Q8BYH8 (CHD9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromodomain-helicase-DNA-binding protein 9
Short name=CHD-9
EC=3.6.4.12

Alternative name(s):
ATP-dependent helicase CHD9
PPAR-alpha-interacting complex protein 320 kDa
Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein

Gene names

Name:	Chd9
Synonyms:	Kiaa0308, Pric320

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2885 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA By similarity. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis.
Catalytic activity	ATP + H2O = ADP + phosphate.
Subunit structure	Interacts with PPARA. Probably interacts with ESR1 and NR1I3 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Tissue specificity	Expressed in osteoprogenitor cells during development and in mature bone (at protein level). Ref.6
Developmental stage	Expressed from embryonic day 16.5 dpc in mesenchymal cartilage surrounding bone cartilage and newly formed bone trabecular spicules. Detected in bone sections of 4-day-old newborn and 3-week-old mice. Ref.6
Post-translational modification	Phosphorylated on serine and tyrosine residues By similarity.
Sequence similarities	Belongs to the SNF2/RAD54 helicase family. Contains 2 chromo domains. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.
Sequence caution	The sequence AAH52896.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Chromatin regulator Helicase Hydrolase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW helicase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8BYH8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BYH8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2335-2350: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2885	2885	Chromodomain-helicase-DNA-binding protein 9		PRO_0000233173
Regions
	Domain	689 – 760	72	Chromo 1
	Domain	772 – 838	67	Chromo 2
	Domain	871 – 1045	175	Helicase ATP-binding
	Domain	1185 – 1336	152	Helicase C-terminal
	Nucleotide binding	884 – 891	8	ATP Potential
	Region	2331 – 2471	141	Binds A/T-rich DNA By similarity
	Region	2428 – 2435	8	A.T hook-like
	Motif	867 – 871	5	LXXLL motif 1
	Motif	996 – 999	4	DEAH box
	Motif	1035 – 1039	5	LXXLL motif 2
	Motif	2030 – 2034	5	LXXLL motif 3
	Motif	2710 – 2714	5	LXXLL motif 4
	Motif	2782 – 2787	6	LXXLL motif 5
Amino acid modifications
	Modified residue	498	1	N6-acetyllysine By similarity
	Modified residue	549	1	Phosphoserine By similarity
	Modified residue	610	1	Phosphoserine By similarity
	Modified residue	644	1	Phosphotyrosine Ref.7
