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Protein

ABI gene family member 3

Gene

Abi3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits ectopic tumor cell metastasis of SRD cells. In vitro, reduces cell motility.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ABI gene family member 3
Alternative name(s):
New molecule including SH3
Short name:
Nesh
Gene namesi
Name:Abi3
Synonyms:Nesh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913860. Abi3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367ABI gene family member 3PRO_0000191793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161PhosphoserineCombined sources
Modified residuei219 – 2191PhosphoserineCombined sources
Modified residuei343 – 3431PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BYZ1.
MaxQBiQ8BYZ1.
PaxDbiQ8BYZ1.
PRIDEiQ8BYZ1.

PTM databases

iPTMnetiQ8BYZ1.
PhosphoSiteiQ8BYZ1.

Expressioni

Gene expression databases

BgeeiQ8BYZ1.
CleanExiMM_ABI3.
ExpressionAtlasiQ8BYZ1. baseline and differential.
GenevisibleiQ8BYZ1. MM.

Interactioni

Subunit structurei

May interact with PAK1 and PAK2. Probably interacts with TARSH (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061893.

Structurei

3D structure databases

ProteinModelPortaliQ8BYZ1.
SMRiQ8BYZ1. Positions 4-157, 302-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini309 – 36759SH3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili36 – 6429Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi235 – 30773Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the ABI family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG2546. Eukaryota.
ENOG410Y0MH. LUCA.
GeneTreeiENSGT00390000003756.
HOGENOMiHOG000293213.
HOVERGENiHBG050446.
InParanoidiQ8BYZ1.
OMAiGWCEGIS.
OrthoDBiEOG7673BC.
TreeFamiTF314303.

Family and domain databases

InterProiIPR028457. ABI.
IPR028455. ABI3.
IPR012849. Abl-interactor_HHR_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10460. PTHR10460. 1 hit.
PTHR10460:SF7. PTHR10460:SF7. 1 hit.
PfamiPF07815. Abi_HHR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BYZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELQQLQQL QEFDIPTGRE ALRGNHSALL RVANYCEDNY LQATDKRKAL
60 70 80 90 100
EETMAFTTQA LASVAYQVGN LAGHTLRMLD LQGAALRQVE AKMSTLGQMV
110 120 130 140 150
NMHMEKVARR EIGTLATVVR LPSNQKVIPP ESLPSLTPYH RKPLNFACLD
160 170 180 190 200
DIGHGVKDLS TQLSRTGTLS RKSIKAPATP VSATLGRPPR IPEPVQLPAV
210 220 230 240 250
PDGKLSAASS ASSLASAGSA EGASGIPQSK GQVAPATPPP PPVAPVTPPP
260 270 280 290 300
PPLSAEVFLP PPPLEVSQPP LEAELPLPPP PALEGDELGL LPPPPPGFGP
310 320 330 340 350
DEPSWVPASY LEKVVTLYPY TRQKDNELSF SEGTVICVTR RYSDGWCEGV
360
SSEGTGFFPG NYVEPSC
Length:367
Mass (Da):39,107
Last modified:July 27, 2011 - v3
Checksum:i0CEC0279F45A62F7
GO
Isoform 2 (identifier: Q8BYZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:314
Mass (Da):33,004
Checksum:i8C8306D9DBA06EE0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti339 – 3391T → I in AAH58260 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5353Missing in isoform 2. 1 PublicationVSP_010773Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008928 mRNA. Translation: BAB25972.1.
AK037144 mRNA. Translation: BAC29720.1.
AK172098 mRNA. Translation: BAE42824.1.
AL593858 Genomic DNA. Translation: CAM15513.1.
CH466556 Genomic DNA. Translation: EDL15995.1.
BC058260 mRNA. Translation: AAH58260.1.
CCDSiCCDS25283.1. [Q8BYZ1-1]
RefSeqiNP_001156936.1. NM_001163464.1. [Q8BYZ1-2]
NP_079935.1. NM_025659.4. [Q8BYZ1-1]
UniGeneiMm.485545.

Genome annotation databases

EnsembliENSMUST00000059026; ENSMUSP00000061893; ENSMUSG00000018381. [Q8BYZ1-1]
GeneIDi66610.
KEGGimmu:66610.
UCSCiuc007lat.2. mouse. [Q8BYZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008928 mRNA. Translation: BAB25972.1.
AK037144 mRNA. Translation: BAC29720.1.
AK172098 mRNA. Translation: BAE42824.1.
AL593858 Genomic DNA. Translation: CAM15513.1.
CH466556 Genomic DNA. Translation: EDL15995.1.
BC058260 mRNA. Translation: AAH58260.1.
CCDSiCCDS25283.1. [Q8BYZ1-1]
RefSeqiNP_001156936.1. NM_001163464.1. [Q8BYZ1-2]
NP_079935.1. NM_025659.4. [Q8BYZ1-1]
UniGeneiMm.485545.

3D structure databases

ProteinModelPortaliQ8BYZ1.
SMRiQ8BYZ1. Positions 4-157, 302-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061893.

PTM databases

iPTMnetiQ8BYZ1.
PhosphoSiteiQ8BYZ1.

Proteomic databases

EPDiQ8BYZ1.
MaxQBiQ8BYZ1.
PaxDbiQ8BYZ1.
PRIDEiQ8BYZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059026; ENSMUSP00000061893; ENSMUSG00000018381. [Q8BYZ1-1]
GeneIDi66610.
KEGGimmu:66610.
UCSCiuc007lat.2. mouse. [Q8BYZ1-1]

Organism-specific databases

CTDi51225.
MGIiMGI:1913860. Abi3.

Phylogenomic databases

eggNOGiKOG2546. Eukaryota.
ENOG410Y0MH. LUCA.
GeneTreeiENSGT00390000003756.
HOGENOMiHOG000293213.
HOVERGENiHBG050446.
InParanoidiQ8BYZ1.
OMAiGWCEGIS.
OrthoDBiEOG7673BC.
TreeFamiTF314303.

Miscellaneous databases

PROiQ8BYZ1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BYZ1.
CleanExiMM_ABI3.
ExpressionAtlasiQ8BYZ1. baseline and differential.
GenevisibleiQ8BYZ1. MM.

Family and domain databases

InterProiIPR028457. ABI.
IPR028455. ABI3.
IPR012849. Abl-interactor_HHR_dom.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10460. PTHR10460. 1 hit.
PTHR10460:SF7. PTHR10460:SF7. 1 hit.
PfamiPF07815. Abi_HHR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Skin, Spleen and Stomach.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Colon.
  5. "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells."
    Ichigotani Y., Yokozaki S., Fukuda Y., Hamaguchi M., Matsuda S.
    Cancer Res. 62:2215-2219(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216 AND SER-219, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Liver, Pancreas and Spleen.

Entry informationi

Entry nameiABI3_MOUSE
AccessioniPrimary (citable) accession number: Q8BYZ1
Secondary accession number(s): Q3TA46, Q6PE63, Q9D7S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.