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Q8BZ00

- SL9A9_MOUSE

UniProt

Q8BZ00 - SL9A9_MOUSE

Protein

Sodium/hydrogen exchanger 9

Gene

Slc9a9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May act in electroneutral exchange of protons for Na+ across membranes. Involved in the effusion of Golgi luminal H+ in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell By similarity.By similarity

    GO - Molecular functioni

    1. sodium:proton antiporter activity Source: InterPro

    GO - Biological processi

    1. regulation of pH Source: InterPro

    Keywords - Biological processi

    Antiport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/hydrogen exchanger 9
    Alternative name(s):
    Na(+)/H(+) exchanger 9
    Short name:
    NHE-9
    Solute carrier family 9 member 9
    Gene namesi
    Name:Slc9a9
    Synonyms:Nhe9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2679732. Slc9a9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. late endosome membrane Source: UniProtKB-SubCell
    3. recycling endosome Source: Ensembl

    Keywords - Cellular componenti

    Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 644644Sodium/hydrogen exchanger 9PRO_0000052368Add
    BLAST

    Proteomic databases

    PRIDEiQ8BZ00.

    PTM databases

    PhosphoSiteiQ8BZ00.

    Expressioni

    Gene expression databases

    BgeeiQ8BZ00.
    GenevestigatoriQ8BZ00.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BZ00.
    SMRiQ8BZ00. Positions 202-230, 320-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei46 – 6621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei365 – 38521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei387 – 40721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei430 – 45021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei467 – 48721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0025.
    GeneTreeiENSGT00560000076802.
    HOGENOMiHOG000172307.
    HOVERGENiHBG055575.
    InParanoidiQ8BZ00.
    KOiK14725.
    OMAiFAMGSAY.
    OrthoDBiEOG7NW69D.
    PhylomeDBiQ8BZ00.
    TreeFamiTF318755.

    Family and domain databases

    InterProiIPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR002090. Na/H_exchanger_6.
    IPR018416. Na/H_exchanger_9.
    IPR004709. NaH_exchanger.
    [Graphical view]
    PANTHERiPTHR10110. PTHR10110. 1 hit.
    PTHR10110:SF61. PTHR10110:SF61. 1 hit.
    PfamiPF00999. Na_H_Exchanger. 1 hit.
    [Graphical view]
    PRINTSiPR01084. NAHEXCHNGR.
    PR01088. NAHEXCHNGR6.
    TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8BZ00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGQLRFTSG KDEDHFQHQG AVELLAFNFL LILTILTIWL FKNHRFRFLH    50
    ETGGAMVYGL IMGLILRYAT APTDIDSGTV YNCGNLFFSP STLLVNITDQ 100
    VYEYKYQREI NQHNISPHQG NAILEKMTFD PEIFFNVLLP PIIFHAGYSL 150
    KKRHFFQNLG SILTYAFLGT AISCVVIGLI MYGFVKAMVH AGQLKSGDFH 200
    FTDCLFFGSL MSATDPVTVL AIFHELHVDP DLYTLLFGES VLNDAVAIVL 250
    TYSISIYSPK ENPNAFDTAA FFQSVGNFLG IFAGSFAMGS AYAVVTALLT 300
    KFTKLREFPM LETGLFFLLS WSAFLSAEAA GLTGIVAVLF CGVTQAHYTY 350
    NNLSSDSKLR TKQLFEFMNF LAENVIFCYM GLALFTFQNH IFNALFILGA 400
    FLAIFVARAC NIYPLSFLLN LGRKQKIPWN FQHMMMFSGL RGAIAFALAI 450
    RNTESQPKQM MFTTTLLLVF FTVWVFGGGT TPMLTWLQIR VGVDLDESLK 500
    EEPSSQQEAN KLDKNMTKTE SAQLFRMWYG FDHKYLKPIL THSGPPLTTT 550
    LPAWCGPVSR LLTSPQAYGE QLKEDDVECI VNQDELAMNY QEQSPSPSSP 600
    TTKLALDQKS SGQTPGKENI YEGDLGLGGY DLKLEQTRGQ PQMD 644
    Length:644
    Mass (Da):72,133
    Last modified:March 1, 2003 - v1
    Checksum:iF356BC4916DBA9FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK037058 mRNA. Translation: BAC29688.1.
    AK156494 mRNA. Translation: BAE33731.1.
    CCDSiCCDS40726.1.
    RefSeqiNP_808577.3. NM_177909.5.
    UniGeneiMm.326125.

    Genome annotation databases

    EnsembliENSMUST00000033463; ENSMUSP00000033463; ENSMUSG00000031129.
    GeneIDi331004.
    KEGGimmu:331004.
    UCSCiuc009ray.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK037058 mRNA. Translation: BAC29688.1 .
    AK156494 mRNA. Translation: BAE33731.1 .
    CCDSi CCDS40726.1.
    RefSeqi NP_808577.3. NM_177909.5.
    UniGenei Mm.326125.

    3D structure databases

    ProteinModelPortali Q8BZ00.
    SMRi Q8BZ00. Positions 202-230, 320-347.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BZ00.

    Proteomic databases

    PRIDEi Q8BZ00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033463 ; ENSMUSP00000033463 ; ENSMUSG00000031129 .
    GeneIDi 331004.
    KEGGi mmu:331004.
    UCSCi uc009ray.2. mouse.

    Organism-specific databases

    CTDi 285195.
    MGIi MGI:2679732. Slc9a9.

    Phylogenomic databases

    eggNOGi COG0025.
    GeneTreei ENSGT00560000076802.
    HOGENOMi HOG000172307.
    HOVERGENi HBG055575.
    InParanoidi Q8BZ00.
    KOi K14725.
    OMAi FAMGSAY.
    OrthoDBi EOG7NW69D.
    PhylomeDBi Q8BZ00.
    TreeFami TF318755.

    Miscellaneous databases

    NextBioi 399683.
    PROi Q8BZ00.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BZ00.
    Genevestigatori Q8BZ00.

    Family and domain databases

    InterProi IPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR002090. Na/H_exchanger_6.
    IPR018416. Na/H_exchanger_9.
    IPR004709. NaH_exchanger.
    [Graphical view ]
    PANTHERi PTHR10110. PTHR10110. 1 hit.
    PTHR10110:SF61. PTHR10110:SF61. 1 hit.
    Pfami PF00999. Na_H_Exchanger. 1 hit.
    [Graphical view ]
    PRINTSi PR01084. NAHEXCHNGR.
    PR01088. NAHEXCHNGR6.
    TIGRFAMsi TIGR00840. b_cpa1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Spleen and Vagina.

    Entry informationi

    Entry nameiSL9A9_MOUSE
    AccessioniPrimary (citable) accession number: Q8BZ00
    Secondary accession number(s): Q3U0X0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3