	Modified residue	1467	1	Phosphoserine By similarity
	Modified residue	1471	1	Phosphoserine By similarity
	Modified residue	2025	1	Phosphoserine By similarity
	Modified residue	2057	1	Phosphoserine By similarity
	Modified residue	2058	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	2335 – 2350	16	Missing in isoform 2.		VSP_018087
Experimental info
	Sequence conflict	101	1	N → I in BAC39090. Ref.2
	Sequence conflict	584	1	Y → D in BAC28711. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 2, 2006. Version 2. Checksum: B820BE8EA9CC2915	FASTA	2,885	323,860
	10 20 30 40 50 60 MTDPMMDFFD DANLFGETLE GLSDDTFVQP GPVSLVDELN LGAEFEPLHI DSLNHVQGTP 70 80 90 100 110 120 THQKMADFEQ LSQFDSMKFH PVNQSFGSPV EHVLSPHSQF NCSPIHPPNQ PNGLFQDVAD 130 140 150 160 170 180 GSPMWGHQTA TGLANQNGSP FHQPGHSHSL HQNKSFVAHP DFALFQASEH QTQCSSLHSQ 190 200 210 220 230 240 QSRSNLNPGQ NSLGQAKNFL DANVSGAHRV NVNHLATAPS SQQTLPVQFS PTANPPAHFL 250 260 270 280 290 300 KCSSHQEGNY NRPSPSMTSC SVSNSQQFPS HYSFSSGHVS PSSLLQSSAG LAPGHTNQAL 310 320 330 340 350 360 SDFAGSNSFS PHRGMKQEPT QHLLNPTPSL NSNNFQILHS SHPQGNYSNS KLSPVHMNFP 370 380 390 400 410 420 DPVDAGPPVG HFNDHAETNG FSSLEENLLH HVDSHAEPFA GLDPEDLLQE GLLPQFDESP 430 440 450 460 470 480 FGQDNSNHVL DHDLDRQFTS HLVSRPSDMA QTQLQYQARG WPSPLSTNHQ HLHSRNHLCL 490 500 510 520 530 540 QRQPPSSKKS DGSGTYTKLQ NTQVRVMSEK KPRKRVESES KQEKANRIIS EAIARAKERG 550 560 570 580 590 600 ERNIPRVMSP ENFPSASVEG KEEKRGRRMK SKPKDRDNKK PKTYSKLKEK TKIGKLIITL 610 620 630 640 650 660 GKKHKRRNES SDELSDAEQR SQHTFKEQHS QKRRSNRQIK RKKYAEDAEG KQSEEEVKGS 670 680 690 700 710 720 LRVKRNSAPP PGEQPLQLFV ENPSEEDAAI VDKILACRTV KKEVSPGVML DIEEFFVKYK 730 740 750 760 770 780 NYSYLHCEWA TEQQLLKDKR IQQKIKRFKL RQAQRAHFLA DMEEEPFNPD YVEVDRILEV 790 800 810 820 830 840 SFCEDKDTGE SVIYYLVKWC SLPYEDSTWE LKEDVDLAKI EEFEQLQASR PDTRHLDRPP 850 860 870 880 890 900 SNIWKKIEQS REYKNGNQLR EYQLEGLNWL LFNWYNRRNC ILADEMGLGK TIQSITFLYE 910 920 930 940 950 960 ILLTGIRGPF LIIAPLSTIA NWEREFRTWT DINVVVYHGS LISRQMIQQY EMYFRDSQGR 970 980 990 1000 1010 1020 IIRGAYRFQA IITTFEMILG GCGELNAIDW RCVIIDEAHR LKNKNCKLLE GLKLMNLEHK 1030 1040 1050 1060 1070 1080 VLLTGTPLQN TVEELFSLLH FLEPLRFPSE STFMQEFGDL KTEEQVQKLQ AILKPMMLRR 1090 1100 1110 1120 1130 1140 LKEDVEKKLA PKEETIIEVE LTNIQKKYYR AILEKNFSFL SKGAGQTNVP NLVNTMMELR 1150 1160 1170 1180 1190 1200 KCCNHPYLIK GAEEKILGEF RDTYNPSASD FHLQAMIQSA GKLVLIDKLL PKMKAGGHKV 1210 1220 1230 1240 1250 1260 LIFSQMVRCL DILEDYLIHK RYLYERIDGR VRGNLRQAAI DRFSKPDSDR