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Protein

Oxysterol-binding protein-related protein 6

Gene

Osbpl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Weakly binds 25-hydroxycholesterol.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 6
Short name:
ORP-6
Short name:
OSBP-related protein 6
Gene namesi
Name:Osbpl6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139014. Osbpl6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 959958Oxysterol-binding protein-related protein 6PRO_0000100376Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei35 – 351PhosphoserineBy similarity
Modified residuei69 – 691PhosphoserineBy similarity
Modified residuei190 – 1901PhosphoserineBy similarity
Modified residuei290 – 2901PhosphoserineBy similarity
Modified residuei369 – 3691PhosphoserineBy similarity
Modified residuei509 – 5091PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8BXR9.
PaxDbiQ8BXR9.
PeptideAtlasiQ8BXR9.
PRIDEiQ8BXR9.

PTM databases

iPTMnetiQ8BXR9.
PhosphoSiteiQ8BXR9.

Expressioni

Tissue specificityi

Expressed in skin, respiratory epithelium, small intestine epithelium, pancreas, striated muscle, brain, spinal ganglia, and nervous plexus of the intestine (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000042359.
CleanExiMM_OSBPL6.
ExpressionAtlasiQ8BXR9. baseline and differential.
GenevisibleiQ8BXR9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077123.

Structurei

3D structure databases

ProteinModelPortaliQ8BXR9.
SMRiQ8BXR9. Positions 83-184, 580-959.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 18196PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the OSBP family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1737. Eukaryota.
ENOG410XP9E. LUCA.
GeneTreeiENSGT00760000119155.
HOGENOMiHOG000231072.
HOVERGENiHBG058934.
InParanoidiQ8BXR9.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BXR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSDEKGISP AHKTSTPTHR SASSSTSSQR ESRQSIHVLE RTASSSTEPS
60 70 80 90 100
VSRQLLEPEP IPLSKEADSW EIIEGLKIGQ TNVQKPDRHE GFMLKKRKWP
110 120 130 140 150
LKGWHKRFFV LDNGMLKYSK APLDIQKGKV HGSIDVGLSV MSIKKKARRI
160 170 180 190 200
DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR LYRQNEIVRS PRDASFHIFP
210 220 230 240 250
ATSTAESSPA ANVSVVDGKM QPNSFPWQSP LPCSNSLPAT CTTGQSKVAA
260 270 280 290 300
WLQDSEEMDR CAEDLAHCQS NLVELSKLLQ NLEILQRTQS APNFTDMQAN
310 320 330 340 350
CVDISKKDKR VTRRWRTKSV SKDTKIQLQE GPPAKGQFNT TRRRQRLAAA
360 370 380 390 400
VATTVPFSAT MSPVRLHSSN PNLCADIEFQ TPPSHLTDPL ESSTDYTKLQ
410 420 430 440 450
EEFCLIAQKV HSLLKSAFNS IAIEKEKLKQ VVSEQDHNKG HSTQMARLRQ
460 470 480 490 500
SLSQALNQNA ELRSRLNRIH SESTICDHVV SVNIIPSPDE PGEQIHVSLP
510 520 530 540 550
LSQQVANESR LSMSESVSEF FDAQEVLLSA SSSENEASDD ESYISDVSDN
560 570 580 590 600
ISEDNTSVAD NISRQILNGE LTGGAFRNGR RTCLPAPCPD TSNINLWNIL
610 620 630 640 650
RNNIGKDLSK VSMPVELNEP LNTLQHLCEE MEYSELLDKA SETDDPYERM
660 670 680 690 700
VLVAAFAVSG YCSTYFRAGS KPFNPVLGET YECIREDKGF RFFSEQVSHH
710 720 730 740 750
PPISACHCES KNFVFWQDIR WKNKFWGKSM EILPVGTLNV TLPKYGDYYV
760 770 780 790 800
WNKVTTCIHN ILSGRRWIEH YGEVTLRNTK SSVCICKLTF VKVNYWNSNV
810 820 830 840 850
NEVQGVVIDQ EGKVVHRLFG KWHEGLYCGV APSAKCIWRP GSLPTNYELY
860 870 880 890 900
YGFTRFAVEL NELDPVLKDL LPPTDARFRP DQRFLEEGNL EAAAAEKQRV
910 920 930 940 950
EELQRSRRRY MEENNLEHIP KFFKKVIDAN QREAWVSNDT YWELRKDPGF

SKVDSPVLW
Length:959
Mass (Da):108,920
Last modified:March 1, 2003 - v1
Checksum:i5D50B27C0065C361
GO
Isoform 2 (identifier: Q8BXR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-329: Missing.

Show »
Length:928
Mass (Da):105,249
Checksum:i7AA58BA3B96105DC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti796 – 7961W → L in BAC29854 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei299 – 32931Missing in isoform 2. 1 PublicationVSP_010012Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037703 mRNA. Translation: BAC29854.1.
AK044411 mRNA. Translation: BAC31907.1.
CCDSiCCDS71078.1. [Q8BXR9-1]
CCDS71079.1. [Q8BXR9-2]
RefSeqiNP_001277662.1. NM_001290733.1. [Q8BXR9-1]
NP_001277663.1. NM_001290734.1. [Q8BXR9-2]
NP_663500.2. NM_145525.3.
XP_011238164.1. XM_011239862.1. [Q8BXR9-1]
XP_011238165.1. XM_011239863.1. [Q8BXR9-1]
UniGeneiMm.240435.

Genome annotation databases

EnsembliENSMUST00000111929; ENSMUSP00000107560; ENSMUSG00000042359. [Q8BXR9-1]
ENSMUST00000111930; ENSMUSP00000107561; ENSMUSG00000042359. [Q8BXR9-2]
GeneIDi99031.
KEGGimmu:99031.
UCSCiuc008kfb.2. mouse. [Q8BXR9-1]
uc008kfc.2. mouse. [Q8BXR9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037703 mRNA. Translation: BAC29854.1.
AK044411 mRNA. Translation: BAC31907.1.
CCDSiCCDS71078.1. [Q8BXR9-1]
CCDS71079.1. [Q8BXR9-2]
RefSeqiNP_001277662.1. NM_001290733.1. [Q8BXR9-1]
NP_001277663.1. NM_001290734.1. [Q8BXR9-2]
NP_663500.2. NM_145525.3.
XP_011238164.1. XM_011239862.1. [Q8BXR9-1]
XP_011238165.1. XM_011239863.1. [Q8BXR9-1]
UniGeneiMm.240435.

3D structure databases

ProteinModelPortaliQ8BXR9.
SMRiQ8BXR9. Positions 83-184, 580-959.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077123.

PTM databases

iPTMnetiQ8BXR9.
PhosphoSiteiQ8BXR9.

Proteomic databases

MaxQBiQ8BXR9.
PaxDbiQ8BXR9.
PeptideAtlasiQ8BXR9.
PRIDEiQ8BXR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111929; ENSMUSP00000107560; ENSMUSG00000042359. [Q8BXR9-1]
ENSMUST00000111930; ENSMUSP00000107561; ENSMUSG00000042359. [Q8BXR9-2]
GeneIDi99031.
KEGGimmu:99031.
UCSCiuc008kfb.2. mouse. [Q8BXR9-1]
uc008kfc.2. mouse. [Q8BXR9-2]

Organism-specific databases

CTDi114880.
MGIiMGI:2139014. Osbpl6.

Phylogenomic databases

eggNOGiKOG1737. Eukaryota.
ENOG410XP9E. LUCA.
GeneTreeiENSGT00760000119155.
HOGENOMiHOG000231072.
HOVERGENiHBG058934.
InParanoidiQ8BXR9.

Miscellaneous databases

PROiQ8BXR9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042359.
CleanExiMM_OSBPL6.
ExpressionAtlasiQ8BXR9. baseline and differential.
GenevisibleiQ8BXR9. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSBL6_MOUSE
AccessioniPrimary (citable) accession number: Q8BXR9
Secondary accession number(s): Q8BYW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.