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Q8BYY1

- Q8BYY1_MOUSE

UniProt

Q8BYY1 - Q8BYY1_MOUSE

Protein
Submitted name:

Nerve growth factor receptor (TNFR superfamily, member 16)

Gene

Ngfr

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. death receptor activity Source: MGI
    2. nerve growth factor binding Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. axon guidance Source: MGI
    2. central nervous system development Source: MGI
    3. detection of temperature stimulus Source: MGI
    4. hair follicle morphogenesis Source: MGI
    5. negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
    6. negative regulation of hair follicle development Source: MGI
    7. nerve development Source: MGI
    8. positive regulation of apoptotic signaling pathway Source: MGI
    9. positive regulation of fibroblast proliferation Source: MGI
    10. positive regulation of odontogenesis of dentin-containing tooth Source: MGI
    11. programmed cell death Source: GOC
    12. regulation of gene expression Source: MGI
    13. skin development Source: MGI

    Keywords - Molecular functioni

    ReceptorImported

    Enzyme and pathway databases

    ReactomeiREACT_202086. p75NTR negatively regulates cell cycle via SC1.
    REACT_202271. NRIF signals cell death from the nucleus.
    REACT_203657. Axonal growth inhibition (RHOA activation).
    REACT_207546. NFG and proNGF binds to p75NTR.
    REACT_209641. NRAGE signals death through JNK.
    REACT_210754. NADE modulates death signalling.
    REACT_214242. Axonal growth stimulation.
    REACT_214670. p75NTR recruits signalling complexes.
    REACT_217312. Ceramide signalling.
    REACT_218614. Regulated proteolysis of p75NTR.
    REACT_218887. NF-kB is activated and signals survival.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Nerve growth factor receptor (TNFR superfamily, member 16)Imported
    Gene namesi
    Name:NgfrImported
    ORF Names:mCG_8463Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97323. Ngfr.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. neuronal postsynaptic density Source: MGI
    3. plasma membrane Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ8BYY1.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG060431.
    InParanoidiQ8BYY1.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022325. TNFR_16.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF00020. TNFR_c6. 3 hits.
    [Graphical view]
    PRINTSiPR01966. TNFACTORR16.
    SMARTiSM00005. DEATH. 1 hit.
    SM00208. TNFR. 4 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 3 hits.
    PS50050. TNFR_NGFR_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BYY1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRLRLLLLL LLLLGVSFGG AKETCSTGMY THSGECCKAC NLGEGVAQPC    50
    GANQTVCEPC LDSVTFSDVV SATEPCKPCT ECLGLQSMSA PCVEADDAVC 100
    RCSYGYYQDE ETGRCEACSV CGVGSGLVFS CQDKQNTVCE ECPEGTYSDE 150
    ANHVDPCLPC TVCEDTERQL RECTPWADAE CEEIPGRWIT RSTPPEGSDV 200
    TTPSTQEPEA PPERDLIAST VADTVTTVMG SSQPVVTRGT ADNLIPVYCS 250
    ILAAVVVGLV AYIAFKRWNS CKQNKQGANS RPVNQTPPPE GEKLHSDSGI 300
    SVDSQSLHDQ QTHTQTASGQ ALKGDGNLYS SLPLTKREEV EKLLNGDTWR 350
    HLAGELGYQP EHIDSFTHEA CPVRALLASW GAQDSATLDA LLAALRRIQR 400
    ADIVESLCSE STATSPV 417
    Length:417
    Mass (Da):44,672
    Last modified:March 1, 2003 - v1
    Checksum:iCD0440EF7E70A617
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK037248 mRNA. Translation: BAC29775.1.
    CH466556 Genomic DNA. Translation: EDL15985.1.
    UniGeneiMm.283893.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK037248 mRNA. Translation: BAC29775.1 .
    CH466556 Genomic DNA. Translation: EDL15985.1 .
    UniGenei Mm.283893.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97323. Ngfr.

    Phylogenomic databases

    HOVERGENi HBG060431.
    InParanoidi Q8BYY1.

    Enzyme and pathway databases

    Reactomei REACT_202086. p75NTR negatively regulates cell cycle via SC1.
    REACT_202271. NRIF signals cell death from the nucleus.
    REACT_203657. Axonal growth inhibition (RHOA activation).
    REACT_207546. NFG and proNGF binds to p75NTR.
    REACT_209641. NRAGE signals death through JNK.
    REACT_210754. NADE modulates death signalling.
    REACT_214242. Axonal growth stimulation.
    REACT_214670. p75NTR recruits signalling complexes.
    REACT_217312. Ceramide signalling.
    REACT_218614. Regulated proteolysis of p75NTR.
    REACT_218887. NF-kB is activated and signals survival.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8BYY1.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022325. TNFR_16.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF00020. TNFR_c6. 3 hits.
    [Graphical view ]
    PRINTSi PR01966. TNFACTORR16.
    SMARTi SM00005. DEATH. 1 hit.
    SM00208. TNFR. 4 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 3 hits.
    PS50050. TNFR_NGFR_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: SkinImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: SkinImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: SkinImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: SkinImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: SkinImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: SkinImported.
    7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: SkinImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: SkinImported.
    10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ8BYY1_MOUSE
    AccessioniPrimary (citable) accession number: Q8BYY1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)