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Protein

Poly [ADP-ribose] polymerase 12

Gene

Parp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 128C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri164 – 188C3H1-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri189 – 211C3H1-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 307C3H1-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri281 – 306C3H1-type 3PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 12 (EC:2.4.2.30)
Short name:
PARP-12
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 12
Short name:
ARTD12
Zinc finger CCCH domain-containing protein 1
Gene namesi
Name:Parp12
Synonyms:Zc3hdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2143990. Parp12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113421 – 711Poly [ADP-ribose] polymerase 12Add BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei268PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BZ20.
PaxDbiQ8BZ20.
PRIDEiQ8BZ20.

PTM databases

iPTMnetiQ8BZ20.
PhosphoSitePlusiQ8BZ20.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038507.
CleanExiMM_PARP12.
GenevisibleiQ8BZ20. MM.

Interactioni

Protein-protein interaction databases

BioGridi232556. 2 interactors.
STRINGi10090.ENSMUSP00000039704.

Structurei

3D structure databases

ProteinModelPortaliQ8BZ20.
SMRiQ8BZ20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini308 – 371WWE 1PROSITE-ProRule annotationAdd BLAST64
Domaini374 – 468WWE 2PROSITE-ProRule annotationAdd BLAST95
Domaini494 – 708PARP catalyticPROSITE-ProRule annotationAdd BLAST215

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi66 – 70Poly-Ala5

Sequence similaritiesi

Contains 4 C3H1-type zinc fingers.PROSITE-ProRule annotation
Contains 1 PARP catalytic domain.PROSITE-ProRule annotation
Contains 2 WWE domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 128C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri164 – 188C3H1-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri189 – 211C3H1-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 307C3H1-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri281 – 306C3H1-type 3PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEI4. Eukaryota.
ENOG410ZFB8. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000236279.
HOVERGENiHBG050384.
InParanoidiQ8BZ20.
KOiK15259.
OMAiRWQFLDR.
OrthoDBiEOG091G14UY.
TreeFamiTF338389.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 2 hits.
PS50103. ZF_C3H1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZ20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAAVAVAE VTQLLCAAGG ALELAELRRR LRTSLGTDAL ERLLRDCGRF
60 70 80 90 100
VVASRAVVAV GAGREAAAAA SERLVLAVSS LRLCRAHQGP KPGCTGLCAQ
110 120 130 140 150
LHLCKFLIYG NCKFLKTGKN CRNGHNLKTD HNLSVLRTHG VDHLTYTELC
160 170 180 190 200
QLLLQNDPSL LPDICLHYNK GDGPFGSCSF QKQCIKLHIC QYFLQGECKF
210 220 230 240 250
GTSCKRSHEF TNSESLEQLE RLGLSSDLVS RLLSTYRNAY DIKNKGSALS
260 270 280 290 300
KVSPSPAGPQ GSSERKDSSG PVSPGTPSQE ESEQICLYHI RKSCSFQEKC
310 320 330 340 350
HRVHFHLPYR WQFLDGGKWK DLDNMELIEE AYSNPSKDRI VYTESAAGFH
360 370 380 390 400
FDNLDFNSMK FGNTLARRLS TASSVTKPPH FILTTDWIWY WMDEFGSWQE
410 420 430 440 450
YGRQGSGHPV TTISSSDVER AYLAFCAPGA DAQAATLKFQ AGKHNYELHF
460 470 480 490 500
KAFLQKNLVY GTIRKVCRRP KYVSPQDVQM KQSCNTKLHG PKSIPDYWDP
510 520 530 540 550
AALPDLGFKK ITLSSSSEEY QKVWNIFNRT LPFYFVQKIE RIQNMGLWEV
560 570 580 590 600
YQWQKCQMQK QNGGKEVDER QLFHGTSANF VDAICQQNFD WRVCGLHGTS
610 620 630 640 650
YGKGSYFARD AAYSHHYSKS DTHSHMMFLA RVLVGDFVRG STSFVRPPAK
660 670 680 690 700
EGQSNAFYDS CVNSMSDPTI FVVFEKHQVY PEYLIQYSTS SKPPASPSIF
710
VALGNLFTSR Q
Length:711
Mass (Da):79,917
Last modified:July 27, 2011 - v3
Checksum:i5172C6602CDDB4B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91K → I in BAC29622 (PubMed:16141072).Curated1
Sequence conflicti400E → K in BAC29622 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036886 mRNA. Translation: BAC29622.1.
CH466533 Genomic DNA. Translation: EDL13617.1.
BC120733 mRNA. Translation: AAI20734.1.
BC137645 mRNA. Translation: AAI37646.1.
BC024579 mRNA. Translation: AAH24579.1.
BC028906 mRNA. Translation: AAH28906.1.
BC048927 mRNA. Translation: AAH48927.1.
CCDSiCCDS20019.1.
RefSeqiNP_766481.2. NM_172893.3.
UniGeneiMm.268462.

Genome annotation databases

EnsembliENSMUST00000038398; ENSMUSP00000039704; ENSMUSG00000038507.
GeneIDi243771.
KEGGimmu:243771.
UCSCiuc009blg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036886 mRNA. Translation: BAC29622.1.
CH466533 Genomic DNA. Translation: EDL13617.1.
BC120733 mRNA. Translation: AAI20734.1.
BC137645 mRNA. Translation: AAI37646.1.
BC024579 mRNA. Translation: AAH24579.1.
BC028906 mRNA. Translation: AAH28906.1.
BC048927 mRNA. Translation: AAH48927.1.
CCDSiCCDS20019.1.
RefSeqiNP_766481.2. NM_172893.3.
UniGeneiMm.268462.

3D structure databases

ProteinModelPortaliQ8BZ20.
SMRiQ8BZ20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232556. 2 interactors.
STRINGi10090.ENSMUSP00000039704.

PTM databases

iPTMnetiQ8BZ20.
PhosphoSitePlusiQ8BZ20.

Proteomic databases

MaxQBiQ8BZ20.
PaxDbiQ8BZ20.
PRIDEiQ8BZ20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038398; ENSMUSP00000039704; ENSMUSG00000038507.
GeneIDi243771.
KEGGimmu:243771.
UCSCiuc009blg.2. mouse.

Organism-specific databases

CTDi64761.
MGIiMGI:2143990. Parp12.

Phylogenomic databases

eggNOGiENOG410IEI4. Eukaryota.
ENOG410ZFB8. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000236279.
HOVERGENiHBG050384.
InParanoidiQ8BZ20.
KOiK15259.
OMAiRWQFLDR.
OrthoDBiEOG091G14UY.
TreeFamiTF338389.

Miscellaneous databases

PROiQ8BZ20.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038507.
CleanExiMM_PARP12.
GenevisibleiQ8BZ20. MM.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 2 hits.
PS50103. ZF_C3H1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAR12_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ20
Secondary accession number(s): Q0VB94
, Q80VL6, Q8K333, Q8R3U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.