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Protein

Mitochondrial 2-oxodicarboxylate carrier

Gene

Slc25a21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-71064 Lysine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 21
Gene namesi
Name:Slc25a21
Synonyms:Odc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2445059 Slc25a21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei69 – 88Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei276 – 296Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906451 – 298Mitochondrial 2-oxodicarboxylate carrierAdd BLAST298

Proteomic databases

MaxQBiQ8BZ09
PaxDbiQ8BZ09
PRIDEiQ8BZ09

PTM databases

PhosphoSitePlusiQ8BZ09

Expressioni

Gene expression databases

BgeeiENSMUSG00000035472
ExpressionAtlasiQ8BZ09 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106308

Structurei

3D structure databases

ProteinModelPortaliQ8BZ09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 99Solcar 1Add BLAST90
Repeati106 – 195Solcar 2Add BLAST90
Repeati204 – 293Solcar 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0754 Eukaryota
ENOG410XRZG LUCA
GeneTreeiENSGT00730000111119
HOVERGENiHBG105598
InParanoidiQ8BZ09
KOiK15110
TreeFamiTF314035

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q8BZ09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASNVSLLH ETSRQVAAGG SAGLVEICLM HPLDVVKTRF QVQRSVTDPQ
60 70 80 90 100
SYRTVRGSFQ MIFRTEGLFG FYKGIIPPIL AETPKRAVKF STFELYKKFL
110 120 130 140 150
GYMSLSPGLT FLIAGLGSGL TEAVVVNPFE VVKVGLQVNR NLFKEQPSTF
160 170 180 190 200
AYARQIIKKE GLGFQGLNKG LTATLGRHGI FNMVYFGFYH NVKNIIPSSK
210 220 230 240 250
DPTLEFLRKF GIGFVSGTMG SVFNIPFDVA KSRIQGPQPV PGEIKYRSCF
260 270 280 290
KTMEMIYREE GILALYKGLV PKVMRLGPGG GVMLLVYEYT YAWLQENW
Length:298
Mass (Da):33,229
Last modified:March 1, 2003 - v1
Checksum:i69D73C860216E2BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168N → D in BAC31036 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036988 mRNA Translation: BAC29659.1
AK041694 mRNA Translation: BAC31036.1
BC057980 mRNA Translation: AAH57980.1
CCDSiCCDS25925.1
RefSeqiNP_766165.2, NM_172577.3
UniGeneiMm.32835

Genome annotation databases

EnsembliENSMUST00000044634; ENSMUSP00000039289; ENSMUSG00000035472
GeneIDi217593
KEGGimmu:217593
UCSCiuc007npj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiODC_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ09
Secondary accession number(s): Q8BY72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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