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Protein

Probable G-protein coupled receptor 152

Gene

Gpr152

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 152
Gene namesi
Name:Gpr152
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2685519. Gpr152.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence analysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini55 – 6511CytoplasmicSequence analysisAdd
BLAST
Transmembranei66 – 8621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini87 – 10519ExtracellularSequence analysisAdd
BLAST
Transmembranei106 – 12621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini127 – 14822CytoplasmicSequence analysisAdd
BLAST
Transmembranei149 – 16921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini170 – 19425ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 25843CytoplasmicSequence analysisAdd
BLAST
Transmembranei259 – 27921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini280 – 2823ExtracellularSequence analysis
Transmembranei283 – 30321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini304 – 511208CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Probable G-protein coupled receptor 152PRO_0000069636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8BXS7.
PRIDEiQ8BXS7.

PTM databases

PhosphoSiteiQ8BXS7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044724.
CleanExiMM_GPR152.
GenevisibleiQ8BXS7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094062.

Structurei

3D structure databases

ProteinModelPortaliQ8BXS7.
SMRiQ8BXS7. Positions 33-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVEY. Eukaryota.
ENOG410XYP4. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000112775.
HOVERGENiHBG051788.
InParanoidiQ8BXS7.
KOiK08436.
OMAiYYFLWGV.
OrthoDBiEOG091G0A6G.
PhylomeDBiQ8BXS7.
TreeFamiTF338313.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027313. GPR152_orphan_prd.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF1. PTHR11334:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BXS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTAVEANLG AAGHGPRTEL SDEDYYPQGS WDTVFLVALL LLGLPANGLM
60 70 80 90 100
AWLAGSQARH GAGTRLALLL LSLALSDFLF LAAATFQILE IQHGGHWPLG
110 120 130 140 150
TAACRFYYFL WGVSYSSGLF LLTALSLDRC LLALCPRWYP GHRPARLPLW
160 170 180 190 200
VCAGVWVLAT LFSVPWLVFP EAAVWWYDLV ICLDFWDTEE LPLRMLEILG
210 220 230 240 250
GFLPFLLLLV CHVLTQATAC RTCCGHQPRR MACHGFARVA KTILSAYVVL
260 270 280 290 300
RLPYQLAQLL YLAFLWDVYP GYLLWEALVY SDYLILLNSC LSPFLCLAAS
310 320 330 340 350
ADLRALLRTV LSSFAAAVCE ERPGSFIPAE PQTLPGPTSE GQSRLDSVVQ
360 370 380 390 400
PQVNPSVQLQ SDSVVQPEVS PSAQPQSDSV AQPTVGSLIQ PPLDTVVQLE
410 420 430 440 450
VNPLTQPQLD PMAQPQVNPS AQPQSKSVVQ PQVDPLTQPQ LDPVAQPQSN
460 470 480 490 500
TETPIPAFGD ESASNPGEEN SSGPCPDPTP GTPENLDRPA VPQEKSPSNV
510
PPEEAPSAGP T
Length:511
Mass (Da):55,420
Last modified:March 1, 2003 - v1
Checksum:iEE5D248FAD382CB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044366 mRNA. Translation: BAC31886.1.
BC099681 mRNA. Translation: AAH99681.1.
CCDSiCCDS29417.1.
RefSeqiNP_996856.1. NM_206973.2.
XP_006531825.1. XM_006531762.2.
XP_006544961.1. XM_006544898.2.
UniGeneiMm.131677.

Genome annotation databases

EnsembliENSMUST00000096338; ENSMUSP00000094062; ENSMUSG00000044724.
ENSMUST00000181548; ENSMUSP00000137706; ENSMUSG00000097905.
GeneIDi269053.
KEGGimmu:269053.
UCSCiuc008fyx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044366 mRNA. Translation: BAC31886.1.
BC099681 mRNA. Translation: AAH99681.1.
CCDSiCCDS29417.1.
RefSeqiNP_996856.1. NM_206973.2.
XP_006531825.1. XM_006531762.2.
XP_006544961.1. XM_006544898.2.
UniGeneiMm.131677.

3D structure databases

ProteinModelPortaliQ8BXS7.
SMRiQ8BXS7. Positions 33-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094062.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8BXS7.

Proteomic databases

PaxDbiQ8BXS7.
PRIDEiQ8BXS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096338; ENSMUSP00000094062; ENSMUSG00000044724.
ENSMUST00000181548; ENSMUSP00000137706; ENSMUSG00000097905.
GeneIDi269053.
KEGGimmu:269053.
UCSCiuc008fyx.1. mouse.

Organism-specific databases

CTDi390212.
MGIiMGI:2685519. Gpr152.

Phylogenomic databases

eggNOGiENOG410IVEY. Eukaryota.
ENOG410XYP4. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000112775.
HOVERGENiHBG051788.
InParanoidiQ8BXS7.
KOiK08436.
OMAiYYFLWGV.
OrthoDBiEOG091G0A6G.
PhylomeDBiQ8BXS7.
TreeFamiTF338313.

Miscellaneous databases

PROiQ8BXS7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044724.
CleanExiMM_GPR152.
GenevisibleiQ8BXS7. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027313. GPR152_orphan_prd.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF1. PTHR11334:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP152_MOUSE
AccessioniPrimary (citable) accession number: Q8BXS7
Secondary accession number(s): Q499X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.