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Q8BZ09 (ODC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial 2-oxodicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 21
Gene names
Name:Slc25a21
Synonyms:Odc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298Mitochondrial 2-oxodicarboxylate carrier
PRO_0000090645

Regions

Transmembrane16 – 3621Helical; Name=1; Potential
Transmembrane69 – 8820Helical; Name=2; Potential
Transmembrane112 – 13221Helical; Name=3; Potential
Transmembrane166 – 18621Helical; Name=4; Potential
Transmembrane204 – 22421Helical; Name=5; Potential
Transmembrane276 – 29621Helical; Name=6; Potential
Repeat10 – 9990Solcar 1
Repeat106 – 19590Solcar 2
Repeat204 – 29390Solcar 3

Experimental info

Sequence conflict1681N → D in BAC31036. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BZ09 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 69D73C860216E2BD

FASTA29833,229
        10         20         30         40         50         60 
MSASNVSLLH ETSRQVAAGG SAGLVEICLM HPLDVVKTRF QVQRSVTDPQ SYRTVRGSFQ 

        70         80         90        100        110        120 
MIFRTEGLFG FYKGIIPPIL AETPKRAVKF STFELYKKFL GYMSLSPGLT FLIAGLGSGL 

       130        140        150        160        170        180 
TEAVVVNPFE VVKVGLQVNR NLFKEQPSTF AYARQIIKKE GLGFQGLNKG LTATLGRHGI 

       190        200        210        220        230        240 
FNMVYFGFYH NVKNIIPSSK DPTLEFLRKF GIGFVSGTMG SVFNIPFDVA KSRIQGPQPV 

       250        260        270        280        290 
PGEIKYRSCF KTMEMIYREE GILALYKGLV PKVMRLGPGG GVMLLVYEYT YAWLQENW 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus and Vagina.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK036988 mRNA. Translation: BAC29659.1.
AK041694 mRNA. Translation: BAC31036.1.
BC057980 mRNA. Translation: AAH57980.1.
RefSeqNP_766165.2. NM_172577.3.
UniGeneMm.32835.

3D structure databases

ProteinModelPortalQ8BZ09.
SMRQ8BZ09. Positions 11-288.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000039289.

PTM databases

PhosphoSiteQ8BZ09.

Proteomic databases

PaxDbQ8BZ09.
PRIDEQ8BZ09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044634; ENSMUSP00000039289; ENSMUSG00000035472.
GeneID217593.
KEGGmmu:217593.
UCSCuc007npj.2. mouse.

Organism-specific databases

CTD89874.
MGIMGI:2445059. Slc25a21.

Phylogenomic databases

eggNOGNOG325140.
GeneTreeENSGT00730000111119.
HOVERGENHBG105598.
InParanoidQ8BZ09.
KOK15110.
OrthoDBEOG74N5H8.
TreeFamTF314035.

Gene expression databases

ArrayExpressQ8BZ09.
BgeeQ8BZ09.
GenevestigatorQ8BZ09.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC25A21. mouse.
NextBio375903.
PROQ8BZ09.
SOURCESearch...

Entry information

Entry nameODC_MOUSE
AccessionPrimary (citable) accession number: Q8BZ09
Secondary accession number(s): Q8BY72
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: March 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot