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Q8BY39

- Q8BY39_MOUSE

UniProt

Q8BY39 - Q8BY39_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene

Notch1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. chromatin DNA binding Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. anagen Source: MGI
  2. aortic valve morphogenesis Source: Ensembl
  3. apoptotic process involved in embryonic digit morphogenesis Source: MGI
  4. auditory receptor cell fate commitment Source: MGI
  5. axonogenesis Source: MGI
  6. branching morphogenesis of an epithelial tube Source: MGI
  7. cardiac right ventricle formation Source: MGI
  8. cell differentiation Source: MGI
  9. cell fate commitment Source: MGI
  10. cell fate specification Source: MGI
  11. cellular response to follicle-stimulating hormone stimulus Source: Ensembl
  12. cellular response to vascular endothelial growth factor stimulus Source: Ensembl
  13. compartment pattern specification Source: MGI
  14. determination of left/right symmetry Source: MGI
  15. embryonic hindlimb morphogenesis Source: MGI
  16. embryonic limb morphogenesis Source: MGI
  17. endoderm development Source: MGI
  18. epidermis development Source: MGI
  19. epithelial to mesenchymal transition Source: MGI
  20. forebrain development Source: MGI
  21. foregut morphogenesis Source: MGI
  22. glial cell differentiation Source: MGI
  23. hair follicle morphogenesis Source: MGI
  24. heart development Source: MGI
  25. humoral immune response Source: MGI
  26. inflammatory response to antigenic stimulus Source: MGI
  27. interleukin-4 secretion Source: MGI
  28. in utero embryonic development Source: MGI
  29. keratinocyte differentiation Source: MGI
  30. liver development Source: MGI
  31. lung development Source: MGI
  32. mitral valve formation Source: Ensembl
  33. negative regulation of anoikis Source: Ensembl
  34. negative regulation of calcium ion-dependent exocytosis Source: MGI
  35. negative regulation of canonical Wnt signaling pathway Source: MGI
  36. negative regulation of cell death Source: MGI
  37. negative regulation of cell differentiation Source: MGI
  38. negative regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
  39. negative regulation of cell proliferation Source: Ensembl
  40. negative regulation of cell-substrate adhesion Source: Ensembl
  41. negative regulation of endothelial cell chemotaxis Source: Ensembl
  42. negative regulation of myoblast differentiation Source: Ensembl
  43. negative regulation of neuron differentiation Source: MGI
  44. negative regulation of photoreceptor cell differentiation Source: MGI
  45. negative regulation of stem cell differentiation Source: Ensembl
  46. neural tube development Source: MGI
  47. neuronal stem cell maintenance Source: Ensembl
  48. neuron differentiation Source: MGI
  49. neuron fate commitment Source: MGI
  50. Notch signaling pathway Source: MGI
  51. Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation Source: MGI
  52. positive regulation of apoptotic process Source: MGI
  53. positive regulation of cell proliferation Source: MGI
  54. positive regulation of epithelial cell proliferation Source: MGI
  55. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  56. positive regulation of keratinocyte differentiation Source: MGI
  57. positive regulation of transcription, DNA-templated Source: MGI
  58. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  59. positive regulation of transcription of Notch receptor target Source: MGI
  60. prostate gland epithelium morphogenesis Source: MGI
  61. pulmonary valve morphogenesis Source: Ensembl
  62. regulation of epithelial cell proliferation Source: MGI
  63. regulation of epithelial cell proliferation involved in prostate gland development Source: MGI
  64. regulation of gene expression Source: MGI
  65. regulation of neurogenesis Source: MGI
  66. regulation of somitogenesis Source: MGI
  67. regulation of transcription from RNA polymerase II promoter Source: MGI
  68. secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source: MGI
  69. skeletal muscle cell differentiation Source: MGI
  70. somatic stem cell division Source: MGI
  71. sprouting angiogenesis Source: MGI
  72. tube formation Source: Ensembl
  73. ventricular septum morphogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Notch1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97363. Notch1.

Subcellular locationi

GO - Cellular componenti

  1. cell periphery Source: MGI
  2. cell surface Source: MGI
  3. cytoplasm Source: MGI
  4. MAML1-RBP-Jkappa- ICN1 complex Source: Ensembl
  5. nucleus Source: MGI
  6. plasma membrane Source: MGI
  7. receptor complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8BY39.
ExpressionAtlasiQ8BY39. baseline and differential.
GenevestigatoriQ8BY39.

Family & Domainsi

Family and domain databases

InterProiIPR024600. DUF3454_notch.
[Graphical view]
PfamiPF11936. DUF3454. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8BY39-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RLSHLPVASS ASTVLSTNGT GAMNFTVGAP ASLNGQCEWL PRLQNGMVPS
60 70 80 90 100
QYNPLRPGVT PGTLSTQAAG LQHSMMGPLH SSLSTNTLSP IIYQGLPNTR
110 120 130 140 150
LATQPHLVQT QQVQPQNLQL QPQNLQPPSQ PHLSVSSAAN GHLGRSFLSG
160 170 180 190 200
EPSQADVQPL GPSSLPVHTI LPQESQALPT SLPSSMVPPM TTTQFLTPPS
210 220 230 240 250
QHSYSSSPVD NTPSHQLQVP EHPFLTPSPE SPDQWSSSSP HSNISDWSEG
260 270
ISSPPTTMPS QITHIPEAFK
Length:270
Mass (Da):28,658
Last modified:March 1, 2003 - v1
Checksum:i018C5C622D3435F7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK042197 mRNA. Translation: BAC31194.1.
UniGeneiMm.290610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK042197 mRNA. Translation: BAC31194.1 .
UniGenei Mm.290610.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:97363. Notch1.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Bgeei Q8BY39.
ExpressionAtlasi Q8BY39. baseline and differential.
Genevestigatori Q8BY39.

Family and domain databases

InterProi IPR024600. DUF3454_notch.
[Graphical view ]
Pfami PF11936. DUF3454. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.

Entry informationi

Entry nameiQ8BY39_MOUSE
AccessioniPrimary (citable) accession number: Q8BY39
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)