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Protein

Choline transporter-like protein 2

Gene

Slc44a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Choline transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-1483191. Synthesis of PC.
R-MMU-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.
R-MMU-6798695. Neutrophil degranulation.

Protein family/group databases

TCDBi2.A.92.1.2. the choline transporter-like (ctl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 2
Alternative name(s):
Solute carrier family 44 member 2
Gene namesi
Name:Slc44a2
Synonyms:Ctl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1915932. Slc44a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 232ExtracellularSequence analysisAdd BLAST178
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 256CytoplasmicSequence analysis3
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 315ExtracellularSequence analysisAdd BLAST38
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 364CytoplasmicSequence analysisAdd BLAST28
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 454ExtracellularSequence analysisAdd BLAST69
Transmembranei455 – 477HelicalSequence analysisAdd BLAST23
Topological domaini478 – 504CytoplasmicSequence analysisAdd BLAST27
Transmembranei505 – 525HelicalSequence analysisAdd BLAST21
Topological domaini526 – 563ExtracellularSequence analysisAdd BLAST38
Transmembranei564 – 584HelicalSequence analysisAdd BLAST21
Topological domaini585 – 599CytoplasmicSequence analysisAdd BLAST15
Transmembranei600 – 620HelicalSequence analysisAdd BLAST21
Topological domaini621 – 638ExtracellularSequence analysisAdd BLAST18
Transmembranei639 – 659HelicalSequence analysisAdd BLAST21
Topological domaini660 – 706CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917181 – 706Choline transporter-like protein 2Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Glycosylationi187N-linked (GlcNAc...)2 Publications1
Glycosylationi200N-linked (GlcNAc...)2 Publications1
Glycosylationi417N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8BY89.
PeptideAtlasiQ8BY89.
PRIDEiQ8BY89.

PTM databases

iPTMnetiQ8BY89.
PhosphoSitePlusiQ8BY89.
SwissPalmiQ8BY89.

Expressioni

Tissue specificityi

Expressed at high levels in lung, colon, inner ear and spleen (at protein level). Progressively lower levels in brain, tongue, liver and kidney (at protein level). In the kidney, prominent expression in glomeruli in the lining of Bowman's capsule and on the mesangial cells adjacent to the vessels within the glomerulus (at protein level). Strongly expressed on the membranes of splenocytes and in lung parenchyme (at protein level). Isoform 1 is expressed at higher levels than isoform 2 in colon, heart, kidney, lung, cochlea, tongue and muscle, as well as in the inner ear. Isoform 2 is predominant in brain, liver and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000057193.
CleanExiMM_SLC44A2.
GenevisibleiQ8BY89. MM.

Interactioni

Subunit structurei

Interacts with COCH.By similarity

Protein-protein interaction databases

IntActiQ8BY89. 1 interactor.
MINTiMINT-4997673.
STRINGi10090.ENSMUSP00000034697.

Structurei

3D structure databases

ProteinModelPortaliQ8BY89.
SMRiQ8BY89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1362. Eukaryota.
ENOG410XS0P. LUCA.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000007110.
HOVERGENiHBG062155.
InParanoidiQ8BY89.
KOiK15377.
OMAiQHYYGKH.
OrthoDBiEOG091G04CQ.
TreeFamiTF313325.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 2 hits.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform 1 (identifier: Q8BY89-1) [UniParc]FASTAAdd to basket
Also known as: CTL2a, CTL2P2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKDSQNYYG KHGTPQKYDP TFKGPIYNRG CTDVICCVLL FLAIVGYVAV
60 70 80 90 100
GIIAWTHGDP RKVIYPTDSR GEFCGQKGTK NADKPFLFYF NIVKCANPLV
110 120 130 140 150
LLEFHCPTPQ ICVKQCPDRY LTLLSARNTR DFDYYKQFCV PGFQNNKGVT
160 170 180 190 200
EILRDGECPA VITPSKPLAQ RCFPAIHASK GVLMVGNETT YEDGHGARKN
210 220 230 240 250
ITDLVEGAKK ANKILEARQL AMQIFEDYTV SWYWIIIGLV IAMVLSLLFI
260 270 280 290 300
VLLRFLAGIM VWVMIVMVIL VLGYGIFHCY MEYSRLRGEA GSDVSLVDLG
310 320 330 340 350
FQTDLRVYLH LRQTWMAFMI ILSILEVVII LLLIFLRKRI LIAIALIKEA
360 370 380 390 400
SRAVGHVMCS LLYPLVTFFL LCLCIAYWAS TSVFLSTSNT AVYKVVDDTA
410 420 430 440 450
CPLLRKTCNP ETFPLRNESL QCPTARCQFA FYGGESTYHR ALLGLQIFNA
460 470 480 490 500
FMFFWLANFV LALGQVTLAG AFASYYWAMR KPDDMPAFPL FSAFGRALRY
510 520 530 540 550
HTGSLAFGSL ILAIVQIIRV MLEYLDQRLK AAQNKFAKFL MVCLKCCFWC
560 570 580 590 600
LEKFIKFLNR NAYIMIAIYG TNFCTSARNA FFLLMRNIIR VAVLDKVTDF
610 620 630 640 650
LFLLGKLLIV GSVGILAFFF FTHRIRIVQD TAPPLNYYWV PILTVIIGSY
660 670 680 690 700
LIAHGFFSVY GMCVDTLFLC FLEDLERNDG SAERPYFMSS TLKKLLNKTN

