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Protein

TBC1 domain family member 17

Gene

Tbc1d17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei377Arginine fingerBy similarity1
Sitei418Glutamine fingerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
Biological processAutophagy, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-8854214 TBC/RABGAPs

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 17
Gene namesi
Name:Tbc1d17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2449973 Tbc1d17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002080461 – 645TBC1 domain family member 17Add BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei602PhosphoserineBy similarity1
Modified residuei604PhosphoserineBy similarity1
Modified residuei608PhosphoserineBy similarity1
Modified residuei615PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BYH7
MaxQBiQ8BYH7
PaxDbiQ8BYH7
PRIDEiQ8BYH7

PTM databases

iPTMnetiQ8BYH7
PhosphoSitePlusiQ8BYH7

Expressioni

Gene expression databases

BgeeiENSMUSG00000038520
ExpressionAtlasiQ8BYH7 baseline and differential
GenevisibleiQ8BYH7 MM

Interactioni

Subunit structurei

Interacts with OPTN.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231386, 1 interactor
STRINGi10090.ENSMUSP00000048260

Structurei

3D structure databases

ProteinModelPortaliQ8BYH7
SMRiQ8BYH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini310 – 520Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST211

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni217 – 309Required for interaction with OPTNBy similarityAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi597 – 631Pro-richAdd BLAST35

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Phylogenomic databases

eggNOGiKOG2197 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00550000074386
HOVERGENiHBG057668
InParanoidiQ8BYH7
KOiK19945
OMAiHDVLMTY
OrthoDBiEOG091G04IX
TreeFamiTF314296

Family and domain databases

InterProiView protein in InterPro
IPR021935 DUF3548
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF12068 DUF3548, 1 hit
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BYH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSSYRVVF EKGGVYLHTS ARKHQDPDSL IAGVIRVVEK DSDVFLHWAP
60 70 80 90 100
VEEAGDPTQI LFKKDPSRGE PSTSEEEPTF DPGYEPDWAV ISTVRPQPHL
110 120 130 140 150
AEPRKGAEPS SSRSSWAFSV SLGELKSIRR SKPGLSWAYL VLVTQAGGSL
160 170 180 190 200
PALHFHRGGT RALLRVLSRY LLLASSPQDS RLYLVFPQDP SALSDSFHHL
210 220 230 240 250
QLFDQDSSNV VSRFLQDPYS TTFSSFSRVT NFFRGALQPH PEGASSPNLP
260 270 280 290 300
PLPDDEPEPG FEVISCVELG QRPTVERAPP VTEEEWNRYV GPEGRLQNVP
310 320 330 340 350
ELKNRIFSGG LSPGLRREAW KFLLGYLSWE SSAEEHKAHV RKKTDEYFRM
360 370 380 390 400
KLQWKSVSAE QERRNSLLHG YRSLIERDVS RTDRTNKFYE GPENPGLSLL
410 420 430 440 450
HDILLTYCMY HFDLGYVQGM SDLLSPILFV VQNEVDAFWC FCGFMELVHG
460 470 480 490 500
NFEESQETMK RQLGQLLLLL RVLDQPLCDF LDSQDSGSLC FCFRWLLIWF
510 520 530 540 550
KREFPFPDVL RLWEVLWTGL PGPNLHLLVA CAILDMERDT LMLSGFGSNE
560 570 580 590 600
ILKHINELTM KLSVEDVLTR AEALYRQLTA CPELPHNVQE ILGLAQPEEP
610 620 630 640
SSPSPPVSPM PLSPTRAPLP PPLPEEVIPQ PDSSLEILPE DEDGA
Length:645
Mass (Da):72,860
Last modified:July 27, 2011 - v2
Checksum:iB0C3FC3C0F4A27E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75E → Q in BAC30387 (PubMed:16141072).Curated1
Sequence conflicti608S → F in BAC30387 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136705 mRNA Translation: BAE23103.1
AK170821 mRNA Translation: BAE42052.1
AK039566 mRNA Translation: BAC30387.1
CH466603 Genomic DNA Translation: EDL22756.1
CCDSiCCDS39944.1
RefSeqiNP_001036120.1, NM_001042655.1
UniGeneiMm.27567

Genome annotation databases

EnsembliENSMUST00000047085; ENSMUSP00000048260; ENSMUSG00000038520
GeneIDi233204
KEGGimmu:233204
UCSCiuc009grc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTBC17_MOUSE
AccessioniPrimary (citable) accession number: Q8BYH7
Secondary accession number(s): Q3TCA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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