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Protein

Engulfment and cell motility protein 3

Gene

Elmo3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Phagocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Engulfment and cell motility protein 3
Gene namesi
Name:Elmo3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2679007. Elmo3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 720720Engulfment and cell motility protein 3PRO_0000153717Add
BLAST

Proteomic databases

EPDiQ8BYZ7.
MaxQBiQ8BYZ7.
PaxDbiQ8BYZ7.
PeptideAtlasiQ8BYZ7.
PRIDEiQ8BYZ7.

PTM databases

PhosphoSiteiQ8BYZ7.

Expressioni

Gene expression databases

BgeeiQ8BYZ7.
GenevisibleiQ8BYZ7. MM.

Interactioni

Subunit structurei

Probably interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1 (By similarity). Interacts with ADGRB3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Dock1Q8BUR44EBI-646035,EBI-646023

Protein-protein interaction databases

IntActiQ8BYZ7. 1 interaction.
STRINGi10090.ENSMUSP00000105000.

Structurei

3D structure databases

ProteinModelPortaliQ8BYZ7.
SMRiQ8BYZ7. Positions 516-714.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini307 – 479173ELMOPROSITE-ProRule annotationAdd
BLAST
Domaini542 – 664123PHAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi696 – 70611SH3-bindingAdd
BLAST

Sequence similaritiesi

Contains 1 ELMO domain.PROSITE-ProRule annotation
Contains 1 PH domain.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG2999. Eukaryota.
ENOG410XPKN. LUCA.
GeneTreeiENSGT00390000014155.
HOGENOMiHOG000230985.
HOVERGENiHBG051463.
InParanoidiQ8BYZ7.
KOiK19241.
OMAiMGSEQTR.
OrthoDBiEOG7D85VW.
PhylomeDBiQ8BYZ7.
TreeFamiTF312966.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR024574. DUF3361.
IPR030719. ELMO3.
IPR006816. ELMO_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR12771:SF16. PTHR12771:SF16. 1 hit.
PfamiPF11841. DUF3361. 1 hit.
PF04727. ELMO_CED12. 1 hit.
PF16457. PH_12. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS51335. ELMO. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BYZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPRNVVKI AVQMSDAIPQ LIQLDQAKPL ATVLKEVCDA WSLTHPEHYA
60 70 80 90 100
LQFADGHRKY ITENNRLEIK NGSILCLSTA PDLKAQQLLG RLQNTSREGC
110 120 130 140 150
CEVLRNLVLL ASDMTFAQEV ISRDGLQKLS TIIENGDDLG EMLALGLRAF
160 170 180 190 200
LELMEHGVVS WETLSISFVR KVISYVNMNL MDASVQPLAL RLLESVTLSS
210 220 230 240 250
PALGQLVKSE VPLDRLLVHL QVMNHQLQTK AMALLTALLQ GASPTERKEM
260 270 280 290 300
LDHLWKKNLR QFIYKNIIHS ATPMGDEMAH HLYVLQALTL GLLEPRMRTP
310 320 330 340 350
LDPYSQEQRD QLQALRQAAF EPEGESLGTG LSADRRRSLC VREFRKLGFS
360 370 380 390 400
NSNPAQDLER VPPGLLALDN MLYFSRHAPS AYSRFVLENS SREDKHECPF
410 420 430 440 450
ARSSIQLTAL LCELLRVGEP CSETAQDFSP MFFSQDHSFH ELFCVAIQLL
460 470 480 490 500
NKTWKEMRAT QEDFDKVMQV VREQLARTLA LKPTSLELFR TKVNALTYGE
510 520 530 540 550
VLRLRQTERL HQEGTLAPPI LELREKLKPE LMGLIRQQRL LRLCEGMLFR
560 570 580 590 600
KISSRRRQDK LWFCCLSPNH KVLQYGDVEE GAKPPTLESL PEQLPVADIR
610 620 630 640 650
ALLMGKDCPH VREKGSGKQN KDLYELAFSI SYDHGEEEAY LNFIAPSKRD
660 670 680 690 700
FYLWTDGLSA LLGSTMGSEL TRLDLEQLLT METKLRLLEL ENVPIPEQPP
710 720
PVPPPPTNFN FCYDYSITEP
Length:720
Mass (Da):81,758
Last modified:May 26, 2009 - v2
Checksum:iFDDB6FCDA422309B
GO
Isoform 2 (identifier: Q8BYZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.

Show »
Length:607
Mass (Da):69,214
Checksum:i67DF4EAF4E3F85E9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 113113Missing in isoform 2. 1 PublicationVSP_037343Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037067 mRNA. Translation: BAC29692.1.
CH466525 Genomic DNA. Translation: EDL11267.1.
BC058752 mRNA. Translation: AAH58752.3.
BC138887 mRNA. Translation: AAI38888.1.
CCDSiCCDS22598.1. [Q8BYZ7-1]
RefSeqiNP_766348.3. NM_172760.3. [Q8BYZ7-1]
UniGeneiMm.237966.

Genome annotation databases

EnsembliENSMUST00000109375; ENSMUSP00000105000; ENSMUSG00000014791. [Q8BYZ7-1]
GeneIDi234683.
KEGGimmu:234683.
UCSCiuc009ncn.2. mouse. [Q8BYZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037067 mRNA. Translation: BAC29692.1.
CH466525 Genomic DNA. Translation: EDL11267.1.
BC058752 mRNA. Translation: AAH58752.3.
BC138887 mRNA. Translation: AAI38888.1.
CCDSiCCDS22598.1. [Q8BYZ7-1]
RefSeqiNP_766348.3. NM_172760.3. [Q8BYZ7-1]
UniGeneiMm.237966.

3D structure databases

ProteinModelPortaliQ8BYZ7.
SMRiQ8BYZ7. Positions 516-714.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BYZ7. 1 interaction.
STRINGi10090.ENSMUSP00000105000.

PTM databases

PhosphoSiteiQ8BYZ7.

Proteomic databases

EPDiQ8BYZ7.
MaxQBiQ8BYZ7.
PaxDbiQ8BYZ7.
PeptideAtlasiQ8BYZ7.
PRIDEiQ8BYZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109375; ENSMUSP00000105000; ENSMUSG00000014791. [Q8BYZ7-1]
GeneIDi234683.
KEGGimmu:234683.
UCSCiuc009ncn.2. mouse. [Q8BYZ7-1]

Organism-specific databases

CTDi79767.
MGIiMGI:2679007. Elmo3.

Phylogenomic databases

eggNOGiKOG2999. Eukaryota.
ENOG410XPKN. LUCA.
GeneTreeiENSGT00390000014155.
HOGENOMiHOG000230985.
HOVERGENiHBG051463.
InParanoidiQ8BYZ7.
KOiK19241.
OMAiMGSEQTR.
OrthoDBiEOG7D85VW.
PhylomeDBiQ8BYZ7.
TreeFamiTF312966.

Miscellaneous databases

PROiQ8BYZ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BYZ7.
GenevisibleiQ8BYZ7. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR024574. DUF3361.
IPR030719. ELMO3.
IPR006816. ELMO_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR12771:SF16. PTHR12771:SF16. 1 hit.
PfamiPF11841. DUF3361. 1 hit.
PF04727. ELMO_CED12. 1 hit.
PF16457. PH_12. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS51335. ELMO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Vagina.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 607-612, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Liver, Lung and Pancreas.

Entry informationi

Entry nameiELMO3_MOUSE
AccessioniPrimary (citable) accession number: Q8BYZ7
Secondary accession number(s): Q6PDE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 26, 2009
Last modified: July 6, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.