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Protein

Ankyrin repeat and protein kinase domain-containing protein 1

Gene

Ankk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631ATPPROSITE-ProRule annotation
Active sitei157 – 1571Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 489ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and protein kinase domain-containing protein 1 (EC:2.7.11.1)
Gene namesi
Name:Ankk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3045301. Ankk1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745Ankyrin repeat and protein kinase domain-containing protein 1PRO_0000085621Add
BLAST

Proteomic databases

PaxDbiQ8BZ25.
PRIDEiQ8BZ25.

PTM databases

iPTMnetiQ8BZ25.
PhosphoSiteiQ8BZ25.

Expressioni

Gene expression databases

BgeeiQ8BZ25.
CleanExiMM_ANKK1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034792.

Structurei

3D structure databases

ProteinModelPortaliQ8BZ25.
SMRiQ8BZ25. Positions 32-745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 301268Protein kinasePROSITE-ProRule annotationAdd
BLAST
Repeati369 – 39830ANK 1Add
BLAST
Repeati402 – 43130ANK 2Add
BLAST
Repeati435 – 46430ANK 3Add
BLAST
Repeati468 – 49730ANK 4Add
BLAST
Repeati501 – 53030ANK 5Add
BLAST
Repeati534 – 56330ANK 6Add
BLAST
Repeati567 – 59630ANK 7Add
BLAST
Repeati600 – 62930ANK 8Add
BLAST
Repeati633 – 66230ANK 9Add
BLAST
Repeati666 – 69530ANK 10Add
BLAST
Repeati699 – 72830ANK 11Add
BLAST

Sequence similaritiesi

Contains 11 ANK repeats.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KDMN. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00550000074536.
HOVERGENiHBG061582.
InParanoidiQ8BZ25.
KOiK16289.
OMAiPCFLDIT.
OrthoDBiEOG7P02H2.
PhylomeDBiQ8BZ25.
TreeFamiTF106506.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 4 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 11 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZ25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPHRARRLL NPMAVGPLAQ QLGSLTVFTR DDFEEEWHLV ASGGFSKVFQ
60 70 80 90 100
ARHKRWRTQY AIKCSPCLQK ETTSSEVTCL FEEAVKMEKI KFQHIVSIYG
110 120 130 140 150
VCKQPLGIVM EFMASGSLEK TLPTHSLCWP LKLRIIHETS LAMNFLHSIK
160 170 180 190 200
PPLLHLDLKP GNILLDNNMH VKISDFGLSK WMEQSTQKQY IERSALRGTL
210 220 230 240 250
SYIPPEMFLE NNKAPGPEYD VYSFAIVIWE ILTQKKPYAG LNMMTIIIRV
260 270 280 290 300
AAGMRPSLQD VSDEWPEEVH QMVNLMKRCW DQDPKKRPCF LNVAVETDML
310 320 330 340 350
LSLFQSPMTD PGCEALTQKV SCKPSLSQPH KVSKEVNQEI ADSVSSDSLK
360 370 380 390 400
WILQLSDSKS LVASDVYENR VTPLHFLVAG GSLEQVRLLL SHDVDVDCQT
410 420 430 440 450
ASGYTPLLIA TQDQQPDLCA LLLAHGADTN LADEDGWAPL HFAAQNGDDH
460 470 480 490 500
TARLLLDHGA LVNAREHEGW TPLHLAAQNN FENVARLLVS RQADLSPHEA
510 520 530 540 550
EGKTPLHVAA YFGHIGLVKL LSGQGAELDA QQRNLRTPLH LAVERGKVRA
560 570 580 590 600
IQHLLKCGAL PDALDHSGYS PLHIAAARGK DLIFKMLLRY GASLELRTQQ
610 620 630 640 650
GWTPLHLATY KGHLEIIHQL AKSHVDLDAL GSMQWTPLHL AAFQGEEGVM
660 670 680 690 700
LALLQCGANP NAAEQSGWTP LHLAVHKGTF LGITHLLEYG ADIHACNKVG
710 720 730 740
WTPAHLAALK GNTAILKVLV KAAAQVDVKG GVSCTPLQLA IHSPK
Length:745
Mass (Da):82,480
Last modified:March 1, 2003 - v1
Checksum:iDDD391ECD19EB84D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036872 mRNA. Translation: BAC29613.1.
CCDSiCCDS40616.1.
RefSeqiNP_766510.1. NM_172922.3.
UniGeneiMm.119994.

Genome annotation databases

EnsembliENSMUST00000034792; ENSMUSP00000034792; ENSMUSG00000032257.
GeneIDi244859.
KEGGimmu:244859.
UCSCiuc009pjb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036872 mRNA. Translation: BAC29613.1.
CCDSiCCDS40616.1.
RefSeqiNP_766510.1. NM_172922.3.
UniGeneiMm.119994.

3D structure databases

ProteinModelPortaliQ8BZ25.
SMRiQ8BZ25. Positions 32-745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034792.

PTM databases

iPTMnetiQ8BZ25.
PhosphoSiteiQ8BZ25.

Proteomic databases

PaxDbiQ8BZ25.
PRIDEiQ8BZ25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034792; ENSMUSP00000034792; ENSMUSG00000032257.
GeneIDi244859.
KEGGimmu:244859.
UCSCiuc009pjb.1. mouse.

Organism-specific databases

CTDi255239.
MGIiMGI:3045301. Ankk1.

Phylogenomic databases

eggNOGiENOG410KDMN. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00550000074536.
HOVERGENiHBG061582.
InParanoidiQ8BZ25.
KOiK16289.
OMAiPCFLDIT.
OrthoDBiEOG7P02H2.
PhylomeDBiQ8BZ25.
TreeFamiTF106506.

Miscellaneous databases

PROiQ8BZ25.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BZ25.
CleanExiMM_ANKK1.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 4 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 11 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Vagina.

Entry informationi

Entry nameiANKK1_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.