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Protein

Histone acetyltransferase type B catalytic subunit

Gene

Hat1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei273Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Alternative name(s):
Histone acetyltransferase 1
Gene namesi
Name:Hat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96013 Hat1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002277292 – 416Histone acetyltransferase type B catalytic subunitAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei6N6-acetyllysineCombined sources1
Modified residuei12N6-acetyllysineCombined sources1
Modified residuei340PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BY71
MaxQBiQ8BY71
PaxDbiQ8BY71
PeptideAtlasiQ8BY71
PRIDEiQ8BY71

PTM databases

iPTMnetiQ8BY71
PhosphoSitePlusiQ8BY71

Expressioni

Gene expression databases

BgeeiENSMUSG00000027018
CleanExiMM_HAT1
ExpressionAtlasiQ8BY71 baseline and differential
GenevisibleiQ8BY71 MM

Interactioni

Subunit structurei

Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei196Interaction with histone H4 N-terminusBy similarity1

GO - Molecular functioni

Protein-protein interaction databases

BioGridi223283, 2 interactors
IntActiQ8BY71, 4 interactors
STRINGi10090.ENSMUSP00000028408

Structurei

3D structure databases

ProteinModelPortaliQ8BY71
SMRiQ8BY71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 61Interaction with histone H4 N-terminusBy similarity3
Regioni222 – 224Interaction with histone H4 N-terminusBy similarity3
Regioni238 – 240Acetyl-CoA bindingBy similarity3
Regioni245 – 251Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiKOG2696 Eukaryota
ENOG410XPH4 LUCA
GeneTreeiENSGT00390000007069
HOGENOMiHOG000231943
HOVERGENiHBG005945
InParanoidiQ8BY71
KOiK11303

Family and domain databases

Gene3Di1.10.10.390, 1 hit
3.90.360.10, 2 hits
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR019467 Hat1_N
IPR037113 Hat1_N_sf
IPR017380 Hist_AcTrfase_B-typ_cat-su
IPR013523 Hist_AcTrfase_HAT1_C
PANTHERiPTHR12046 PTHR12046, 1 hit
PfamiView protein in Pfam
PF10394 Hat1_N, 1 hit
PIRSFiPIRSF038084 HAT-B_cat, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BY71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALEKFLVE YKSAVEKKLA EYKCNTNTAI ELKLVRFPED LENDIRTFFP
60 70 80 90 100
EYTHQLFGDD ETAFGYKGLK ILLYYIAGSL STLFRVEYSS KVDENFDCVE
110 120 130 140 150
ADDVEGKIRQ IIPPGFCTNT NDFLSLLEKE TNFKPFGTLL HTYTVPSQTG
160 170 180 190 200
GETFTFQIHK ADMTCRGFRE YHERLQTFLM WFIETASFID VDDERWHYFL
210 220 230 240 250
VFEKYNKDGA TLFATVGYMT VYNYYVYPDK TRPRVSQMLI LTPFQGQGHG
260 270 280 290 300
AQLLETVHRY YISFPTVLDI TAEDPSRSYL KLRDFVLVKF CQFLPSFSRE
310 320 330 340 350
RLLQGFSEDM AIQAQQMFKI NKQHARRVYE ILRLLVTDMS DAEQYRSYRL
360 370 380 390 400
DIKRRLISPY KKKQRDLAKM KKCLRPEELT NQMNQIEISV QHEQLEERFQ
410
ELVEDYRRVI ERLAQE
Length:416
Mass (Da):49,278
Last modified:March 1, 2003 - v1
Checksum:iA20D53ABF1A7C824
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041700 mRNA Translation: BAC31038.1
AK169315 mRNA Translation: BAE41070.1
BC055460 mRNA Translation: AAH55460.1
CCDSiCCDS16114.1
RefSeqiNP_080391.2, NM_026115.4
UniGeneiMm.272472

Genome annotation databases

EnsembliENSMUST00000028408; ENSMUSP00000028408; ENSMUSG00000027018
GeneIDi107435
KEGGimmu:107435
UCSCiuc008kap.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHAT1_MOUSE
AccessioniPrimary (citable) accession number: Q8BY71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health