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Q8BYM5

- NLGN3_MOUSE

UniProt

Q8BYM5 - NLGN3_MOUSE

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Protein
Neuroligin-3
Gene
Nlgn3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.1 Publication

GO - Molecular functioni

  1. cell adhesion molecule binding Source: BHF-UCL
  2. neurexin family protein binding Source: BHF-UCL
  3. receptor activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. adult behavior Source: Ensembl
  2. axon extension Source: BHF-UCL
  3. neuron cell-cell adhesion Source: BHF-UCL
  4. oligodendrocyte differentiation Source: MGI
  5. positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
  6. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
  7. positive regulation of synapse assembly Source: BHF-UCL
  8. positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
  9. postsynaptic membrane assembly Source: BHF-UCL
  10. presynaptic membrane assembly Source: BHF-UCL
  11. receptor-mediated endocytosis Source: BHF-UCL
  12. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: BHF-UCL
  13. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
  14. regulation of dendritic spine morphogenesis Source: BHF-UCL
  15. regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
  16. regulation of inhibitory postsynaptic membrane potential Source: BHF-UCL
  17. regulation of long-term synaptic potentiation Source: BHF-UCL
  18. regulation of respiratory gaseous exchange by neurological system process Source: MGI
  19. regulation of synaptic transmission Source: MGI
  20. regulation of synaptic transmission, glutamatergic Source: BHF-UCL
  21. regulation of terminal button organization Source: BHF-UCL
  22. rhythmic synaptic transmission Source: BHF-UCL
  23. social behavior Source: BHF-UCL
  24. synapse assembly Source: RefGenome
  25. synapse organization Source: MGI
  26. visual learning Source: MGI
  27. vocalization behavior Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

MEROPSiS09.987.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroligin-3
Alternative name(s):
Gliotactin homolog
Gene namesi
Name:Nlgn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2444609. Nlgn3.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Cell junctionsynapse
Note: Detected at both glutamatergic and GABAergic synapses.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 686652Extracellular Reviewed prediction
Add
BLAST
Transmembranei687 – 70721Helical; Reviewed prediction
Add
BLAST
Topological domaini708 – 825118Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell surface Source: BHF-UCL
  3. endocytic vesicle Source: BHF-UCL
  4. excitatory synapse Source: BHF-UCL
  5. integral component of plasma membrane Source: BHF-UCL
  6. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

No obvious phenotype, but mice present subtle behavorial changes with reduced ultrasound vocalization and impaired response to olfactory cues. In addition, mice have reduced brain volume. Mice lacking both NLGN1 and NLGN3, or NLGN2 and NLGN3, are viable, but have impaired breathing, drastically reduced reproduction rates and striking deficits in raising their offspring. Mice lacking NLGN1, NLGN2 and NLGN3 are born at the expected Mendelian rate, but die shortly after birth due to respiratory failure. They do not show a significant change in the number of synapses, but synapse function is strongly impaired.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed prediction
Add
BLAST
Chaini35 – 825791Neuroligin-3
PRO_0000008646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi103 ↔ 138 By similarity
Disulfide bondi317 ↔ 328 By similarity
Disulfide bondi487 ↔ 521 By similarity
Glycosylationi522 – 5221N-linked (GlcNAc...) Reviewed prediction
Modified residuei769 – 7691Phosphotyrosine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BYM5.
PaxDbiQ8BYM5.
PRIDEiQ8BYM5.

PTM databases

PhosphoSiteiQ8BYM5.

Expressioni

Tissue specificityi

Brain and arteries (at protein level). Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Expressed in olfactory bulb and olfactory epithelium. Found in olfactory ensheathing glia but not in olfactory neurons, and in developing peripheral glia.5 Publications

Developmental stagei

Detected at embryonic day E17 and postnatal day P1 in retinal astrocytes, spinal chord astrocytes and Schwann cells of the dorsal root ganglion.1 Publication

Gene expression databases

BgeeiQ8BYM5.
CleanExiMM_NLGN3.
GenevestigatoriQ8BYM5.

Interactioni

Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) By similarity. Homodimer, and heterodimer with NLGN1 and NLGN2 By similarity.1 Publication

Protein-protein interaction databases

IntActiQ8BYM5. 2 interactions.
MINTiMINT-4103912.

Structurei

3D structure databases

ProteinModelPortaliQ8BYM5.
SMRiQ8BYM5. Positions 39-606.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2272.
GeneTreeiENSGT00690000101920.
HOGENOMiHOG000231424.
HOVERGENiHBG008839.
KOiK07378.
TreeFamiTF326187.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Neuroligin.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR01090. NEUROLIGIN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BYM5-1 [UniParc]FASTAAdd to Basket

