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Q8BYB9

- PGLT1_MOUSE

UniProt

Q8BYB9 - PGLT1_MOUSE

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Protein
Protein O-glucosyltransferase 1
Gene
Poglut1, Clp46, Ktelc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Dual specificity glycosyltransferase. Catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to EGF repeats, such as those found in F7, F9 and NOTCH2, on the consensus sequence C-X-S-X-P-C. Positively regulates Notch signaling without affecting Notch ligand binding.1 Publication

Catalytic activityi

Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate.

Pathwayi

GO - Molecular functioni

  1. UDP-glucosyltransferase activity Source: UniProtKB
  2. UDP-xylosyltransferase activity Source: MGI
  3. glucosyltransferase activity Source: MGI
  4. protein xylosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cardiovascular system development Source: MGI
  2. protein O-linked glycosylation Source: MGI
  3. regulation of Notch signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_196492. Pre-NOTCH Processing in the Endoplasmic Reticulum.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein O-glucosyltransferase 1 (EC:2.4.1.-)
Alternative name(s):
CAP10-like 46 kDa protein
KTEL motif-containing protein 1
O-glucosyltransferase Rumi homolog
Short name:
Rumi
Protein O-xylosyltransferase (EC:2.4.2.26)
Gene namesi
Name:Poglut1
Synonyms:Clp46, Ktelc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2444232. Poglut1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

Mutant embryos die at or before 9.5 dpc. At 7.0 to 7.5 dpc, they cannot be morphologically distinguished from wild-type littermates. At 8.0 dpc, mutant embryos exhibit an abnormally expanded neural plate that does not fold properly, absence of heart rudiments and posterior axis truncation.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi389 – 3924Missing: Significantly more secreted than wild-type. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 392369Protein O-glucosyltransferase 1
PRO_0000246686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi204 – 2041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi373 – 3731N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BYB9.
PaxDbiQ8BYB9.
PRIDEiQ8BYB9.

PTM databases

PhosphoSiteiQ8BYB9.

Expressioni

Tissue specificityi

Widely expressed in newborn and adult tissues (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ8BYB9.
BgeeiQ8BYB9.
CleanExiMM_KTELC1.
GenevestigatoriQ8BYB9.

Interactioni

Protein-protein interaction databases

BioGridi230254. 1 interaction.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi389 – 3924Endoplasmic reticulum retention signal

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248922.
GeneTreeiENSGT00530000063132.
HOVERGENiHBG069044.
InParanoidiQ8BYB9.
KOiK13667.
OMAiINHLQMD.
OrthoDBiEOG7R831J.
PhylomeDBiQ8BYB9.
TreeFamiTF323280.

Family and domain databases

InterProiIPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BYB9-1 [UniParc]FASTAAdd to Basket

« Hide

MERRAGSRLR AWMLLLLLCP VQGRQKDSGS KWKVFLDQIN RALENYEPCS    50
SQNCSCYHGV IEEDLTPFRG GISRKMMAEV VRRKLGTHYQ IIKNRLFRED 100
DCMFPSRCSG VEHFILEVIH RLPDMEMVIN VRDYPQVPKW MEPTIPVFSF 150
SKTSEYHDIM YPAWTFWEGG PAVWPLYPTG LGRWDLFRED LLRSAAQWPW 200
EKKNSTAYFR GSRTSPERDP LILLSRKNPK LVDAEYTKNQ AWKSMKDTLG 250
KPAAKDVHLI DHCKYRYLFN FRGVAASFRF KHLFLCGSLV FHVGDEWVEF 300
FYPQLKPWVH YIPVKTDLSN VQELLQFVKA NDDIAQEIAK RGSQFIINHL 350
QMDDITCYWE NLLTDYSKFL SYNVTRRKDY YQIVPRRLKT EL 392
Length:392
Mass (Da):46,379
Last modified:July 25, 2006 - v2
Checksum:iCAAD9133E47D3EF0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531N → S in BAC30905. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031608 mRNA. Translation: BAC27475.1.
AK035948 mRNA. Translation: BAC29255.1.
AK036224 mRNA. Translation: BAC29351.1.
AK041321 mRNA. Translation: BAC30905.1.
BC026809 mRNA. Translation: AAH26809.1.
CCDSiCCDS28170.1.
RefSeqiNP_759012.1. NM_172380.3.
UniGeneiMm.284366.
Mm.475345.

Genome annotation databases

EnsembliENSMUST00000036210; ENSMUSP00000038166; ENSMUSG00000034064.
GeneIDi224143.
KEGGimmu:224143.
UCSCiuc007zfc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031608 mRNA. Translation: BAC27475.1 .
AK035948 mRNA. Translation: BAC29255.1 .
AK036224 mRNA. Translation: BAC29351.1 .
AK041321 mRNA. Translation: BAC30905.1 .
BC026809 mRNA. Translation: AAH26809.1 .
CCDSi CCDS28170.1.
RefSeqi NP_759012.1. NM_172380.3.
UniGenei Mm.284366.
Mm.475345.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

BioGridi 230254. 1 interaction.

Protein family/group databases

CAZyi GT90. Glycosyltransferase Family 90.

PTM databases

PhosphoSitei Q8BYB9.

Proteomic databases

MaxQBi Q8BYB9.
PaxDbi Q8BYB9.
PRIDEi Q8BYB9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036210 ; ENSMUSP00000038166 ; ENSMUSG00000034064 .
GeneIDi 224143.
KEGGi mmu:224143.
UCSCi uc007zfc.1. mouse.

Organism-specific databases

CTDi 56983.
MGIi MGI:2444232. Poglut1.

Phylogenomic databases

eggNOGi NOG248922.
GeneTreei ENSGT00530000063132.
HOVERGENi HBG069044.
InParanoidi Q8BYB9.
KOi K13667.
OMAi INHLQMD.
OrthoDBi EOG7R831J.
PhylomeDBi Q8BYB9.
TreeFami TF323280.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_196492. Pre-NOTCH Processing in the Endoplasmic Reticulum.

Miscellaneous databases

ChiTaRSi POGLUT1. mouse.
NextBioi 377117.
PROi Q8BYB9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BYB9.
Bgeei Q8BYB9.
CleanExi MM_KTELC1.
Genevestigatori Q8BYB9.

Family and domain databases

InterProi IPR006598. LipoPS_modifying.
[Graphical view ]
Pfami PF05686. Glyco_transf_90. 1 hit.
[Graphical view ]
SMARTi SM00672. CAP10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Testis and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi."
    Fernandez-Valdivia R., Takeuchi H., Samarghandi A., Lopez M., Leonardi J., Haltiwanger R.S., Jafar-Nejad H.
    Development 138:1925-1934(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  4. Cited for: FUNCTION, MUTAGENESIS OF 389-LYS--LEU-392.

Entry informationi

Entry nameiPGLT1_MOUSE
AccessioniPrimary (citable) accession number: Q8BYB9
Secondary accession number(s): Q8R0H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: September 3, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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