FVFLLCTRAG 1270 1280 1290 1300 1310 1320 GLGINLTAAD TCIIFDSDWN PQNDLQAQAR CHRIGQNKAV KVYRLVTRNS YEREMFDRAS 1330 1340 1350 1360 1370 1380 LKLGLDKAVL QSMSGRDSNV SGIQQLSKKE IEDLLRRGAY GAIMEEEDEG SKFCEEDIDQ 1390 1400 1410 1420 1430 1440 ILLRRTKTIT IESEGRGSTF AKASFVASGN RTDISLDDPN FWQKWAKKAE LDIDTISGRN 1450 1460 1470 1480 1490 1500 SLVIDTPRIR KQTRPFSATK DELAELSEAE SEGEEKPKLR RPCDRSGGYG RTECFRVEKN 1510 1520 1530 1540 1550 1560 LLVYGWGRWR EILSHGRFKR QLNEHDVEVI CRALLAYCLI HYRGDEKIKG FIWDLITPTE 1570 1580 1590 1600 1610 1620 DGQTRELQNH LGLSAPVPRG RKGKKVKTQT SSFDIQKAEW LRKYNPEQLL QDEGYKKHVK 1630 1640 1650 1660 1670 1680 HHCNKVLLRV RMLYYLKQEV IGNESQKVFD GVDASDIDVW VPEPDHSEVP AAWWDFDADK 1690 1700 1710 1720 1730 1740 SLLIGVFKHG YEKYNTIRAD PALCFLERVG KPDDKAVAAE QRANDYMDGD VEDPEYKPAP 1750 1760 1770 1780 1790 1800 AIFKDDIEDD VSSPGDLVIA DGEGQLMEGD KVYWPTPSAL TTRLRRLITA YQRTNKNRHI 1810 1820 1830 1840 1850 1860 QQMQPTFSLP ANAMQPLYEE ATLNPKMAAK IERQQRWTRR EEADFYRVVS TFGVVFDPDR 1870 1880 1890 1900 1910 1920 GQFDWTKFRA LARLHKKTDN SLEKYLCAFM SMCRRVCRLP SKEELVDPNI FIQPITEERA 1930 1940 1950 1960 1970 1980 SRTLYRIELL RKVREQALRH PQLFERLKLC HPNPDLPIWW ECGSHDRDLL IGAAKHGVSR 1990 2000 2010 2020 2030 2040 TDYHILRDPE LSFMAAQRNY NQSKAAHSRT SAPLLQQYQV ALSASPLTSL PRLLGAKGTL 2050 2060 2070 2080 2090 2100 LEDMKVKSES LTEEPQSSEE ESMSSMETRT RVKSEPVSPK NGVLSQATGD QKSGGKSETD 2110 2120 2130 2140 2150 2160 RRMVAARTEP LTPNPASKKP RVHKRGSQSS SDSDSDSARS SCSSRSSSSS SSSSSCSHSR 2170 2180 2190 2200 2210 2220 SGSSSSSSSS CSSASSSSSS SSSSSSSSSS SSSEESDSEE DVQKREGTPH RKAYDEESVA 2230 2240 2250 2260 2270 2280 SLSTTQDETQ DSFQANNGTP ESAYLLQGGY MLAASYWPKD RVMINRLDSI CQTVLKGKWP 2290 2300 2310 2320 2330 2340 SARRHYDANT VASFYTTKLL DSPGAATERG EPSVPTPPAV AVREEHEQSA QMSKVKKHVR 2350 2360 2370 2380 2390 2400 EKEFTVKIKD EGGLKLTFQK QGLAQKRPFD GEDGALGQQQ YLTRLRELQS TSETSLVNLP 2410 2420 2430 2440 2450 2460 KAVPASGTSI QPTLGANGAI LDSQPIVKKR RGRRRNVEGA DILFLNRNKP PNHIPTGMNP 2470 2480 2490 2500 2510 2520 ALSYPQPQRI PDTESPVPVI NLKDGTRLAG DDAPKRKDLD RWLKEHPGYV EDLGAFIPRV 2530 2540 2550 2560 2570 2580 QLHEGRPKQK RHRCRNPNKL DINSLTGEER VQLINRRNAR KVGGAFAPPL KDLCRFLKEN 2590 2600 2610 2620 2630 2640 SEYGVAPEWG DVVKQSGFLP ESMFERILTG PVVREEVSRR GRRPKSGIAK ATTAAAVPAG 2650 2660 2670 2680 2690 2700 SVPGNPLLAN GLLPGVDLTA LQALQQNLQN LQSLQVTAGL MGMPAGLSSG GETKNMAAMF 2710 2720 2730 2740 2750 2760 PMLFSGMAGL PNLLGMGGLL SKTAESGAEE KRGNDSKELE GKKERTESQS PENGGERCVP 2770 2780 2790 2800 2810 2820 GSPSTSSTAA LSSAAAAKPI ALNPLLLSNI LYPGMLLTPG LNLHLPTLSQ SNAFDVQKNK 2830 2840 2850 2860 2870 2880 SDDLDSSKSV EIKEENSRVR DQEEKGGTEP SPLNENSTDE GSERASSGSD SSSSSSEDSD SSNED
	Isoform 2 [UniParc]. Checksum: A684A06A35C83F91	FASTA	2,869	321,894
	10 20 30 40 50 60 MTDPMMDFFD DANLFGETLE GLSDDTFVQP GPVSLVDELN LGAEFEPLHI DSLNHVQGTP 70 80 90 100 110 120 THQKMADFEQ LSQFDSMKFH PVNQSFGSPV EHVLSPHSQF NCSPIHPPNQ PNGLFQDVAD 130 140 150 160 170 180 GSPMWGHQTA TGLANQNGSP FHQPGHSHSL HQNKSFVAHP DFALFQASEH QTQCSSLHSQ 190 200 210 220 230 240 QSRSNLNPGQ NSLGQAKNFL DANVSGAHRV NVNHLATAPS SQQTLPVQFS PTANPPAHFL 250 260 270 280 290 300 KCSSHQEGNY NRPSPSMTSC SVSNSQQFPS HYSFSSGHVS PSSLLQSSAG LAPGHTNQAL 310 320 330 340 350 360 SDFAGSNSFS PHRGMKQEPT QHLLNPTPSL NSNNFQILHS SHPQGNYSNS KLSPVHMNFP 370 380 390 400 410 420 DPVDAGPPVG HFNDHAETNG FSSLEENLLH HVDSHAEPFA GLDPEDLLQE GLLPQFDESP 430 440 450 460 470 480 FGQDNSNHVL DHDLDRQFTS HLVSRPSDMA QTQLQYQARG WPSPLSTNHQ HLHSRNHLCL 490 500 510 520 530 540 QRQPPSSKKS DGSGTYTKLQ NTQVRVMSEK KPRKRVESES KQEKANRIIS EAIARAKERG 550 560 570 580 590 600 ERNIPRVMSP ENFPSASVEG KEEKRGRRMK SKPKDRDNKK PKTYSKLKEK TKIGKLIITL 610 620 630 640 650 660 GKKHKRRNES SDELSDAEQR SQHTFKEQHS QKRRSNRQIK RKKYAEDAEG KQSEEEVKGS 670 680 690 700 710 720 LRVKRNSAPP PGEQPLQLFV ENPSEEDAAI VDKILACRTV KKEVSPGVML DIEEFFVKYK 730 740 750 760 770 780 NYSYLHCEWA TEQQLLKDKR IQQKIKRFKL RQAQRAHFLA DMEEEPFNPD YVEVDRILEV 790 800 810 820 830 840 SFCEDKDTGE SVIYYLVKWC SLPYEDSTWE LKEDVDLAKI EEFEQLQASR PDTRHLDRPP 850 860 870 880 890 900 SNIWKKIEQS REYKNGNQLR EYQLEGLNWL LFNWYNRRNC ILADEMGLGK TIQSITFLYE 910 920 930 940 950 960 ILLTGIRGPF LIIAPLSTIA NWEREFRTWT DINVVVYHGS LISRQMIQQY EMYFRDSQGR 970 980 990 1000 1010 1020 IIRGAYRFQA IITTFEMILG GCGELNAIDW RCVIIDEAHR LKNKNCKLLE GLKLMNLEHK 1030 1040 1050 1060 1070 1080 VLLTGTPLQN TVEELFSLLH FLEPLRFPSE STFMQEFGDL KTEEQVQKLQ AILKPMMLRR 1090 1100 1110 1120 1130 1140 LKEDVEKKLA PKEETIIEVE LTNIQKKYYR AILEKNFSFL SKGAGQTNVP NLVNTMMELR 1150 1160 1170 1180 1190 1200 KCCNHPYLIK GAEEKILGEF RDTYNPSASD FHLQAMIQSA GKLVLIDKLL PKMKAGGHKV 1210 1220 1230 1240 1250 1260 LIFSQMVRCL DILEDYLIHK RYLYERIDGR VRGNLRQAAI DRFSKPDSDR FVFLLCTRAG 1270 1280 1290 1300 1310 1320 GLGINLTAAD TCIIFDSDWN PQNDLQAQAR CHRIGQNKAV KVYRLVTRNS YEREMFDRAS 1330 1340 1350 1360 1370 1380 LKLGLDKAVL QSMSGRDSNV SGIQQLSKKE IEDLLRRGAY GAIMEEEDEG SKFCEEDIDQ 1390 1400 1410 1420 1430 1440 ILLRRTKTIT IESEGRGSTF AKASFVASGN RTDISLDDPN FWQKWAKKAE LDIDTISGRN 1450 1460 1470 1480 1490 1500 SLVIDTPRIR KQTRPFSATK DELAELSEAE SEGEEKPKLR RPCDRSGGYG RTECFRVEKN 1510 1520 1530 1540 1550 1560 LLVYGWGRWR EILSHGRFKR QLNEHDVEVI CRALLAYCLI HYRGDEKIKG FIWDLITPTE 1570 1580 1590 1600 1610 1620 DGQTRELQNH LGLSAPVPRG RKGKKVKTQT SSFDIQKAEW LRKYNPEQLL QDEGYKKHVK 1630 1640 1650 1660 1670 1680 HHCNKVLLRV RMLYYLKQEV IGNESQKVFD GVDASDIDVW VPEPDHSEVP AAWWDFDADK 1690 1700 1710 1720 1730 1740 SLLIGVFKHG YEKYNTIRAD PALCFLERVG KPDDKAVAAE QRANDYMDGD VEDPEYKPAP 1750 1760 1770 1780 1790 1800 AIFKDDIEDD VSSPGDLVIA DGEGQLMEGD KVYWPTPSAL TTRLRRLITA YQRTNKNRHI 1810 1820 1830 1840 1850 1860 QQMQPTFSLP ANAMQPLYEE ATLNPKMAAK IERQQRWTRR EEADFYRVVS TFGVVFDPDR 1870 1880 1890 1900 1910 1920 GQFDWTKFRA LARLHKKTDN SLEKYLCAFM SMCRRVCRLP SKEELVDPNI FIQPITEERA 1930 1940 1950 1960 1970 1980 SRTLYRIELL RKVREQALRH PQLFERLKLC HPNPDLPIWW ECGSHDRDLL IGAAKHGVSR 1990 2000 2010 2020 2030 2040 TDYHILRDPE LSFMAAQRNY NQSKAAHSRT SAPLLQQYQV ALSASPLTSL PRLLGAKGTL 2050 2060 2070 2080 2090 2100 LEDMKVKSES LTEEPQSSEE ESMSSMETRT RVKSEPVSPK NGVLSQATGD QKSGGKSETD 2110 2120 2130 2140 2150 2160 RRMVAARTEP LTPNPASKKP RVHKRGSQSS SDSDSDSARS SCSSRSSSSS SSSSSCSHSR 2170 2180 2190 2200 2210 2220 SGSSSSSSSS CSSASSSSSS SSSSSSSSSS SSSEESDSEE DVQKREGTPH RKAYDEESVA 2230 2240 2250 2260 2270 2280 SLSTTQDETQ DSFQANNGTP ESAYLLQGGY MLAASYWPKD RVMINRLDSI CQTVLKGKWP 2290 2300 2310 2320 2330 2340 SARRHYDANT VASFYTTKLL DSPGAATERG EPSVPTPPAV AVREEHEQSA QMSKEGGLKL 2350 2360 2370 2380 2390 2400 TFQKQGLAQK RPFDGEDGAL GQQQYLTRLR ELQSTSETSL VNLPKAVPAS GTSIQPTLGA 2410 2420 2430 2440 2450 2460 NGAILDSQPI VKKRRGRRRN VEGADILFLN RNKPPNHIPT GMNPALSYPQ PQRIPDTESP 2470 2480 2490 2500 2510 2520 VPVINLKDGT RLAGDDAPKR KDLDRWLKEH PGYVEDLGAF IPRVQLHEGR PKQKRHRCRN 2530 2540 2550 2560 2570 2580 PNKLDINSLT GEERVQLINR RNARKVGGAF APPLKDLCRF LKENSEYGVA PEWGDVVKQS 2590 2600 2610 2620 2630 2640 GFLPESMFER ILTGPVVREE VSRRGRRPKS GIAKATTAAA VPAGSVPGNP LLANGLLPGV 2650 2660 2670 2680 2690 2700 DLTALQALQQ NLQNLQSLQV TAGLMGMPAG LSSGGETKNM AAMFPMLFSG MAGLPNLLGM 2710 2720 2730 2740 2750 2760 GGLLSKTAES GAEEKRGNDS KELEGKKERT ESQSPENGGE RCVPGSPSTS STAALSSAAA 2770 2780 2790 2800 2810 2820 AKPIALNPLL LSNILYPGML LTPGLNLHLP TLSQSNAFDV QKNKSDDLDS SKSVEIKEEN 2830 2840 2850 2860 SRVRDQEEKG GTEPSPLNEN STDEGSERAS SGSDSSSSSS EDSDSSNED

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex." Surapureddi S., Viswakarma N., Yu S., Guo D., Rao M.S., Reddy J.K. Biochem. Biophys. Res. Commun. 343:535-543(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1104 (ISOFORMS 1/2). Strain: C57BL/6J. Tissue: Diencephalon, Spinal cord and Spinal ganglion.
[3]	"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H. DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 980-2885 (ISOFORM 2). Tissue: Pancreatic islet.
[4]	Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2207-2885 (ISOFORM 1). Strain: C3H/He. Tissue: Mesenchymal stem cell.
[6]	"In vivo association of CReMM/CHD9 with promoters in osteogenic cells." Shur I., Socher R., Benayahu D. J. Cell. Physiol. 207:374-378(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[7]	"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-644, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ127229 mRNA. Translation: AAZ73184.2. AK034446 mRNA. Translation: BAC28711.1. AK039562 mRNA. Translation: BAC30385.1. AK084000 mRNA. Translation: BAC39090.1. AB093226 mRNA. Translation: BAC41410.3. BC052896 mRNA. Translation: AAH52896.1. Different initiation.
IPI	IPI00229650. IPI00758139.
RefSeq	NP_796198.1. NM_177224.2.
UniGene	Mm.100615.
3D structure databases
ProteinModelPortal	Q8BYH8.
SMR	Q8BYH8. Positions 714-1326, 2472-2519, 2535-2616.
ModBase	Search...
PTM databases
PhosphoSite	Q8BYH8.
Proteomic databases
PaxDb	Q8BYH8.
PRIDE	Q8BYH8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000048665; ENSMUSP00000046356; ENSMUSG00000056608. ENSMUST00000109614; ENSMUSP00000105243; ENSMUSG00000056608.
GeneID	109151.
KEGG	mmu:109151.
UCSC	uc009msf.2. mouse. uc009msi.2. mouse.
Organism-specific databases
CTD	80205.
MGI	MGI:1924001. Chd9.
Rouge	Search...
Phylogenomic databases
eggNOG	COG0553.
GeneTree	ENSGT00560000077077.
HOGENOM	HOG000246942.
HOVERGEN	HBG081150.
InParanoid	Q8BYH8.
KO	K14438.
OMA	MWGHQTA.
OrthoDB	EOG4548XQ.
Gene expression databases
ArrayExpress	Q8BYH8.
Bgee	Q8BYH8.
CleanEx	MM_CHD9.
Genevestigator	Q8BYH8.
Family and domain databases
InterPro	IPR006576. BRK_domain. IPR023780. Chromo_domain. IPR000953. Chromo_domain/shadow. IPR016197. Chromodomain-like. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR000330. SNF2_N. [Graphical view]
Pfam	PF07533. BRK. 2 hits. PF00385. Chromo. 2 hits. PF00271. Helicase_C. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view]
SMART	SM00592. BRK. 2 hits. SM00298. CHROMO. 2 hits. SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
SUPFAM	SSF54160. Chromodomain-like. 1 hit.
PROSITE	PS00598. CHROMO_1. False negative. PS50013. CHROMO_2. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CHD9. mouse.
NextBio	361700.
SOURCE	Search...

Entry information

Entry name

CHD9_MOUSE

Accession

Primary (citable) accession number: Q8BYH8
Secondary accession number(s): Q7TMV5 , Q8BJG8, Q8BZJ2, Q8CHG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	May 2, 2006
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program