Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and BTB domain-containing protein 49

Gene

Zbtb49

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri386 – 408C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCell cycle, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 49
Alternative name(s):
Zinc finger protein 509
Gene namesi
Name:Zbtb49
Synonyms:Zfp509, Znf509
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1922329 Zbtb49

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476271 – 756Zinc finger and BTB domain-containing protein 49Add BLAST756

Proteomic databases

PaxDbiQ8BXX2
PRIDEiQ8BXX2

PTM databases

iPTMnetiQ8BXX2
PhosphoSitePlusiQ8BXX2

Expressioni

Tissue specificityi

Widely expressed, with highest levels in white adipose tissue and kidney, intermediate levels in brain, liver and heart, and lowest levels in spleen, brown adipose tissue and muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000029127
CleanExiMM_ZFP509
ExpressionAtlasiQ8BXX2 baseline and differential
GenevisibleiQ8BXX2 MM

Interactioni

Subunit structurei

Interacts with EP300, KAT5/Tip60 and ZBTB17. The interaction with EP300 is direct and leads to synergistic induction of CDKN1A. On the CDKN1A promoter, forms a complex with ZBTB17; this interaction leads to additive CDKN1A transactivation. The interaction with ZBTB17 may block ZBTB17 repressor activity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092429

Structurei

3D structure databases

ProteinModelPortaliQ8BXX2
SMRiQ8BXX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 91BTBPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri386 – 408C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144063
HOGENOMiHOG000140405
HOVERGENiHBG061540
InParanoidiQ8BXX2
OMAiMPVSVKL
OrthoDBiEOG091G02EX
PhylomeDBiQ8BXX2
TreeFamiTF330993

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BXX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPVAVHSCH LLQQLREQRI QGLLCDCMLV VRGVCFKAHK NVLAAFSQYF
60 70 80 90 100
RSLFQNSSSQ KNDVFHLDVT NVSGIGQILD FMYTSRLDLN QDNIQVMLDT
110 120 130 140 150
AQCLQVQNVL NLCHTFLKSA PAAQLPGLPC AGGFSLQSVA LDGTCAVSEH
160 170 180 190 200
YPPPSLQECP VEGPQAKVPA EVNARAPSAN FSRPTEVSKP DAAGGSCPEL
210 220 230 240 250
PCKQPNHYYK LRTLYSKQYY KQTACPSQVP ATQQPLTRSA STDLAAADSQ
260 270 280 290 300
PPVEGRPAVL ETPEHLPSTF VAPPVRNSGN DSEADPLSEP PAKQMRLKKA
310 320 330 340 350
MHLKKLNFLK SQQSAECTSH PEPDNGLARR EESAAKEDAV ERAGSQTAEE
360 370 380 390 400
KGRGELGPES SREEELPGAP ASWEDPSQAL QPQKQYACEL CGKPFKHPSN
410 420 430 440 450
LELHKRSHTG EKPFECNICG KHFSQAGNLQ THLRRHSGEK PYICEICGKR
460 470 480 490 500
FAASGDVQRH IIIHSGEKPH LCDTCGRGFS NFSNLKEHKK THTADKVFTC
510 520 530 540 550
DECGKSFNMQ RKLVKHRVRH TGERPYSCPA CGKCFGGSGD LRRHVRTHTG
560 570 580 590 600
EKPYSCEVCS KCFTRSAVLR RHKRMHGRAD ARSPVVLGEL SRPIEPSDLD
610 620 630 640 650
RSQSSDSFSQ DVSVTLMPVS VKLPVQPVES SVAGFDGHCS GSYCKLRSML
660 670 680 690 700
RPPGMSDQDR LSLEPSKLAK PPELQSQPQA YAYSDVEPSA GVEQPQADGM
710 720 730 740 750
AVSRSSLATL DNHCTEPLGS RAPSVTYRNS EGQFFSSMTL WGLAMKTLQN

EHELEQ
Length:756
Mass (Da):83,091
Last modified:March 1, 2003 - v1
Checksum:i0D7E6261C61F3225
GO
Isoform 2 (identifier: Q8BXX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-284: Missing.
     285-424: DPLSEPPAKQ...ECNICGKHFS → MGWPGGRSLL...AIWSCTNGLI

Note: No experimental confirmation available.
Show »
Length:416
Mass (Da):46,283
Checksum:iD2728A6C8D44E502
GO
Isoform 3 (identifier: Q8BXX2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-508: Missing.

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):27,350
Checksum:i9ACADFB99B33B384
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0163441 – 508Missing in isoform 3. 1 PublicationAdd BLAST508
Alternative sequenceiVSP_0163451 – 284Missing in isoform 2. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_016346285 – 424DPLSE…GKHFS → MGWPGGRSLLLRKMQWRELE ARLLKKKGGENWVQRAAVRR SCQEPQLPGKTRPRLSSPRN SMHVNCVGSLLNTQAIWSCT NGLI in isoform 2. 1 PublicationAdd BLAST140

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043044 mRNA Translation: BAC31447.1
AK140546 mRNA Translation: BAE24420.1
BC028988 mRNA Translation: AAH28988.1
BC029122 mRNA Translation: AAH29122.1
CCDSiCCDS19252.1 [Q8BXX2-1]
RefSeqiNP_083438.1, NM_029162.2 [Q8BXX2-1]
XP_006504228.1, XM_006504165.3
UniGeneiMm.258741

Genome annotation databases

EnsembliENSMUST00000094833; ENSMUSP00000092429; ENSMUSG00000029127 [Q8BXX2-1]
GeneIDi75079
KEGGimmu:75079
UCSCiuc008xgc.1 mouse [Q8BXX2-1]
uc008xge.1 mouse [Q8BXX2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZBT49_MOUSE
AccessioniPrimary (citable) accession number: Q8BXX2
Secondary accession number(s): Q8CID4, Q8K2Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health