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Protein

Poly [ADP-ribose] polymerase 12

Gene

Parp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 12826C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 18825C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C3H1-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30728C3H1-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30626C3H1-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. NAD+ ADP-ribosyltransferase activity Source: UniProtKB-EC
  3. poly(A) RNA binding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 12 (EC:2.4.2.30)
Short name:
PARP-12
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 12
Short name:
ARTD12
Zinc finger CCCH domain-containing protein 1
Gene namesi
Name:Parp12
Synonyms:Zc3hdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2143990. Parp12.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711Poly [ADP-ribose] polymerase 12PRO_0000211342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei268 – 2681PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BZ20.
PaxDbiQ8BZ20.
PRIDEiQ8BZ20.

PTM databases

PhosphoSiteiQ8BZ20.

Expressioni

Gene expression databases

BgeeiQ8BZ20.
CleanExiMM_PARP12.
GenevestigatoriQ8BZ20.

Structurei

3D structure databases

ProteinModelPortaliQ8BZ20.
SMRiQ8BZ20. Positions 11-240, 507-690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini308 – 37164WWE 1PROSITE-ProRule annotationAdd
BLAST
Domaini374 – 46895WWE 2PROSITE-ProRule annotationAdd
BLAST
Domaini494 – 708215PARP catalyticPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi66 – 705Poly-Ala

Sequence similaritiesi

Contains 4 C3H1-type zinc fingers.PROSITE-ProRule annotation
Contains 1 PARP catalytic domain.PROSITE-ProRule annotation
Contains 2 WWE domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 12826C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 18825C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri189 – 21123C3H1-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30728C3H1-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30626C3H1-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG83866.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000236279.
HOVERGENiHBG050384.
InParanoidiQ8BZ20.
KOiK15259.
OMAiRWQFLDR.
OrthoDBiEOG7P5T0J.
TreeFamiTF338389.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 2 hits.
PS50103. ZF_C3H1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZ20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAAVAVAE VTQLLCAAGG ALELAELRRR LRTSLGTDAL ERLLRDCGRF
60 70 80 90 100
VVASRAVVAV GAGREAAAAA SERLVLAVSS LRLCRAHQGP KPGCTGLCAQ
110 120 130 140 150
LHLCKFLIYG NCKFLKTGKN CRNGHNLKTD HNLSVLRTHG VDHLTYTELC
160 170 180 190 200
QLLLQNDPSL LPDICLHYNK GDGPFGSCSF QKQCIKLHIC QYFLQGECKF
210 220 230 240 250
GTSCKRSHEF TNSESLEQLE RLGLSSDLVS RLLSTYRNAY DIKNKGSALS
260 270 280 290 300
KVSPSPAGPQ GSSERKDSSG PVSPGTPSQE ESEQICLYHI RKSCSFQEKC
310 320 330 340 350
HRVHFHLPYR WQFLDGGKWK DLDNMELIEE AYSNPSKDRI VYTESAAGFH
360 370 380 390 400
FDNLDFNSMK FGNTLARRLS TASSVTKPPH FILTTDWIWY WMDEFGSWQE
410 420 430 440 450
YGRQGSGHPV TTISSSDVER AYLAFCAPGA DAQAATLKFQ AGKHNYELHF
460 470 480 490 500
KAFLQKNLVY GTIRKVCRRP KYVSPQDVQM KQSCNTKLHG PKSIPDYWDP
510 520 530 540 550
AALPDLGFKK ITLSSSSEEY QKVWNIFNRT LPFYFVQKIE RIQNMGLWEV
560 570 580 590 600
YQWQKCQMQK QNGGKEVDER QLFHGTSANF VDAICQQNFD WRVCGLHGTS
610 620 630 640 650
YGKGSYFARD AAYSHHYSKS DTHSHMMFLA RVLVGDFVRG STSFVRPPAK
660 670 680 690 700
EGQSNAFYDS CVNSMSDPTI FVVFEKHQVY PEYLIQYSTS SKPPASPSIF
710
VALGNLFTSR Q
Length:711
Mass (Da):79,917
Last modified:July 27, 2011 - v3
Checksum:i5172C6602CDDB4B9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911K → I in BAC29622 (PubMed:16141072).Curated
Sequence conflicti400 – 4001E → K in BAC29622 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036886 mRNA. Translation: BAC29622.1.
CH466533 Genomic DNA. Translation: EDL13617.1.
BC120733 mRNA. Translation: AAI20734.1.
BC137645 mRNA. Translation: AAI37646.1.
BC024579 mRNA. Translation: AAH24579.1.
BC028906 mRNA. Translation: AAH28906.1.
BC048927 mRNA. Translation: AAH48927.1.
CCDSiCCDS20019.1.
RefSeqiNP_766481.2. NM_172893.3.
UniGeneiMm.268462.

Genome annotation databases

EnsembliENSMUST00000038398; ENSMUSP00000039704; ENSMUSG00000038507.
GeneIDi243771.
KEGGimmu:243771.
UCSCiuc009blg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036886 mRNA. Translation: BAC29622.1.
CH466533 Genomic DNA. Translation: EDL13617.1.
BC120733 mRNA. Translation: AAI20734.1.
BC137645 mRNA. Translation: AAI37646.1.
BC024579 mRNA. Translation: AAH24579.1.
BC028906 mRNA. Translation: AAH28906.1.
BC048927 mRNA. Translation: AAH48927.1.
CCDSiCCDS20019.1.
RefSeqiNP_766481.2. NM_172893.3.
UniGeneiMm.268462.

3D structure databases

ProteinModelPortaliQ8BZ20.
SMRiQ8BZ20. Positions 11-240, 507-690.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8BZ20.

Proteomic databases

MaxQBiQ8BZ20.
PaxDbiQ8BZ20.
PRIDEiQ8BZ20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038398; ENSMUSP00000039704; ENSMUSG00000038507.
GeneIDi243771.
KEGGimmu:243771.
UCSCiuc009blg.2. mouse.

Organism-specific databases

CTDi64761.
MGIiMGI:2143990. Parp12.

Phylogenomic databases

eggNOGiNOG83866.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000236279.
HOVERGENiHBG050384.
InParanoidiQ8BZ20.
KOiK15259.
OMAiRWQFLDR.
OrthoDBiEOG7P5T0J.
TreeFamiTF338389.

Miscellaneous databases

NextBioi385918.
PROiQ8BZ20.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BZ20.
CleanExiMM_PARP12.
GenevestigatoriQ8BZ20.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 2 hits.
PS50103. ZF_C3H1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Vagina.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Mammary tumor and Olfactory epithelium.

Entry informationi

Entry nameiPAR12_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ20
Secondary accession number(s): Q0VB94
, Q80VL6, Q8K333, Q8R3U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: July 27, 2011
Last modified: March 4, 2015
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.