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Protein

G-protein coupled receptor 20

Gene

Gpr20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 20
Gene namesi
Name:Gpr20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2441803. Gpr20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularSequence analysisAdd BLAST46
Transmembranei47 – 67Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini68 – 84CytoplasmicSequence analysisAdd BLAST17
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini106 – 123ExtracellularSequence analysisAdd BLAST18
Transmembranei124 – 144Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini145 – 166CytoplasmicSequence analysisAdd BLAST22
Transmembranei167 – 188Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini189 – 195ExtracellularSequence analysis7
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 237CytoplasmicSequence analysisAdd BLAST21
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 274ExtracellularSequence analysisAdd BLAST16
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini296 – 358CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003032331 – 358G-protein coupled receptor 20Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BYC4.
PRIDEiQ8BYC4.

PTM databases

PhosphoSitePlusiQ8BYC4.

Expressioni

Tissue specificityi

Ubiquitous expressed with abundant expression in intestinal tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000045281.
CleanExiMM_GPR20.
GenevisibleiQ8BYC4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063910.

Structurei

3D structure databases

ProteinModelPortaliQ8BYC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II20. Eukaryota.
ENOG410ZKM2. LUCA.
GeneTreeiENSGT00860000133901.
HOGENOMiHOG000112787.
HOVERGENiHBG051800.
InParanoidiQ8BYC4.
KOiK04317.
OMAiCLRCAFP.
OrthoDBiEOG091G09CE.
PhylomeDBiQ8BYC4.
TreeFamiTF330828.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BYC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSALSMRPW DAALPNTTAA AWTNGSVPEM PLFHHFARLD EELQATFPSL
60 70 80 90 100
WQALMVVHGT IFLAGLVLNG LALYVFCCRT RAKTPSVTYT INLVVTDLLV
110 120 130 140 150
GLSLPTRFAV FYGARGCLRC AFPHVLGYFL NMHCSILFLT CICVDRYLAI
160 170 180 190 200
VQPEGSRRWR QPACAKAVCI FVWLAAGVVT LSVLGVKSGG RSCCRVFALT
210 220 230 240 250
VLEFLLPLLV ISVFTGRIMC ALSRPGLLRQ GRQRRVRAMQ LLLTVLVIFL
260 270 280 290 300
VCFTPFHARQ VAVALWPNVP KHTSLVAYHV AVTLSSLNSC MDPIVYCFIT
310 320 330 340 350
SGFQATVRGL FYQRGEEFKP SSMDVVSMHK STKASAPIHI LSIGSHTLTQ

PLTNGPEP
Length:358
Mass (Da):39,432
Last modified:March 1, 2003 - v1
Checksum:iC6F7842ABDE9CA8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC117783 mRNA. Translation: AAI17784.1.
AK040547 mRNA. Translation: BAC30623.1.
AY255575 mRNA. Translation: AAO85087.1.
CCDSiCCDS27518.1.
RefSeqiNP_775541.1. NM_173365.2.
XP_006520990.1. XM_006520927.2.
UniGeneiMm.122997.

Genome annotation databases

EnsembliENSMUST00000064166; ENSMUSP00000063910; ENSMUSG00000045281.
GeneIDi239530.
KEGGimmu:239530.
UCSCiuc007wci.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC117783 mRNA. Translation: AAI17784.1.
AK040547 mRNA. Translation: BAC30623.1.
AY255575 mRNA. Translation: AAO85087.1.
CCDSiCCDS27518.1.
RefSeqiNP_775541.1. NM_173365.2.
XP_006520990.1. XM_006520927.2.
UniGeneiMm.122997.

3D structure databases

ProteinModelPortaliQ8BYC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063910.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8BYC4.

Proteomic databases

PaxDbiQ8BYC4.
PRIDEiQ8BYC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064166; ENSMUSP00000063910; ENSMUSG00000045281.
GeneIDi239530.
KEGGimmu:239530.
UCSCiuc007wci.1. mouse.

Organism-specific databases

CTDi2843.
MGIiMGI:2441803. Gpr20.

Phylogenomic databases

eggNOGiENOG410II20. Eukaryota.
ENOG410ZKM2. LUCA.
GeneTreeiENSGT00860000133901.
HOGENOMiHOG000112787.
HOVERGENiHBG051800.
InParanoidiQ8BYC4.
KOiK04317.
OMAiCLRCAFP.
OrthoDBiEOG091G09CE.
PhylomeDBiQ8BYC4.
TreeFamiTF330828.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ8BYC4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045281.
CleanExiMM_GPR20.
GenevisibleiQ8BYC4. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR20_MOUSE
AccessioniPrimary (citable) accession number: Q8BYC4
Secondary accession number(s): Q80T63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.