Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8BY39 (Q8BY39_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Notch1 MGI 97363
OrganismMus musculus (Mouse) EMBL BAC31194.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length270 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processNotch signaling pathway

Inferred from direct assay PubMed 21419176. Source: MGI

Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation

Inferred from mutant phenotype PubMed 19620969. Source: MGI

anagen

Inferred from mutant phenotype PubMed 15978571. Source: MGI

aortic valve morphogenesis

Inferred from electronic annotation. Source: Ensembl

apoptotic process involved in embryonic digit morphogenesis

Inferred from mutant phenotype PubMed 16245338. Source: MGI

auditory receptor cell fate commitment

Inferred from mutant phenotype PubMed 19154718. Source: MGI

axonogenesis

Inferred from direct assay PubMed 15598981. Source: MGI

branching morphogenesis of an epithelial tube

Inferred from mutant phenotype PubMed 15064243. Source: MGI

cardiac right ventricle formation

Inferred from mutant phenotype PubMed 19620969. Source: MGI

cell differentiation

Inferred from mutant phenotype PubMed 12186854PubMed 14657333. Source: MGI

cell fate commitment

Inferred from mutant phenotype PubMed 16107537. Source: MGI

cell fate specification

Inferred from mutant phenotype PubMed 15068794. Source: MGI

cellular response to follicle-stimulating hormone stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to vascular endothelial growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

compartment pattern specification

Inferred from mutant phenotype PubMed 12001066. Source: MGI

determination of left/right symmetry

Inferred from mutant phenotype PubMed 12730124PubMed 7789282. Source: MGI

embryonic hindlimb morphogenesis

Inferred from mutant phenotype PubMed 16245338. Source: MGI

embryonic limb morphogenesis

Inferred from genetic interaction PubMed 16169548. Source: MGI

endoderm development

Inferred from mutant phenotype PubMed 14657333. Source: MGI

epidermis development

Inferred from genetic interaction PubMed 15525534. Source: MGI

epithelial to mesenchymal transition

Inferred from mutant phenotype PubMed 14701881. Source: MGI

forebrain development

Inferred from mutant phenotype PubMed 16120638. Source: MGI

foregut morphogenesis

Inferred from mutant phenotype PubMed 16107537. Source: MGI

glial cell differentiation

Inferred from mutant phenotype PubMed 15965470. Source: MGI

hair follicle morphogenesis

Inferred from mutant phenotype PubMed 15525534PubMed 15978571. Source: MGI

heart development

Inferred from mutant phenotype PubMed 14701881. Source: MGI

humoral immune response

Inferred from genetic interaction PubMed 17658279. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 7789282. Source: MGI

inflammatory response to antigenic stimulus

Inferred from genetic interaction PubMed 17658279. Source: MGI

interleukin-4 secretion

Inferred from genetic interaction PubMed 17658279. Source: MGI

keratinocyte differentiation

Inferred from mutant phenotype PubMed 15068794. Source: MGI

liver development

Inferred from mutant phenotype PubMed 15226394. Source: MGI

lung development

Inferred from mutant phenotype PubMed 15064243. Source: MGI

mitral valve formation

Inferred from electronic annotation. Source: Ensembl

negative regulation of anoikis

Inferred from electronic annotation. Source: Ensembl

negative regulation of calcium ion-dependent exocytosis

Inferred from mutant phenotype PubMed 19251639. Source: MGI

negative regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 19620969. Source: MGI

negative regulation of cell death

Inferred from mutant phenotype PubMed 7789282. Source: MGI

negative regulation of cell differentiation

Inferred from mutant phenotype PubMed 15064243. Source: MGI

negative regulation of cell migration involved in sprouting angiogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell-substrate adhesion

Inferred from electronic annotation. Source: Ensembl

negative regulation of endothelial cell chemotaxis

Inferred from electronic annotation. Source: Ensembl

negative regulation of myoblast differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron differentiation

