Q8BY39 (Q8BY39_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAC31194.1

Gene names

Name:

Notch1 MGI 97363

Organism

Mus musculus (Mouse) EMBL BAC31194.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	270 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation Inferred from mutant phenotype PubMed 19620969. Source: MGI anagen Inferred from mutant phenotype PubMed 15978571. Source: MGI aortic valve morphogenesis Inferred from electronic annotation. Source: Compara auditory receptor cell fate commitment Inferred from mutant phenotype PubMed 19154718. Source: MGI axonogenesis Inferred from direct assay PubMed 15598981. Source: MGI branching morphogenesis of an epithelial tube Inferred from mutant phenotype PubMed 15064243. Source: MGI cardiac right ventricle formation Inferred from mutant phenotype PubMed 19620969. Source: MGI cell fate specification Inferred from mutant phenotype PubMed 15068794. Source: MGI cellular response to follicle-stimulating hormone stimulus Inferred from electronic annotation. Source: Compara compartment pattern specification Inferred from mutant phenotype PubMed 12001066. Source: MGI determination of left/right symmetry Inferred from mutant phenotype PubMed 12730124PubMed 7789282. Source: MGI embryonic hindlimb morphogenesis Inferred from mutant phenotype PubMed 16245338. Source: MGI endoderm development Inferred from mutant phenotype PubMed 14657333. Source: MGI epithelial to mesenchymal transition Inferred from mutant phenotype PubMed 14701881. Source: MGI forebrain development Inferred from mutant phenotype PubMed 16120638. Source: MGI foregut morphogenesis Inferred from mutant phenotype PubMed 16107537. Source: MGI glial cell differentiation Inferred from mutant phenotype PubMed 15965470. Source: MGI hair follicle morphogenesis Inferred from mutant phenotype PubMed 15525534PubMed 15978571. Source: MGI humoral immune response Inferred from genetic interaction PubMed 17658279. Source: MGI in utero embryonic development Inferred from mutant phenotype PubMed 7789282. Source: MGI inflammatory response to antigenic stimulus Inferred from genetic interaction PubMed 17658279. Source: MGI interleukin-4 secretion Inferred from genetic interaction PubMed 17658279. Source: MGI keratinocyte differentiation Inferred from mutant phenotype PubMed 15068794. Source: MGI liver development Inferred from mutant phenotype PubMed 15226394. Source: MGI lung development Inferred from mutant phenotype PubMed 15064243. Source: MGI mitral valve formation Inferred from electronic annotation. Source: Compara negative regulation of anoikis Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from mutant phenotype PubMed 16245338. Source: MGI negative regulation of calcium ion-dependent exocytosis Inferred from mutant phenotype PubMed 19251639. Source: MGI negative regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 19620969. Source: MGI negative regulation of cell-substrate adhesion Inferred from electronic annotation. Source: Compara negative regulation of myoblast differentiation Inferred from electronic annotation. Source: Compara negative regulation of photoreceptor cell differentiation Inferred from mutant phenotype PubMed 16452096. Source: MGI negative regulation of stem cell differentiation Inferred from electronic annotation. Source: Compara neural tube development Inferred from mutant phenotype PubMed 7789282. Source: MGI neuronal stem cell maintenance Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from direct assay PubMed 15081359. Source: MGI positive regulation of epithelial cell proliferation Inferred from genetic interaction PubMed 19251639. Source: MGI positive regulation of epithelial to mesenchymal transition Inferred from electronic annotation. Source: Compara positive regulation of keratinocyte differentiation Inferred from direct assay PubMed 17079689. Source: MGI positive regulation of transcription of Notch receptor target Inferred from genetic interaction PubMed 12794108. Source: MGI prostate gland epithelium morphogenesis Inferred from mutant phenotype PubMed 16360140. Source: MGI pulmonary valve morphogenesis Inferred from electronic annotation. Source: Compara regulation of epithelial cell proliferation involved in prostate gland development Inferred from mutant phenotype PubMed 16360140. Source: MGI regulation of somitogenesis Inferred from mutant phenotype PubMed 7789282. Source: MGI secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Inferred from mutant phenotype PubMed 16360140. Source: MGI skeletal muscle cell differentiation Inferred from mutant phenotype PubMed 22147266. Source: MGI somatic stem cell division Inferred from direct assay PubMed 12717450. Source: MGI sprouting angiogenesis Inferred from mutant phenotype PubMed 15809373. Source: MGI ventricular septum morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	MAML1-RBP-Jkappa- ICN1 complex Inferred from electronic annotation. Source: Compara cell surface Inferred from direct assay PubMed 15574878. Source: MGI cytoplasm Inferred from direct assay PubMed 15965470. Source: MGI nucleus Inferred from direct assay PubMed 10206645PubMed 16324690PubMed 16607638PubMed 17079689. Source: MGI plasma membrane Inferred from direct assay PubMed 17079689. Source: MGI
Molecular_function	chromatin DNA binding Inferred from direct assay PubMed 17658278. Source: MGI sequence-specific DNA binding Inferred from direct assay PubMed 17658278. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 17658278PubMed 9111338. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAC31194.1

Sequences

	Sequence		Length	Mass (Da)
	Q8BY39 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 018C5C622D3435F7	FASTA	270	28,658
	10 20 30 40 50 60 RLSHLPVASS ASTVLSTNGT GAMNFTVGAP ASLNGQCEWL PRLQNGMVPS QYNPLRPGVT 70 80 90 100 110 120 PGTLSTQAAG LQHSMMGPLH SSLSTNTLSP IIYQGLPNTR LATQPHLVQT QQVQPQNLQL 130 140 150 160 170 180 QPQNLQPPSQ PHLSVSSAAN GHLGRSFLSG EPSQADVQPL GPSSLPVHTI LPQESQALPT 190 200 210 220 230 240 SLPSSMVPPM TTTQFLTPPS QHSYSSSPVD NTPSHQLQVP EHPFLTPSPE SPDQWSSSSP 250 260 270 HSNISDWSEG ISSPPTTMPS QITHIPEAFK

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC31194.1. Tissue: Thymus EMBL BAC31194.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC31194.1. Tissue: Thymus EMBL BAC31194.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC31194.1. Tissue: Thymus EMBL BAC31194.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC31194.1. Tissue: Thymus EMBL BAC31194.1.
[5]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC31194.1. Tissue: Thymus EMBL BAC31194.1.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC31194.1. Tissue: Thymus EMBL BAC31194.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC31194.1. Tissue: Thymus EMBL BAC31194.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC31194.1. Tissue: Thymus EMBL BAC31194.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK042197 mRNA. Translation: BAC31194.1.
IPI	IPI00875032.
UniGene	Mm.290610.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8BY39.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:97363. Notch1.
Phylogenomic databases
InParanoid	Q8BY39.
Gene expression databases
ArrayExpress	Q8BY39.
Bgee	Q8BY39.
Genevestigator	Q8BY39.
Family and domain databases
InterPro	IPR024600. DUF3454_notch. [Graphical view]
Pfam	PF11936. DUF3454. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q8BY39_MOUSE

Accession

Primary (citable) accession number: Q8BY39

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)