Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BRI3-binding protein

Gene

Bri3bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in tumorigenesis and may function by stabilizing p53/TP53.1 Publication

Protein family/group databases

TCDBi1.A.74.2.1. the mitsugumin 23 (mg23) family.

Names & Taxonomyi

Protein namesi
Recommended name:
BRI3-binding protein
Short name:
I3-binding protein
Gene namesi
Name:Bri3bpImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1924059. Bri3bp.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei164 – 181HelicalSequence analysisAdd BLAST18
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297481 – 253BRI3-binding proteinAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei250PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BXV2.
MaxQBiQ8BXV2.
PaxDbiQ8BXV2.
PeptideAtlasiQ8BXV2.
PRIDEiQ8BXV2.

PTM databases

iPTMnetiQ8BXV2.
PhosphoSitePlusiQ8BXV2.
SwissPalmiQ8BXV2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037905.
CleanExiMM_BRI3BP.
ExpressionAtlasiQ8BXV2. baseline and differential.
GenevisibleiQ8BXV2. MM.

Interactioni

Subunit structurei

Interacts with LETMD1.By similarity

Protein-protein interaction databases

IntActiQ8BXV2. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ8BXV2.
SMRiQ8BXV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili219 – 253Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ5B. Eukaryota.
ENOG410ZDYG. LUCA.
GeneTreeiENSGT00390000002024.
HOGENOMiHOG000285949.
HOVERGENiHBG058925.
InParanoidiQ8BXV2.
OMAiSCLYILQ.
OrthoDBiEOG091G0P3Q.
PhylomeDBiQ8BXV2.
TreeFamiTF332238.

Family and domain databases

InterProiIPR033367. BRI3BP.
[Graphical view]
PANTHERiPTHR31253. PTHR31253. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BXV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARASQEPR TRVRAGLRVL LPVLLLALLL LALVAPGAQG ARGRGAADKN
60 70 80 90 100
SHRRATSSFS QSVSSLFGED NVRAAQKLLS RLTERFVQGV DMFLETLWKV
110 120 130 140 150
WMELLEVLGL DVSNLSQYFS PASVSNSPTR ALVLVGVVLL AYWFLSLTLG
160 170 180 190 200
FTFSLLHLVF GRFFWLVRVI LFSMSCVYIL HKYEGEPEHA VLPLCVVVAI
210 220 230 240 250
YFMTGPMGYW RGSPGGLCSP SVEEKLEHLE NQVRLLNIRL NRVLENLDRS

KDK
Length:253
Mass (Da):28,263
Last modified:March 1, 2003 - v1
Checksum:i9FEBE500086CAC68
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7Q → E in BAC31982 (PubMed:16141072).Curated1
Sequence conflicti217L → F in BAB27196 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010810 mRNA. Translation: BAB27196.1.
AK043288 mRNA. Translation: BAC31516.1.
AK044565 mRNA. Translation: BAC31982.1.
AK143538 mRNA. Translation: BAE25425.1.
BC039941 mRNA. Translation: AAH39941.1.
CCDSiCCDS19686.1.
RefSeqiNP_084028.1. NM_029752.2.
UniGeneiMm.290720.

Genome annotation databases

EnsembliENSMUST00000049040; ENSMUSP00000037609; ENSMUSG00000037905.
GeneIDi76809.
KEGGimmu:76809.
UCSCiuc008zrr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010810 mRNA. Translation: BAB27196.1.
AK043288 mRNA. Translation: BAC31516.1.
AK044565 mRNA. Translation: BAC31982.1.
AK143538 mRNA. Translation: BAE25425.1.
BC039941 mRNA. Translation: AAH39941.1.
CCDSiCCDS19686.1.
RefSeqiNP_084028.1. NM_029752.2.
UniGeneiMm.290720.

3D structure databases

ProteinModelPortaliQ8BXV2.
SMRiQ8BXV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BXV2. 1 interactor.

Protein family/group databases

TCDBi1.A.74.2.1. the mitsugumin 23 (mg23) family.

PTM databases

iPTMnetiQ8BXV2.
PhosphoSitePlusiQ8BXV2.
SwissPalmiQ8BXV2.

Proteomic databases

EPDiQ8BXV2.
MaxQBiQ8BXV2.
PaxDbiQ8BXV2.
PeptideAtlasiQ8BXV2.
PRIDEiQ8BXV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049040; ENSMUSP00000037609; ENSMUSG00000037905.
GeneIDi76809.
KEGGimmu:76809.
UCSCiuc008zrr.1. mouse.

Organism-specific databases

CTDi140707.
MGIiMGI:1924059. Bri3bp.

Phylogenomic databases

eggNOGiENOG410IJ5B. Eukaryota.
ENOG410ZDYG. LUCA.
GeneTreeiENSGT00390000002024.
HOGENOMiHOG000285949.
HOVERGENiHBG058925.
InParanoidiQ8BXV2.
OMAiSCLYILQ.
OrthoDBiEOG091G0P3Q.
PhylomeDBiQ8BXV2.
TreeFamiTF332238.

Miscellaneous databases

ChiTaRSiBri3bp. mouse.
PROiQ8BXV2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037905.
CleanExiMM_BRI3BP.
ExpressionAtlasiQ8BXV2. baseline and differential.
GenevisibleiQ8BXV2. MM.

Family and domain databases

InterProiIPR033367. BRI3BP.
[Graphical view]
PANTHERiPTHR31253. PTHR31253. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBRI3B_MOUSE
AccessioniPrimary (citable) accession number: Q8BXV2
Secondary accession number(s): Q8BXP1, Q9CWE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.