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Q8BY02

- NKRF_MOUSE

UniProt

Q8BY02 - NKRF_MOUSE

Protein

NF-kappa-B-repressing factor

Gene

Nkrf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi296 – 38893By similarityAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: Ensembl
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NF-kappa-B-repressing factor
    Short name:
    NFkB-repressing factor
    Alternative name(s):
    Transcription factor NRF
    Gene namesi
    Name:Nkrf
    Synonyms:Nrf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1924536. Nkrf.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 690690NF-kappa-B-repressing factorPRO_0000096870Add
    BLAST

    Proteomic databases

    PaxDbiQ8BY02.
    PRIDEiQ8BY02.

    PTM databases

    PhosphoSiteiQ8BY02.

    Expressioni

    Gene expression databases

    BgeeiQ8BY02.
    CleanExiMM_NKRF.
    GenevestigatoriQ8BY02.

    Interactioni

    Subunit structurei

    Interacts with NF-kappa-B.By similarity

    Protein-protein interaction databases

    BioGridi218599. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BY02.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini551 – 59646G-patchPROSITE-ProRule annotationAdd
    BLAST
    Domaini600 – 66465R3HPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 296296Active repression domainBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi25 – 4521Nuclear localization signalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 G-patch domain.PROSITE-ProRule annotation
    Contains 1 R3H domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG123689.
    GeneTreeiENSGT00530000063234.
    HOGENOMiHOG000230930.
    HOVERGENiHBG052630.
    InParanoidiA2A3V7.
    OMAiWRYSHES.
    OrthoDBiEOG7XWPN1.
    TreeFamiTF326321.

    Family and domain databases

    Gene3Di3.30.1370.50. 1 hit.
    3.30.160.20. 1 hit.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR000467. G_patch_dom.
    IPR001374. R3H_ss-bd.
    [Graphical view]
    PfamiPF01585. G-patch. 1 hit.
    PF01424. R3H. 1 hit.
    [Graphical view]
    SMARTiSM00358. DSRM. 2 hits.
    SM00443. G_patch. 1 hit.
    SM00393. R3H. 1 hit.
    [Graphical view]
    SUPFAMiSSF82708. SSF82708. 1 hit.
    PROSITEiPS50174. G_PATCH. 1 hit.
    PS51061. R3H. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BY02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKILHMAEG IDIGEMPSYD LMLPKPSKGQ KRYLSTYDGQ NPPKKQAGSK    50
    FHVRARFEPV HFVASSSKAE RQEDPYGPQT KDVNGRTHFA SMPRNFYQDY 100
    TQDSFSIQDG NSQYCNSSGF IFTKDQPVAT NMYFDSGNPA PSSTSQQANC 150
    QPAPEPPPSQ MYPESLVAEK QYFIEKLTAT IWKNLSNPEM TSGSDKINYT 200
    YMLTRCIQAC KTNPEYIYAP LKEIPPADIP KNKKLLTDGY ACEVRCQNIY 250
    LTTGYAGSKN GSRDRATELA VKLLQKRIEV RVVRRKFKHI IGEDLVVCQI 300
    GMLSYEFPPA LKPPEDLVVL GKDASGQPIF NSSAKHWTNF VITENANDAI 350
    GILNNSASFN KMSIEYKYEM MPNRTWRCRV FLQDHCLAEG YGTKKTSKHA 400
    AADEALKVLQ KTQPTYPSVK SSQCHSGSSP KGSGKKKDIK DLVVYENSSN 450
    PVCTLNDTAQ FNRMTVEYVY ERMTGLRWKC KVILESEVIA EAVGVKKSVK 500
    YEAAGEAVKT LKKTQPTVIN NLKKGTVEDV ISRNEIQGRS AEEAYKQQIK 550
    EDNIGNQLLR KMGWTGGGLG KSGEGIREPI SVKEQHKREG LGLDVERVNK 600
    IAKRDIEQII RNYARSESHS DLTFSTELTN DERKQIHQIA QKYGLKSKSH 650
    GVGHDRYLVV GRKRRKEDLL DQLKQEGQVG HYELVMPQAN 690
    Length:690
    Mass (Da):77,739
    Last modified:July 27, 2011 - v3
    Checksum:i0A99E1141183F999
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti686 – 6861M → V in BAC37550. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK020455 mRNA. Translation: BAB32107.1.
    AK042690 mRNA. Translation: BAC31334.1.
    AK079123 mRNA. Translation: BAC37550.1.
    AL450399 Genomic DNA. Translation: CAM19779.1.
    BC138828 mRNA. Translation: AAI38829.1.
    BC138829 mRNA. Translation: AAI38830.1.
    CCDSiCCDS30065.1.
    RefSeqiNP_084167.2. NM_029891.2.
    UniGeneiMm.21649.

    Genome annotation databases

    EnsembliENSMUST00000057093; ENSMUSP00000061546; ENSMUSG00000044149.
    GeneIDi77286.
    KEGGimmu:77286.
    UCSCiuc009sxw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK020455 mRNA. Translation: BAB32107.1 .
    AK042690 mRNA. Translation: BAC31334.1 .
    AK079123 mRNA. Translation: BAC37550.1 .
    AL450399 Genomic DNA. Translation: CAM19779.1 .
    BC138828 mRNA. Translation: AAI38829.1 .
    BC138829 mRNA. Translation: AAI38830.1 .
    CCDSi CCDS30065.1.
    RefSeqi NP_084167.2. NM_029891.2.
    UniGenei Mm.21649.

    3D structure databases

    ProteinModelPortali Q8BY02.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 218599. 3 interactions.

    PTM databases

    PhosphoSitei Q8BY02.

    Proteomic databases

    PaxDbi Q8BY02.
    PRIDEi Q8BY02.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057093 ; ENSMUSP00000061546 ; ENSMUSG00000044149 .
    GeneIDi 77286.
    KEGGi mmu:77286.
    UCSCi uc009sxw.1. mouse.

    Organism-specific databases

    CTDi 55922.
    MGIi MGI:1924536. Nkrf.

    Phylogenomic databases

    eggNOGi NOG123689.
    GeneTreei ENSGT00530000063234.
    HOGENOMi HOG000230930.
    HOVERGENi HBG052630.
    InParanoidi A2A3V7.
    OMAi WRYSHES.
    OrthoDBi EOG7XWPN1.
    TreeFami TF326321.

    Miscellaneous databases

    ChiTaRSi NKRF. mouse.
    NextBioi 346701.
    PROi Q8BY02.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BY02.
    CleanExi MM_NKRF.
    Genevestigatori Q8BY02.

    Family and domain databases

    Gene3Di 3.30.1370.50. 1 hit.
    3.30.160.20. 1 hit.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR000467. G_patch_dom.
    IPR001374. R3H_ss-bd.
    [Graphical view ]
    Pfami PF01585. G-patch. 1 hit.
    PF01424. R3H. 1 hit.
    [Graphical view ]
    SMARTi SM00358. DSRM. 2 hits.
    SM00443. G_patch. 1 hit.
    SM00393. R3H. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82708. SSF82708. 1 hit.
    PROSITEi PS50174. G_PATCH. 1 hit.
    PS51061. R3H. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiNKRF_MOUSE
    AccessioniPrimary (citable) accession number: Q8BY02
    Secondary accession number(s): A2A3V7, Q8BJU5, Q9CRL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3