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Protein

E3 ubiquitin-protein ligase pellino homolog 3

Gene

Peli3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • ligase activity Source: UniProtKB-KW
  • ubiquitin protein ligase activity Source: MGI
  • ubiquitin-protein transferase activity Source: MGI

GO - Biological processi

  • defense response to Gram-negative bacterium Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  • negative regulation of protein ubiquitination Source: MGI
  • negative regulation of Toll signaling pathway Source: MGI
  • negative regulation of tumor necrosis factor-mediated signaling pathway Source: MGI
  • negative regulation of type I interferon production Source: MGI
  • positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Source: MGI
  • protein K63-linked ubiquitination Source: MGI
  • regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway Source: MGI
  • Toll signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase pellino homolog 3 (EC:6.3.2.-)
Short name:
Pellino-3
Gene namesi
Name:Peli3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1924963. Peli3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941771 – 445E3 ubiquitin-protein ligase pellino homolog 3Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by IRAK1 enhancing its E3 ligase activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BXR6.
PaxDbiQ8BXR6.
PRIDEiQ8BXR6.

PTM databases

PhosphoSitePlusiQ8BXR6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024901.
CleanExiMM_PELI3.

Interactioni

Subunit structurei

Interacts with TRAF6, IRAK1, MAP3K14 and MAP3K7.By similarity

Protein-protein interaction databases

BioGridi232208. 2 interactors.
STRINGi10090.ENSMUSP00000025834.

Structurei

3D structure databases

ProteinModelPortaliQ8BXR6.
SMRiQ8BXR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pellino family.Curated

Phylogenomic databases

eggNOGiKOG3842. Eukaryota.
ENOG410XP3S. LUCA.
HOGENOMiHOG000234110.
HOVERGENiHBG053559.
InParanoidiQ8BXR6.
KOiK11964.
PhylomeDBiQ8BXR6.
TreeFamiTF314338.

Family and domain databases

InterProiIPR006800. Pellino_fam.
[Graphical view]
PANTHERiPTHR12098. PTHR12098. 1 hit.
PfamiPF04710. Pellino. 1 hit.
[Graphical view]
PIRSFiPIRSF038886. Pellino. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BXR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLEGNPDVG SPRTSDLQHP GSQGSCILSC PGEEALAGEE PIKYGELIVL
60 70 80 90 100
GYNGCLASGD KGRRRSRLAL SRRPHANGVK PDVMHHISTP LVSKALSNRG
110 120 130 140 150
QHSISFTLSR SHSVIVEYTH DSDKDMFQIG RSTENMIDFV VTDTSPGGGA
160 170 180 190 200
TEGPSAQSTI SRYACRILCD RRPPYTARIY AAGFDASSNI FLGERAAKWR
210 220 230 240 250
TPDGLMDGLT TNGVLVMHPA GGFSEDSAPG VWREISVCGN VYTLRDSRSA
260 270 280 290 300
QQRGKLVENE SNVLQDGSLI DLCGATLLWR TPAGLLRAPT LKQLEAQRQE
310 320 330 340 350
ANAARPQCPV GLSTLAFPSP ARGRTAPDKQ QPWVYVRCGH VHGYHGWGCR
360 370 380 390 400
RERGPQEREC PLCRLVGPYV PLWLGQEAGL CLDPGPPSHA FAPCGHVCSE
410 420 430 440
KTARYWAQTP LPHGTHAFHA ACPFCGAWLT GELGCVRLIF QGPLD
Length:445
Mass (Da):48,168
Last modified:October 24, 2003 - v2
Checksum:i4C09BE147D5BD941
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353R → Q in BAC31913 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044418 mRNA. Translation: BAC31913.1.
BC028931 mRNA. Translation: AAH28931.1.
CCDSiCCDS37888.1.
RefSeqiNP_766423.3. NM_172835.3.
XP_006531808.1. XM_006531745.1.
UniGeneiMm.277580.

Genome annotation databases

GeneIDi240518.
KEGGimmu:240518.
UCSCiuc012bgq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044418 mRNA. Translation: BAC31913.1.
BC028931 mRNA. Translation: AAH28931.1.
CCDSiCCDS37888.1.
RefSeqiNP_766423.3. NM_172835.3.
XP_006531808.1. XM_006531745.1.
UniGeneiMm.277580.

3D structure databases

ProteinModelPortaliQ8BXR6.
SMRiQ8BXR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232208. 2 interactors.
STRINGi10090.ENSMUSP00000025834.

PTM databases

PhosphoSitePlusiQ8BXR6.

Proteomic databases

MaxQBiQ8BXR6.
PaxDbiQ8BXR6.
PRIDEiQ8BXR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi240518.
KEGGimmu:240518.
UCSCiuc012bgq.1. mouse.

Organism-specific databases

CTDi246330.
MGIiMGI:1924963. Peli3.

Phylogenomic databases

eggNOGiKOG3842. Eukaryota.
ENOG410XP3S. LUCA.
HOGENOMiHOG000234110.
HOVERGENiHBG053559.
InParanoidiQ8BXR6.
KOiK11964.
PhylomeDBiQ8BXR6.
TreeFamiTF314338.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8BXR6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024901.
CleanExiMM_PELI3.

Family and domain databases

InterProiIPR006800. Pellino_fam.
[Graphical view]
PANTHERiPTHR12098. PTHR12098. 1 hit.
PfamiPF04710. Pellino. 1 hit.
[Graphical view]
PIRSFiPIRSF038886. Pellino. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPELI3_MOUSE
AccessioniPrimary (citable) accession number: Q8BXR6
Secondary accession number(s): Q8K329
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: November 2, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.