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Q8BZ20

- PAR12_MOUSE

UniProt

Q8BZ20 - PAR12_MOUSE

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Protein
Poly [ADP-ribose] polymerase 12
Gene
Parp12, Zc3hdc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 12826C3H1-type 1
Add
BLAST
Zinc fingeri164 – 18825C3H1-type 2
Add
BLAST
Zinc fingeri189 – 21123C3H1-type 3
Add
BLAST
Zinc fingeri280 – 30728C3H1-type 4
Add
BLAST
Zinc fingeri281 – 30626C3H1-type 3
Add
BLAST

GO - Molecular functioni

  1. NAD+ ADP-ribosyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly [ADP-ribose] polymerase 12 (EC:2.4.2.30)
    Short name:
    PARP-12
    Alternative name(s):
    ADP-ribosyltransferase diphtheria toxin-like 12
    Short name:
    ARTD12
    Zinc finger CCCH domain-containing protein 1
    Gene namesi
    Name:Parp12
    Synonyms:Zc3hdc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2143990. Parp12.

    Subcellular locationi

    Nucleus Inferred

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 711711Poly [ADP-ribose] polymerase 12
    PRO_0000211342Add
    BLAST

    Proteomic databases

    MaxQBiQ8BZ20.
    PaxDbiQ8BZ20.
    PRIDEiQ8BZ20.

    PTM databases

    PhosphoSiteiQ8BZ20.

    Expressioni

    Gene expression databases

    BgeeiQ8BZ20.
    CleanExiMM_PARP12.
    GenevestigatoriQ8BZ20.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BZ20.
    SMRiQ8BZ20. Positions 11-240, 507-690.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini308 – 37164WWE 1
    Add
    BLAST
    Domaini374 – 46895WWE 2
    Add
    BLAST
    Domaini494 – 708215PARP catalytic
    Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi66 – 705Poly-Ala

    Sequence similaritiesi

    Contains 2 WWE domains.

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG83866.
    GeneTreeiENSGT00740000115062.
    HOGENOMiHOG000236279.
    HOVERGENiHBG050384.
    InParanoidiQ0VB94.
    KOiK15259.
    OMAiRWQFLDR.
    OrthoDBiEOG7P5T0J.
    TreeFamiTF338389.

    Family and domain databases

    Gene3Di3.90.228.10. 1 hit.
    InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
    IPR004170. WWE-dom.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PfamiPF00644. PARP. 1 hit.
    PF00642. zf-CCCH. 1 hit.
    [Graphical view]
    SMARTiSM00356. ZnF_C3H1. 3 hits.
    [Graphical view]
    PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
    PS50918. WWE. 2 hits.
    PS50103. ZF_C3H1. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BZ20-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQAAVAVAE VTQLLCAAGG ALELAELRRR LRTSLGTDAL ERLLRDCGRF    50
    VVASRAVVAV GAGREAAAAA SERLVLAVSS LRLCRAHQGP KPGCTGLCAQ 100
    LHLCKFLIYG NCKFLKTGKN CRNGHNLKTD HNLSVLRTHG VDHLTYTELC 150
    QLLLQNDPSL LPDICLHYNK GDGPFGSCSF QKQCIKLHIC QYFLQGECKF 200
    GTSCKRSHEF TNSESLEQLE RLGLSSDLVS RLLSTYRNAY DIKNKGSALS 250
    KVSPSPAGPQ GSSERKDSSG PVSPGTPSQE ESEQICLYHI RKSCSFQEKC 300
    HRVHFHLPYR WQFLDGGKWK DLDNMELIEE AYSNPSKDRI VYTESAAGFH 350
    FDNLDFNSMK FGNTLARRLS TASSVTKPPH FILTTDWIWY WMDEFGSWQE 400
    YGRQGSGHPV TTISSSDVER AYLAFCAPGA DAQAATLKFQ AGKHNYELHF 450
    KAFLQKNLVY GTIRKVCRRP KYVSPQDVQM KQSCNTKLHG PKSIPDYWDP 500
    AALPDLGFKK ITLSSSSEEY QKVWNIFNRT LPFYFVQKIE RIQNMGLWEV 550
    YQWQKCQMQK QNGGKEVDER QLFHGTSANF VDAICQQNFD WRVCGLHGTS 600
    YGKGSYFARD AAYSHHYSKS DTHSHMMFLA RVLVGDFVRG STSFVRPPAK 650
    EGQSNAFYDS CVNSMSDPTI FVVFEKHQVY PEYLIQYSTS SKPPASPSIF 700
    VALGNLFTSR Q 711
    Length:711
    Mass (Da):79,917
    Last modified:July 27, 2011 - v3
    Checksum:i5172C6602CDDB4B9
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911K → I in BAC29622. 1 Publication
    Sequence conflicti400 – 4001E → K in BAC29622. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036886 mRNA. Translation: BAC29622.1.
    CH466533 Genomic DNA. Translation: EDL13617.1.
    BC120733 mRNA. Translation: AAI20734.1.
    BC137645 mRNA. Translation: AAI37646.1.
    BC024579 mRNA. Translation: AAH24579.1.
    BC028906 mRNA. Translation: AAH28906.1.
    BC048927 mRNA. Translation: AAH48927.1.
    CCDSiCCDS20019.1.
    RefSeqiNP_766481.2. NM_172893.3.
    UniGeneiMm.268462.

