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Protein

Ephrin type-A receptor 10

Gene

Epha10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5 (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-A receptor 10 (EC:2.7.10.1)
Gene namesi
Name:Epha10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3586824. Epha10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 565543ExtracellularSequence analysisAdd
BLAST
Transmembranei566 – 58621HelicalSequence analysisAdd
BLAST
Topological domaini587 – 1007421CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 1007985Ephrin type-A receptor 10PRO_0000280444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence analysis
Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BYG9.
PeptideAtlasiQ8BYG9.
PRIDEiQ8BYG9.

PTM databases

iPTMnetiQ8BYG9.
PhosphoSiteiQ8BYG9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028876.
CleanExiMM_EPHA10.
ExpressionAtlasiQ8BYG9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ8BYG9.
SMRiQ8BYG9. Positions 35-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 216182Eph LBDPROSITE-ProRule annotationAdd
BLAST
Domaini340 – 452113Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini456 – 55499Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini644 – 899256Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini932 – 99665SAMPROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
Contains 1 Eph LBD (Eph ligand-binding) domain.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00740000115264.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiQ8BYG9.
PhylomeDBiQ8BYG9.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BYG9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METGAGPHPL RLFVCLIPLC LALLLGPGRP GTAEEVILLD SKASQAELGW
60 70 80 90 100
TALPSTGWEE ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR
110 120 130 140 150
IFVELQFTLR DCSSIPGATG TCKETFNAYY LETETDLGRG RPRLGGNRPR
160 170 180 190 200
KIDTIAADES FTQGDLGERK MKLNTEVREI GPLSRQGFHL AFQDVGACVA
210 220 230 240 250
LVSVRVYYKQ CRATVRGLAA FPATAAESAF STLVEVAGTC VAHSEGEPSS
260 270 280 290 300
PPRMHCGADG EWLVPVGRCS CSAGFQEHGD ICEACPPGFY KVSPRRPLCS
310 320 330 340 350
PCPEHSLALE NASTFCVCQD TYARSPTDPP SASCTRPPSA PRDLQYSLSR
360 370 380 390 400
SPLALRLRWL PPADSGGRSD VTYSLLCLRC GRDGPAGACQ PCGPRVAFVP
410 420 430 440 450
RQAGLRERAA TLLHLRPGAR YTVRVAALNG VSGPAAAAGA TYAQVTVSTG
460 470 480 490 500
PGAPWEEDEI RRDRVEPQSV SLSWREPVPA GAPGTNSTEY EIRYYEKGQS
510 520 530 540 550
EQTYSTVKTG APAVTVTNLK PATRYVFQIR AASPGPLWEA QSFSPSIEVQ
560 570 580 590 600
TPGEVAPGSR DQSPAVVVTV VTISALLVLG SVMSVLAIWR RPCDGKGSGN
610 620 630 640 650
AHDEEELYFH FKVPTRRTFL DPQSCGDPLQ AVHLFAKELD AKSVTLEKSL
660 670 680 690 700
GAGRFGTLCC GCLQLPGRQE LPVAVHTLRD GCSDSQRLSF LAEALTLGQF
710 720 730 740 750
DHSHIVRLEG VVTRGNPLMI VTEYMNLGAL DDFLRHHEGE LVAAQLMGLL
760 770 780 790 800
PGLASAMKYL SEMGYVHRGL AARRVLVSSG LLCKISGFGR GPRDRAEAVY
810 820 830 840 850
TTMSGRSPAL WAAPETLQFG HFSSASDVWS FGIVMWEVMA FGERPYWDMS
860 870 880 890 900
GQDVIKAVED GFRLPPPRNC PSQLHRLMLE CWQKDPSERP RFSQIHSILS
910 920 930 940 950
KMGQEPEPSK CASTTCLRPP TPLADRAFST FPSFGSVGAW LEALDLCRYK
960 970 980 990 1000
DNFSAAGYGS LEAVAEMTAQ DLGSLGISST EHRESLLSGI SALQTRVLQL

QGQGVQV
Length:1,007
Mass (Da):109,100
Last modified:March 20, 2007 - v2
Checksum:i157A0E17CDCB9ED9
GO
Isoform 2 (identifier: Q8BYG9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-292: ACPPGFYKV → GIQGPRGMG
     293-1007: Missing.

Show »
Length:292
Mass (Da):31,593
Checksum:i4CA95ED12646A858
GO

Sequence cautioni

The sequence CAM16104 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561A → S in BAC30423 (PubMed:16141072).Curated
Sequence conflicti657 – 6571T → D in CAM16104 (PubMed:19468303).Curated
Sequence conflicti980 – 9801T → A in CAM16104 (PubMed:19468303).Curated
Sequence conflicti985 – 9851S → A in CAM16104 (PubMed:19468303).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei284 – 2929ACPPGFYKV → GIQGPRGMG in isoform 2. 2 PublicationsVSP_023676
Alternative sequencei293 – 1007715Missing in isoform 2. 2 PublicationsVSP_023677Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039700 mRNA. Translation: BAC30423.1.
AK143168 mRNA. Translation: BAE25289.1.
AL606933 Genomic DNA. Translation: CAM16103.1.
AL606933 Genomic DNA. Translation: CAM16104.1. Sequence problems.
BC116991 mRNA. Translation: AAI16992.1.
BC119084 mRNA. Translation: AAI19085.1.
CCDSiCCDS18630.1. [Q8BYG9-2]
RefSeqiNP_808339.2. NM_177671.5. [Q8BYG9-2]
UniGeneiMm.171490.
Mm.491537.

Genome annotation databases

EnsembliENSMUST00000059343; ENSMUSP00000050810; ENSMUSG00000028876. [Q8BYG9-2]
GeneIDi230735.
KEGGimmu:230735.
UCSCiuc008urh.2. mouse. [Q8BYG9-2]
uc008uri.2. mouse. [Q8BYG9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039700 mRNA. Translation: BAC30423.1.
AK143168 mRNA. Translation: BAE25289.1.
AL606933 Genomic DNA. Translation: CAM16103.1.
AL606933 Genomic DNA. Translation: CAM16104.1. Sequence problems.
BC116991 mRNA. Translation: AAI16992.1.
BC119084 mRNA. Translation: AAI19085.1.
CCDSiCCDS18630.1. [Q8BYG9-2]
RefSeqiNP_808339.2. NM_177671.5. [Q8BYG9-2]
UniGeneiMm.171490.
Mm.491537.

3D structure databases

ProteinModelPortaliQ8BYG9.
SMRiQ8BYG9. Positions 35-210.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8BYG9.
PhosphoSiteiQ8BYG9.

Proteomic databases

MaxQBiQ8BYG9.
PeptideAtlasiQ8BYG9.
PRIDEiQ8BYG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059343; ENSMUSP00000050810; ENSMUSG00000028876. [Q8BYG9-2]
GeneIDi230735.
KEGGimmu:230735.
UCSCiuc008urh.2. mouse. [Q8BYG9-2]
uc008uri.2. mouse. [Q8BYG9-1]

Organism-specific databases

CTDi284656.
MGIiMGI:3586824. Epha10.

Phylogenomic databases

GeneTreeiENSGT00740000115264.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiQ8BYG9.
PhylomeDBiQ8BYG9.

Miscellaneous databases

PROiQ8BYG9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028876.
CleanExiMM_EPHA10.
ExpressionAtlasiQ8BYG9. baseline and differential.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEPHAA_MOUSE
AccessioniPrimary (citable) accession number: Q8BYG9
Secondary accession number(s): A2A7J5, Q3UPV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.