Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 35 member G1

Gene

Slc35g1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell (By similarity).By similarity

GO - Biological processi

Protein family/group databases

TCDBi2.A.7.28.1 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member G1
Alternative name(s):
Transmembrane protein 20
Gene namesi
Name:Slc35g1
Synonyms:Tmem20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2444789 Slc35g1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444641 – 368Solute carrier family 35 member G1Add BLAST368

Proteomic databases

PaxDbiQ8BY79
PeptideAtlasiQ8BY79
PRIDEiQ8BY79

PTM databases

PhosphoSitePlusiQ8BY79

Expressioni

Gene expression databases

BgeeiENSMUSG00000044026
CleanExiMM_TMEM20
GenevisibleiQ8BY79 MM

Interactioni

Subunit structurei

Interacts with STIM1; stimulated by depletion of intracellular calcium. Interacts with ORAI1. Interacts with the plasma membrane calcium-transporting ATPases ATP2B1 and ATP2B4. Interacts with ATP1A1, ATP2A2, KPNB1 and XPO1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi232219, 1 interactor
IntActiQ8BY79, 1 interactor
MINTiQ8BY79

Structurei

3D structure databases

ProteinModelPortaliQ8BY79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 205EamA 1Add BLAST123
Domaini236 – 360EamA 2Add BLAST125

Sequence similaritiesi

Belongs to the TMEM20 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4510 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00730000111035
HOGENOMiHOG000045867
HOVERGENiHBG094068
InParanoidiQ8BY79
OMAiEYTRIVW
OrthoDBiEOG091G0AJI
PhylomeDBiQ8BY79
TreeFamiTF323956

Family and domain databases

InterProiView protein in InterPro
IPR000620 EamA_dom
PfamiView protein in Pfam
PF00892 EamA, 2 hits

Sequencei

Sequence statusi: Complete.

Q8BY79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPESAAEL AAEAVELREP ELQLADPASP GEEHVDVEAE GAPGRGRCWP
60 70 80 90 100
CGAWACGSRG EPEAKKKAPC PGLGLFYTVL SAFLFSVASL FVKKVQGVHA
110 120 130 140 150
VEISAFRCVV QMLVIIPCLI YRKTGFIGPK GQRLFLFLRG VFGSSAMILM
160 170 180 190 200
YYAFQTTSLA DATVIAFSCP VFTSIFAWIF LKEKYSLWDA FFTLFAIAGV
210 220 230 240 250
ILIVRPPFIF GSDTSGMRES YSEHIKGTFA AIGHAVLAAI TLVILRKMGK
260 270 280 290 300
SVDYFLSIWY YVILGLPEAI IILFVIGEWS LPYCGLDRLF LILIGLLGLG
310 320 330 340 350
GQIFITKAVQ IEKAGLVAIM KTMDIVFAFI FQIAFFDNVP TWWTVGGALC
360
VVVSTTGATI RRWLQGSK
Length:368
Mass (Da):40,217
Last modified:March 1, 2003 - v1
Checksum:iF0BEC10BC67457DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041618 mRNA Translation: BAC31006.1
AK171987 mRNA Translation: BAE42760.1
BC137663 mRNA Translation: AAI37664.1
BC137664 mRNA Translation: AAI37665.1
CCDSiCCDS29787.1
RefSeqiNP_780716.1, NM_175507.3
UniGeneiMm.262085

Genome annotation databases

EnsembliENSMUST00000054098; ENSMUSP00000061282; ENSMUSG00000044026
GeneIDi240660
KEGGimmu:240660
UCSCiuc008hjn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiS35G1_MOUSE
AccessioniPrimary (citable) accession number: Q8BY79
Secondary accession number(s): B2RPY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health