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Protein

Histone acetyltransferase type B catalytic subunit

Gene

Hat1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei273Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Alternative name(s):
Histone acetyltransferase 1
Gene namesi
Name:Hat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96013. Hat1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002277292 – 416Histone acetyltransferase type B catalytic subunitAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei6N6-acetyllysineCombined sources1
Modified residuei12N6-acetyllysineCombined sources1
Modified residuei340PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BY71.
MaxQBiQ8BY71.
PaxDbiQ8BY71.
PeptideAtlasiQ8BY71.
PRIDEiQ8BY71.

PTM databases

iPTMnetiQ8BY71.
PhosphoSitePlusiQ8BY71.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027018.
CleanExiMM_HAT1.
ExpressionAtlasiQ8BY71. baseline and differential.
GenevisibleiQ8BY71. MM.

Interactioni

Subunit structurei

Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A. The interaction is dependent of the ability of RBBP7 to bind to the N-terminus of histones. Component of the histone H3.1 and H3.3 complexes.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei196Interaction with histone H4 N-terminusBy similarity1

GO - Molecular functioni

Protein-protein interaction databases

BioGridi223283. 1 interactor.
IntActiQ8BY71. 4 interactors.
STRINGi10090.ENSMUSP00000028408.

Structurei

3D structure databases

ProteinModelPortaliQ8BY71.
SMRiQ8BY71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 61Interaction with histone H4 N-terminusBy similarity3
Regioni222 – 224Interaction with histone H4 N-terminusBy similarity3
Regioni238 – 240Acetyl-CoA bindingBy similarity3
Regioni245 – 251Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiKOG2696. Eukaryota.
ENOG410XPH4. LUCA.
GeneTreeiENSGT00390000007069.
HOGENOMiHOG000231943.
HOVERGENiHBG005945.
InParanoidiQ8BY71.
KOiK11303.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BY71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALEKFLVE YKSAVEKKLA EYKCNTNTAI ELKLVRFPED LENDIRTFFP
60 70 80 90 100
EYTHQLFGDD ETAFGYKGLK ILLYYIAGSL STLFRVEYSS KVDENFDCVE
110 120 130 140 150
ADDVEGKIRQ IIPPGFCTNT NDFLSLLEKE TNFKPFGTLL HTYTVPSQTG
160 170 180 190 200
GETFTFQIHK ADMTCRGFRE YHERLQTFLM WFIETASFID VDDERWHYFL
210 220 230 240 250
VFEKYNKDGA TLFATVGYMT VYNYYVYPDK TRPRVSQMLI LTPFQGQGHG
260 270 280 290 300
AQLLETVHRY YISFPTVLDI TAEDPSRSYL KLRDFVLVKF CQFLPSFSRE
310 320 330 340 350
RLLQGFSEDM AIQAQQMFKI NKQHARRVYE ILRLLVTDMS DAEQYRSYRL
360 370 380 390 400
DIKRRLISPY KKKQRDLAKM KKCLRPEELT NQMNQIEISV QHEQLEERFQ
410
ELVEDYRRVI ERLAQE
Length:416
Mass (Da):49,278
Last modified:March 1, 2003 - v1
Checksum:iA20D53ABF1A7C824
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041700 mRNA. Translation: BAC31038.1.
AK169315 mRNA. Translation: BAE41070.1.
BC055460 mRNA. Translation: AAH55460.1.
CCDSiCCDS16114.1.
RefSeqiNP_080391.2. NM_026115.4.
UniGeneiMm.272472.

Genome annotation databases

EnsembliENSMUST00000028408; ENSMUSP00000028408; ENSMUSG00000027018.
GeneIDi107435.
KEGGimmu:107435.
UCSCiuc008kap.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041700 mRNA. Translation: BAC31038.1.
AK169315 mRNA. Translation: BAE41070.1.
BC055460 mRNA. Translation: AAH55460.1.
CCDSiCCDS16114.1.
RefSeqiNP_080391.2. NM_026115.4.
UniGeneiMm.272472.

3D structure databases

ProteinModelPortaliQ8BY71.
SMRiQ8BY71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223283. 1 interactor.
IntActiQ8BY71. 4 interactors.
STRINGi10090.ENSMUSP00000028408.

PTM databases

iPTMnetiQ8BY71.
PhosphoSitePlusiQ8BY71.

Proteomic databases

EPDiQ8BY71.
MaxQBiQ8BY71.
PaxDbiQ8BY71.
PeptideAtlasiQ8BY71.
PRIDEiQ8BY71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028408; ENSMUSP00000028408; ENSMUSG00000027018.
GeneIDi107435.
KEGGimmu:107435.
UCSCiuc008kap.1. mouse.

Organism-specific databases

CTDi8520.
MGIiMGI:96013. Hat1.

Phylogenomic databases

eggNOGiKOG2696. Eukaryota.
ENOG410XPH4. LUCA.
GeneTreeiENSGT00390000007069.
HOGENOMiHOG000231943.
HOVERGENiHBG005945.
InParanoidiQ8BY71.
KOiK11303.

Enzyme and pathway databases

ReactomeiR-MMU-3214847. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiHat1. mouse.
PROiQ8BY71.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027018.
CleanExiMM_HAT1.
ExpressionAtlasiQ8BY71. baseline and differential.
GenevisibleiQ8BY71. MM.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHAT1_MOUSE
AccessioniPrimary (citable) accession number: Q8BY71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.