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Protein

ABI gene family member 3

Gene

Abi3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits ectopic tumor cell metastasis of SRD cells. In vitro, reduces cell motility.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ABI gene family member 3
Alternative name(s):
New molecule including SH3
Short name:
Nesh
Gene namesi
Name:Abi3
Synonyms:Nesh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913860 Abi3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917931 – 367ABI gene family member 3Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei343PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BYZ1
PaxDbiQ8BYZ1
PRIDEiQ8BYZ1

PTM databases

iPTMnetiQ8BYZ1
PhosphoSitePlusiQ8BYZ1

Expressioni

Gene expression databases

BgeeiENSMUSG00000018381
CleanExiMM_ABI3
ExpressionAtlasiQ8BYZ1 baseline and differential
GenevisibleiQ8BYZ1 MM

Interactioni

Subunit structurei

May interact with PAK1 and PAK2. Probably interacts with TARSH (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061893

Structurei

3D structure databases

ProteinModelPortaliQ8BYZ1
SMRiQ8BYZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 367SH3PROSITE-ProRule annotationAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili36 – 64Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi235 – 307Pro-richAdd BLAST73

Sequence similaritiesi

Belongs to the ABI family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG2546 Eukaryota
ENOG410Y0MH LUCA
GeneTreeiENSGT00390000003756
HOGENOMiHOG000293213
HOVERGENiHBG050446
InParanoidiQ8BYZ1
OMAiSWVPASY
OrthoDBiEOG091G0AN8
TreeFamiTF314303

Family and domain databases

InterProiView protein in InterPro
IPR028457 ABI
IPR028455 ABI3
IPR012849 Abl-interactor_HHR_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10460 PTHR10460, 1 hit
PTHR10460:SF7 PTHR10460:SF7, 1 hit
PfamiView protein in Pfam
PF07815 Abi_HHR, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BYZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELQQLQQL QEFDIPTGRE ALRGNHSALL RVANYCEDNY LQATDKRKAL
60 70 80 90 100
EETMAFTTQA LASVAYQVGN LAGHTLRMLD LQGAALRQVE AKMSTLGQMV
110 120 130 140 150
NMHMEKVARR EIGTLATVVR LPSNQKVIPP ESLPSLTPYH RKPLNFACLD
160 170 180 190 200
DIGHGVKDLS TQLSRTGTLS RKSIKAPATP VSATLGRPPR IPEPVQLPAV
210 220 230 240 250
PDGKLSAASS ASSLASAGSA EGASGIPQSK GQVAPATPPP PPVAPVTPPP
260 270 280 290 300
PPLSAEVFLP PPPLEVSQPP LEAELPLPPP PALEGDELGL LPPPPPGFGP
310 320 330 340 350
DEPSWVPASY LEKVVTLYPY TRQKDNELSF SEGTVICVTR RYSDGWCEGV
360
SSEGTGFFPG NYVEPSC
Length:367
Mass (Da):39,107
Last modified:July 27, 2011 - v3
Checksum:i0CEC0279F45A62F7
GO
Isoform 2 (identifier: Q8BYZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:314
Mass (Da):33,004
Checksum:i8C8306D9DBA06EE0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti339T → I in AAH58260 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0107731 – 53Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008928 mRNA Translation: BAB25972.1
AK037144 mRNA Translation: BAC29720.1
AK172098 mRNA Translation: BAE42824.1
AL593858 Genomic DNA Translation: CAM15513.1
CH466556 Genomic DNA Translation: EDL15995.1
BC058260 mRNA Translation: AAH58260.1
CCDSiCCDS25283.1 [Q8BYZ1-1]
RefSeqiNP_001156936.1, NM_001163464.1 [Q8BYZ1-2]
NP_079935.1, NM_025659.4 [Q8BYZ1-1]
XP_017170199.1, XM_017314710.1 [Q8BYZ1-2]
UniGeneiMm.485545

Genome annotation databases

EnsembliENSMUST00000059026; ENSMUSP00000061893; ENSMUSG00000018381 [Q8BYZ1-1]
GeneIDi66610
KEGGimmu:66610
UCSCiuc007lat.2 mouse [Q8BYZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiABI3_MOUSE
AccessioniPrimary (citable) accession number: Q8BYZ1
Secondary accession number(s): Q3TA46, Q6PE63, Q9D7S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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