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Q8BYH8 (CHD9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromodomain-helicase-DNA-binding protein 9

Short name=CHD-9
EC=3.6.4.12
Alternative name(s):
ATP-dependent helicase CHD9
PPAR-alpha-interacting complex protein 320 kDa
Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein
Gene names
Name:Chd9
Synonyms:Kiaa0308, Pric320
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2885 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA By similarity. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subunit structure

Interacts with PPARA. Probably interacts with ESR1 and NR1I3 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Tissue specificity

Expressed in osteoprogenitor cells during development and in mature bone (at protein level). Ref.6

Developmental stage

Expressed from embryonic day 16.5 dpc in mesenchymal cartilage surrounding bone cartilage and newly formed bone trabecular spicules. Detected in bone sections of 4-day-old newborn and 3-week-old mice. Ref.6

Post-translational modification

Phosphorylated on serine and tyrosine residues By similarity.

Sequence similarities

Belongs to the SNF2/RAD54 helicase family.

Contains 2 chromo domains.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Sequence caution

The sequence AAH52896.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8BYH8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BYH8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2335-2350: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 28852885Chromodomain-helicase-DNA-binding protein 9
PRO_0000233173

Regions

Domain689 – 76072Chromo 1
Domain772 – 83867Chromo 2
Domain871 – 1045175Helicase ATP-binding
Domain1185 – 1336152Helicase C-terminal
Nucleotide binding884 – 8918ATP Potential
Region2331 – 2471141Binds A/T-rich DNA By similarity
Region2428 – 24358A.T hook-like
Motif867 – 8715LXXLL motif 1
Motif996 – 9994DEAH box
Motif1035 – 10395LXXLL motif 2
Motif2030 – 20345LXXLL motif 3
Motif2710 – 27145LXXLL motif 4
Motif2782 – 27876LXXLL motif 5

Amino acid modifications

Modified residue4981N6-acetyllysine By similarity
Modified residue5491Phosphoserine By similarity
Modified residue6101Phosphoserine By similarity
Modified residue14671Phosphoserine By similarity
Modified residue14711Phosphoserine By similarity
Modified residue20251Phosphoserine By similarity
Modified residue20571Phosphoserine By similarity
Modified residue20581Phosphoserine By similarity

Natural variations

Alternative sequence2335 – 235016Missing in isoform 2.
VSP_018087

Experimental info

Sequence conflict1011N → I in BAC39090. Ref.2
Sequence conflict5841Y → D in BAC28711. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: B820BE8EA9CC2915

FASTA2,885323,860
        10         20         30         40         50         60 
MTDPMMDFFD DANLFGETLE GLSDDTFVQP GPVSLVDELN LGAEFEPLHI DSLNHVQGTP 

        70         80         90        100        110        120 
THQKMADFEQ LSQFDSMKFH PVNQSFGSPV EHVLSPHSQF NCSPIHPPNQ PNGLFQDVAD 

       130        140        150        160        170        180 
GSPMWGHQTA TGLANQNGSP FHQPGHSHSL HQNKSFVAHP DFALFQASEH QTQCSSLHSQ 

       190        200        210        220        230        240 
QSRSNLNPGQ NSLGQAKNFL DANVSGAHRV NVNHLATAPS SQQTLPVQFS PTANPPAHFL 

       250        260        270        280        290        300 
KCSSHQEGNY NRPSPSMTSC SVSNSQQFPS HYSFSSGHVS PSSLLQSSAG LAPGHTNQAL 

       310        320        330        340        350        360 
SDFAGSNSFS PHRGMKQEPT QHLLNPTPSL NSNNFQILHS SHPQGNYSNS KLSPVHMNFP 

       370        380        390        400        410        420 
DPVDAGPPVG HFNDHAETNG FSSLEENLLH HVDSHAEPFA GLDPEDLLQE GLLPQFDESP 

       430        440        450        460        470        480 
FGQDNSNHVL DHDLDRQFTS HLVSRPSDMA QTQLQYQARG WPSPLSTNHQ HLHSRNHLCL 

       490        500        510        520        530        540 
QRQPPSSKKS DGSGTYTKLQ NTQVRVMSEK KPRKRVESES KQEKANRIIS EAIARAKERG 

       550        560        570        580        590        600 
ERNIPRVMSP ENFPSASVEG KEEKRGRRMK SKPKDRDNKK PKTYSKLKEK TKIGKLIITL 

       610        620        630        640        650        660 
GKKHKRRNES SDELSDAEQR SQHTFKEQHS QKRRSNRQIK RKKYAEDAEG KQSEEEVKGS 

       670        680        690        700        710        720 
LRVKRNSAPP PGEQPLQLFV ENPSEEDAAI VDKILACRTV KKEVSPGVML DIEEFFVKYK 

       730        740        750        760        770        780 
NYSYLHCEWA TEQQLLKDKR IQQKIKRFKL RQAQRAHFLA DMEEEPFNPD YVEVDRILEV 

       790        800        810        820        830        840 
SFCEDKDTGE SVIYYLVKWC SLPYEDSTWE LKEDVDLAKI EEFEQLQASR PDTRHLDRPP 

       850        860        870        880        890        900 
SNIWKKIEQS REYKNGNQLR EYQLEGLNWL LFNWYNRRNC ILADEMGLGK TIQSITFLYE 

       910        920        930        940        950        960 
ILLTGIRGPF LIIAPLSTIA NWEREFRTWT DINVVVYHGS LISRQMIQQY EMYFRDSQGR 

       970        980        990       1000       1010       1020 
IIRGAYRFQA IITTFEMILG GCGELNAIDW RCVIIDEAHR LKNKNCKLLE GLKLMNLEHK 

      1030       1040       1050       1060       1070       1080 
VLLTGTPLQN TVEELFSLLH FLEPLRFPSE STFMQEFGDL KTEEQVQKLQ AILKPMMLRR 

      1090       1100       1110       1120       1130       1140 
LKEDVEKKLA PKEETIIEVE LTNIQKKYYR AILEKNFSFL SKGAGQTNVP NLVNTMMELR 

      1150       1160       1170       1180       1190       1200 
KCCNHPYLIK GAEEKILGEF RDTYNPSASD FHLQAMIQSA GKLVLIDKLL PKMKAGGHKV 

      1210       1220       1230       1240       1250       1260 
LIFSQMVRCL DILEDYLIHK RYLYERIDGR VRGNLRQAAI DRFSKPDSDR FVFLLCTRAG 

      1270       1280       1290       1300       1310       1320 
GLGINLTAAD TCIIFDSDWN PQNDLQAQAR CHRIGQNKAV KVYRLVTRNS YEREMFDRAS 

      1330       1340       1350       1360       1370       1380 
LKLGLDKAVL QSMSGRDSNV SGIQQLSKKE IEDLLRRGAY GAIMEEEDEG SKFCEEDIDQ 

      1390       1400       1410       1420       1430       1440 
ILLRRTKTIT IESEGRGSTF AKASFVASGN RTDISLDDPN FWQKWAKKAE LDIDTISGRN 

      1450       1460       1470       1480       1490       1500 
SLVIDTPRIR KQTRPFSATK DELAELSEAE SEGEEKPKLR RPCDRSGGYG RTECFRVEKN 

      1510       1520       1530       1540       1550       1560 
LLVYGWGRWR EILSHGRFKR QLNEHDVEVI CRALLAYCLI HYRGDEKIKG FIWDLITPTE 

      1570       1580       1590       1600       1610       1620 
DGQTRELQNH LGLSAPVPRG RKGKKVKTQT SSFDIQKAEW LRKYNPEQLL QDEGYKKHVK 

      1630       1640       1650       1660       1670       1680 
HHCNKVLLRV RMLYYLKQEV IGNESQKVFD GVDASDIDVW VPEPDHSEVP AAWWDFDADK 

      1690       1700       1710       1720       1730       1740 
SLLIGVFKHG YEKYNTIRAD PALCFLERVG KPDDKAVAAE QRANDYMDGD VEDPEYKPAP 

      1750       1760       1770       1780       1790       1800 
AIFKDDIEDD VSSPGDLVIA DGEGQLMEGD KVYWPTPSAL TTRLRRLITA YQRTNKNRHI 

      1810       1820       1830       1840       1850       1860 
QQMQPTFSLP ANAMQPLYEE ATLNPKMAAK IERQQRWTRR EEADFYRVVS TFGVVFDPDR 

      1870       1880       1890       1900       1910       1920 
GQFDWTKFRA LARLHKKTDN SLEKYLCAFM SMCRRVCRLP SKEELVDPNI FIQPITEERA 

      1930       1940       1950       1960       1970       1980 
SRTLYRIELL RKVREQALRH PQLFERLKLC HPNPDLPIWW ECGSHDRDLL IGAAKHGVSR 

      1990       2000       2010       2020       2030       2040 
TDYHILRDPE LSFMAAQRNY NQSKAAHSRT SAPLLQQYQV ALSASPLTSL PRLLGAKGTL 

      2050       2060       2070       2080       2090       2100 
LEDMKVKSES LTEEPQSSEE ESMSSMETRT RVKSEPVSPK NGVLSQATGD QKSGGKSETD 

      2110       2120       2130       2140       2150       2160 
RRMVAARTEP LTPNPASKKP RVHKRGSQSS SDSDSDSARS SCSSRSSSSS SSSSSCSHSR 

      2170       2180       2190       2200       2210       2220 
SGSSSSSSSS CSSASSSSSS SSSSSSSSSS SSSEESDSEE DVQKREGTPH RKAYDEESVA 

      2230       2240       2250       2260       2270       2280 
SLSTTQDETQ DSFQANNGTP ESAYLLQGGY MLAASYWPKD RVMINRLDSI CQTVLKGKWP 

      2290       2300       2310       2320       2330       2340 
SARRHYDANT VASFYTTKLL DSPGAATERG EPSVPTPPAV AVREEHEQSA QMSKVKKHVR 

      2350       2360       2370       2380       2390       2400 
EKEFTVKIKD EGGLKLTFQK QGLAQKRPFD GEDGALGQQQ YLTRLRELQS TSETSLVNLP 

      2410       2420       2430       2440       2450       2460 
KAVPASGTSI QPTLGANGAI LDSQPIVKKR RGRRRNVEGA DILFLNRNKP PNHIPTGMNP 

      2470       2480       2490       2500       2510       2520 
ALSYPQPQRI PDTESPVPVI NLKDGTRLAG DDAPKRKDLD RWLKEHPGYV EDLGAFIPRV 

      2530       2540       2550       2560       2570       2580 
QLHEGRPKQK RHRCRNPNKL DINSLTGEER VQLINRRNAR KVGGAFAPPL KDLCRFLKEN 

      2590       2600       2610       2620       2630       2640 
SEYGVAPEWG DVVKQSGFLP ESMFERILTG PVVREEVSRR GRRPKSGIAK ATTAAAVPAG 

      2650       2660       2670       2680       2690       2700 
SVPGNPLLAN GLLPGVDLTA LQALQQNLQN LQSLQVTAGL MGMPAGLSSG GETKNMAAMF 

      2710       2720       2730       2740       2750       2760 
PMLFSGMAGL PNLLGMGGLL SKTAESGAEE KRGNDSKELE GKKERTESQS PENGGERCVP 

      2770       2780       2790       2800       2810       2820 
GSPSTSSTAA LSSAAAAKPI ALNPLLLSNI LYPGMLLTPG LNLHLPTLSQ SNAFDVQKNK 

      2830       2840       2850       2860       2870       2880 
SDDLDSSKSV EIKEENSRVR DQEEKGGTEP SPLNENSTDE GSERASSGSD SSSSSSEDSD 


SSNED 

« Hide

Isoform 2 [UniParc].

Checksum: A684A06A35C83F91
Show »

FASTA2,869321,894

References

« Hide 'large scale' references
[1]"PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex."
Surapureddi S., Viswakarma N., Yu S., Guo D., Rao M.S., Reddy J.K.
Biochem. Biophys. Res. Commun. 343:535-543(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1104 (ISOFORMS 1/2).
Strain: C57BL/6J.
Tissue: Diencephalon, Spinal cord and Spinal ganglion.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 980-2885 (ISOFORM 2).
Tissue: Pancreatic islet.
[4]Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2207-2885 (ISOFORM 1).
Strain: C3H/He.
Tissue: Mesenchymal stem cell.
[6]"In vivo association of CReMM/CHD9 with promoters in osteogenic cells."
Shur I., Socher R., Benayahu D.
J. Cell. Physiol. 207:374-378(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ127229 mRNA. Translation: AAZ73184.2.
AK034446 mRNA. Translation: BAC28711.1.
AK039562 mRNA. Translation: BAC30385.1.
AK084000 mRNA. Translation: BAC39090.1.
AB093226 mRNA. Translation: BAC41410.3.
BC052896 mRNA. Translation: AAH52896.1. Different initiation.
CCDSCCDS22517.1. [Q8BYH8-2]
RefSeqNP_796198.1. NM_177224.2. [Q8BYH8-2]
XP_006530631.1. XM_006530568.1. [Q8BYH8-1]
XP_006530632.1. XM_006530569.1. [Q8BYH8-1]
UniGeneMm.100615.

3D structure databases

ProteinModelPortalQ8BYH8.
SMRQ8BYH8. Positions 714-1326, 2472-2519, 2535-2616.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BYH8.

Proteomic databases

PaxDbQ8BYH8.
PRIDEQ8BYH8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048665; ENSMUSP00000046356; ENSMUSG00000056608. [Q8BYH8-2]
ENSMUST00000109614; ENSMUSP00000105243; ENSMUSG00000056608. [Q8BYH8-1]
GeneID109151.
KEGGmmu:109151.
UCSCuc009msf.2. mouse. [Q8BYH8-2]
uc009msi.2. mouse. [Q8BYH8-1]

Organism-specific databases

CTD80205.
MGIMGI:1924001. Chd9.
RougeSearch...

Phylogenomic databases

eggNOGCOG0553.
GeneTreeENSGT00560000077077.
HOGENOMHOG000246942.
HOVERGENHBG081150.
InParanoidQ8BYH8.
KOK14438.
OMAQEDKGGT.
OrthoDBEOG7NSB1C.
PhylomeDBQ8BYH8.
TreeFamTF313572.

Gene expression databases

ArrayExpressQ8BYH8.
BgeeQ8BYH8.
CleanExMM_CHD9.
GenevestigatorQ8BYH8.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR006576. BRK_domain.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamPF07533. BRK. 2 hits.
PF00385. Chromo. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTSM00592. BRK. 2 hits.
SM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEPS50013. CHROMO_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCHD9. mouse.
NextBio361700.
PROQ8BYH8.
SOURCESearch...

Entry information

Entry nameCHD9_MOUSE
AccessionPrimary (citable) accession number: Q8BYH8
Secondary accession number(s): Q7TMV5 expand/collapse secondary AC list , Q8BJG8, Q8BZJ2, Q8CHG8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot