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Q8BY39

- Q8BY39_MOUSE

UniProt

Q8BY39 - Q8BY39_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Notch1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. chromatin DNA binding Source: MGI
    3. protein binding Source: MGI
    4. sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. anagen Source: MGI
    2. aortic valve morphogenesis Source: Ensembl
    3. apoptotic process involved in embryonic digit morphogenesis Source: MGI
    4. auditory receptor cell fate commitment Source: MGI
    5. axonogenesis Source: MGI
    6. branching morphogenesis of an epithelial tube Source: MGI
    7. cardiac right ventricle formation Source: MGI
    8. cell differentiation Source: MGI
    9. cell fate commitment Source: MGI
    10. cell fate specification Source: MGI
    11. cellular response to follicle-stimulating hormone stimulus Source: Ensembl
    12. cellular response to vascular endothelial growth factor stimulus Source: Ensembl
    13. compartment pattern specification Source: MGI
    14. determination of left/right symmetry Source: MGI
    15. embryonic hindlimb morphogenesis Source: MGI
    16. embryonic limb morphogenesis Source: MGI
    17. endoderm development Source: MGI
    18. epidermis development Source: MGI
    19. epithelial to mesenchymal transition Source: MGI
    20. forebrain development Source: MGI
    21. foregut morphogenesis Source: MGI
    22. glial cell differentiation Source: MGI
    23. hair follicle morphogenesis Source: MGI
    24. heart development Source: MGI
    25. humoral immune response Source: MGI
    26. inflammatory response to antigenic stimulus Source: MGI
    27. interleukin-4 secretion Source: MGI
    28. in utero embryonic development Source: MGI
    29. keratinocyte differentiation Source: MGI
    30. liver development Source: MGI
    31. lung development Source: MGI
    32. mitral valve formation Source: Ensembl
    33. negative regulation of anoikis Source: Ensembl
    34. negative regulation of calcium ion-dependent exocytosis Source: MGI
    35. negative regulation of canonical Wnt signaling pathway Source: MGI
    36. negative regulation of cell death Source: MGI
    37. negative regulation of cell differentiation Source: MGI
    38. negative regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
    39. negative regulation of cell proliferation Source: Ensembl
    40. negative regulation of cell-substrate adhesion Source: Ensembl
    41. negative regulation of endothelial cell chemotaxis Source: Ensembl
    42. negative regulation of myoblast differentiation Source: Ensembl
    43. negative regulation of neuron differentiation Source: MGI
    44. negative regulation of photoreceptor cell differentiation Source: MGI
    45. negative regulation of stem cell differentiation Source: Ensembl
    46. neural tube development Source: MGI
    47. neuronal stem cell maintenance Source: Ensembl
    48. neuron differentiation Source: MGI
    49. neuron fate commitment Source: MGI
    50. Notch signaling pathway Source: MGI
    51. Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation Source: MGI
    52. positive regulation of apoptotic process Source: MGI
    53. positive regulation of cell proliferation Source: MGI
    54. positive regulation of epithelial cell proliferation Source: MGI
    55. positive regulation of epithelial to mesenchymal transition Source: Ensembl
    56. positive regulation of keratinocyte differentiation Source: MGI
    57. positive regulation of transcription, DNA-templated Source: MGI
    58. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    59. positive regulation of transcription of Notch receptor target Source: MGI
    60. prostate gland epithelium morphogenesis Source: MGI
    61. pulmonary valve morphogenesis Source: Ensembl
    62. regulation of epithelial cell proliferation Source: MGI
    63. regulation of epithelial cell proliferation involved in prostate gland development Source: MGI
    64. regulation of gene expression Source: MGI
    65. regulation of neurogenesis Source: MGI
    66. regulation of somitogenesis Source: MGI
    67. regulation of transcription from RNA polymerase II promoter Source: MGI
    68. secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source: MGI
    69. skeletal muscle cell differentiation Source: MGI
    70. somatic stem cell division Source: MGI
    71. sprouting angiogenesis Source: MGI
    72. tube formation Source: Ensembl
    73. ventricular septum morphogenesis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Notch1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97363. Notch1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell periphery Source: MGI
    2. cell surface Source: MGI
    3. cytoplasm Source: MGI
    4. MAML1-RBP-Jkappa- ICN1 complex Source: Ensembl
    5. nucleus Source: MGI
    6. plasma membrane Source: MGI
    7. receptor complex Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BY39.
    BgeeiQ8BY39.
    GenevestigatoriQ8BY39.

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ8BY39.

    Family and domain databases

    InterProiIPR024600. DUF3454_notch.
    [Graphical view]
    PfamiPF11936. DUF3454. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8BY39-1 [UniParc]FASTAAdd to Basket

    « Hide

    RLSHLPVASS ASTVLSTNGT GAMNFTVGAP ASLNGQCEWL PRLQNGMVPS    50
    QYNPLRPGVT PGTLSTQAAG LQHSMMGPLH SSLSTNTLSP IIYQGLPNTR 100
    LATQPHLVQT QQVQPQNLQL QPQNLQPPSQ PHLSVSSAAN GHLGRSFLSG 150
    EPSQADVQPL GPSSLPVHTI LPQESQALPT SLPSSMVPPM TTTQFLTPPS 200
    QHSYSSSPVD NTPSHQLQVP EHPFLTPSPE SPDQWSSSSP HSNISDWSEG 250
    ISSPPTTMPS QITHIPEAFK 270
    Length:270
    Mass (Da):28,658
    Last modified:March 1, 2003 - v1
    Checksum:i018C5C622D3435F7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK042197 mRNA. Translation: BAC31194.1.
    UniGeneiMm.290610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK042197 mRNA. Translation: BAC31194.1 .
    UniGenei Mm.290610.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97363. Notch1.

    Phylogenomic databases

    InParanoidi Q8BY39.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BY39.
    Bgeei Q8BY39.
    Genevestigatori Q8BY39.

    Family and domain databases

    InterProi IPR024600. DUF3454_notch.
    [Graphical view ]
    Pfami PF11936. DUF3454. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: ThymusImported.

    Entry informationi

    Entry nameiQ8BY39_MOUSE
    AccessioniPrimary (citable) accession number: Q8BY39
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)