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Q8BY89

- CTL2_MOUSE

UniProt

Q8BY89 - CTL2_MOUSE

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Protein
Choline transporter-like protein 2
Gene
Slc44a2, Ctl2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Choline transporter By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
  2. signal transducer activity Source: Ensembl

GO - Biological processi

  1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_207335. Synthesis of PC.
REACT_217615. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi2.A.92.1.2. the choline transporter-like (ctl) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 2
Alternative name(s):
Solute carrier family 44 member 2
Gene namesi
Name:Slc44a2
Synonyms:Ctl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1915932. Slc44a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei34 – 5421Helical; Reviewed prediction
Add
BLAST
Topological domaini55 – 232178Extracellular Reviewed prediction
Add
BLAST
Transmembranei233 – 25321Helical; Reviewed prediction
Add
BLAST
Topological domaini254 – 2563Cytoplasmic Reviewed prediction
Transmembranei257 – 27721Helical; Reviewed prediction
Add
BLAST
Topological domaini278 – 31538Extracellular Reviewed prediction
Add
BLAST
Transmembranei316 – 33621Helical; Reviewed prediction
Add
BLAST
Topological domaini337 – 36428Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei365 – 38521Helical; Reviewed prediction
Add
BLAST
Topological domaini386 – 45469Extracellular Reviewed prediction
Add
BLAST
Transmembranei455 – 47723Helical; Reviewed prediction
Add
BLAST
Topological domaini478 – 50427Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei505 – 52521Helical; Reviewed prediction
Add
BLAST
Topological domaini526 – 56338Extracellular Reviewed prediction
Add
BLAST
Transmembranei564 – 58421Helical; Reviewed prediction
Add
BLAST
Topological domaini585 – 59915Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei600 – 62021Helical; Reviewed prediction
Add
BLAST
Topological domaini621 – 63818Extracellular Reviewed prediction
Add
BLAST
Transmembranei639 – 65921Helical; Reviewed prediction
Add
BLAST
Topological domaini660 – 70647Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Choline transporter-like protein 2
PRO_0000191718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi187 – 1871N-linked (GlcNAc...)2 Publications
Glycosylationi200 – 2001N-linked (GlcNAc...)2 Publications
Glycosylationi417 – 4171N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BY89.
PaxDbiQ8BY89.
PRIDEiQ8BY89.

PTM databases

PhosphoSiteiQ8BY89.

Expressioni

Tissue specificityi

Expressed at high levels in lung, colon, inner ear and spleen (at protein level). Progressively lower levels in brain, tongue, liver and kidney (at protein level). In the kidney, prominent expression in glomeruli in the lining of Bowman's capsule and on the mesangial cells adjacent to the vessels within the glomerulus (at protein level). Strongly expressed on the membranes of splenocytes and in lung parenchyme (at protein level). Isoform 1 is expressed at higher levels than isoform 2 in colon, heart, kidney, lung, cochlea, tongue and muscle, as well as in the inner ear. Isoform 2 is predominant in brain, liver and spleen.1 Publication

Gene expression databases

BgeeiQ8BY89.
CleanExiMM_SLC44A2.
GenevestigatoriQ8BY89.

Interactioni

Subunit structurei

Interacts with COCH By similarity.

Protein-protein interaction databases

IntActiQ8BY89. 1 interaction.
MINTiMINT-4997673.
STRINGi10090.ENSMUSP00000034697.

Structurei

3D structure databases

ProteinModelPortaliQ8BY89.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG310633.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000007110.
HOVERGENiHBG062155.
KOiK15377.
OMAiQTWMAFM.
OrthoDBiEOG7FR7G4.
TreeFamiTF313325.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 1 hit.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. Align

Isoform 1 (identifier: Q8BY89-1) [UniParc]FASTAAdd to Basket

Also known as: CTL2a, CTL2P2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGKDSQNYYG KHGTPQKYDP TFKGPIYNRG CTDVICCVLL FLAIVGYVAV    50
GIIAWTHGDP RKVIYPTDSR GEFCGQKGTK NADKPFLFYF NIVKCANPLV 100
LLEFHCPTPQ ICVKQCPDRY LTLLSARNTR DFDYYKQFCV PGFQNNKGVT 150
EILRDGECPA VITPSKPLAQ RCFPAIHASK GVLMVGNETT YEDGHGARKN 200
ITDLVEGAKK ANKILEARQL AMQIFEDYTV SWYWIIIGLV IAMVLSLLFI 250
VLLRFLAGIM VWVMIVMVIL VLGYGIFHCY MEYSRLRGEA GSDVSLVDLG 300
FQTDLRVYLH LRQTWMAFMI ILSILEVVII LLLIFLRKRI LIAIALIKEA 350
SRAVGHVMCS LLYPLVTFFL LCLCIAYWAS TSVFLSTSNT AVYKVVDDTA 400
CPLLRKTCNP ETFPLRNESL QCPTARCQFA FYGGESTYHR ALLGLQIFNA 450
FMFFWLANFV LALGQVTLAG AFASYYWAMR KPDDMPAFPL FSAFGRALRY 500
HTGSLAFGSL ILAIVQIIRV MLEYLDQRLK AAQNKFAKFL MVCLKCCFWC 550
LEKFIKFLNR NAYIMIAIYG TNFCTSARNA FFLLMRNIIR VAVLDKVTDF 600
LFLLGKLLIV GSVGILAFFF FTHRIRIVQD TAPPLNYYWV PILTVIIGSY 650
LIAHGFFSVY GMCVDTLFLC FLEDLERNDG SAERPYFMSS TLKKLLNKTN 700
KKVAES 706
Length:706
Mass (Da):80,110
Last modified:September 21, 2011 - v2
Checksum:i954AFD393C69A009
GO
Isoform 2 (identifier: Q8BY89-2) [UniParc]FASTAAdd to Basket

Also known as: CTL2b, CTL2P1

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MGKDSQNYYGKH → MEDDRKDAVY

Note: Produced by alternative promoter usage.

Show »
Length:704
Mass (Da):79,924
Checksum:i17E13C468805E580
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212MGKDS…YYGKH → MEDDRKDAVY in isoform 2.
VSP_015432Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK041533 mRNA. Translation: BAC30976.1.
AK048648 mRNA. Translation: BAC33409.1.
BC031535 mRNA. Translation: AAH31535.1.
CCDSiCCDS22903.1. [Q8BY89-1]
RefSeqiNP_001186115.1. NM_001199186.1. [Q8BY89-2]
NP_690021.1. NM_152808.3. [Q8BY89-1]
UniGeneiMm.148425.

Genome annotation databases

EnsembliENSMUST00000034697; ENSMUSP00000034697; ENSMUSG00000057193. [Q8BY89-1]
GeneIDi68682.
KEGGimmu:68682.
UCSCiuc009okz.2. mouse. [Q8BY89-2]
uc009ola.2. mouse. [Q8BY89-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK041533 mRNA. Translation: BAC30976.1 .
AK048648 mRNA. Translation: BAC33409.1 .
BC031535 mRNA. Translation: AAH31535.1 .
CCDSi CCDS22903.1. [Q8BY89-1 ]
RefSeqi NP_001186115.1. NM_001199186.1. [Q8BY89-2 ]
NP_690021.1. NM_152808.3. [Q8BY89-1 ]
UniGenei Mm.148425.

3D structure databases

ProteinModelPortali Q8BY89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8BY89. 1 interaction.
MINTi MINT-4997673.
STRINGi 10090.ENSMUSP00000034697.

Protein family/group databases

TCDBi 2.A.92.1.2. the choline transporter-like (ctl) family.

PTM databases

PhosphoSitei Q8BY89.

Proteomic databases

MaxQBi Q8BY89.
PaxDbi Q8BY89.
PRIDEi Q8BY89.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034697 ; ENSMUSP00000034697 ; ENSMUSG00000057193 . [Q8BY89-1 ]
GeneIDi 68682.
KEGGi mmu:68682.
UCSCi uc009okz.2. mouse. [Q8BY89-2 ]
uc009ola.2. mouse. [Q8BY89-1 ]

Organism-specific databases

CTDi 57153.
MGIi MGI:1915932. Slc44a2.

Phylogenomic databases

eggNOGi NOG310633.
GeneTreei ENSGT00550000074521.
HOGENOMi HOG000007110.
HOVERGENi HBG062155.
KOi K15377.
OMAi QTWMAFM.
OrthoDBi EOG7FR7G4.
TreeFami TF313325.

Enzyme and pathway databases

Reactomei REACT_207335. Synthesis of PC.
REACT_217615. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

ChiTaRSi SLC44A2. mouse.
NextBioi 327690.
PROi Q8BY89.
SOURCEi Search...

Gene expression databases

Bgeei Q8BY89.
CleanExi MM_SLC44A2.
Genevestigatori Q8BY89.

Family and domain databases

InterProi IPR007603. Choline_transptr-like.
[Graphical view ]
PANTHERi PTHR12385. PTHR12385. 1 hit.
Pfami PF04515. Choline_transpo. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Czech II.
    Tissue: Mammary gland.
  3. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-187 AND ASN-200.
    Tissue: Myoblast.
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-187 AND ASN-200.
  5. "Isoforms, expression, glycosylation, and tissue distribution of CTL2/SLC44A2."
    Kommareddi P.K., Nair T.S., Thang L.V., Galano M.M., Babu E., Ganapathy V., Kanazawa T., McHugh J.B., Carey T.E.
    Protein J. 29:417-426(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ISOFORMS 1 AND 3, ALTERNATIVE PROMOTER USAGE, TISSUE SPECIFICITY, GLYCOSYLATION.

Entry informationi

Entry nameiCTL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BY89
Secondary accession number(s): Q8K2F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi