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Q8BY89

- CTL2_MOUSE

UniProt

Q8BY89 - CTL2_MOUSE

Protein

Choline transporter-like protein 2

Gene

Slc44a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Choline transporter.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. signal transducer activity Source: Ensembl

    GO - Biological processi

    1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    2. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_207335. Synthesis of PC.
    REACT_217615. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Protein family/group databases

    TCDBi2.A.92.1.2. the choline transporter-like (ctl) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Choline transporter-like protein 2
    Alternative name(s):
    Solute carrier family 44 member 2
    Gene namesi
    Name:Slc44a2
    Synonyms:Ctl2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1915932. Slc44a2.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosomal membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 706706Choline transporter-like protein 2PRO_0000191718Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi187 – 1871N-linked (GlcNAc...)3 Publications
    Glycosylationi200 – 2001N-linked (GlcNAc...)3 Publications
    Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8BY89.
    PaxDbiQ8BY89.
    PRIDEiQ8BY89.

    PTM databases

    PhosphoSiteiQ8BY89.

    Expressioni

    Tissue specificityi

    Expressed at high levels in lung, colon, inner ear and spleen (at protein level). Progressively lower levels in brain, tongue, liver and kidney (at protein level). In the kidney, prominent expression in glomeruli in the lining of Bowman's capsule and on the mesangial cells adjacent to the vessels within the glomerulus (at protein level). Strongly expressed on the membranes of splenocytes and in lung parenchyme (at protein level). Isoform 1 is expressed at higher levels than isoform 2 in colon, heart, kidney, lung, cochlea, tongue and muscle, as well as in the inner ear. Isoform 2 is predominant in brain, liver and spleen.1 Publication

    Gene expression databases

    BgeeiQ8BY89.
    CleanExiMM_SLC44A2.
    GenevestigatoriQ8BY89.

    Interactioni

    Subunit structurei

    Interacts with COCH.By similarity

    Protein-protein interaction databases

    IntActiQ8BY89. 1 interaction.
    MINTiMINT-4997673.
    STRINGi10090.ENSMUSP00000034697.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BY89.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini55 – 232178ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini254 – 2563CytoplasmicSequence Analysis
    Topological domaini278 – 31538ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini337 – 36428CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini386 – 45469ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini478 – 50427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini526 – 56338ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini585 – 59915CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini621 – 63818ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini660 – 70647CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei365 – 38521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei455 – 47723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei505 – 52521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei564 – 58421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei600 – 62021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei639 – 65921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG310633.
    GeneTreeiENSGT00550000074521.
    HOGENOMiHOG000007110.
    HOVERGENiHBG062155.
    KOiK15377.
    OMAiQTWMAFM.
    OrthoDBiEOG7FR7G4.
    TreeFamiTF313325.

    Family and domain databases

    InterProiIPR007603. Choline_transptr-like.
    [Graphical view]
    PANTHERiPTHR12385. PTHR12385. 1 hit.
    PfamiPF04515. Choline_transpo. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative promoter usage. Align

    Isoform 1 (identifier: Q8BY89-1) [UniParc]FASTAAdd to Basket

    Also known as: CTL2a, CTL2P2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGKDSQNYYG KHGTPQKYDP TFKGPIYNRG CTDVICCVLL FLAIVGYVAV    50
    GIIAWTHGDP RKVIYPTDSR GEFCGQKGTK NADKPFLFYF NIVKCANPLV 100
    LLEFHCPTPQ ICVKQCPDRY LTLLSARNTR DFDYYKQFCV PGFQNNKGVT 150
    EILRDGECPA VITPSKPLAQ RCFPAIHASK GVLMVGNETT YEDGHGARKN 200
    ITDLVEGAKK ANKILEARQL AMQIFEDYTV SWYWIIIGLV IAMVLSLLFI 250
    VLLRFLAGIM VWVMIVMVIL VLGYGIFHCY MEYSRLRGEA GSDVSLVDLG 300
    FQTDLRVYLH LRQTWMAFMI ILSILEVVII LLLIFLRKRI LIAIALIKEA 350
    SRAVGHVMCS LLYPLVTFFL LCLCIAYWAS TSVFLSTSNT AVYKVVDDTA 400
    CPLLRKTCNP ETFPLRNESL QCPTARCQFA FYGGESTYHR ALLGLQIFNA 450
    FMFFWLANFV LALGQVTLAG AFASYYWAMR KPDDMPAFPL FSAFGRALRY 500
    HTGSLAFGSL ILAIVQIIRV MLEYLDQRLK AAQNKFAKFL MVCLKCCFWC 550
    LEKFIKFLNR NAYIMIAIYG TNFCTSARNA FFLLMRNIIR VAVLDKVTDF 600
    LFLLGKLLIV GSVGILAFFF FTHRIRIVQD TAPPLNYYWV PILTVIIGSY 650
    LIAHGFFSVY GMCVDTLFLC FLEDLERNDG SAERPYFMSS TLKKLLNKTN 700
    KKVAES 706
    Length:706
    Mass (Da):80,110
    Last modified:September 21, 2011 - v2
    Checksum:i954AFD393C69A009
    GO
    Isoform 2 (identifier: Q8BY89-2) [UniParc]FASTAAdd to Basket

