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Q8BZ20

- PAR12_MOUSE

UniProt

Q8BZ20 - PAR12_MOUSE

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Protein

Poly [ADP-ribose] polymerase 12

Gene
Parp12, Zc3hdc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 12826C3H1-type 1Add
BLAST
Zinc fingeri164 – 18825C3H1-type 2Add
BLAST
Zinc fingeri189 – 21123C3H1-type 3Add
BLAST
Zinc fingeri280 – 30728C3H1-type 4Add
BLAST
Zinc fingeri281 – 30626C3H1-type 3Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. NAD+ ADP-ribosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 12 (EC:2.4.2.30)
Short name:
PARP-12
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 12
Short name:
ARTD12
Zinc finger CCCH domain-containing protein 1
Gene namesi
Name:Parp12
Synonyms:Zc3hdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2143990. Parp12.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711Poly [ADP-ribose] polymerase 12PRO_0000211342Add
BLAST

Proteomic databases

MaxQBiQ8BZ20.
PaxDbiQ8BZ20.
PRIDEiQ8BZ20.

PTM databases

PhosphoSiteiQ8BZ20.

Expressioni

Gene expression databases

BgeeiQ8BZ20.
CleanExiMM_PARP12.
GenevestigatoriQ8BZ20.

Structurei

3D structure databases

ProteinModelPortaliQ8BZ20.
SMRiQ8BZ20. Positions 11-240, 507-690.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini308 – 37164WWE 1Add
BLAST
Domaini374 – 46895WWE 2Add
BLAST
Domaini494 – 708215PARP catalyticAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi66 – 705Poly-Ala

Sequence similaritiesi

Contains 2 WWE domains.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri103 – 12826C3H1-type 1Add
BLAST
Zinc fingeri164 – 18825C3H1-type 2Add
BLAST
Zinc fingeri189 – 21123C3H1-type 3Add
BLAST
Zinc fingeri280 – 30728C3H1-type 4Add
BLAST
Zinc fingeri281 – 30626C3H1-type 3Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG83866.
GeneTreeiENSGT00740000115062.
HOGENOMiHOG000236279.
HOVERGENiHBG050384.
InParanoidiQ0VB94.
KOiK15259.
OMAiRWQFLDR.
OrthoDBiEOG7P5T0J.
TreeFamiTF338389.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 2 hits.
PS50103. ZF_C3H1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZ20-1 [UniParc]FASTAAdd to Basket

« Hide

MAQAAVAVAE VTQLLCAAGG ALELAELRRR LRTSLGTDAL ERLLRDCGRF    50
VVASRAVVAV GAGREAAAAA SERLVLAVSS LRLCRAHQGP KPGCTGLCAQ 100
LHLCKFLIYG NCKFLKTGKN CRNGHNLKTD HNLSVLRTHG VDHLTYTELC 150
QLLLQNDPSL LPDICLHYNK GDGPFGSCSF QKQCIKLHIC QYFLQGECKF 200
GTSCKRSHEF TNSESLEQLE RLGLSSDLVS RLLSTYRNAY DIKNKGSALS 250
KVSPSPAGPQ GSSERKDSSG PVSPGTPSQE ESEQICLYHI RKSCSFQEKC 300
HRVHFHLPYR WQFLDGGKWK DLDNMELIEE AYSNPSKDRI VYTESAAGFH 350
FDNLDFNSMK FGNTLARRLS TASSVTKPPH FILTTDWIWY WMDEFGSWQE 400
YGRQGSGHPV TTISSSDVER AYLAFCAPGA DAQAATLKFQ AGKHNYELHF 450
KAFLQKNLVY GTIRKVCRRP KYVSPQDVQM KQSCNTKLHG PKSIPDYWDP 500
AALPDLGFKK ITLSSSSEEY QKVWNIFNRT LPFYFVQKIE RIQNMGLWEV 550
YQWQKCQMQK QNGGKEVDER QLFHGTSANF VDAICQQNFD WRVCGLHGTS 600
YGKGSYFARD AAYSHHYSKS DTHSHMMFLA RVLVGDFVRG STSFVRPPAK 650
EGQSNAFYDS CVNSMSDPTI FVVFEKHQVY PEYLIQYSTS SKPPASPSIF 700
VALGNLFTSR Q 711
Length:711
Mass (Da):79,917
Last modified:July 27, 2011 - v3
Checksum:i5172C6602CDDB4B9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911K → I in BAC29622. 1 Publication
Sequence conflicti400 – 4001E → K in BAC29622. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036886 mRNA. Translation: BAC29622.1.
CH466533 Genomic DNA. Translation: EDL13617.1.
BC120733 mRNA. Translation: AAI20734.1.
BC137645 mRNA. Translation: AAI37646.1.
BC024579 mRNA. Translation: AAH24579.1.
BC028906 mRNA. Translation: AAH28906.1.
BC048927 mRNA. Translation: AAH48927.1.
CCDSiCCDS20019.1.
RefSeqiNP_766481.2. NM_172893.3.
UniGeneiMm.268462.

Genome annotation databases

EnsembliENSMUST00000038398; ENSMUSP00000039704; ENSMUSG00000038507.
GeneIDi243771.
KEGGimmu:243771.
UCSCiuc009blg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036886 mRNA. Translation: BAC29622.1 .
CH466533 Genomic DNA. Translation: EDL13617.1 .
BC120733 mRNA. Translation: AAI20734.1 .
BC137645 mRNA. Translation: AAI37646.1 .
BC024579 mRNA. Translation: AAH24579.1 .
BC028906 mRNA. Translation: AAH28906.1 .
BC048927 mRNA. Translation: AAH48927.1 .
CCDSi CCDS20019.1.
RefSeqi NP_766481.2. NM_172893.3.
UniGenei Mm.268462.

3D structure databases

ProteinModelPortali Q8BZ20.
SMRi Q8BZ20. Positions 11-240, 507-690.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BZ20.

Proteomic databases

MaxQBi Q8BZ20.
PaxDbi Q8BZ20.
PRIDEi Q8BZ20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038398 ; ENSMUSP00000039704 ; ENSMUSG00000038507 .
GeneIDi 243771.
KEGGi mmu:243771.
UCSCi uc009blg.2. mouse.

Organism-specific databases

CTDi 64761.
MGIi MGI:2143990. Parp12.

Phylogenomic databases

eggNOGi NOG83866.
GeneTreei ENSGT00740000115062.
HOGENOMi HOG000236279.
HOVERGENi HBG050384.
InParanoidi Q0VB94.
KOi K15259.
OMAi RWQFLDR.
OrthoDBi EOG7P5T0J.
TreeFami TF338389.

Miscellaneous databases

ChiTaRSi PARP12. mouse.
NextBioi 385918.
PROi Q8BZ20.
SOURCEi Search...

Gene expression databases

Bgeei Q8BZ20.
CleanExi MM_PARP12.
Genevestigatori Q8BZ20.

Family and domain databases

Gene3Di 3.90.228.10. 1 hit.
InterProi IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view ]
Pfami PF00644. PARP. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view ]
SMARTi SM00356. ZnF_C3H1. 3 hits.
[Graphical view ]
PROSITEi PS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 2 hits.
PS50103. ZF_C3H1. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Vagina.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Mammary tumor and Olfactory epithelium.

Entry informationi

Entry nameiPAR12_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ20
Secondary accession number(s): Q0VB94
, Q80VL6, Q8K333, Q8R3U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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