Inferred from mutant phenotype PubMed 16120638. Source: MGI

negative regulation of photoreceptor cell differentiation

Inferred from mutant phenotype PubMed 16452096. Source: MGI

negative regulation of stem cell differentiation

Inferred from electronic annotation. Source: Ensembl

neural tube development

Inferred from mutant phenotype PubMed 7789282. Source: MGI

neuron differentiation

Inferred from mutant phenotype PubMed 9102301. Source: MGI

neuron fate commitment

Inferred from genetic interaction PubMed 16120638. Source: MGI

neuronal stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from direct assay PubMed 15081359. Source: MGI

positive regulation of cell proliferation

Inferred from genetic interaction PubMed 15509736. Source: MGI

positive regulation of epithelial cell proliferation

Inferred from genetic interaction PubMed 19251639. Source: MGI

positive regulation of epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Ensembl

positive regulation of keratinocyte differentiation

Inferred from direct assay PubMed 17079689. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12783854PubMed 15902259PubMed 16145673PubMed 16618808PubMed 17658278. Source: MGI

positive regulation of transcription of Notch receptor target

Inferred from genetic interaction PubMed 12794108. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 9111338. Source: MGI

prostate gland epithelium morphogenesis

Inferred from mutant phenotype PubMed 16360140. Source: MGI

pulmonary valve morphogenesis

Inferred from electronic annotation. Source: Ensembl

regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 16107537. Source: MGI

regulation of epithelial cell proliferation involved in prostate gland development

Inferred from mutant phenotype PubMed 16360140. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 9102301. Source: MGI

regulation of neurogenesis

Inferred from mutant phenotype PubMed 9102301. Source: MGI

regulation of somitogenesis

Inferred from mutant phenotype PubMed 7789282. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 15689374. Source: MGI

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

Inferred from mutant phenotype PubMed 16360140. Source: MGI

skeletal muscle cell differentiation

Inferred from mutant phenotype PubMed 22147266. Source: MGI

somatic stem cell division

Inferred from direct assay PubMed 12717450. Source: MGI

sprouting angiogenesis

Inferred from mutant phenotype PubMed 15809373. Source: MGI

tube formation

Inferred from electronic annotation. Source: Ensembl

ventricular septum morphogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentMAML1-RBP-Jkappa- ICN1 complex

Inferred from electronic annotation. Source: Ensembl

cell periphery

Inferred from direct assay PubMed 23284756. Source: MGI

cell surface

Inferred from direct assay PubMed 15574878. Source: MGI

cytoplasm

Inferred from direct assay PubMed 15965470. Source: MGI

nucleus

Inferred from direct assay PubMed 10206645PubMed 16324690PubMed 16607638PubMed 17079689. Source: MGI

plasma membrane

Inferred from direct assay PubMed 17079689. Source: MGI

receptor complex

Inferred from sequence orthology PubMed 23382219. Source: MGI

   Molecular_functionchromatin DNA binding

Inferred from direct assay PubMed 17658278. Source: MGI

chromatin binding

Inferred from direct assay PubMed 15689374. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 17658278. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 17658278PubMed 9111338. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL BAC31194.1

Sequences

Sequence LengthMass (Da)Tools
Q8BY39 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 018C5C622D3435F7

FASTA27028,658
        10         20         30         40         50         60 
RLSHLPVASS ASTVLSTNGT GAMNFTVGAP ASLNGQCEWL PRLQNGMVPS QYNPLRPGVT 

        70         80         90        100        110        120 
PGTLSTQAAG LQHSMMGPLH SSLSTNTLSP IIYQGLPNTR LATQPHLVQT QQVQPQNLQL 

       130        140        150        160        170        180 
QPQNLQPPSQ PHLSVSSAAN GHLGRSFLSG EPSQADVQPL GPSSLPVHTI LPQESQALPT 

       190        200        210        220        230        240 
SLPSSMVPPM TTTQFLTPPS QHSYSSSPVD NTPSHQLQVP EHPFLTPSPE SPDQWSSSSP 

       250        260        270 
HSNISDWSEG ISSPPTTMPS QITHIPEAFK 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC31194.1.
Tissue: Thymus EMBL BAC31194.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC31194.1.
Tissue: Thymus EMBL BAC31194.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC31194.1.
Tissue: Thymus EMBL BAC31194.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC31194.1.
Tissue: Thymus EMBL BAC31194.1.
[5]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC31194.1.
Tissue: Thymus EMBL BAC31194.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC31194.1.
Tissue: Thymus EMBL BAC31194.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC31194.1.
Tissue: Thymus EMBL BAC31194.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC31194.1.
Tissue: Thymus EMBL BAC31194.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK042197 mRNA. Translation: BAC31194.1.
UniGeneMm.290610.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97363. Notch1.

Phylogenomic databases

InParanoidQ8BY39.

Gene expression databases

ArrayExpressQ8BY39.
BgeeQ8BY39.
GenevestigatorQ8BY39.

Family and domain databases

InterProIPR024600. DUF3454_notch.
[Graphical view]
PfamPF11936. DUF3454. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ8BY39_MOUSE
AccessionPrimary (citable) accession number: Q8BY39
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)