KKVAES
Length:706
Mass (Da):80,110
Last modified:September 21, 2011 - v2
Checksum:i954AFD393C69A009
GO
Isoform 2 (identifier: Q8BY89-2) [UniParc]FASTAAdd to basket
Also known as: CTL2b, CTL2P1

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MGKDSQNYYGKH → MEDDRKDAVY

Note: Produced by alternative promoter usage.
Show »
Length:704
Mass (Da):79,924
Checksum:i17E13C468805E580
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0154321 – 12MGKDS…YYGKH → MEDDRKDAVY in isoform 2. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041533 mRNA. Translation: BAC30976.1.
AK048648 mRNA. Translation: BAC33409.1.
BC031535 mRNA. Translation: AAH31535.1.
CCDSiCCDS22903.1. [Q8BY89-1]
RefSeqiNP_001186115.1. NM_001199186.1. [Q8BY89-2]
NP_690021.1. NM_152808.3. [Q8BY89-1]
UniGeneiMm.148425.

Genome annotation databases

EnsembliENSMUST00000034697; ENSMUSP00000034697; ENSMUSG00000057193. [Q8BY89-1]
GeneIDi68682.
KEGGimmu:68682.
UCSCiuc009okz.2. mouse. [Q8BY89-2]
uc009ola.2. mouse. [Q8BY89-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041533 mRNA. Translation: BAC30976.1.
AK048648 mRNA. Translation: BAC33409.1.
BC031535 mRNA. Translation: AAH31535.1.
CCDSiCCDS22903.1. [Q8BY89-1]
RefSeqiNP_001186115.1. NM_001199186.1. [Q8BY89-2]
NP_690021.1. NM_152808.3. [Q8BY89-1]
UniGeneiMm.148425.

3D structure databases

ProteinModelPortaliQ8BY89.
SMRiQ8BY89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BY89. 1 interactor.
MINTiMINT-4997673.
STRINGi10090.ENSMUSP00000034697.

Protein family/group databases

TCDBi2.A.92.1.2. the choline transporter-like (ctl) family.

PTM databases

iPTMnetiQ8BY89.
PhosphoSitePlusiQ8BY89.
SwissPalmiQ8BY89.

Proteomic databases

PaxDbiQ8BY89.
PeptideAtlasiQ8BY89.
PRIDEiQ8BY89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034697; ENSMUSP00000034697; ENSMUSG00000057193. [Q8BY89-1]
GeneIDi68682.
KEGGimmu:68682.
UCSCiuc009okz.2. mouse. [Q8BY89-2]
uc009ola.2. mouse. [Q8BY89-1]

Organism-specific databases

CTDi57153.
MGIiMGI:1915932. Slc44a2.

Phylogenomic databases

eggNOGiKOG1362. Eukaryota.
ENOG410XS0P. LUCA.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000007110.
HOVERGENiHBG062155.
InParanoidiQ8BY89.
KOiK15377.
OMAiQHYYGKH.
OrthoDBiEOG091G04CQ.
TreeFamiTF313325.

Enzyme and pathway databases

ReactomeiR-MMU-1483191. Synthesis of PC.
R-MMU-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiSlc44a2. mouse.
PROiQ8BY89.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057193.
CleanExiMM_SLC44A2.
GenevisibleiQ8BY89. MM.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 2 hits.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BY89
Secondary accession number(s): Q8K2F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: September 21, 2011
Last modified: November 30, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.