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Protein

Mitochondrial 2-oxodicarboxylate carrier

Gene

Slc25a21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-71064. Lysine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 21
Gene namesi
Name:Slc25a21
Synonyms:Odc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2445059. Slc25a21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei69 – 88Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei276 – 296Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906451 – 298Mitochondrial 2-oxodicarboxylate carrierAdd BLAST298

Proteomic databases

MaxQBiQ8BZ09.
PaxDbiQ8BZ09.
PRIDEiQ8BZ09.

PTM databases

PhosphoSitePlusiQ8BZ09.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035472.
ExpressionAtlasiQ8BZ09. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106308.

Structurei

3D structure databases

ProteinModelPortaliQ8BZ09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 99Solcar 1Add BLAST90
Repeati106 – 195Solcar 2Add BLAST90
Repeati204 – 293Solcar 3Add BLAST90

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0754. Eukaryota.
ENOG410XRZG. LUCA.
GeneTreeiENSGT00730000111119.
HOVERGENiHBG105598.
InParanoidiQ8BZ09.
KOiK15110.
TreeFamiTF314035.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZ09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASNVSLLH ETSRQVAAGG SAGLVEICLM HPLDVVKTRF QVQRSVTDPQ
60 70 80 90 100
SYRTVRGSFQ MIFRTEGLFG FYKGIIPPIL AETPKRAVKF STFELYKKFL
110 120 130 140 150
GYMSLSPGLT FLIAGLGSGL TEAVVVNPFE VVKVGLQVNR NLFKEQPSTF
160 170 180 190 200
AYARQIIKKE GLGFQGLNKG LTATLGRHGI FNMVYFGFYH NVKNIIPSSK
210 220 230 240 250
DPTLEFLRKF GIGFVSGTMG SVFNIPFDVA KSRIQGPQPV PGEIKYRSCF
260 270 280 290
KTMEMIYREE GILALYKGLV PKVMRLGPGG GVMLLVYEYT YAWLQENW
Length:298
Mass (Da):33,229
Last modified:March 1, 2003 - v1
Checksum:i69D73C860216E2BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168N → D in BAC31036 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036988 mRNA. Translation: BAC29659.1.
AK041694 mRNA. Translation: BAC31036.1.
BC057980 mRNA. Translation: AAH57980.1.
CCDSiCCDS25925.1.
RefSeqiNP_766165.2. NM_172577.3.
UniGeneiMm.32835.

Genome annotation databases

EnsembliENSMUST00000044634; ENSMUSP00000039289; ENSMUSG00000035472.
GeneIDi217593.
KEGGimmu:217593.
UCSCiuc007npj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036988 mRNA. Translation: BAC29659.1.
AK041694 mRNA. Translation: BAC31036.1.
BC057980 mRNA. Translation: AAH57980.1.
CCDSiCCDS25925.1.
RefSeqiNP_766165.2. NM_172577.3.
UniGeneiMm.32835.

3D structure databases

ProteinModelPortaliQ8BZ09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106308.

PTM databases

PhosphoSitePlusiQ8BZ09.

Proteomic databases

MaxQBiQ8BZ09.
PaxDbiQ8BZ09.
PRIDEiQ8BZ09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044634; ENSMUSP00000039289; ENSMUSG00000035472.
GeneIDi217593.
KEGGimmu:217593.
UCSCiuc007npj.2. mouse.

Organism-specific databases

CTDi89874.
MGIiMGI:2445059. Slc25a21.

Phylogenomic databases

eggNOGiKOG0754. Eukaryota.
ENOG410XRZG. LUCA.
GeneTreeiENSGT00730000111119.
HOVERGENiHBG105598.
InParanoidiQ8BZ09.
KOiK15110.
TreeFamiTF314035.

Enzyme and pathway databases

ReactomeiR-MMU-71064. Lysine catabolism.

Miscellaneous databases

ChiTaRSiSlc25a21. mouse.
PROiQ8BZ09.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035472.
ExpressionAtlasiQ8BZ09. baseline and differential.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiODC_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ09
Secondary accession number(s): Q8BY72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.