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Reviewed, UniProtKB/Swiss-Prot Q8BZ20 (PAR12_MOUSE)

Last modified October 13, 2009. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Poly [ADP-ribose] polymerase 12
      Short name=PARP-12
    EC=2.4.2.30
Alternative name(s):
    Zinc finger CCCH domain-containing protein 1
Gene names
Name: Parp12
Synonyms: Zc3hdc1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length711 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 4 C3H1-type zinc fingers.

Contains 1 PARP catalytic domain.

Contains 2 WWE domains.

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Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
NAD
Zinc
   Molecular functionTransferase
   PTMPhosphoprotein
Gene Ontology (GO)
   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD+ ADP-ribosyltransferase activity

Inferred from electronic annotation. Source: EC

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 711711Poly [ADP-ribose] polymerase 12
PRO_0000211342

Regions

Domain308 – 37164WWE 1
Domain374 – 46895WWE 2
Domain494 – 708215PARP catalytic
Zinc finger103 – 12826C3H1-type 1
Zinc finger164 – 18825C3H1-type 2
Zinc finger189 – 21123C3H1-type 3
Zinc finger280 – 30728C3H1-type 4
Zinc finger281 – 30626C3H1-type 3
Compositional bias66 – 705Poly-Ala

Amino acid modifications

Modified residue2681Phosphoserine By similarity
Modified residue2731Phosphoserine By similarity

Experimental info

Sequence conflict4001E → K in BAC29622. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q8BZ20-1 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: 77A9AB642F25469C

FASTA71179,902
        10         20         30         40         50         60 
MAQAAVAVAE VTQLLCAAGG ALELAELRRR LRTSLGTDAL ERLLRDCGRF VVASRAVVAV 

        70         80         90        100        110        120 
GAGREAAAAA SERLVLAVSS LRLCRAHQGP IPGCTGLCAQ LHLCKFLIYG NCKFLKTGKN 

       130        140        150        160        170        180 
CRNGHNLKTD HNLSVLRTHG VDHLTYTELC QLLLQNDPSL LPDICLHYNK GDGPFGSCSF 

       190        200        210        220        230        240 
QKQCIKLHIC QYFLQGECKF GTSCKRSHEF TNSESLEQLE RLGLSSDLVS RLLSTYRNAY 

       250        260        270        280        290        300 
DIKNKGSALS KVSPSPAGPQ GSSERKDSSG PVSPGTPSQE ESEQICLYHI RKSCSFQEKC 

       310        320        330        340        350        360 
HRVHFHLPYR WQFLDGGKWK DLDNMELIEE AYSNPSKDRI VYTESAAGFH FDNLDFNSMK 

       370        380        390        400        410        420 
FGNTLARRLS TASSVTKPPH FILTTDWIWY WMDEFGSWQE YGRQGSGHPV TTISSSDVER 

       430        440        450        460        470        480 
AYLAFCAPGA DAQAATLKFQ AGKHNYELHF KAFLQKNLVY GTIRKVCRRP KYVSPQDVQM 

       490        500        510        520        530        540 
KQSCNTKLHG PKSIPDYWDP AALPDLGFKK ITLSSSSEEY QKVWNIFNRT LPFYFVQKIE 

       550        560        570        580        590        600 
RIQNMGLWEV YQWQKCQMQK QNGGKEVDER QLFHGTSANF VDAICQQNFD WRVCGLHGTS 

       610        620        630        640        650        660 
YGKGSYFARD AAYSHHYSKS DTHSHMMFLA RVLVGDFVRG STSFVRPPAK EGQSNAFYDS 

       670        680        690        700        710 
CVNSMSDPTI FVVFEKHQVY PEYLIQYSTS SKPPASPSIF VALGNLFTSR Q

« Hide

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References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Vagina.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 321-711.
Tissue: Mammary tumor and Olfactory epithelium.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AK036886 mRNA. Translation: BAC29622.1.
BC024579 mRNA. Translation: AAH24579.1.
BC028906 mRNA. Translation: AAH28906.1.
BC048927 mRNA. Translation: AAH48927.1.
IPIIPI00227251.
RefSeqNP_766481.2.
UniGeneMm.268462

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ8BZ20.

PTM databases

PhosphoSiteQ8BZ20.

Proteomic databases

PRIDEQ8BZ20.

Genome annotation databases

EnsemblENSMUST00000038398; ENSMUSP00000039704; ENSMUSG00000038507; Mus musculus. [Genome view]
GeneID243771.
KEGGmmu:243771.

Organism-specific databases

CTD243771.
MGIMGI:2143990. Parp12.

Phylogenomic databases

HOVERGENQ8BZ20.

Enzyme and pathway databases

BRENDA2.4.2.30. 244.

Gene expression databases

ArrayExpressQ8BZ20.
BgeeQ8BZ20.
CleanExMM_PARP12.
GenevestigatorQ8BZ20.
GermOnlineENSMUSG00000038507. Mus musculus.

Family and domain databases

InterProIPR012317. PARP_catalytic.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamPF00644. PARP. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 2 hits.
PS50103. ZF_C3H1. 4 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio385918.
SOURCESearch...

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Entry information

Entry namePAR12_MOUSE
AccessionPrimary (citable) accession number: Q8BZ20
Secondary accession number(s): Q80VL6, Q8K333, Q8R3U2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: October 13, 2009
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents