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Q8BYJ6

- TBCD4_MOUSE

UniProt

Q8BYJ6 - TBCD4_MOUSE

Protein

TBC1 domain family member 4

Gene

Tbc1d4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. Rab GTPase activator activity Source: InterPro

    GO - Biological processi

    1. cellular response to insulin stimulus Source: UniProtKB
    2. vesicle-mediated transport Source: UniProtKB

    Keywords - Molecular functioni

    GTPase activation

    Enzyme and pathway databases

    ReactomeiREACT_199054. Translocation of GLUT4 to the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TBC1 domain family member 4
    Alternative name(s):
    Akt substrate of 160 kDa
    Short name:
    AS160
    Gene namesi
    Name:Tbc1d4
    Synonyms:As160, Kiaa0603
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2429660. Tbc1d4.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Cytoplasmic perinuclear.By similarity

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13071307TBC1 domain family member 4PRO_0000208027Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei324 – 3241Phosphoserine; by PKB/AKT11 Publication
    Modified residuei348 – 3481Phosphoserine; by PKB/AKT11 Publication
    Modified residuei351 – 3511PhosphoserineBy similarity
    Modified residuei484 – 4841N6-acetyllysineBy similarity
    Modified residuei573 – 5731PhosphoserineBy similarity
    Modified residuei575 – 5751PhosphothreonineBy similarity
    Modified residuei577 – 5771Phosphoserine; by PKB/AKT11 Publication
    Modified residuei595 – 5951Phosphoserine; by PKB/AKT12 Publications
    Modified residuei598 – 5981PhosphoserineBy similarity
    Modified residuei649 – 6491Phosphothreonine; by PKB/AKT12 Publications
    Modified residuei758 – 7581Phosphoserine; by PKB/AKT11 Publication

    Post-translational modificationi

    Phosphorylated by AKT1; insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization.4 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8BYJ6.
    PaxDbiQ8BYJ6.
    PRIDEiQ8BYJ6.

    PTM databases

    PhosphoSiteiQ8BYJ6.

    Expressioni

    Tissue specificityi

    Widely expressed, including in pancreatic beta cells.2 Publications

    Gene expression databases

    ArrayExpressiQ8BYJ6.
    BgeeiQ8BYJ6.
    CleanExiMM_TBC1D4.
    GenevestigatoriQ8BYJ6.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    YwhaeP622596EBI-7920707,EBI-356480

    Protein-protein interaction databases

    BioGridi229182. 1 interaction.
    IntActiQ8BYJ6. 2 interactions.
    MINTiMINT-4113377.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BYJ6.
    SMRiQ8BYJ6. Positions 883-1177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 209157PID 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini319 – 475157PID 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini927 – 1121195Rab-GAP TBCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PID domains.PROSITE-ProRule annotation
    Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5210.
    HOVERGENiHBG059376.
    InParanoidiQ3T9E8.
    KOiK17902.
    PhylomeDBiQ8BYJ6.

    Family and domain databases

    Gene3Di2.30.29.30. 3 hits.
    InterProiIPR021785. DUF3350.
    IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    IPR000195. Rab-GTPase-TBC_dom.
    [Graphical view]
    PfamiPF11830. DUF3350. 1 hit.
    PF00640. PID. 2 hits.
    PF00566. RabGAP-TBC. 1 hit.
    [Graphical view]
    SMARTiSM00462. PTB. 2 hits.
    SM00164. TBC. 1 hit.
    [Graphical view]
    SUPFAMiSSF47923. SSF47923. 2 hits.
    PROSITEiPS01179. PID. 1 hit.
    PS50086. TBC_RABGAP. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8BYJ6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESPSCIQDE PFPHPLEPEP SAPAQPGATK PGDKRFRLWY VGGSCLDRRT     50
    TLPMLPWLMA EIRRRSQKPD AGGCGAPAAR EVILVLSAPF LRCVPAPGAG 100
    VGGGAGSGAV QPNTGVFIFE HKAQHISRFI HNSHDLTYFA YLIKAQPDDP 150
    ESQMACHVFR ATDPNQVPDV ISSIRQLSKA AMKEDSKPSK DNEDAFYNSQ 200
    KFEVLYCGRV IVTHKKAPSS LIDDCKDKFS LHEQQRLKLQ GERGGDPGDE 250
    MGVLEVESPV SPDDSLPEKA DGTVNSPRAL PSLASLPALA SQPALASSRV 300
    CFPERILEDC GFDEQQEFRS RCSSVTGVMQ KKVHENNQKT QPRRRHASAP 350
    SHVQPSDSEK NRTMLFQVGR FEINLISPDT KSVVLEKNFK DISSCSQGIK 400
    HVDHFGFICR ESPEPGLSQY ICYVFQCANE SLVDEVMLTL KQAFSTAAAL 450
    QSAKTQIKLC ETCPMHSLHK LCERIEGLYP PRAKLVIQRH LSSLTDNEQA 500
    DIFERVQKMK PISDQEENEL VILHLRQLCE AKQRTHVHIG EGPAIISNST 550
    IPENVTSGGR FKLDVLKNKA KRSLTSSLEN IFSRGANRMR GRLGSMDSFE 600
    RANSLASEKD FSPGDSPPGT PPASPLSSAW HAFPEEDSDS PQFRRRAHTF 650
    SHPPSSSRRK LNLQDGKAHG LRSPLLRQSS SEQCSIVPSA RRMYKESNSS 700
    CSLPSLHTSF SAPSFTAPSF LKSFYQNSGR LSPQYENEIR QDTASESSDG 750
    EGRKRTSSTC SNESLNAGGT PVTPRRVSWR QRIFLRVASP VNKSPSAMQQ 800
    QKDGLDRTEL LPLSPLSPTM EEEPLIIFLS GDEDTEKVEE KKKSKELKSL 850
    WKKAIHQQIL LLRMEKENQK LEEARRDELQ SRKVKLDYEE VGTCQKEILI 900
    AWDKKLLNCR TKIRCDMEDI HTSLKEGVPK SRRGEIWQFL ALQYRLRHRL 950
    PNKHQPPDTS YKELLKQLTA QQHAILVDLG RTFPTHPYFS VQLGAGQLSL 1000
    FNLLKAYSLL DKEVGYCQGI SFVAGVLLLH MSEEQAFEML KFLMYDLGFR 1050
    KQYRPDMMSL QIQMYQLSRL LHDYHRELYN HLEENEISPS LYAAPWFLTL 1100
    FASQFPLGFV ARVFDIIFLQ GTEVIFKVAL SLLSSQEALI MECENFENIV 1150
    EFLKSTLPDM NTTEMEKIIT QVFEMDISKQ LHAYEVEYHV LQDELLESSY 1200
    ACEDNESLEK LERANNQLKR QNMDLLEKLQ VAHAKIQALE SNLETLLTRE 1250
    TKMKALIRTL EQDKMAYQKT VEQIRKLLPA DALANCELLL KDLTHPTNDK 1300
    AKAGNKP 1307
    Length:1,307
    Mass (Da):147,451
    Last modified:June 7, 2005 - v2
    Checksum:i60B37CC6ED1D2F55
    GO
    Isoform 2 (identifier: Q8BYJ6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         685-747: Missing.
         873-873: E → G
         874-1307: Missing.

    Show »
    Length:810
    Mass (Da):89,865
    Checksum:iD9755CCAE0FD49EF
    GO
    Isoform 3 (identifier: Q8BYJ6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         685-739: Missing.
         873-873: E → G
         874-1307: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:818
    Mass (Da):90,740
    Checksum:i923910C328DA9D00
    GO
    Isoform 4 (identifier: Q8BYJ6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         508-508: Missing.
         685-747: Missing.
         873-873: E → G
         874-1307: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:809
    Mass (Da):89,737
    Checksum:i49D29FA0DEC1CA40
    GO
    Isoform 5 (identifier: Q8BYJ6-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-793: Missing.
         794-802: SPSAMQQQK → MPLTVFFSA
         873-873: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:513
    Mass (Da):59,706
    Checksum:iAD9462305438B697
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti171 – 1711I → V in BAC30322. (PubMed:16141072)Curated
    Sequence conflicti631 – 6311H → Y in BAC30322. (PubMed:16141072)Curated
    Sequence conflicti840 – 8401E → A in BAC30322. (PubMed:16141072)Curated
    Sequence conflicti840 – 8401E → K in AAH64433. (PubMed:15489334)Curated
    Sequence conflicti844 – 8441S → K in AAH80762. (PubMed:15489334)Curated
    Sequence conflicti880 – 8801Q → L in BAE42613. (PubMed:16141072)Curated
    Sequence conflicti914 – 9141R → K in BAE42613. (PubMed:16141072)Curated
    Sequence conflicti974 – 9741A → T in BAE42613. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 793793Missing in isoform 5. 1 PublicationVSP_036872Add
    BLAST
    Alternative sequencei508 – 5081Missing in isoform 4. 1 PublicationVSP_036873
    Alternative sequencei685 – 74763Missing in isoform 2 and isoform 4. 3 PublicationsVSP_013891Add
    BLAST
    Alternative sequencei685 – 73955Missing in isoform 3. 1 PublicationVSP_036874Add
    BLAST
    Alternative sequencei794 – 8029SPSAMQQQK → MPLTVFFSA in isoform 5. 1 PublicationVSP_036875
    Alternative sequencei873 – 8731E → G in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_036876
    Alternative sequencei873 – 8731Missing in isoform 5. 1 PublicationVSP_036877
    Alternative sequencei874 – 1307434Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_036878Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK039337 mRNA. Translation: BAC30322.2.
    AK044719 mRNA. Translation: BAC32048.1.
    AK031120 mRNA. Translation: BAC27263.1.
    AK171689 mRNA. Translation: BAE42613.1.
    AK172575 mRNA. Translation: BAE43074.1.
    BC064433 mRNA. Translation: AAH64433.1.
    BC080762 mRNA. Translation: AAH80762.1.
    BC117869 mRNA. Translation: AAI17870.1.
    BC117870 mRNA. Translation: AAI17871.1.
    AK220347 mRNA. Translation: BAD90243.1.
    RefSeqiNP_001074747.2. NM_001081278.2.
    XP_006518822.1. XM_006518759.1. [Q8BYJ6-1]
    UniGeneiMm.320639.

    Genome annotation databases

    GeneIDi210789.
    KEGGimmu:210789.
    UCSCiuc007uvl.1. mouse. [Q8BYJ6-5]
    uc007uvo.2. mouse. [Q8BYJ6-3]
    uc007uvp.2. mouse. [Q8BYJ6-4]
    uc007uvq.2. mouse. [Q8BYJ6-2]
    uc007uvr.2. mouse. [Q8BYJ6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK039337 mRNA. Translation: BAC30322.2 .
    AK044719 mRNA. Translation: BAC32048.1 .
    AK031120 mRNA. Translation: BAC27263.1 .
    AK171689 mRNA. Translation: BAE42613.1 .
    AK172575 mRNA. Translation: BAE43074.1 .
    BC064433 mRNA. Translation: AAH64433.1 .
    BC080762 mRNA. Translation: AAH80762.1 .
    BC117869 mRNA. Translation: AAI17870.1 .
    BC117870 mRNA. Translation: AAI17871.1 .
    AK220347 mRNA. Translation: BAD90243.1 .
    RefSeqi NP_001074747.2. NM_001081278.2.
    XP_006518822.1. XM_006518759.1. [Q8BYJ6-1 ]
    UniGenei Mm.320639.

    3D structure databases

    ProteinModelPortali Q8BYJ6.
    SMRi Q8BYJ6. Positions 883-1177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229182. 1 interaction.
    IntActi Q8BYJ6. 2 interactions.
    MINTi MINT-4113377.

    PTM databases

    PhosphoSitei Q8BYJ6.

    Proteomic databases

    MaxQBi Q8BYJ6.
    PaxDbi Q8BYJ6.
    PRIDEi Q8BYJ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 210789.
    KEGGi mmu:210789.
    UCSCi uc007uvl.1. mouse. [Q8BYJ6-5 ]
    uc007uvo.2. mouse. [Q8BYJ6-3 ]
    uc007uvp.2. mouse. [Q8BYJ6-4 ]
    uc007uvq.2. mouse. [Q8BYJ6-2 ]
    uc007uvr.2. mouse. [Q8BYJ6-1 ]

    Organism-specific databases

    CTDi 9882.
    MGIi MGI:2429660. Tbc1d4.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5210.
    HOVERGENi HBG059376.
    InParanoidi Q3T9E8.
    KOi K17902.
    PhylomeDBi Q8BYJ6.

    Enzyme and pathway databases

    Reactomei REACT_199054. Translocation of GLUT4 to the plasma membrane.

    Miscellaneous databases

    NextBioi 373057.
    PROi Q8BYJ6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BYJ6.
    Bgeei Q8BYJ6.
    CleanExi MM_TBC1D4.
    Genevestigatori Q8BYJ6.

    Family and domain databases

    Gene3Di 2.30.29.30. 3 hits.
    InterProi IPR021785. DUF3350.
    IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    IPR000195. Rab-GTPase-TBC_dom.
    [Graphical view ]
    Pfami PF11830. DUF3350. 1 hit.
    PF00640. PID. 2 hits.
    PF00566. RabGAP-TBC. 1 hit.
    [Graphical view ]
    SMARTi SM00462. PTB. 2 hits.
    SM00164. TBC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47923. SSF47923. 2 hits.
    PROSITEi PS01179. PID. 1 hit.
    PS50086. TBC_RABGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-840 (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Forelimb, Retina, Spinal cord and Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-844 (ISOFORM 2).
      Strain: NMRI.
      Tissue: Mammary tumor.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 289-1307 (ISOFORM 2).
      Tissue: Fetal brain.
    4. "A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain."
      Kane S., Sano H., Liu S.C.H., Asara J.M., Lane W.S., Garner C.C., Lienhard G.E.
      J. Biol. Chem. 277:22115-22118(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-595 AND THR-649, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation."
      Sano H., Kane S., Sano E., Miinea C.P., Asara J.M., Lane W.S., Garner C.W., Lienhard G.E.
      J. Biol. Chem. 278:14599-14602(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-324; SER-348; SER-577; SER-595; THR-649 AND SER-758.
    6. "Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160."
      Zeigerer A., McBrayer M.K., McGraw T.E.
      Mol. Biol. Cell 15:4406-4415(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: EFFECT ON GLUT4 TRANSLOCATION.
    7. Cited for: PHOSPHORYLATION BY AMPK.
    8. "Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle."
      Kramer H.F., Witczak C.A., Fujii N., Jessen N., Taylor E.B., Arnolds D.E., Sakamoto K., Hirshman M.F., Goodyear L.J.
      Diabetes 55:2067-2076(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY AMPK.
    9. "Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells."
      Bouzakri K., Ribaux P., Tomas A., Parnaud G., Rickenbach K., Halban P.A.
      Diabetes 57:1195-1204(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTBCD4_MOUSE
    AccessioniPrimary (citable) accession number: Q8BYJ6
    Secondary accession number(s): Q149C0
    , Q149C1, Q3T9E8, Q3TAQ5, Q5DU23, Q66JU2, Q6P2M2, Q8BMH6, Q8BXM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3