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Protein
Submitted name:

Nerve growth factor receptor (TNFR superfamily, member 16)

Gene

Ngfr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Nerve growth factor receptor (TNFR superfamily, member 16)Imported
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:NgfrImported
ORF Names:mCG_8463Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97323. Ngfr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501014569322 – 417Sequence analysisAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 50PROSITE-ProRule annotation
Disulfide bondi79 ↔ 92PROSITE-ProRule annotation
Disulfide bondi82 ↔ 100PROSITE-ProRule annotation
Disulfide bondi118 ↔ 131PROSITE-ProRule annotation
Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
Disulfide bondi142 ↔ 157PROSITE-ProRule annotation
Disulfide bondi160 ↔ 173PROSITE-ProRule annotation
Disulfide bondi163 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000000120.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000122.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 57TNFR-CysInterPro annotationAdd BLAST34
Repeati24 – 57TNFR-CysPROSITE-ProRule annotationAdd BLAST34
Domaini59 – 100TNFR-CysInterPro annotationAdd BLAST42
Repeati59 – 100TNFR-CysPROSITE-ProRule annotationAdd BLAST42
Domaini101 – 139TNFR-CysInterPro annotationAdd BLAST39
Repeati101 – 139TNFR-CysPROSITE-ProRule annotationAdd BLAST39
Domaini141 – 181TNFR-CysInterPro annotationAdd BLAST41
Repeati141 – 181TNFR-CysPROSITE-ProRule annotationAdd BLAST41
Domaini346 – 411DeathInterPro annotationAdd BLAST66

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQFC. Eukaryota.
ENOG4111F3C. LUCA.
HOVERGENiHBG060431.

Family and domain databases

CDDicd13416. TNFRSF16. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
IPR034046. TNFRSF16_N.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
PRINTSiPR01966. TNFACTORR16.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q8BYY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRLRLLLLL LLLLGVSFGG AKETCSTGMY THSGECCKAC NLGEGVAQPC
60 70 80 90 100
GANQTVCEPC LDSVTFSDVV SATEPCKPCT ECLGLQSMSA PCVEADDAVC
110 120 130 140 150
RCSYGYYQDE ETGRCEACSV CGVGSGLVFS CQDKQNTVCE ECPEGTYSDE
160 170 180 190 200
ANHVDPCLPC TVCEDTERQL RECTPWADAE CEEIPGRWIT RSTPPEGSDV
210 220 230 240 250
TTPSTQEPEA PPERDLIAST VADTVTTVMG SSQPVVTRGT ADNLIPVYCS
260 270 280 290 300
ILAAVVVGLV AYIAFKRWNS CKQNKQGANS RPVNQTPPPE GEKLHSDSGI
310 320 330 340 350
SVDSQSLHDQ QTHTQTASGQ ALKGDGNLYS SLPLTKREEV EKLLNGDTWR
360 370 380 390 400
HLAGELGYQP EHIDSFTHEA CPVRALLASW GAQDSATLDA LLAALRRIQR
410
ADIVESLCSE STATSPV
Length:417
Mass (Da):44,672
Last modified:March 1, 2003 - v1
Checksum:iCD0440EF7E70A617
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037248 mRNA. Translation: BAC29775.1.
CH466556 Genomic DNA. Translation: EDL15985.1.
UniGeneiMm.283893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037248 mRNA. Translation: BAC29775.1.
CH466556 Genomic DNA. Translation: EDL15985.1.
UniGeneiMm.283893.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000122.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97323. Ngfr.

Phylogenomic databases

eggNOGiENOG410IQFC. Eukaryota.
ENOG4111F3C. LUCA.
HOVERGENiHBG060431.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000120.

Family and domain databases

CDDicd13416. TNFRSF16. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
IPR034046. TNFRSF16_N.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
PRINTSiPR01966. TNFACTORR16.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8BYY1_MOUSE
AccessioniPrimary (citable) accession number: Q8BYY1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 10, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.