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Q8BYW9

- EOGT_MOUSE

UniProt

Q8BYW9 - EOGT_MOUSE

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Protein
EGF domain-specific O-linked N-acetylglucosamine transferase
Gene
Eogt, Aer61, Eogt1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.1 Publication

Catalytic activityi

UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine.1 Publication
UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine.

GO - Molecular functioni

  1. protein N-acetylglucosaminyltransferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. metabolic process Source: UniProtKB
  2. protein O-linked glycosylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT61. Glycosyltransferase Family 61.

Names & Taxonomyi

Protein namesi
Recommended name:
EGF domain-specific O-linked N-acetylglucosamine transferase (EC:2.4.1.255)
Alternative name(s):
Extracellular O-linked N-acetylglucosamine transferase
Gene namesi
Name:Eogt
Synonyms:Aer61, Eogt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2141669. Eogt.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 527508EGF domain-specific O-linked N-acetylglucosamine transferase
PRO_0000301972Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi354 – 3541N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BYW9.
PaxDbiQ8BYW9.
PRIDEiQ8BYW9.

PTM databases

PhosphoSiteiQ8BYW9.

Expressioni

Tissue specificityi

Widely expressed. Expressed in brain, heart, kidney, lung, skeletal muscles and thymus. Highest expression is observed in lung and the lowest in skeletal muscles.1 Publication

Developmental stagei

Expressed at embryonic day (E) 10.5 in the growing edge of the limb buds. At E11.5, enriched in the apical ectodermal ridge of the limbs. By E12.5, expression assumes a digit-condensation pattern in the 4 limbs.1 Publication

Gene expression databases

ArrayExpressiQ8BYW9.
BgeeiQ8BYW9.
CleanExiMM_A130022J15RIK.
GenevestigatoriQ8BYW9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061610.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi295 – 2973Required for optimal activity By similarity
Motifi524 – 5274Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG320328.
GeneTreeiENSGT00750000117715.
HOGENOMiHOG000033829.
HOVERGENiHBG056678.
InParanoidiQ8BYW9.
KOiK18134.
OMAiDSKRVCF.
OrthoDBiEOG7D2FDQ.
PhylomeDBiQ8BYW9.
TreeFamiTF313716.

Family and domain databases

InterProiIPR007657. Glycosyltransferase_AER61.
[Graphical view]
PfamiPF04577. DUF563. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BYW9-1 [UniParc]FASTAAdd to Basket

« Hide

MLMLLVFGVL LHEVPLSGQD KAHSEADDAP GKALYDYSSL RLPAEHIPFF    50
LHNNRHVASV CREDSHCPYK KHLENLNYCW GYEKSCAPEF RFGSPVCSYV 100
DLGWTDTLES AQDMFWRQAD FGYARERLGE IRTICQPERA SDSSLVCSRY 150
LQYCRATGLY LDLRNIKRNH DRFKEDFLQG GEIGGYCKLD SHALVSEGQR 200
KSPLQSWFAE LQGYTQLNFR PIEDAKCDIV VEKPTYFMKL DAGINMYHHF 250
CDFLNLYLTQ HVNNSFSTDV YIVMWDTSTY GYGDLFSDTW KAFTDYDVIH 300
LKTYDSKKVC FKEAVFSLLP RMRYGLFYNT PLISGCQNTG LFRAFSQHVL 350
HRLNITQEGP KDGKVRVTIL ARSTEYRKIL NQDELVNALK TVSTFEVRVV 400
DYKYRELGFL DQLRITHNTD IFIGMHGAGL THLLFLPDWA AVFELYNCED 450
ERCYLDLARL RGIHYITWRK PSKVFPQDKG HHPTLGEHPK FTNYSFDVEE 500
FMYLVLQAAE HVLQHPQWPF KKKHDEL 527
Length:527
Mass (Da):61,446
Last modified:March 1, 2003 - v1
Checksum:i793D0E8F481AD5E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK037507 mRNA. Translation: BAC29821.1.
BC048939 mRNA. Translation: AAH48939.1.
CCDSiCCDS20383.1.
RefSeqiNP_780522.1. NM_175313.4.
XP_006505321.1. XM_006505258.1.
XP_006505322.1. XM_006505259.1.
UniGeneiMm.251789.
Mm.486365.

Genome annotation databases

EnsembliENSMUST00000054344; ENSMUSP00000061610; ENSMUSG00000035245.
GeneIDi101351.
KEGGimmu:101351.
UCSCiuc009dai.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK037507 mRNA. Translation: BAC29821.1 .
BC048939 mRNA. Translation: AAH48939.1 .
CCDSi CCDS20383.1.
RefSeqi NP_780522.1. NM_175313.4.
XP_006505321.1. XM_006505258.1.
XP_006505322.1. XM_006505259.1.
UniGenei Mm.251789.
Mm.486365.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000061610.

Protein family/group databases

CAZyi GT61. Glycosyltransferase Family 61.

PTM databases

PhosphoSitei Q8BYW9.

Proteomic databases

MaxQBi Q8BYW9.
PaxDbi Q8BYW9.
PRIDEi Q8BYW9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054344 ; ENSMUSP00000061610 ; ENSMUSG00000035245 .
GeneIDi 101351.
KEGGi mmu:101351.
UCSCi uc009dai.1. mouse.

Organism-specific databases

CTDi 285203.
MGIi MGI:2141669. Eogt.

Phylogenomic databases

eggNOGi NOG320328.
GeneTreei ENSGT00750000117715.
HOGENOMi HOG000033829.
HOVERGENi HBG056678.
InParanoidi Q8BYW9.
KOi K18134.
OMAi DSKRVCF.
OrthoDBi EOG7D2FDQ.
PhylomeDBi Q8BYW9.
TreeFami TF313716.

Miscellaneous databases

NextBioi 354880.
PROi Q8BYW9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BYW9.
Bgeei Q8BYW9.
CleanExi MM_A130022J15RIK.
Genevestigatori Q8BYW9.

Family and domain databases

InterProi IPR007657. Glycosyltransferase_AER61.
[Graphical view ]
Pfami PF04577. DUF563. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  3. "O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1."
    Sakaidani Y., Ichiyanagi N., Saito C., Nomura T., Ito M., Nishio Y., Nadano D., Matsuda T., Furukawa K., Okajima T.
    Biochem. Biophys. Res. Commun. 419:14-19(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
  4. Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiEOGT_MOUSE
AccessioniPrimary (citable) accession number: Q8BYW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi