DR   MGI; MGI:3045301; Ankk1.
DR   HOGENOM; Q8BZ25; -.
DR   HOVERGEN; Q8BZ25; -.
DR   OMA; Q8BZ25; VETDMLL.
DR   BRENDA; 2.7.11.1; 244.
DR   NextBio; 386440; -.
DR   ArrayExpress; Q8BZ25; -.
DR   Bgee; Q8BZ25; -.
DR   CleanEx; MM_ANKK1; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR002110; ANK.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   Gene3D; G3DSA:1.25.40.20; ANK; 2.
DR   Pfam; PF00023; Ank; 11.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00248; ANK; 11.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 11.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Repeat; Serine/threonine-protein kinase; Transferase.
FT   CHAIN         1    745       Ankyrin repeat and protein kinase domain-
FT                                containing protein 1.
FT                                /FTId=PRO_0000085621.
FT   DOMAIN       34    301       Protein kinase.
FT   REPEAT      369    398       ANK 1.
FT   REPEAT      402    431       ANK 2.
FT   REPEAT      435    464       ANK 3.
FT   REPEAT      468    497       ANK 4.
FT   REPEAT      501    530       ANK 5.
FT   REPEAT      534    563       ANK 6.
FT   REPEAT      567    596       ANK 7.
FT   REPEAT      600    629       ANK 8.
FT   REPEAT      633    662       ANK 9.
FT   REPEAT      666    695       ANK 10.
FT   REPEAT      699    728       ANK 11.
FT   NP_BIND      40     48       ATP (By similarity).
FT   ACT_SITE    157    157       Proton acceptor (By similarity).
FT   BINDING      63     63       ATP (By similarity).
FT   MOD_RES     702    702       Phosphothreonine (By similarity).
SQ   SEQUENCE   745 AA;  82480 MW;  DDD391ECD19EB84D CRC64;
     MVPHRARRLL NPMAVGPLAQ QLGSLTVFTR DDFEEEWHLV ASGGFSKVFQ ARHKRWRTQY
     AIKCSPCLQK ETTSSEVTCL FEEAVKMEKI KFQHIVSIYG VCKQPLGIVM EFMASGSLEK
     TLPTHSLCWP LKLRIIHETS LAMNFLHSIK PPLLHLDLKP GNILLDNNMH VKISDFGLSK
     WMEQSTQKQY IERSALRGTL SYIPPEMFLE NNKAPGPEYD VYSFAIVIWE ILTQKKPYAG
     LNMMTIIIRV AAGMRPSLQD VSDEWPEEVH QMVNLMKRCW DQDPKKRPCF LNVAVETDML
     LSLFQSPMTD PGCEALTQKV SCKPSLSQPH KVSKEVNQEI ADSVSSDSLK WILQLSDSKS
     LVASDVYENR VTPLHFLVAG GSLEQVRLLL SHDVDVDCQT ASGYTPLLIA TQDQQPDLCA
     LLLAHGADTN LADEDGWAPL HFAAQNGDDH TARLLLDHGA LVNAREHEGW TPLHLAAQNN
     FENVARLLVS RQADLSPHEA EGKTPLHVAA YFGHIGLVKL LSGQGAELDA QQRNLRTPLH
     LAVERGKVRA IQHLLKCGAL PDALDHSGYS PLHIAAARGK DLIFKMLLRY GASLELRTQQ
     GWTPLHLATY KGHLEIIHQL AKSHVDLDAL GSMQWTPLHL AAFQGEEGVM LALLQCGANP
     NAAEQSGWTP LHLAVHKGTF LGITHLLEYG ADIHACNKVG WTPAHLAALK GNTAILKVLV
     KAAAQVDVKG GVSCTPLQLA IHSPK
//