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Protein

Solute carrier family 35 member G1

Gene

Slc35g1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi2.A.7.28.1. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member G1
Alternative name(s):
Transmembrane protein 20
Gene namesi
Name:Slc35g1
Synonyms:Tmem20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2444789. Slc35g1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei72 – 9221HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence analysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence analysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence analysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Solute carrier family 35 member G1PRO_0000244464Add
BLAST

Proteomic databases

PaxDbiQ8BY79.
PeptideAtlasiQ8BY79.
PRIDEiQ8BY79.

PTM databases

PhosphoSiteiQ8BY79.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044026.
CleanExiMM_TMEM20.
GenevisibleiQ8BY79. MM.

Interactioni

Subunit structurei

Interacts with STIM1; stimulated by depletion of intracellular calcium. Interacts with ORAI1. Interacts with the plasma membrane calcium-transporting ATPases ATP2B1 and ATP2B4. Interacts with ATP1A1, ATP2A2, KPNB1 and XPO1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi232219. 1 interaction.
IntActiQ8BY79. 1 interaction.
MINTiMINT-4113466.
STRINGi10090.ENSMUSP00000061282.

Structurei

3D structure databases

ProteinModelPortaliQ8BY79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 205123EamA 1Add
BLAST
Domaini236 – 360125EamA 2Add
BLAST

Sequence similaritiesi

Belongs to the TMEM20 family.Curated
Contains 2 EamA domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4510. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00730000111035.
HOGENOMiHOG000045867.
HOVERGENiHBG094068.
InParanoidiQ8BY79.
OMAiSIWYYVI.
OrthoDBiEOG091G0AJI.
PhylomeDBiQ8BY79.
TreeFamiTF323956.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BY79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPPESAAEL AAEAVELREP ELQLADPASP GEEHVDVEAE GAPGRGRCWP
60 70 80 90 100
CGAWACGSRG EPEAKKKAPC PGLGLFYTVL SAFLFSVASL FVKKVQGVHA
110 120 130 140 150
VEISAFRCVV QMLVIIPCLI YRKTGFIGPK GQRLFLFLRG VFGSSAMILM
160 170 180 190 200
YYAFQTTSLA DATVIAFSCP VFTSIFAWIF LKEKYSLWDA FFTLFAIAGV
210 220 230 240 250
ILIVRPPFIF GSDTSGMRES YSEHIKGTFA AIGHAVLAAI TLVILRKMGK
260 270 280 290 300
SVDYFLSIWY YVILGLPEAI IILFVIGEWS LPYCGLDRLF LILIGLLGLG
310 320 330 340 350
GQIFITKAVQ IEKAGLVAIM KTMDIVFAFI FQIAFFDNVP TWWTVGGALC
360
VVVSTTGATI RRWLQGSK
Length:368
Mass (Da):40,217
Last modified:March 1, 2003 - v1
Checksum:iF0BEC10BC67457DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041618 mRNA. Translation: BAC31006.1.
AK171987 mRNA. Translation: BAE42760.1.
BC137663 mRNA. Translation: AAI37664.1.
BC137664 mRNA. Translation: AAI37665.1.
CCDSiCCDS29787.1.
RefSeqiNP_780716.1. NM_175507.3.
UniGeneiMm.262085.

Genome annotation databases

EnsembliENSMUST00000054098; ENSMUSP00000061282; ENSMUSG00000044026.
GeneIDi240660.
KEGGimmu:240660.
UCSCiuc008hjn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041618 mRNA. Translation: BAC31006.1.
AK171987 mRNA. Translation: BAE42760.1.
BC137663 mRNA. Translation: AAI37664.1.
BC137664 mRNA. Translation: AAI37665.1.
CCDSiCCDS29787.1.
RefSeqiNP_780716.1. NM_175507.3.
UniGeneiMm.262085.

3D structure databases

ProteinModelPortaliQ8BY79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232219. 1 interaction.
IntActiQ8BY79. 1 interaction.
MINTiMINT-4113466.
STRINGi10090.ENSMUSP00000061282.

Protein family/group databases

TCDBi2.A.7.28.1. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteiQ8BY79.

Proteomic databases

PaxDbiQ8BY79.
PeptideAtlasiQ8BY79.
PRIDEiQ8BY79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054098; ENSMUSP00000061282; ENSMUSG00000044026.
GeneIDi240660.
KEGGimmu:240660.
UCSCiuc008hjn.1. mouse.

Organism-specific databases

CTDi159371.
MGIiMGI:2444789. Slc35g1.

Phylogenomic databases

eggNOGiKOG4510. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00730000111035.
HOGENOMiHOG000045867.
HOVERGENiHBG094068.
InParanoidiQ8BY79.
OMAiSIWYYVI.
OrthoDBiEOG091G0AJI.
PhylomeDBiQ8BY79.
TreeFamiTF323956.

Miscellaneous databases

PROiQ8BY79.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044026.
CleanExiMM_TMEM20.
GenevisibleiQ8BY79. MM.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS35G1_MOUSE
AccessioniPrimary (citable) accession number: Q8BY79
Secondary accession number(s): B2RPY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.