Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8BYJ6

- TBCD4_MOUSE

UniProt

Q8BYJ6 - TBCD4_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

TBC1 domain family member 4

Gene

Tbc1d4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake By similarity.By similarity

GO - Molecular functioni

  1. Rab GTPase activator activity Source: InterPro

GO - Biological processi

  1. cellular response to insulin stimulus Source: UniProtKB
  2. vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_199054. Translocation of GLUT4 to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 4
Alternative name(s):
Akt substrate of 160 kDa
Short name:
AS160
Gene namesi
Name:Tbc1d4
Synonyms:As160, Kiaa0603
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2429660. Tbc1d4.

Subcellular locationi

Cytoplasm 1 Publication
Note: Cytoplasmic perinuclear.By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13071307TBC1 domain family member 4PRO_0000208027Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei324 – 3241Phosphoserine; by PKB/AKT11 Publication
Modified residuei348 – 3481Phosphoserine; by PKB/AKT11 Publication
Modified residuei351 – 3511PhosphoserineBy similarity
Modified residuei484 – 4841N6-acetyllysineBy similarity
Modified residuei573 – 5731PhosphoserineBy similarity
Modified residuei575 – 5751PhosphothreonineBy similarity
Modified residuei577 – 5771Phosphoserine; by PKB/AKT11 Publication
Modified residuei595 – 5951Phosphoserine; by PKB/AKT12 Publications
Modified residuei598 – 5981PhosphoserineBy similarity
Modified residuei649 – 6491Phosphothreonine; by PKB/AKT12 Publications
Modified residuei758 – 7581Phosphoserine; by PKB/AKT11 Publication

Post-translational modificationi

Phosphorylated by AKT1; insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization.4 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BYJ6.
PaxDbiQ8BYJ6.
PRIDEiQ8BYJ6.

PTM databases

PhosphoSiteiQ8BYJ6.

Expressioni

Tissue specificityi

Widely expressed, including in pancreatic beta cells.2 Publications

Gene expression databases

BgeeiQ8BYJ6.
CleanExiMM_TBC1D4.
ExpressionAtlasiQ8BYJ6. baseline and differential.
GenevestigatoriQ8BYJ6.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
YwhaeP622596EBI-7920707,EBI-356480

Protein-protein interaction databases

BioGridi229182. 1 interaction.
IntActiQ8BYJ6. 2 interactions.
MINTiMINT-4113377.

Structurei

3D structure databases

ProteinModelPortaliQ8BYJ6.
SMRiQ8BYJ6. Positions 367-445, 883-1177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 209157PID 1PROSITE-ProRule annotationAdd
BLAST
Domaini319 – 475157PID 2PROSITE-ProRule annotationAdd
BLAST
Domaini927 – 1121195Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PID domains.PROSITE-ProRule annotation
Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5210.
HOVERGENiHBG059376.
InParanoidiQ8BYJ6.
KOiK17902.
PhylomeDBiQ8BYJ6.

Family and domain databases

Gene3Di2.30.29.30. 3 hits.
InterProiIPR021785. DUF3350.
IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF11830. DUF3350. 1 hit.
PF00640. PID. 2 hits.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS01179. PID. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8BYJ6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESPSCIQDE PFPHPLEPEP SAPAQPGATK PGDKRFRLWY VGGSCLDRRT
60 70 80 90 100
TLPMLPWLMA EIRRRSQKPD AGGCGAPAAR EVILVLSAPF LRCVPAPGAG
110 120 130 140 150
VGGGAGSGAV QPNTGVFIFE HKAQHISRFI HNSHDLTYFA YLIKAQPDDP
160 170 180 190 200
ESQMACHVFR ATDPNQVPDV ISSIRQLSKA AMKEDSKPSK DNEDAFYNSQ
210 220 230 240 250
KFEVLYCGRV IVTHKKAPSS LIDDCKDKFS LHEQQRLKLQ GERGGDPGDE
260 270 280 290 300
MGVLEVESPV SPDDSLPEKA DGTVNSPRAL PSLASLPALA SQPALASSRV
310 320 330 340 350
CFPERILEDC GFDEQQEFRS RCSSVTGVMQ KKVHENNQKT QPRRRHASAP
360 370 380 390 400
SHVQPSDSEK NRTMLFQVGR FEINLISPDT KSVVLEKNFK DISSCSQGIK
410 420 430 440 450
HVDHFGFICR ESPEPGLSQY ICYVFQCANE SLVDEVMLTL KQAFSTAAAL
460 470 480 490 500
QSAKTQIKLC ETCPMHSLHK LCERIEGLYP PRAKLVIQRH LSSLTDNEQA
510 520 530 540 550
DIFERVQKMK PISDQEENEL VILHLRQLCE AKQRTHVHIG EGPAIISNST
560 570 580 590 600
IPENVTSGGR FKLDVLKNKA KRSLTSSLEN IFSRGANRMR GRLGSMDSFE
610 620 630 640 650
RANSLASEKD FSPGDSPPGT PPASPLSSAW HAFPEEDSDS PQFRRRAHTF
660 670 680 690 700
SHPPSSSRRK LNLQDGKAHG LRSPLLRQSS SEQCSIVPSA RRMYKESNSS
710 720 730 740 750
CSLPSLHTSF SAPSFTAPSF LKSFYQNSGR LSPQYENEIR QDTASESSDG
760 770 780 790 800
EGRKRTSSTC SNESLNAGGT PVTPRRVSWR QRIFLRVASP VNKSPSAMQQ
810 820 830 840 850
QKDGLDRTEL LPLSPLSPTM EEEPLIIFLS GDEDTEKVEE KKKSKELKSL
860 870 880 890 900
WKKAIHQQIL LLRMEKENQK LEEARRDELQ SRKVKLDYEE VGTCQKEILI
910 920 930 940 950
AWDKKLLNCR TKIRCDMEDI HTSLKEGVPK SRRGEIWQFL ALQYRLRHRL
960 970 980 990 1000
PNKHQPPDTS YKELLKQLTA QQHAILVDLG RTFPTHPYFS VQLGAGQLSL
1010 1020 1030 1040 1050
FNLLKAYSLL DKEVGYCQGI SFVAGVLLLH MSEEQAFEML KFLMYDLGFR
1060 1070 1080 1090 1100
KQYRPDMMSL QIQMYQLSRL LHDYHRELYN HLEENEISPS LYAAPWFLTL
1110 1120 1130 1140 1150
FASQFPLGFV ARVFDIIFLQ GTEVIFKVAL SLLSSQEALI MECENFENIV
1160 1170 1180 1190 1200
EFLKSTLPDM NTTEMEKIIT QVFEMDISKQ LHAYEVEYHV LQDELLESSY
1210 1220 1230 1240 1250
ACEDNESLEK LERANNQLKR QNMDLLEKLQ VAHAKIQALE SNLETLLTRE
1260 1270 1280 1290 1300
TKMKALIRTL EQDKMAYQKT VEQIRKLLPA DALANCELLL KDLTHPTNDK

AKAGNKP
Length:1,307
Mass (Da):147,451
Last modified:June 7, 2005 - v2
Checksum:i60B37CC6ED1D2F55
GO
Isoform 2 (identifier: Q8BYJ6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     685-747: Missing.
     873-873: E → G
     874-1307: Missing.

Show »
Length:810
Mass (Da):89,865
Checksum:iD9755CCAE0FD49EF
GO
Isoform 3 (identifier: Q8BYJ6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     685-739: Missing.
     873-873: E → G
     874-1307: Missing.

Note: No experimental confirmation available.

Show »
Length:818
Mass (Da):90,740
Checksum:i923910C328DA9D00
GO
Isoform 4 (identifier: Q8BYJ6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     508-508: Missing.
     685-747: Missing.
     873-873: E → G
     874-1307: Missing.

Note: No experimental confirmation available.

Show »
Length:809
Mass (Da):89,737
Checksum:i49D29FA0DEC1CA40
GO
Isoform 5 (identifier: Q8BYJ6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-793: Missing.
     794-802: SPSAMQQQK → MPLTVFFSA
     873-873: Missing.

Note: No experimental confirmation available.

Show »
Length:513
Mass (Da):59,706
Checksum:iAD9462305438B697
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711I → V in BAC30322. (PubMed:16141072)Curated
Sequence conflicti631 – 6311H → Y in BAC30322. (PubMed:16141072)Curated
Sequence conflicti840 – 8401E → A in BAC30322. (PubMed:16141072)Curated
Sequence conflicti840 – 8401E → K in AAH64433. (PubMed:15489334)Curated
Sequence conflicti844 – 8441S → K in AAH80762. (PubMed:15489334)Curated
Sequence conflicti880 – 8801Q → L in BAE42613. (PubMed:16141072)Curated
Sequence conflicti914 – 9141R → K in BAE42613. (PubMed:16141072)Curated
Sequence conflicti974 – 9741A → T in BAE42613. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 793793Missing in isoform 5. 1 PublicationVSP_036872Add
BLAST
Alternative sequencei508 – 5081Missing in isoform 4. 1 PublicationVSP_036873
Alternative sequencei685 – 74763Missing in isoform 2 and isoform 4. 3 PublicationsVSP_013891Add
BLAST
Alternative sequencei685 – 73955Missing in isoform 3. 1 PublicationVSP_036874Add
BLAST
Alternative sequencei794 – 8029SPSAMQQQK → MPLTVFFSA in isoform 5. 1 PublicationVSP_036875
Alternative sequencei873 – 8731E → G in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_036876
Alternative sequencei873 – 8731Missing in isoform 5. 1 PublicationVSP_036877
Alternative sequencei874 – 1307434Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_036878Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK039337 mRNA. Translation: BAC30322.2.
AK044719 mRNA. Translation: BAC32048.1.
AK031120 mRNA. Translation: BAC27263.1.
AK171689 mRNA. Translation: BAE42613.1.
AK172575 mRNA. Translation: BAE43074.1.
BC064433 mRNA. Translation: AAH64433.1.
BC080762 mRNA. Translation: AAH80762.1.
BC117869 mRNA. Translation: AAI17870.1.
BC117870 mRNA. Translation: AAI17871.1.
AK220347 mRNA. Translation: BAD90243.1.
RefSeqiNP_001074747.2. NM_001081278.2.
XP_006518822.1. XM_006518759.1. [Q8BYJ6-1]
UniGeneiMm.320639.

Genome annotation databases

GeneIDi210789.
KEGGimmu:210789.
UCSCiuc007uvl.1. mouse. [Q8BYJ6-5]
uc007uvo.2. mouse. [Q8BYJ6-3]
uc007uvp.2. mouse. [Q8BYJ6-4]
uc007uvq.2. mouse. [Q8BYJ6-2]
uc007uvr.2. mouse. [Q8BYJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK039337 mRNA. Translation: BAC30322.2 .
AK044719 mRNA. Translation: BAC32048.1 .
AK031120 mRNA. Translation: BAC27263.1 .
AK171689 mRNA. Translation: BAE42613.1 .
AK172575 mRNA. Translation: BAE43074.1 .
BC064433 mRNA. Translation: AAH64433.1 .
BC080762 mRNA. Translation: AAH80762.1 .
BC117869 mRNA. Translation: AAI17870.1 .
BC117870 mRNA. Translation: AAI17871.1 .
AK220347 mRNA. Translation: BAD90243.1 .
RefSeqi NP_001074747.2. NM_001081278.2.
XP_006518822.1. XM_006518759.1. [Q8BYJ6-1 ]
UniGenei Mm.320639.

3D structure databases

ProteinModelPortali Q8BYJ6.
SMRi Q8BYJ6. Positions 367-445, 883-1177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229182. 1 interaction.
IntActi Q8BYJ6. 2 interactions.
MINTi MINT-4113377.

PTM databases

PhosphoSitei Q8BYJ6.

Proteomic databases

MaxQBi Q8BYJ6.
PaxDbi Q8BYJ6.
PRIDEi Q8BYJ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 210789.
KEGGi mmu:210789.
UCSCi uc007uvl.1. mouse. [Q8BYJ6-5 ]
uc007uvo.2. mouse. [Q8BYJ6-3 ]
uc007uvp.2. mouse. [Q8BYJ6-4 ]
uc007uvq.2. mouse. [Q8BYJ6-2 ]
uc007uvr.2. mouse. [Q8BYJ6-1 ]

Organism-specific databases

CTDi 9882.
MGIi MGI:2429660. Tbc1d4.
Rougei Search...

Phylogenomic databases

eggNOGi COG5210.
HOVERGENi HBG059376.
InParanoidi Q8BYJ6.
KOi K17902.
PhylomeDBi Q8BYJ6.

Enzyme and pathway databases

Reactomei REACT_199054. Translocation of GLUT4 to the plasma membrane.

Miscellaneous databases

NextBioi 373057.
PROi Q8BYJ6.
SOURCEi Search...

Gene expression databases

Bgeei Q8BYJ6.
CleanExi MM_TBC1D4.
ExpressionAtlasi Q8BYJ6. baseline and differential.
Genevestigatori Q8BYJ6.

Family and domain databases

Gene3Di 2.30.29.30. 3 hits.
InterProi IPR021785. DUF3350.
IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view ]
Pfami PF11830. DUF3350. 1 hit.
PF00640. PID. 2 hits.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view ]
SMARTi SM00462. PTB. 2 hits.
SM00164. TBC. 1 hit.
[Graphical view ]
SUPFAMi SSF47923. SSF47923. 2 hits.
PROSITEi PS01179. PID. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-840 (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Forelimb, Retina, Spinal cord and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-844 (ISOFORM 2).
    Strain: NMRI.
    Tissue: Mammary tumor.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 289-1307 (ISOFORM 2).
    Tissue: Fetal brain.
  4. "A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain."
    Kane S., Sano H., Liu S.C.H., Asara J.M., Lane W.S., Garner C.C., Lienhard G.E.
    J. Biol. Chem. 277:22115-22118(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-595 AND THR-649, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation."
    Sano H., Kane S., Sano E., Miinea C.P., Asara J.M., Lane W.S., Garner C.W., Lienhard G.E.
    J. Biol. Chem. 278:14599-14602(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-324; SER-348; SER-577; SER-595; THR-649 AND SER-758.
  6. "Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160."
    Zeigerer A., McBrayer M.K., McGraw T.E.
    Mol. Biol. Cell 15:4406-4415(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: EFFECT ON GLUT4 TRANSLOCATION.
  7. Cited for: PHOSPHORYLATION BY AMPK.
  8. "Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle."
    Kramer H.F., Witczak C.A., Fujii N., Jessen N., Taylor E.B., Arnolds D.E., Sakamoto K., Hirshman M.F., Goodyear L.J.
    Diabetes 55:2067-2076(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY AMPK.
  9. "Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells."
    Bouzakri K., Ribaux P., Tomas A., Parnaud G., Rickenbach K., Halban P.A.
    Diabetes 57:1195-1204(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiTBCD4_MOUSE
AccessioniPrimary (citable) accession number: Q8BYJ6
Secondary accession number(s): Q149C0
, Q149C1, Q3T9E8, Q3TAQ5, Q5DU23, Q66JU2, Q6P2M2, Q8BMH6, Q8BXM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3