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Protein

Engulfment and cell motility protein 3

Gene

Elmo3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Phagocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Engulfment and cell motility protein 3
Gene namesi
Name:Elmo3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2679007 Elmo3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537171 – 720Engulfment and cell motility protein 3Add BLAST720

Proteomic databases

PaxDbiQ8BYZ7
PeptideAtlasiQ8BYZ7
PRIDEiQ8BYZ7

PTM databases

PhosphoSitePlusiQ8BYZ7

Expressioni

Gene expression databases

BgeeiENSMUSG00000014791
ExpressionAtlasiQ8BYZ7 baseline and differential
GenevisibleiQ8BYZ7 MM

Interactioni

Subunit structurei

Probably interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1 (By similarity). Interacts with ADGRB3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Dock1Q8BUR44EBI-646035,EBI-646023

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BYZ7, 1 interactor
STRINGi10090.ENSMUSP00000105000

Structurei

3D structure databases

ProteinModelPortaliQ8BYZ7
SMRiQ8BYZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini307 – 479ELMOPROSITE-ProRule annotationAdd BLAST173
Domaini542 – 664PHAdd BLAST123

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi696 – 706SH3-bindingAdd BLAST11

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG2999 Eukaryota
ENOG410XPKN LUCA
GeneTreeiENSGT00390000014155
HOGENOMiHOG000230985
HOVERGENiHBG051463
InParanoidiQ8BYZ7
KOiK19241
OMAiMGSEQTR
OrthoDBiEOG091G03JJ
PhylomeDBiQ8BYZ7
TreeFamiTF312966

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR024574 DUF3361
IPR030719 ELMO3
IPR006816 ELMO_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR12771:SF16 PTHR12771:SF16, 1 hit
PfamiView protein in Pfam
PF11841 DUF3361, 1 hit
PF04727 ELMO_CED12, 1 hit
PF16457 PH_12, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51335 ELMO, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BYZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPRNVVKI AVQMSDAIPQ LIQLDQAKPL ATVLKEVCDA WSLTHPEHYA
60 70 80 90 100
LQFADGHRKY ITENNRLEIK NGSILCLSTA PDLKAQQLLG RLQNTSREGC
110 120 130 140 150
CEVLRNLVLL ASDMTFAQEV ISRDGLQKLS TIIENGDDLG EMLALGLRAF
160 170 180 190 200
LELMEHGVVS WETLSISFVR KVISYVNMNL MDASVQPLAL RLLESVTLSS
210 220 230 240 250
PALGQLVKSE VPLDRLLVHL QVMNHQLQTK AMALLTALLQ GASPTERKEM
260 270 280 290 300
LDHLWKKNLR QFIYKNIIHS ATPMGDEMAH HLYVLQALTL GLLEPRMRTP
310 320 330 340 350
LDPYSQEQRD QLQALRQAAF EPEGESLGTG LSADRRRSLC VREFRKLGFS
360 370 380 390 400
NSNPAQDLER VPPGLLALDN MLYFSRHAPS AYSRFVLENS SREDKHECPF
410 420 430 440 450
ARSSIQLTAL LCELLRVGEP CSETAQDFSP MFFSQDHSFH ELFCVAIQLL
460 470 480 490 500
NKTWKEMRAT QEDFDKVMQV VREQLARTLA LKPTSLELFR TKVNALTYGE
510 520 530 540 550
VLRLRQTERL HQEGTLAPPI LELREKLKPE LMGLIRQQRL LRLCEGMLFR
560 570 580 590 600
KISSRRRQDK LWFCCLSPNH KVLQYGDVEE GAKPPTLESL PEQLPVADIR
610 620 630 640 650
ALLMGKDCPH VREKGSGKQN KDLYELAFSI SYDHGEEEAY LNFIAPSKRD
660 670 680 690 700
FYLWTDGLSA LLGSTMGSEL TRLDLEQLLT METKLRLLEL ENVPIPEQPP
710 720
PVPPPPTNFN FCYDYSITEP
Length:720
Mass (Da):81,758
Last modified:May 26, 2009 - v2
Checksum:iFDDB6FCDA422309B
GO
Isoform 2 (identifier: Q8BYZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.

Show »
Length:607
Mass (Da):69,214
Checksum:i67DF4EAF4E3F85E9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0373431 – 113Missing in isoform 2. 1 PublicationAdd BLAST113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037067 mRNA Translation: BAC29692.1
CH466525 Genomic DNA Translation: EDL11267.1
BC058752 mRNA Translation: AAH58752.3
BC138887 mRNA Translation: AAI38888.1
CCDSiCCDS22598.1 [Q8BYZ7-1]
RefSeqiNP_766348.3, NM_172760.3 [Q8BYZ7-1]
UniGeneiMm.237966

Genome annotation databases

EnsembliENSMUST00000109375; ENSMUSP00000105000; ENSMUSG00000014791 [Q8BYZ7-1]
GeneIDi234683
KEGGimmu:234683
UCSCiuc009ncn.2 mouse [Q8BYZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiELMO3_MOUSE
AccessioniPrimary (citable) accession number: Q8BYZ7
Secondary accession number(s): Q6PDE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 26, 2009
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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