    Also known as: CTL2b, CTL2P1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: MGKDSQNYYGKH → MEDDRKDAVY

    Note: Produced by alternative promoter usage.

    Show »
    Length:704
    Mass (Da):79,924
    Checksum:i17E13C468805E580
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1212MGKDS…YYGKH → MEDDRKDAVY in isoform 2. 2 PublicationsVSP_015432Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK041533 mRNA. Translation: BAC30976.1.
    AK048648 mRNA. Translation: BAC33409.1.
    BC031535 mRNA. Translation: AAH31535.1.
    CCDSiCCDS22903.1. [Q8BY89-1]
    RefSeqiNP_001186115.1. NM_001199186.1. [Q8BY89-2]
    NP_690021.1. NM_152808.3. [Q8BY89-1]
    UniGeneiMm.148425.

    Genome annotation databases

    EnsembliENSMUST00000034697; ENSMUSP00000034697; ENSMUSG00000057193. [Q8BY89-1]
    GeneIDi68682.
    KEGGimmu:68682.
    UCSCiuc009okz.2. mouse. [Q8BY89-2]
    uc009ola.2. mouse. [Q8BY89-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK041533 mRNA. Translation: BAC30976.1 .
    AK048648 mRNA. Translation: BAC33409.1 .
    BC031535 mRNA. Translation: AAH31535.1 .
    CCDSi CCDS22903.1. [Q8BY89-1 ]
    RefSeqi NP_001186115.1. NM_001199186.1. [Q8BY89-2 ]
    NP_690021.1. NM_152808.3. [Q8BY89-1 ]
    UniGenei Mm.148425.

    3D structure databases

    ProteinModelPortali Q8BY89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BY89. 1 interaction.
    MINTi MINT-4997673.
    STRINGi 10090.ENSMUSP00000034697.

    Protein family/group databases

    TCDBi 2.A.92.1.2. the choline transporter-like (ctl) family.

    PTM databases

    PhosphoSitei Q8BY89.

    Proteomic databases

    MaxQBi Q8BY89.
    PaxDbi Q8BY89.
    PRIDEi Q8BY89.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034697 ; ENSMUSP00000034697 ; ENSMUSG00000057193 . [Q8BY89-1 ]
    GeneIDi 68682.
    KEGGi mmu:68682.
    UCSCi uc009okz.2. mouse. [Q8BY89-2 ]
    uc009ola.2. mouse. [Q8BY89-1 ]

    Organism-specific databases

    CTDi 57153.
    MGIi MGI:1915932. Slc44a2.

    Phylogenomic databases

    eggNOGi NOG310633.
    GeneTreei ENSGT00550000074521.
    HOGENOMi HOG000007110.
    HOVERGENi HBG062155.
    KOi K15377.
    OMAi QTWMAFM.
    OrthoDBi EOG7FR7G4.
    TreeFami TF313325.

    Enzyme and pathway databases

    Reactomei REACT_207335. Synthesis of PC.
    REACT_217615. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

    Miscellaneous databases

    ChiTaRSi SLC44A2. mouse.
    NextBioi 327690.
    PROi Q8BY89.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BY89.
    CleanExi MM_SLC44A2.
    Genevestigatori Q8BY89.

    Family and domain databases

    InterProi IPR007603. Choline_transptr-like.
    [Graphical view ]
    PANTHERi PTHR12385. PTHR12385. 1 hit.
    Pfami PF04515. Choline_transpo. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: Czech II.
      Tissue: Mammary gland.
    3. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-187 AND ASN-200.
      Tissue: Myoblast.
    4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-187 AND ASN-200.
    5. "Isoforms, expression, glycosylation, and tissue distribution of CTL2/SLC44A2."
      Kommareddi P.K., Nair T.S., Thang L.V., Galano M.M., Babu E., Ganapathy V., Kanazawa T., McHugh J.B., Carey T.E.
      Protein J. 29:417-426(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF ISOFORMS 1 AND 3, ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY, GLYCOSYLATION.

    Entry informationi

    Entry nameiCTL2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BY89
    Secondary accession number(s): Q8K2F1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3