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Protein

BRI3-binding protein

Gene

Bri3bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in tumorigenesis and may function by stabilizing p53/TP53.1 Publication

Protein family/group databases

TCDBi1.A.74.2.1. the mitsugumin 23 (mg23) family.

Names & Taxonomyi

Protein namesi
Recommended name:
BRI3-binding protein
Short name:
I3-binding protein
Gene namesi
Name:Bri3bpImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1924059. Bri3bp.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei164 – 18118HelicalSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253BRI3-binding proteinPRO_0000229748Add
BLAST

Proteomic databases

EPDiQ8BXV2.
MaxQBiQ8BXV2.
PaxDbiQ8BXV2.
PRIDEiQ8BXV2.

PTM databases

iPTMnetiQ8BXV2.
PhosphoSiteiQ8BXV2.
SwissPalmiQ8BXV2.

Expressioni

Gene expression databases

BgeeiQ8BXV2.
CleanExiMM_BRI3BP.
ExpressionAtlasiQ8BXV2. baseline and differential.
GenevisibleiQ8BXV2. MM.

Interactioni

Subunit structurei

Interacts with LETMD1.By similarity

Protein-protein interaction databases

IntActiQ8BXV2. 1 interaction.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili219 – 25335Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ5B. Eukaryota.
ENOG410ZDYG. LUCA.
GeneTreeiENSGT00390000002024.
HOGENOMiHOG000285949.
HOVERGENiHBG058925.
InParanoidiQ8BXV2.
OMAiSCLYILQ.
OrthoDBiEOG7327Q9.
PhylomeDBiQ8BXV2.
TreeFamiTF332238.

Family and domain databases

InterProiIPR033367. BRI3BP.
[Graphical view]
PANTHERiPTHR31253. PTHR31253. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BXV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARASQEPR TRVRAGLRVL LPVLLLALLL LALVAPGAQG ARGRGAADKN
60 70 80 90 100
SHRRATSSFS QSVSSLFGED NVRAAQKLLS RLTERFVQGV DMFLETLWKV
110 120 130 140 150
WMELLEVLGL DVSNLSQYFS PASVSNSPTR ALVLVGVVLL AYWFLSLTLG
160 170 180 190 200
FTFSLLHLVF GRFFWLVRVI LFSMSCVYIL HKYEGEPEHA VLPLCVVVAI
210 220 230 240 250
YFMTGPMGYW RGSPGGLCSP SVEEKLEHLE NQVRLLNIRL NRVLENLDRS

KDK
Length:253
Mass (Da):28,263
Last modified:March 1, 2003 - v1
Checksum:i9FEBE500086CAC68
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71Q → E in BAC31982 (PubMed:16141072).Curated
Sequence conflicti217 – 2171L → F in BAB27196 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010810 mRNA. Translation: BAB27196.1.
AK043288 mRNA. Translation: BAC31516.1.
AK044565 mRNA. Translation: BAC31982.1.
AK143538 mRNA. Translation: BAE25425.1.
BC039941 mRNA. Translation: AAH39941.1.
CCDSiCCDS19686.1.
RefSeqiNP_084028.1. NM_029752.2.
UniGeneiMm.290720.

Genome annotation databases

EnsembliENSMUST00000049040; ENSMUSP00000037609; ENSMUSG00000037905.
GeneIDi76809.
KEGGimmu:76809.
UCSCiuc008zrr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010810 mRNA. Translation: BAB27196.1.
AK043288 mRNA. Translation: BAC31516.1.
AK044565 mRNA. Translation: BAC31982.1.
AK143538 mRNA. Translation: BAE25425.1.
BC039941 mRNA. Translation: AAH39941.1.
CCDSiCCDS19686.1.
RefSeqiNP_084028.1. NM_029752.2.
UniGeneiMm.290720.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BXV2. 1 interaction.

Protein family/group databases

TCDBi1.A.74.2.1. the mitsugumin 23 (mg23) family.

PTM databases

iPTMnetiQ8BXV2.
PhosphoSiteiQ8BXV2.
SwissPalmiQ8BXV2.

Proteomic databases

EPDiQ8BXV2.
MaxQBiQ8BXV2.
PaxDbiQ8BXV2.
PRIDEiQ8BXV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049040; ENSMUSP00000037609; ENSMUSG00000037905.
GeneIDi76809.
KEGGimmu:76809.
UCSCiuc008zrr.1. mouse.

Organism-specific databases

CTDi140707.
MGIiMGI:1924059. Bri3bp.

Phylogenomic databases

eggNOGiENOG410IJ5B. Eukaryota.
ENOG410ZDYG. LUCA.
GeneTreeiENSGT00390000002024.
HOGENOMiHOG000285949.
HOVERGENiHBG058925.
InParanoidiQ8BXV2.
OMAiSCLYILQ.
OrthoDBiEOG7327Q9.
PhylomeDBiQ8BXV2.
TreeFamiTF332238.

Miscellaneous databases

ChiTaRSiBri3bp. mouse.
PROiQ8BXV2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BXV2.
CleanExiMM_BRI3BP.
ExpressionAtlasiQ8BXV2. baseline and differential.
GenevisibleiQ8BXV2. MM.

Family and domain databases

InterProiIPR033367. BRI3BP.
[Graphical view]
PANTHERiPTHR31253. PTHR31253. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported, EmbryoImported, Embryonic stem cellImported and RetinaImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech IIImported.
    Tissue: Mammary glandImported.
  3. "HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through P53 stabilization."
    Ha S.A., Shin S.M., Lee Y.J., Kim S., Kim H.K., Namkoong H., Lee H., Lee Y.S., Cho Y.S., Park Y.G., Jeon H.M., Oh C., Kim J.W.
    Int. J. Cancer 122:501-508(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PROTO-ONCOGENICITY.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiBRI3B_MOUSE
AccessioniPrimary (citable) accession number: Q8BXV2
Secondary accession number(s): Q8BXP1, Q9CWE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.