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Protein

Tyrosine--tRNA ligase, mitochondrial

Gene

Yars2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).By similarity

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei72TyrosineBy similarity1
Binding sitei76ATPBy similarity1
Binding sitei116TyrosineBy similarity1
Binding sitei216TyrosineBy similarity1
Binding sitei220TyrosineBy similarity1
Binding sitei223TyrosineBy similarity1
Binding sitei242TyrosineBy similarity1
Binding sitei269ATP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei279ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligase, mitochondrial (EC:6.1.1.1By similarity)
Alternative name(s):
Tyrosyl-tRNA synthetase
Short name:
TyrRS
Gene namesi
Name:Yars2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1917370 Yars2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000035831? – 472Tyrosine--tRNA ligase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei350N6-acetyllysineBy similarity1
Modified residuei362N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BYL4
MaxQBiQ8BYL4
PaxDbiQ8BYL4
PeptideAtlasiQ8BYL4
PRIDEiQ8BYL4

PTM databases

iPTMnetiQ8BYL4
PhosphoSitePlusiQ8BYL4

Expressioni

Gene expression databases

BgeeiENSMUSG00000022792
CleanExiMM_YARS2
ExpressionAtlasiQ8BYL4 baseline and differential
GenevisibleiQ8BYL4 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055277

Structurei

3D structure databases

ProteinModelPortaliQ8BYL4
SMRiQ8BYL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi77 – 86"HIGH" region10
Motifi276 – 280"KMSKS" region5

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2623 Eukaryota
COG0162 LUCA
GeneTreeiENSGT00390000013709
HOGENOMiHOG000242790
HOVERGENiHBG056052
InParanoidiQ8BYL4
KOiK01866
OMAiVNYMMAK
OrthoDBiEOG091G06NG
PhylomeDBiQ8BYL4
TreeFamiTF105974

Family and domain databases

CDDicd00805 TyrRS_core, 1 hit
Gene3Di3.10.290.10, 1 hit
3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR036986 S4_RNA-bd_sf
IPR002307 Tyr-tRNA-ligase
IPR024088 Tyr-tRNA-ligase_bac-type
PANTHERiPTHR11766 PTHR11766, 1 hit
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01040 TRNASYNTHTYR
TIGRFAMsiTIGR00234 tyrS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BYL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPMLRRLC RVPQSLVWLR GSRAVRPGAR GMLVAPRARG LFKEFFPESG
60 70 80 90 100
TKTELPELFD RRRAGSSPQT VYCGFDPTGD SLHVGHLLTL LGLFHFQRAG
110 120 130 140 150
HNVIALVGGS TALLGDPSGR TKGREALSAE CVRANAHALR RGLEALAANH
160 170 180 190 200
ARLFADGRPW GSFTVLDNAA WFQEQHLVDF LATVGGHFRM GTLLSRLSVQ
210 220 230 240 250
SRLKSPEGMS LAEFFYQVLQ AYDFYYLFQH YGCRVQLGGS DQLGNIMSGY
260 270 280 290 300
EFIHKLTGED VFGITVPLIT STTGAKLGKS AGNAVWLNRE KTSPFELYQF
310 320 330 340 350
FVRQQDDSVE RYLKLFTFLP LPEIDHIMQL HVKEPEKRVA QKRLAAEVTK
360 370 380 390 400
LVHGQEGLDS AKRCTQALYH SSIEALEVMS DQELKELFKE ASFSELVLDP
410 420 430 440 450
GTSVIDTCRK ANAIPDGPRG YRMITEGGVS INHRQVTNPE SVLVIGQHIL
460 470
KNGLSLLKIG KRNFYIIKWL QL
Length:472
Mass (Da):52,597
Last modified:July 19, 2004 - v2
Checksum:i7775B040E3E8A2F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060295 mRNA Translation: AAH60295.1
AK039123 mRNA Translation: BAC30245.1
CCDSiCCDS27983.1
RefSeqiNP_937889.1, NM_198246.2
UniGeneiMm.37486

Genome annotation databases

EnsembliENSMUST00000059955; ENSMUSP00000055277; ENSMUSG00000022792
GeneIDi70120
KEGGimmu:70120
UCSCiuc007yie.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSYYM_MOUSE
AccessioniPrimary (citable) accession number: Q8BYL4
Secondary accession number(s): Q6PAH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health