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Protein

Poly [ADP-ribose] polymerase 12

Gene

Parp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 128C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri164 – 188C3H1-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri189 – 211C3H1-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 307C3H1-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri281 – 306C3H1-type 3PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 12 (EC:2.4.2.30)
Short name:
PARP-12
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 12
Short name:
ARTD12
Zinc finger CCCH domain-containing protein 1
Gene namesi
Name:Parp12
Synonyms:Zc3hdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2143990 Parp12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113421 – 711Poly [ADP-ribose] polymerase 12Add BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei268PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BZ20
PaxDbiQ8BZ20
PRIDEiQ8BZ20

PTM databases

iPTMnetiQ8BZ20
PhosphoSitePlusiQ8BZ20

Expressioni

Gene expression databases

BgeeiENSMUSG00000038507
CleanExiMM_PARP12
GenevisibleiQ8BZ20 MM

Interactioni

Protein-protein interaction databases

BioGridi232556, 2 interactors
STRINGi10090.ENSMUSP00000039704

Structurei

3D structure databases

ProteinModelPortaliQ8BZ20
SMRiQ8BZ20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini308 – 371WWE 1PROSITE-ProRule annotationAdd BLAST64
Domaini374 – 468WWE 2PROSITE-ProRule annotationAdd BLAST95
Domaini494 – 708PARP catalyticPROSITE-ProRule annotationAdd BLAST215

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi66 – 70Poly-Ala5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 128C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri164 – 188C3H1-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri189 – 211C3H1-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 307C3H1-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri281 – 306C3H1-type 3PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEI4 Eukaryota
ENOG410ZFB8 LUCA
GeneTreeiENSGT00760000119084
HOGENOMiHOG000236279
HOVERGENiHBG050384
InParanoidiQ8BZ20
KOiK15259
OMAiIKLHICQ
OrthoDBiEOG091G14UY
TreeFamiTF338389

Family and domain databases

Gene3Di3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004170 WWE-dom
IPR037197 WWE_dom_sf
IPR000571 Znf_CCCH
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PF02825 WWE, 1 hit
PF00642 zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 3 hits
SUPFAMiSSF117839 SSF117839, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit
PS50918 WWE, 2 hits
PS50103 ZF_C3H1, 4 hits

Sequencei

Sequence statusi: Complete.

Q8BZ20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAAVAVAE VTQLLCAAGG ALELAELRRR LRTSLGTDAL ERLLRDCGRF
60 70 80 90 100
VVASRAVVAV GAGREAAAAA SERLVLAVSS LRLCRAHQGP KPGCTGLCAQ
110 120 130 140 150
LHLCKFLIYG NCKFLKTGKN CRNGHNLKTD HNLSVLRTHG VDHLTYTELC
160 170 180 190 200
QLLLQNDPSL LPDICLHYNK GDGPFGSCSF QKQCIKLHIC QYFLQGECKF
210 220 230 240 250
GTSCKRSHEF TNSESLEQLE RLGLSSDLVS RLLSTYRNAY DIKNKGSALS
260 270 280 290 300
KVSPSPAGPQ GSSERKDSSG PVSPGTPSQE ESEQICLYHI RKSCSFQEKC
310 320 330 340 350
HRVHFHLPYR WQFLDGGKWK DLDNMELIEE AYSNPSKDRI VYTESAAGFH
360 370 380 390 400
FDNLDFNSMK FGNTLARRLS TASSVTKPPH FILTTDWIWY WMDEFGSWQE
410 420 430 440 450
YGRQGSGHPV TTISSSDVER AYLAFCAPGA DAQAATLKFQ AGKHNYELHF
460 470 480 490 500
KAFLQKNLVY GTIRKVCRRP KYVSPQDVQM KQSCNTKLHG PKSIPDYWDP
510 520 530 540 550
AALPDLGFKK ITLSSSSEEY QKVWNIFNRT LPFYFVQKIE RIQNMGLWEV
560 570 580 590 600
YQWQKCQMQK QNGGKEVDER QLFHGTSANF VDAICQQNFD WRVCGLHGTS
610 620 630 640 650
YGKGSYFARD AAYSHHYSKS DTHSHMMFLA RVLVGDFVRG STSFVRPPAK
660 670 680 690 700
EGQSNAFYDS CVNSMSDPTI FVVFEKHQVY PEYLIQYSTS SKPPASPSIF
710
VALGNLFTSR Q
Length:711
Mass (Da):79,917
Last modified:July 27, 2011 - v3
Checksum:i5172C6602CDDB4B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91K → I in BAC29622 (PubMed:16141072).Curated1
Sequence conflicti400E → K in BAC29622 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036886 mRNA Translation: BAC29622.1
CH466533 Genomic DNA Translation: EDL13617.1
BC120733 mRNA Translation: AAI20734.1
BC137645 mRNA Translation: AAI37646.1
BC024579 mRNA Translation: AAH24579.1
BC028906 mRNA Translation: AAH28906.1
BC048927 mRNA Translation: AAH48927.1
CCDSiCCDS20019.1
RefSeqiNP_766481.2, NM_172893.3
UniGeneiMm.268462

Genome annotation databases

EnsembliENSMUST00000038398; ENSMUSP00000039704; ENSMUSG00000038507
GeneIDi243771
KEGGimmu:243771
UCSCiuc009blg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPAR12_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ20
Secondary accession number(s): Q0VB94
, Q80VL6, Q8K333, Q8R3U2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health