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Q8BY02

- NKRF_MOUSE

UniProt

Q8BY02 - NKRF_MOUSE

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Protein
NF-kappa-B-repressing factor
Gene
Nkrf, Nrf
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi296 – 38893 By similarity
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: Ensembl
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B-repressing factor
Short name:
NFkB-repressing factor
Alternative name(s):
Transcription factor NRF
Gene namesi
Name:Nkrf
Synonyms:Nrf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1924536. Nkrf.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 690690NF-kappa-B-repressing factor
PRO_0000096870Add
BLAST

Proteomic databases

PaxDbiQ8BY02.
PRIDEiQ8BY02.

PTM databases

PhosphoSiteiQ8BY02.

Expressioni

Gene expression databases

BgeeiQ8BY02.
CleanExiMM_NKRF.
GenevestigatoriQ8BY02.

Interactioni

Subunit structurei

Interacts with NF-kappa-B By similarity.

Protein-protein interaction databases

BioGridi218599. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8BY02.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini551 – 59646G-patch
Add
BLAST
Domaini600 – 66465R3H
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 296296Active repression domain By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi25 – 4521Nuclear localization signal By similarity
Add
BLAST

Sequence similaritiesi

Contains 1 G-patch domain.
Contains 1 R3H domain.

Phylogenomic databases

eggNOGiNOG123689.
GeneTreeiENSGT00530000063234.
HOGENOMiHOG000230930.
HOVERGENiHBG052630.
InParanoidiA2A3V7.
OMAiWRYSHES.
OrthoDBiEOG7XWPN1.
TreeFamiTF326321.

Family and domain databases

Gene3Di3.30.1370.50. 1 hit.
3.30.160.20. 1 hit.
InterProiIPR014720. dsRNA-bd_dom.
IPR000467. G_patch_dom.
IPR001374. R3H_ss-bd.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF01424. R3H. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 2 hits.
SM00443. G_patch. 1 hit.
SM00393. R3H. 1 hit.
[Graphical view]
SUPFAMiSSF82708. SSF82708. 1 hit.
PROSITEiPS50174. G_PATCH. 1 hit.
PS51061. R3H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BY02-1 [UniParc]FASTAAdd to Basket

« Hide

MEKILHMAEG IDIGEMPSYD LMLPKPSKGQ KRYLSTYDGQ NPPKKQAGSK    50
FHVRARFEPV HFVASSSKAE RQEDPYGPQT KDVNGRTHFA SMPRNFYQDY 100
TQDSFSIQDG NSQYCNSSGF IFTKDQPVAT NMYFDSGNPA PSSTSQQANC 150
QPAPEPPPSQ MYPESLVAEK QYFIEKLTAT IWKNLSNPEM TSGSDKINYT 200
YMLTRCIQAC KTNPEYIYAP LKEIPPADIP KNKKLLTDGY ACEVRCQNIY 250
LTTGYAGSKN GSRDRATELA VKLLQKRIEV RVVRRKFKHI IGEDLVVCQI 300
GMLSYEFPPA LKPPEDLVVL GKDASGQPIF NSSAKHWTNF VITENANDAI 350
GILNNSASFN KMSIEYKYEM MPNRTWRCRV FLQDHCLAEG YGTKKTSKHA 400
AADEALKVLQ KTQPTYPSVK SSQCHSGSSP KGSGKKKDIK DLVVYENSSN 450
PVCTLNDTAQ FNRMTVEYVY ERMTGLRWKC KVILESEVIA EAVGVKKSVK 500
YEAAGEAVKT LKKTQPTVIN NLKKGTVEDV ISRNEIQGRS AEEAYKQQIK 550
EDNIGNQLLR KMGWTGGGLG KSGEGIREPI SVKEQHKREG LGLDVERVNK 600
IAKRDIEQII RNYARSESHS DLTFSTELTN DERKQIHQIA QKYGLKSKSH 650
GVGHDRYLVV GRKRRKEDLL DQLKQEGQVG HYELVMPQAN 690
Length:690
Mass (Da):77,739
Last modified:July 27, 2011 - v3
Checksum:i0A99E1141183F999
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti686 – 6861M → V in BAC37550. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK020455 mRNA. Translation: BAB32107.1.
AK042690 mRNA. Translation: BAC31334.1.
AK079123 mRNA. Translation: BAC37550.1.
AL450399 Genomic DNA. Translation: CAM19779.1.
BC138828 mRNA. Translation: AAI38829.1.
BC138829 mRNA. Translation: AAI38830.1.
CCDSiCCDS30065.1.
RefSeqiNP_084167.2. NM_029891.2.
UniGeneiMm.21649.

Genome annotation databases

EnsembliENSMUST00000057093; ENSMUSP00000061546; ENSMUSG00000044149.
GeneIDi77286.
KEGGimmu:77286.
UCSCiuc009sxw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK020455 mRNA. Translation: BAB32107.1 .
AK042690 mRNA. Translation: BAC31334.1 .
AK079123 mRNA. Translation: BAC37550.1 .
AL450399 Genomic DNA. Translation: CAM19779.1 .
BC138828 mRNA. Translation: AAI38829.1 .
BC138829 mRNA. Translation: AAI38830.1 .
CCDSi CCDS30065.1.
RefSeqi NP_084167.2. NM_029891.2.
UniGenei Mm.21649.

3D structure databases

ProteinModelPortali Q8BY02.
ModBasei Search...

Protein-protein interaction databases

BioGridi 218599. 3 interactions.

PTM databases

PhosphoSitei Q8BY02.

Proteomic databases

PaxDbi Q8BY02.
PRIDEi Q8BY02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000057093 ; ENSMUSP00000061546 ; ENSMUSG00000044149 .
GeneIDi 77286.
KEGGi mmu:77286.
UCSCi uc009sxw.1. mouse.

Organism-specific databases

CTDi 55922.
MGIi MGI:1924536. Nkrf.

Phylogenomic databases

eggNOGi NOG123689.
GeneTreei ENSGT00530000063234.
HOGENOMi HOG000230930.
HOVERGENi HBG052630.
InParanoidi A2A3V7.
OMAi WRYSHES.
OrthoDBi EOG7XWPN1.
TreeFami TF326321.

Miscellaneous databases

ChiTaRSi NKRF. mouse.
NextBioi 346701.
PROi Q8BY02.
SOURCEi Search...

Gene expression databases

Bgeei Q8BY02.
CleanExi MM_NKRF.
Genevestigatori Q8BY02.

Family and domain databases

Gene3Di 3.30.1370.50. 1 hit.
3.30.160.20. 1 hit.
InterProi IPR014720. dsRNA-bd_dom.
IPR000467. G_patch_dom.
IPR001374. R3H_ss-bd.
[Graphical view ]
Pfami PF01585. G-patch. 1 hit.
PF01424. R3H. 1 hit.
[Graphical view ]
SMARTi SM00358. DSRM. 2 hits.
SM00443. G_patch. 1 hit.
SM00393. R3H. 1 hit.
[Graphical view ]
SUPFAMi SSF82708. SSF82708. 1 hit.
PROSITEi PS50174. G_PATCH. 1 hit.
PS51061. R3H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiNKRF_MOUSE
AccessioniPrimary (citable) accession number: Q8BY02
Secondary accession number(s): A2A3V7, Q8BJU5, Q9CRL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi