SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8BYY1

- Q8BYY1_MOUSE

UniProt

Q8BYY1 - Q8BYY1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Nerve growth factor receptor (TNFR superfamily, member 16)

Gene
Ngfr, mCG_8463
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. death receptor activity Source: MGI
  2. nerve growth factor binding Source: MGI
  3. protein binding Source: MGI

GO - Biological processi

  1. axon guidance Source: MGI
  2. central nervous system development Source: MGI
  3. detection of temperature stimulus Source: MGI
  4. hair follicle morphogenesis Source: MGI
  5. negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  6. negative regulation of hair follicle development Source: MGI
  7. nerve development Source: MGI
  8. positive regulation of apoptotic signaling pathway Source: MGI
  9. positive regulation of fibroblast proliferation Source: MGI
  10. positive regulation of odontogenesis of dentin-containing tooth Source: MGI
  11. programmed cell death Source: GOC
  12. regulation of gene expression Source: MGI
  13. skin development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_202086. p75NTR negatively regulates cell cycle via SC1.
REACT_202271. NRIF signals cell death from the nucleus.
REACT_203657. Axonal growth inhibition (RHOA activation).
REACT_207546. NFG and proNGF binds to p75NTR.
REACT_209641. NRAGE signals death through JNK.
REACT_210754. NADE modulates death signalling.
REACT_214242. Axonal growth stimulation.
REACT_214670. p75NTR recruits signalling complexes.
REACT_217312. Ceramide signalling.
REACT_218614. Regulated proteolysis of p75NTR.
REACT_218887. NF-kB is activated and signals survival.

Names & Taxonomyi

Protein namesi
Submitted name:
Nerve growth factor receptor (TNFR superfamily, member 16)Imported
Gene namesi
Name:NgfrImported
ORF Names:mCG_8463Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97323. Ngfr.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. neuronal postsynaptic density Source: MGI
  3. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8BYY1.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG060431.
InParanoidiQ8BYY1.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01966. TNFACTORR16.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BYY1-1 [UniParc]FASTAAdd to Basket

« Hide

MDRLRLLLLL LLLLGVSFGG AKETCSTGMY THSGECCKAC NLGEGVAQPC    50
GANQTVCEPC LDSVTFSDVV SATEPCKPCT ECLGLQSMSA PCVEADDAVC 100
RCSYGYYQDE ETGRCEACSV CGVGSGLVFS CQDKQNTVCE ECPEGTYSDE 150
ANHVDPCLPC TVCEDTERQL RECTPWADAE CEEIPGRWIT RSTPPEGSDV 200
TTPSTQEPEA PPERDLIAST VADTVTTVMG SSQPVVTRGT ADNLIPVYCS 250
ILAAVVVGLV AYIAFKRWNS CKQNKQGANS RPVNQTPPPE GEKLHSDSGI 300
SVDSQSLHDQ QTHTQTASGQ ALKGDGNLYS SLPLTKREEV EKLLNGDTWR 350
HLAGELGYQP EHIDSFTHEA CPVRALLASW GAQDSATLDA LLAALRRIQR 400
ADIVESLCSE STATSPV 417
Length:417
Mass (Da):44,672
Last modified:March 1, 2003 - v1
Checksum:iCD0440EF7E70A617
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK037248 mRNA. Translation: BAC29775.1.
CH466556 Genomic DNA. Translation: EDL15985.1.
UniGeneiMm.283893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK037248 mRNA. Translation: BAC29775.1 .
CH466556 Genomic DNA. Translation: EDL15985.1 .
UniGenei Mm.283893.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:97323. Ngfr.

Phylogenomic databases

HOVERGENi HBG060431.
InParanoidi Q8BYY1.

Enzyme and pathway databases

Reactomei REACT_202086. p75NTR negatively regulates cell cycle via SC1.
REACT_202271. NRIF signals cell death from the nucleus.
REACT_203657. Axonal growth inhibition (RHOA activation).
REACT_207546. NFG and proNGF binds to p75NTR.
REACT_209641. NRAGE signals death through JNK.
REACT_210754. NADE modulates death signalling.
REACT_214242. Axonal growth stimulation.
REACT_214670. p75NTR recruits signalling complexes.
REACT_217312. Ceramide signalling.
REACT_218614. Regulated proteolysis of p75NTR.
REACT_218887. NF-kB is activated and signals survival.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q8BYY1.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
InterProi IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view ]
Pfami PF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view ]
PRINTSi PR01966. TNFACTORR16.
SMARTi SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: SkinImported.
  10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ8BYY1_MOUSE
AccessioniPrimary (citable) accession number: Q8BYY1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi