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Protein

Regulator of G-protein signaling 8

Gene

Rgs8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 8
Short name:
RGS8
Gene namesi
Name:Rgs8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:108408. Rgs8.

Subcellular locationi

  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Perikaryon By similarity
  • Cell projectiondendrite By similarity
  • Nucleus By similarity

  • Note: Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Regulator of G-protein signaling 8PRO_0000204200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BXT1.
MaxQBiQ8BXT1.
PaxDbiQ8BXT1.
PRIDEiQ8BXT1.

PTM databases

iPTMnetiQ8BXT1.
PhosphoSiteiQ8BXT1.

Expressioni

Gene expression databases

BgeeiQ8BXT1.
CleanExiMM_RGS8.
ExpressionAtlasiQ8BXT1. baseline and differential.
GenevisibleiQ8BXT1. MM.

Interactioni

Subunit structurei

Interacts with GNAO1 and GNAI3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045715.

Structurei

3D structure databases

ProteinModelPortaliQ8BXT1.
SMRiQ8BXT1. Positions 56-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 171116RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ8BXT1.
KOiK16449.
OMAiSHKSDSY.
OrthoDBiEOG7VHSZ5.
PhylomeDBiQ8BXT1.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BXT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA
60 70 80 90 100
TRWAESFDVL LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK
110 120 130 140 150
LVTKAHRIFE EFVDVQAPRE VNIDFQTREA TRKNMQEPSL TCFDQAQGKV
160 170 180
HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS
Length:180
Mass (Da):20,963
Last modified:March 1, 2003 - v1
Checksum:i00FC35E572785856
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044337 mRNA. Translation: BAC31874.1.
AK142301 mRNA. Translation: BAE25020.1.
BC065056 mRNA. Translation: AAH65056.1.
BC094577 mRNA. Translation: AAH94577.1.
CCDSiCCDS15375.1.
RefSeqiNP_080656.2. NM_026380.3.
XP_006529881.1. XM_006529818.2.
XP_006529882.1. XM_006529819.2.
XP_006529883.1. XM_006529820.2.
XP_006529884.1. XM_006529821.2.
UniGeneiMm.379143.

Genome annotation databases

EnsembliENSMUST00000041776; ENSMUSP00000045715; ENSMUSG00000042671.
ENSMUST00000111810; ENSMUSP00000107441; ENSMUSG00000042671.
ENSMUST00000111812; ENSMUSP00000107443; ENSMUSG00000042671.
GeneIDi67792.
KEGGimmu:67792.
UCSCiuc007dad.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044337 mRNA. Translation: BAC31874.1.
AK142301 mRNA. Translation: BAE25020.1.
BC065056 mRNA. Translation: AAH65056.1.
BC094577 mRNA. Translation: AAH94577.1.
CCDSiCCDS15375.1.
RefSeqiNP_080656.2. NM_026380.3.
XP_006529881.1. XM_006529818.2.
XP_006529882.1. XM_006529819.2.
XP_006529883.1. XM_006529820.2.
XP_006529884.1. XM_006529821.2.
UniGeneiMm.379143.

3D structure databases

ProteinModelPortaliQ8BXT1.
SMRiQ8BXT1. Positions 56-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045715.

PTM databases

iPTMnetiQ8BXT1.
PhosphoSiteiQ8BXT1.

Proteomic databases

EPDiQ8BXT1.
MaxQBiQ8BXT1.
PaxDbiQ8BXT1.
PRIDEiQ8BXT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041776; ENSMUSP00000045715; ENSMUSG00000042671.
ENSMUST00000111810; ENSMUSP00000107441; ENSMUSG00000042671.
ENSMUST00000111812; ENSMUSP00000107443; ENSMUSG00000042671.
GeneIDi67792.
KEGGimmu:67792.
UCSCiuc007dad.1. mouse.

Organism-specific databases

CTDi85397.
MGIiMGI:108408. Rgs8.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ8BXT1.
KOiK16449.
OMAiSHKSDSY.
OrthoDBiEOG7VHSZ5.
PhylomeDBiQ8BXT1.
TreeFamiTF315837.

Miscellaneous databases

ChiTaRSiRgs8. mouse.
PROiQ8BXT1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BXT1.
CleanExiMM_RGS8.
ExpressionAtlasiQ8BXT1. baseline and differential.
GenevisibleiQ8BXT1. MM.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart and Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiRGS8_MOUSE
AccessioniPrimary (citable) accession number: Q8BXT1
Secondary accession number(s): Q505F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.