    Genome annotation databases

    EnsembliENSMUST00000038398; ENSMUSP00000039704; ENSMUSG00000038507.
    GeneIDi243771.
    KEGGimmu:243771.
    UCSCiuc009blg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036886 mRNA. Translation: BAC29622.1 .
    CH466533 Genomic DNA. Translation: EDL13617.1 .
    BC120733 mRNA. Translation: AAI20734.1 .
    BC137645 mRNA. Translation: AAI37646.1 .
    BC024579 mRNA. Translation: AAH24579.1 .
    BC028906 mRNA. Translation: AAH28906.1 .
    BC048927 mRNA. Translation: AAH48927.1 .
    CCDSi CCDS20019.1.
    RefSeqi NP_766481.2. NM_172893.3.
    UniGenei Mm.268462.

    3D structure databases

    ProteinModelPortali Q8BZ20.
    SMRi Q8BZ20. Positions 11-240, 507-690.
    ModBasei Search...

    PTM databases

    PhosphoSitei Q8BZ20.

    Proteomic databases

    MaxQBi Q8BZ20.
    PaxDbi Q8BZ20.
    PRIDEi Q8BZ20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038398 ; ENSMUSP00000039704 ; ENSMUSG00000038507 .
    GeneIDi 243771.
    KEGGi mmu:243771.
    UCSCi uc009blg.2. mouse.

    Organism-specific databases

    CTDi 64761.
    MGIi MGI:2143990. Parp12.

    Phylogenomic databases

    eggNOGi NOG83866.
    GeneTreei ENSGT00740000115062.
    HOGENOMi HOG000236279.
    HOVERGENi HBG050384.
    InParanoidi Q0VB94.
    KOi K15259.
    OMAi RWQFLDR.
    OrthoDBi EOG7P5T0J.
    TreeFami TF338389.

    Miscellaneous databases

    ChiTaRSi PARP12. mouse.
    NextBioi 385918.
    PROi Q8BZ20.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BZ20.
    CleanExi MM_PARP12.
    Genevestigatori Q8BZ20.

    Family and domain databases

    Gene3Di 3.90.228.10. 1 hit.
    InterProi IPR012317. Poly(ADP-ribose)pol_cat_dom.
    IPR004170. WWE-dom.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    Pfami PF00644. PARP. 1 hit.
    PF00642. zf-CCCH. 1 hit.
    [Graphical view ]
    SMARTi SM00356. ZnF_C3H1. 3 hits.
    [Graphical view ]
    PROSITEi PS51059. PARP_CATALYTIC. 1 hit.
    PS50918. WWE. 2 hits.
    PS50103. ZF_C3H1. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Vagina.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Mammary tumor and Olfactory epithelium.

    Entry informationi

    Entry nameiPAR12_MOUSE
    AccessioniPrimary (citable) accession number: Q8BZ20
    Secondary accession number(s): Q0VB94
    , Q80VL6, Q8K333, Q8R3U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: July 27, 2011
    Last modified: July 9, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi