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Q8BZ09

- ODC_MOUSE

UniProt

Q8BZ09 - ODC_MOUSE

Protein

Mitochondrial 2-oxodicarboxylate carrier

Gene

Slc25a21

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate By similarity.By similarity

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial 2-oxodicarboxylate carrier
    Alternative name(s):
    Solute carrier family 25 member 21
    Gene namesi
    Name:Slc25a21
    Synonyms:Odc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:2445059. Slc25a21.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298Mitochondrial 2-oxodicarboxylate carrierPRO_0000090645Add
    BLAST

    Proteomic databases

    MaxQBiQ8BZ09.
    PaxDbiQ8BZ09.
    PRIDEiQ8BZ09.

    PTM databases

    PhosphoSiteiQ8BZ09.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BZ09.
    BgeeiQ8BZ09.
    GenevestigatoriQ8BZ09.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000039289.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BZ09.
    SMRiQ8BZ09. Positions 18-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei69 – 8820Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati10 – 9990Solcar 1Add
    BLAST
    Repeati106 – 19590Solcar 2Add
    BLAST
    Repeati204 – 29390Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG325140.
    GeneTreeiENSGT00730000111119.
    HOVERGENiHBG105598.
    InParanoidiQ8BZ09.
    KOiK15110.
    OrthoDBiEOG74N5H8.
    TreeFamiTF314035.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BZ09-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSASNVSLLH ETSRQVAAGG SAGLVEICLM HPLDVVKTRF QVQRSVTDPQ    50
    SYRTVRGSFQ MIFRTEGLFG FYKGIIPPIL AETPKRAVKF STFELYKKFL 100
    GYMSLSPGLT FLIAGLGSGL TEAVVVNPFE VVKVGLQVNR NLFKEQPSTF 150
    AYARQIIKKE GLGFQGLNKG LTATLGRHGI FNMVYFGFYH NVKNIIPSSK 200
    DPTLEFLRKF GIGFVSGTMG SVFNIPFDVA KSRIQGPQPV PGEIKYRSCF 250
    KTMEMIYREE GILALYKGLV PKVMRLGPGG GVMLLVYEYT YAWLQENW 298
    Length:298
    Mass (Da):33,229
    Last modified:March 1, 2003 - v1
    Checksum:i69D73C860216E2BD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti168 – 1681N → D in BAC31036. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036988 mRNA. Translation: BAC29659.1.
    AK041694 mRNA. Translation: BAC31036.1.
    BC057980 mRNA. Translation: AAH57980.1.
    CCDSiCCDS25925.1.
    RefSeqiNP_766165.2. NM_172577.3.
    UniGeneiMm.32835.

    Genome annotation databases

    EnsembliENSMUST00000044634; ENSMUSP00000039289; ENSMUSG00000035472.
    GeneIDi217593.
    KEGGimmu:217593.
    UCSCiuc007npj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036988 mRNA. Translation: BAC29659.1 .
    AK041694 mRNA. Translation: BAC31036.1 .
    BC057980 mRNA. Translation: AAH57980.1 .
    CCDSi CCDS25925.1.
    RefSeqi NP_766165.2. NM_172577.3.
    UniGenei Mm.32835.

    3D structure databases

    ProteinModelPortali Q8BZ09.
    SMRi Q8BZ09. Positions 18-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000039289.

    PTM databases

    PhosphoSitei Q8BZ09.

    Proteomic databases

    MaxQBi Q8BZ09.
    PaxDbi Q8BZ09.
    PRIDEi Q8BZ09.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044634 ; ENSMUSP00000039289 ; ENSMUSG00000035472 .
    GeneIDi 217593.
    KEGGi mmu:217593.
    UCSCi uc007npj.2. mouse.

    Organism-specific databases

    CTDi 89874.
    MGIi MGI:2445059. Slc25a21.

    Phylogenomic databases

    eggNOGi NOG325140.
    GeneTreei ENSGT00730000111119.
    HOVERGENi HBG105598.
    InParanoidi Q8BZ09.
    KOi K15110.
    OrthoDBi EOG74N5H8.
    TreeFami TF314035.

    Miscellaneous databases

    ChiTaRSi SLC25A21. mouse.
    NextBioi 375903.
    PROi Q8BZ09.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BZ09.
    Bgeei Q8BZ09.
    Genevestigatori Q8BZ09.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus and Vagina.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiODC_MOUSE
    AccessioniPrimary (citable) accession number: Q8BZ09
    Secondary accession number(s): Q8BY72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3