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Protein

Ankyrin repeat and protein kinase domain-containing protein 1

Gene

Ankk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63ATPPROSITE-ProRule annotation1
Active sitei157Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 48ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and protein kinase domain-containing protein 1 (EC:2.7.11.1)
Gene namesi
Name:Ankk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3045301. Ankk1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856211 – 745Ankyrin repeat and protein kinase domain-containing protein 1Add BLAST745

Proteomic databases

MaxQBiQ8BZ25.
PaxDbiQ8BZ25.
PRIDEiQ8BZ25.

PTM databases

iPTMnetiQ8BZ25.
PhosphoSitePlusiQ8BZ25.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032257.
CleanExiMM_ANKK1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034792.

Structurei

3D structure databases

ProteinModelPortaliQ8BZ25.
SMRiQ8BZ25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 301Protein kinasePROSITE-ProRule annotationAdd BLAST268
Repeati369 – 398ANK 1Add BLAST30
Repeati402 – 431ANK 2Add BLAST30
Repeati435 – 464ANK 3Add BLAST30
Repeati468 – 497ANK 4Add BLAST30
Repeati501 – 530ANK 5Add BLAST30
Repeati534 – 563ANK 6Add BLAST30
Repeati567 – 596ANK 7Add BLAST30
Repeati600 – 629ANK 8Add BLAST30
Repeati633 – 662ANK 9Add BLAST30
Repeati666 – 695ANK 10Add BLAST30
Repeati699 – 728ANK 11Add BLAST30

Sequence similaritiesi

Contains 11 ANK repeats.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KDMN. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00550000074536.
HOVERGENiHBG061582.
InParanoidiQ8BZ25.
KOiK16289.
OMAiPCFLDIT.
OrthoDBiEOG091G00GN.
PhylomeDBiQ8BZ25.
TreeFamiTF106506.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 4 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 11 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZ25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPHRARRLL NPMAVGPLAQ QLGSLTVFTR DDFEEEWHLV ASGGFSKVFQ
60 70 80 90 100
ARHKRWRTQY AIKCSPCLQK ETTSSEVTCL FEEAVKMEKI KFQHIVSIYG
110 120 130 140 150
VCKQPLGIVM EFMASGSLEK TLPTHSLCWP LKLRIIHETS LAMNFLHSIK
160 170 180 190 200
PPLLHLDLKP GNILLDNNMH VKISDFGLSK WMEQSTQKQY IERSALRGTL
210 220 230 240 250
SYIPPEMFLE NNKAPGPEYD VYSFAIVIWE ILTQKKPYAG LNMMTIIIRV
260 270 280 290 300
AAGMRPSLQD VSDEWPEEVH QMVNLMKRCW DQDPKKRPCF LNVAVETDML
310 320 330 340 350
LSLFQSPMTD PGCEALTQKV SCKPSLSQPH KVSKEVNQEI ADSVSSDSLK
360 370 380 390 400
WILQLSDSKS LVASDVYENR VTPLHFLVAG GSLEQVRLLL SHDVDVDCQT
410 420 430 440 450
ASGYTPLLIA TQDQQPDLCA LLLAHGADTN LADEDGWAPL HFAAQNGDDH
460 470 480 490 500
TARLLLDHGA LVNAREHEGW TPLHLAAQNN FENVARLLVS RQADLSPHEA
510 520 530 540 550
EGKTPLHVAA YFGHIGLVKL LSGQGAELDA QQRNLRTPLH LAVERGKVRA
560 570 580 590 600
IQHLLKCGAL PDALDHSGYS PLHIAAARGK DLIFKMLLRY GASLELRTQQ
610 620 630 640 650
GWTPLHLATY KGHLEIIHQL AKSHVDLDAL GSMQWTPLHL AAFQGEEGVM
660 670 680 690 700
LALLQCGANP NAAEQSGWTP LHLAVHKGTF LGITHLLEYG ADIHACNKVG
710 720 730 740
WTPAHLAALK GNTAILKVLV KAAAQVDVKG GVSCTPLQLA IHSPK
Length:745
Mass (Da):82,480
Last modified:March 1, 2003 - v1
Checksum:iDDD391ECD19EB84D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036872 mRNA. Translation: BAC29613.1.
CCDSiCCDS40616.1.
RefSeqiNP_766510.1. NM_172922.3.
UniGeneiMm.119994.

Genome annotation databases

EnsembliENSMUST00000034792; ENSMUSP00000034792; ENSMUSG00000032257.
GeneIDi244859.
KEGGimmu:244859.
UCSCiuc009pjb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036872 mRNA. Translation: BAC29613.1.
CCDSiCCDS40616.1.
RefSeqiNP_766510.1. NM_172922.3.
UniGeneiMm.119994.

3D structure databases

ProteinModelPortaliQ8BZ25.
SMRiQ8BZ25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034792.

PTM databases

iPTMnetiQ8BZ25.
PhosphoSitePlusiQ8BZ25.

Proteomic databases

MaxQBiQ8BZ25.
PaxDbiQ8BZ25.
PRIDEiQ8BZ25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034792; ENSMUSP00000034792; ENSMUSG00000032257.
GeneIDi244859.
KEGGimmu:244859.
UCSCiuc009pjb.1. mouse.

Organism-specific databases

CTDi255239.
MGIiMGI:3045301. Ankk1.

Phylogenomic databases

eggNOGiENOG410KDMN. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00550000074536.
HOVERGENiHBG061582.
InParanoidiQ8BZ25.
KOiK16289.
OMAiPCFLDIT.
OrthoDBiEOG091G00GN.
PhylomeDBiQ8BZ25.
TreeFamiTF106506.

Miscellaneous databases

PROiQ8BZ25.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032257.
CleanExiMM_ANKK1.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 4 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 11 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANKK1_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.