Reviewed, UniProtKB/Swiss-Prot Q8BZ25 (ANKK1_MOUSE)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat and protein kinase domain-containing protein 1
    EC=2.7.11.1

Gene names

Name:

Ankk1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	745 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 11 ANK repeats. Contains 1 protein kinase domain.

Ontologies

Keywords
Domain	ANK repeat Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 745	745	Ankyrin repeat and protein kinase domain-containing protein 1		PRO_0000085621
Regions
	Domain	34 – 301	268	Protein kinase
	Repeat	369 – 398	30	ANK 1
	Repeat	402 – 431	30	ANK 2
	Repeat	435 – 464	30	ANK 3
	Repeat	468 – 497	30	ANK 4
	Repeat	501 – 530	30	ANK 5
	Repeat	534 – 563	30	ANK 6
	Repeat	567 – 596	30	ANK 7
	Repeat	600 – 629	30	ANK 8
	Repeat	633 – 662	30	ANK 9
	Repeat	666 – 695	30	ANK 10
	Repeat	699 – 728	30	ANK 11
	Nucleotide binding	40 – 48	9	ATP By similarity
Sites
	Active site	157	1	Proton acceptor By similarity
	Binding site	63	1	ATP By similarity
Amino acid modifications
	Modified residue	702	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8BZ25-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: DDD391ECD19EB84D	FASTA	745	82,480
	10 20 30 40 50 60 MVPHRARRLL NPMAVGPLAQ QLGSLTVFTR DDFEEEWHLV ASGGFSKVFQ ARHKRWRTQY 70 80 90 100 110 120 AIKCSPCLQK ETTSSEVTCL FEEAVKMEKI KFQHIVSIYG VCKQPLGIVM EFMASGSLEK 130 140 150 160 170 180 TLPTHSLCWP LKLRIIHETS LAMNFLHSIK PPLLHLDLKP GNILLDNNMH VKISDFGLSK 190 200 210 220 230 240 WMEQSTQKQY IERSALRGTL SYIPPEMFLE NNKAPGPEYD VYSFAIVIWE ILTQKKPYAG 250 260 270 280 290 300 LNMMTIIIRV AAGMRPSLQD VSDEWPEEVH QMVNLMKRCW DQDPKKRPCF LNVAVETDML 310 320 330 340 350 360 LSLFQSPMTD PGCEALTQKV SCKPSLSQPH KVSKEVNQEI ADSVSSDSLK WILQLSDSKS 370 380 390 400 410 420 LVASDVYENR VTPLHFLVAG GSLEQVRLLL SHDVDVDCQT ASGYTPLLIA TQDQQPDLCA 430 440 450 460 470 480 LLLAHGADTN LADEDGWAPL HFAAQNGDDH TARLLLDHGA LVNAREHEGW TPLHLAAQNN 490 500 510 520 530 540 FENVARLLVS RQADLSPHEA EGKTPLHVAA YFGHIGLVKL LSGQGAELDA QQRNLRTPLH 550 560 570 580 590 600 LAVERGKVRA IQHLLKCGAL PDALDHSGYS PLHIAAARGK DLIFKMLLRY GASLELRTQQ 610 620 630 640 650 660 GWTPLHLATY KGHLEIIHQL AKSHVDLDAL GSMQWTPLHL AAFQGEEGVM LALLQCGANP 670 680 690 700 710 720 NAAEQSGWTP LHLAVHKGTF LGITHLLEYG ADIHACNKVG WTPAHLAALK GNTAILKVLV 730 740 KAAAQVDVKG GVSCTPLQLA IHSPK

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Vagina.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK036872 mRNA. Translation: BAC29613.1.
RefSeq	NP_766510.1.
UniGene	Mm.119994
3D structure databases
HSSP	HSSP built from PDB template 1OY3 based on UniProtKB Q60778.
ModBase	Search...
PTM databases
PhosphoSite	Q8BZ25.
Genome annotation databases
Ensembl	ENSMUSG00000032257. Mus musculus. [Contig view]
GeneID	244859.
KEGG	mmu:244859.
Organism-specific databases
MGI	MGI:3045301. Ankk1.
Phylogenomic databases
HOGENOM	Q8BZ25.
HOVERGEN	Q8BZ25.
Gene expression databases
ArrayExpress	Q8BZ25.
CleanEx	MM_ANKK1.
Family and domain databases
InterPro	IPR002110. ANK. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 2 hits.
Pfam	PF00023. Ank. 11 hits. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00248. ANK. 11 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 11 hits. PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	386440.
SOURCE	Search...

Entry information

Entry name

ANKK1_MOUSE

Accession

Primary (citable) accession number: Q8BZ25

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	March 1, 2003
Last modified:	November 25, 2008
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)