Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium/hydrogen exchanger 9

Gene

Slc9a9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act in electroneutral exchange of protons for Na+ across membranes. Involved in the effusion of Golgi luminal H+ in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-425986. Sodium/Proton exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 9
Alternative name(s):
Na(+)/H(+) exchanger 9
Short name:
NHE-9
Solute carrier family 9 member 9
Gene namesi
Name:Slc9a9
Synonyms:Nhe9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2679732. Slc9a9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523681 – 644Sodium/hydrogen exchanger 9Add BLAST644

Proteomic databases

MaxQBiQ8BZ00.
PaxDbiQ8BZ00.
PRIDEiQ8BZ00.

PTM databases

iPTMnetiQ8BZ00.
PhosphoSitePlusiQ8BZ00.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031129.
GenevisibleiQ8BZ00. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033463.

Structurei

3D structure databases

ProteinModelPortaliQ8BZ00.
SMRiQ8BZ00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1965. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00760000119074.
HOGENOMiHOG000172307.
HOVERGENiHBG055575.
InParanoidiQ8BZ00.
KOiK14725.
OMAiNPHQGNA.
OrthoDBiEOG091G0HN5.
PhylomeDBiQ8BZ00.
TreeFamiTF318755.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR018416. Na/H_exchanger_9.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 2 hits.
PTHR10110:SF61. PTHR10110:SF61. 2 hits.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BZ00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQLRFTSG KDEDHFQHQG AVELLAFNFL LILTILTIWL FKNHRFRFLH
60 70 80 90 100
ETGGAMVYGL IMGLILRYAT APTDIDSGTV YNCGNLFFSP STLLVNITDQ
110 120 130 140 150
VYEYKYQREI NQHNISPHQG NAILEKMTFD PEIFFNVLLP PIIFHAGYSL
160 170 180 190 200
KKRHFFQNLG SILTYAFLGT AISCVVIGLI MYGFVKAMVH AGQLKSGDFH
210 220 230 240 250
FTDCLFFGSL MSATDPVTVL AIFHELHVDP DLYTLLFGES VLNDAVAIVL
260 270 280 290 300
TYSISIYSPK ENPNAFDTAA FFQSVGNFLG IFAGSFAMGS AYAVVTALLT
310 320 330 340 350
KFTKLREFPM LETGLFFLLS WSAFLSAEAA GLTGIVAVLF CGVTQAHYTY
360 370 380 390 400
NNLSSDSKLR TKQLFEFMNF LAENVIFCYM GLALFTFQNH IFNALFILGA
410 420 430 440 450
FLAIFVARAC NIYPLSFLLN LGRKQKIPWN FQHMMMFSGL RGAIAFALAI
460 470 480 490 500
RNTESQPKQM MFTTTLLLVF FTVWVFGGGT TPMLTWLQIR VGVDLDESLK
510 520 530 540 550
EEPSSQQEAN KLDKNMTKTE SAQLFRMWYG FDHKYLKPIL THSGPPLTTT
560 570 580 590 600
LPAWCGPVSR LLTSPQAYGE QLKEDDVECI VNQDELAMNY QEQSPSPSSP
610 620 630 640
TTKLALDQKS SGQTPGKENI YEGDLGLGGY DLKLEQTRGQ PQMD
Length:644
Mass (Da):72,133
Last modified:March 1, 2003 - v1
Checksum:iF356BC4916DBA9FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037058 mRNA. Translation: BAC29688.1.
AK156494 mRNA. Translation: BAE33731.1.
CCDSiCCDS40726.1.
RefSeqiNP_808577.3. NM_177909.5.
UniGeneiMm.326125.

Genome annotation databases

EnsembliENSMUST00000033463; ENSMUSP00000033463; ENSMUSG00000031129.
GeneIDi331004.
KEGGimmu:331004.
UCSCiuc009ray.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037058 mRNA. Translation: BAC29688.1.
AK156494 mRNA. Translation: BAE33731.1.
CCDSiCCDS40726.1.
RefSeqiNP_808577.3. NM_177909.5.
UniGeneiMm.326125.

3D structure databases

ProteinModelPortaliQ8BZ00.
SMRiQ8BZ00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033463.

PTM databases

iPTMnetiQ8BZ00.
PhosphoSitePlusiQ8BZ00.

Proteomic databases

MaxQBiQ8BZ00.
PaxDbiQ8BZ00.
PRIDEiQ8BZ00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033463; ENSMUSP00000033463; ENSMUSG00000031129.
GeneIDi331004.
KEGGimmu:331004.
UCSCiuc009ray.2. mouse.

Organism-specific databases

CTDi285195.
MGIiMGI:2679732. Slc9a9.

Phylogenomic databases

eggNOGiKOG1965. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00760000119074.
HOGENOMiHOG000172307.
HOVERGENiHBG055575.
InParanoidiQ8BZ00.
KOiK14725.
OMAiNPHQGNA.
OrthoDBiEOG091G0HN5.
PhylomeDBiQ8BZ00.
TreeFamiTF318755.

Enzyme and pathway databases

ReactomeiR-MMU-425986. Sodium/Proton exchangers.

Miscellaneous databases

PROiQ8BZ00.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031129.
GenevisibleiQ8BZ00. MM.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR018416. Na/H_exchanger_9.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 2 hits.
PTHR10110:SF61. PTHR10110:SF61. 2 hits.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSL9A9_MOUSE
AccessioniPrimary (citable) accession number: Q8BZ00
Secondary accession number(s): Q3U0X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.