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Protein

tRNA:m(4)X modification enzyme TRM13 homolog

Gene

Trmt13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

tRNA methylase which 2'-O-methylates cytidine4 in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine4 in tRNA(His).By similarity

Catalytic activityi

S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.
S-adenosyl-L-methionine + cytidine4 in tRNA(Pro) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNA(Pro).
S-adenosyl-L-methionine + cytidine4 in tRNA(Gly)(GCC) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNA(Gly)(GCC).
S-adenosyl-L-methionine + adenosine4 in tRNA(His) = S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNA(His).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri56 – 8328CHHC U11-48K-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA:m(4)X modification enzyme TRM13 homolog (EC:2.1.1.225)
Alternative name(s):
Coiled-coil domain-containing protein 76
Gene namesi
Name:Trmt13
Synonyms:Ccdc76
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1925219. Trmt13.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 481480tRNA:m(4)X modification enzyme TRM13 homologPRO_0000236679Add
BLAST

Proteomic databases

MaxQBiQ8BYH3.
PaxDbiQ8BYH3.
PeptideAtlasiQ8BYH3.
PRIDEiQ8BYH3.

PTM databases

iPTMnetiQ8BYH3.
PhosphoSiteiQ8BYH3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033439.
CleanExiMM_CCDC76.
ExpressionAtlasiQ8BYH3. baseline and differential.
GenevisibleiQ8BYH3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047320.

Structurei

3D structure databases

ProteinModelPortaliQ8BYH3.
SMRiQ8BYH3. Positions 53-84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili113 – 14028Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRM13 family.Curated
Contains 1 CHHC U11-48K-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri56 – 8328CHHC U11-48K-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2811. Eukaryota.
ENOG410Z6H8. LUCA.
GeneTreeiENSGT00390000003182.
HOGENOMiHOG000000772.
HOVERGENiHBG054828.
InParanoidiQ8BYH3.
KOiK15446.
OMAiATCGMRE.
OrthoDBiEOG091G0B5L.
PhylomeDBiQ8BYH3.
TreeFamiTF317538.

Family and domain databases

InterProiIPR007871. Methyltransferase_TRM13.
IPR022776. TRM13/UPF0224_CHHC_Znf_dom.
IPR021721. Znf_CCCH-type_TRM13.
[Graphical view]
PfamiPF05206. TRM13. 1 hit.
PF11722. zf-TRM13_CCCH. 1 hit.
PF05253. zf-U11-48K. 1 hit.
[Graphical view]
PROSITEiPS51800. ZF_CHHC_U11_48K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BYH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPAATSPS IGFPIDGRCN YFVEKKKRFC RMVAAAGKRF CGEHAGSAEE
60 70 80 90 100
ENTRKRILCP LDPKHTVYED QLAKHLKKCN SREKPKPDFF IQDINAGLKD
110 120 130 140 150
ETEIPEQLVP FSSLSEEQLE NLIKKLRKAS EGLNSTHEDH IMSHPALHDA
160 170 180 190 200
LNDPRNGDCA VKHLKQQASI LGNIEKLKLL GPRRCFVEFG AGKGKLSHWV
210 220 230 240 250
DIALKDAENV HFILVERVTT RFKVDGKHRK KDSVFERLQI DIQHLCLNRV
260 270 280 290 300
PVLREGRLPV VGIGKHLCGV ATDVALRCLV ETYAASFEEK DEEPLAKRIK
310 320 330 340 350
NDKTEKESNT LAKEGSEKDV PETWTPVAGI VIALCCHHRC DWRHYVGKEY
360 370 380 390 400
FKALGLGAVE FYYFQRMSSW ATCGMRTSLE GSDVTPERKD AQRDENEEHD
410 420 430 440 450
DGGDRLTDGN TDSLPGILTV EEKKKIGHLC KLLIDQGRLQ YLQQKGFSPA
460 470 480
LQYYTDPLVS LENVLLTAVP AHPSSQEKHH Q
Length:481
Mass (Da):54,261
Last modified:March 1, 2003 - v1
Checksum:iA301831B337D62B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039588 mRNA. Translation: BAC30394.1.
CCDSiCCDS38612.1.
RefSeqiNP_084292.1. NM_030016.2.
UniGeneiMm.259648.

Genome annotation databases

EnsembliENSMUST00000041524; ENSMUSP00000047320; ENSMUSG00000033439.
GeneIDi229780.
KEGGimmu:229780.
UCSCiuc008rck.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039588 mRNA. Translation: BAC30394.1.
CCDSiCCDS38612.1.
RefSeqiNP_084292.1. NM_030016.2.
UniGeneiMm.259648.

3D structure databases

ProteinModelPortaliQ8BYH3.
SMRiQ8BYH3. Positions 53-84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047320.

PTM databases

iPTMnetiQ8BYH3.
PhosphoSiteiQ8BYH3.

Proteomic databases

MaxQBiQ8BYH3.
PaxDbiQ8BYH3.
PeptideAtlasiQ8BYH3.
PRIDEiQ8BYH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041524; ENSMUSP00000047320; ENSMUSG00000033439.
GeneIDi229780.
KEGGimmu:229780.
UCSCiuc008rck.1. mouse.

Organism-specific databases

CTDi54482.
MGIiMGI:1925219. Trmt13.

Phylogenomic databases

eggNOGiKOG2811. Eukaryota.
ENOG410Z6H8. LUCA.
GeneTreeiENSGT00390000003182.
HOGENOMiHOG000000772.
HOVERGENiHBG054828.
InParanoidiQ8BYH3.
KOiK15446.
OMAiATCGMRE.
OrthoDBiEOG091G0B5L.
PhylomeDBiQ8BYH3.
TreeFamiTF317538.

Miscellaneous databases

PROiQ8BYH3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033439.
CleanExiMM_CCDC76.
ExpressionAtlasiQ8BYH3. baseline and differential.
GenevisibleiQ8BYH3. MM.

Family and domain databases

InterProiIPR007871. Methyltransferase_TRM13.
IPR022776. TRM13/UPF0224_CHHC_Znf_dom.
IPR021721. Znf_CCCH-type_TRM13.
[Graphical view]
PfamiPF05206. TRM13. 1 hit.
PF11722. zf-TRM13_CCCH. 1 hit.
PF05253. zf-U11-48K. 1 hit.
[Graphical view]
PROSITEiPS51800. ZF_CHHC_U11_48K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRM13_MOUSE
AccessioniPrimary (citable) accession number: Q8BYH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.