« Hide

MWLQPSLSLS PTPTVGRSLC LTLGFLSLVL RASTQAPAPT VNTHFGKLRG    50
ARVPLPSEIL GPVDQYLGVP YAAPPIGEKR FLPPEPPPSW SGIRNATHFP 100
PVCPQNIHTA VPEVMLPVWF TANLDIVATY IQEPNEDCLY LNVYVPTEDG 150
SGAKKQGEDL ADNDGDEDED IRDSGAKPVM VYIHGGSYME GTGNMIDGSV 200
LASYGNVIVI TLNYRVGVLG FLSTGDQAAK GNYGLLDQIQ ALRWVSENIA 250
FFGGDPRRIT VFGSGIGASC VSLLTLSHHS EGLFQRAIIQ SGSALSSWAV 300
NYQPVKYTSL LADKVGCNVL DTVDMVDCLR QKSAKELVEQ DIQPARYHVA 350
FGPVIDGDVI PDDPEILMEQ GEFLNYDIML GVNQGEGLKF VEGVVDPEDG 400
VSGTDFDYSV SNFVDNLYGY PEGKDTLRET IKFMYTDWAD RDNPETRRKT 450
LVALFTDHQW VEPSVVTADL HARYGSPTYF YAFYHHCQSL MKPAWSDAAH 500
GDEVPYVFGV PMVGPTDLFP CNFSKNDVML SAVVMTYWTN FAKTGDPNKP 550
VPQDTKFIHT KANRFEEVAW SKYNPRDQLY LHIGLKPRVR DHYRATKVAF 600
WKHLVPHLYN LHDMFHYTST TTKVPPPDTT HSSHITRRPN GKTWSTKRPA 650
ISPAYSNENA PGSWNGDQDA GPLLVENPRD YSTELSVTIA VGASLLFLNV 700
LAFAALYYRK DKRRQEPLRQ PSPQRGTGAP ELGTAPEEEL AALQLGPTHH 750
ECEAGPPHDT LRLTALPDYT LTLRRSPDDI PLMTPNTITM IPNSLVGLQT 800
LHPYNTFAAG FNSTGLPHSH STTRV 825
Length:825
Mass (Da):91,162
Last modified:July 27, 2011 - v2
Checksum:iCEF160C63E0A71A4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641D → E in BAC30207. 1 Publication
Sequence conflicti459 – 4591Q → K in BAC31918. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK039018 mRNA. Translation: BAC30207.1.
AK044438 mRNA. Translation: BAC31918.1.
AL683892 Genomic DNA. Translation: CAM24450.1.
CCDSiCCDS30313.1.
RefSeqiNP_766520.2. NM_172932.4.
UniGeneiMm.121508.

Genome annotation databases

EnsembliENSMUST00000065858; ENSMUSP00000066304; ENSMUSG00000031302.
GeneIDi245537.
KEGGimmu:245537.
UCSCiuc009txj.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK039018 mRNA. Translation: BAC30207.1 .
AK044438 mRNA. Translation: BAC31918.1 .
AL683892 Genomic DNA. Translation: CAM24450.1 .
CCDSi CCDS30313.1.
RefSeqi NP_766520.2. NM_172932.4.
UniGenei Mm.121508.

3D structure databases

ProteinModelPortali Q8BYM5.
SMRi Q8BYM5. Positions 39-606.
ModBasei Search...

Protein-protein interaction databases

IntActi Q8BYM5. 2 interactions.
MINTi MINT-4103912.

Protein family/group databases

MEROPSi S09.987.

PTM databases

PhosphoSitei Q8BYM5.

Proteomic databases

MaxQBi Q8BYM5.
PaxDbi Q8BYM5.
PRIDEi Q8BYM5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065858 ; ENSMUSP00000066304 ; ENSMUSG00000031302 .
GeneIDi 245537.
KEGGi mmu:245537.
UCSCi uc009txj.3. mouse.

Organism-specific databases

CTDi 54413.
MGIi MGI:2444609. Nlgn3.

Phylogenomic databases

eggNOGi COG2272.
GeneTreei ENSGT00690000101920.
HOGENOMi HOG000231424.
HOVERGENi HBG008839.
KOi K07378.
TreeFami TF326187.

Miscellaneous databases

ChiTaRSi NLGN3. mouse.
NextBioi 386794.
PROi Q8BYM5.
SOURCEi Search...

Gene expression databases

Bgeei Q8BYM5.
CleanExi MM_NLGN3.
Genevestigatori Q8BYM5.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Neuroligin.
[Graphical view ]
Pfami PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR01090. NEUROLIGIN.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus and Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia."
    Gilbert M., Smith J., Roskams A.J., Auld V.J.
    Glia 34:151-164(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  4. Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
  5. "Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses."
    Budreck E.C., Scheiffele P.
    Eur. J. Neurosci. 26:1738-1748(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NLGN1 AND NLGN2, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-769, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  7. Cited for: TISSUE SPECIFICITY.
  8. "Neuroligin-3-deficient mice: model of a monogenic heritable form of autism with an olfactory deficit."
    Radyushkin K., Hammerschmidt K., Boretius S., Varoqueaux F., El-Kordi A., Ronnenberg A., Winter D., Frahm J., Fischer J., Brose N., Ehrenreich H.
    Genes Brain Behav. 8:416-425(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  9. "The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions."
    Bottos A., Destro E., Rissone A., Graziano S., Cordara G., Assenzio B., Cera M.R., Mascia L., Bussolino F., Arese M.
    Proc. Natl. Acad. Sci. U.S.A. 106:20782-20787(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNLGN3_MOUSE
AccessioniPrimary (citable) accession number: Q8BYM5
Secondary accession number(s): A2AGI1, Q8BXR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi