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Protein

Mitochondrial 2-oxodicarboxylate carrier

Gene

Slc25a21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate (By similarity).By similarity

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_239844. Lysine catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 21
Gene namesi
Name:Slc25a21
Synonyms:Odc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:2445059. Slc25a21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei69 – 8820Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Mitochondrial 2-oxodicarboxylate carrierPRO_0000090645Add
BLAST

Proteomic databases

MaxQBiQ8BZ09.
PaxDbiQ8BZ09.
PRIDEiQ8BZ09.

PTM databases

PhosphoSiteiQ8BZ09.

Expressioni

Gene expression databases

BgeeiQ8BZ09.
ExpressionAtlasiQ8BZ09. baseline and differential.
GenevestigatoriQ8BZ09.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039289.

Structurei

3D structure databases

ProteinModelPortaliQ8BZ09.
SMRiQ8BZ09. Positions 18-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati10 – 9990Solcar 1Add
BLAST
Repeati106 – 19590Solcar 2Add
BLAST
Repeati204 – 29390Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG325140.
GeneTreeiENSGT00730000111119.
HOVERGENiHBG105598.
InParanoidiQ8BZ09.
KOiK15110.
OrthoDBiEOG74N5H8.
TreeFamiTF314035.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BZ09-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSASNVSLLH ETSRQVAAGG SAGLVEICLM HPLDVVKTRF QVQRSVTDPQ
60 70 80 90 100
SYRTVRGSFQ MIFRTEGLFG FYKGIIPPIL AETPKRAVKF STFELYKKFL
110 120 130 140 150
GYMSLSPGLT FLIAGLGSGL TEAVVVNPFE VVKVGLQVNR NLFKEQPSTF
160 170 180 190 200
AYARQIIKKE GLGFQGLNKG LTATLGRHGI FNMVYFGFYH NVKNIIPSSK
210 220 230 240 250
DPTLEFLRKF GIGFVSGTMG SVFNIPFDVA KSRIQGPQPV PGEIKYRSCF
260 270 280 290
KTMEMIYREE GILALYKGLV PKVMRLGPGG GVMLLVYEYT YAWLQENW
Length:298
Mass (Da):33,229
Last modified:March 1, 2003 - v1
Checksum:i69D73C860216E2BD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681N → D in BAC31036. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036988 mRNA. Translation: BAC29659.1.
AK041694 mRNA. Translation: BAC31036.1.
BC057980 mRNA. Translation: AAH57980.1.
CCDSiCCDS25925.1.
RefSeqiNP_766165.2. NM_172577.3.
UniGeneiMm.32835.

Genome annotation databases

EnsembliENSMUST00000044634; ENSMUSP00000039289; ENSMUSG00000035472.
GeneIDi217593.
KEGGimmu:217593.
UCSCiuc007npj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036988 mRNA. Translation: BAC29659.1.
AK041694 mRNA. Translation: BAC31036.1.
BC057980 mRNA. Translation: AAH57980.1.
CCDSiCCDS25925.1.
RefSeqiNP_766165.2. NM_172577.3.
UniGeneiMm.32835.

3D structure databases

ProteinModelPortaliQ8BZ09.
SMRiQ8BZ09. Positions 18-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039289.

PTM databases

PhosphoSiteiQ8BZ09.

Proteomic databases

MaxQBiQ8BZ09.
PaxDbiQ8BZ09.
PRIDEiQ8BZ09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044634; ENSMUSP00000039289; ENSMUSG00000035472.
GeneIDi217593.
KEGGimmu:217593.
UCSCiuc007npj.2. mouse.

Organism-specific databases

CTDi89874.
MGIiMGI:2445059. Slc25a21.

Phylogenomic databases

eggNOGiNOG325140.
GeneTreeiENSGT00730000111119.
HOVERGENiHBG105598.
InParanoidiQ8BZ09.
KOiK15110.
OrthoDBiEOG74N5H8.
TreeFamiTF314035.

Enzyme and pathway databases

ReactomeiREACT_239844. Lysine catabolism.

Miscellaneous databases

ChiTaRSiSlc25a21. mouse.
NextBioi375903.
PROiQ8BZ09.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BZ09.
ExpressionAtlasiQ8BZ09. baseline and differential.
GenevestigatoriQ8BZ09.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus and Vagina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiODC_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ09
Secondary accession number(s): Q8BY72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.