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Protein

Leucine-rich repeat and transmembrane domain-containing protein 1

Gene

Lrtm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and transmembrane domain-containing protein 1
Gene namesi
Name:Lrtm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2442106. Lrtm1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 299ExtracellularSequence analysisAdd BLAST267
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Topological domaini321 – 356CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000027975733 – 356Leucine-rich repeat and transmembrane domain-containing protein 1Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BXQ3.
PRIDEiQ8BXQ3.

PTM databases

PhosphoSitePlusiQ8BXQ3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045776.
CleanExiMM_LRTM1.
ExpressionAtlasiQ8BXQ3. baseline and differential.
GenevisibleiQ8BXQ3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061828.

Structurei

3D structure databases

ProteinModelPortaliQ8BXQ3.
SMRiQ8BXQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 62LRRNTAdd BLAST30
Repeati63 – 84LRR 1Add BLAST22
Repeati87 – 108LRR 2Add BLAST22
Repeati111 – 132LRR 3Add BLAST22
Repeati135 – 156LRR 4Add BLAST22
Repeati159 – 180LRR 5Add BLAST22
Domaini192 – 246LRRCTAdd BLAST55

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00880000137863.
HOGENOMiHOG000290674.
HOVERGENiHBG067803.
InParanoidiQ8BXQ3.
OMAiIYGCTYA.
OrthoDBiEOG091G0BZH.
PhylomeDBiQ8BXQ3.
TreeFamiTF351114.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
PfamiView protein in Pfam
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 4 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BXQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNEGLCCGA WAMKGTLLLV SSVGLLLPGV GSCPMKCLCH PSSNSVDCSG
60 70 80 90 100
QGLSKVPRDL PPWTVTLLLQ DNRIHWLPAL AFQSVSLLST LNLSNNSLSN
110 120 130 140 150
LAAEAFYGLP HLRVLNVTQN SLLSIESSFA HALPGLRELD LSSNSLRILP
160 170 180 190 200
TSLGKPWENL TVFAVQQNHL LHLDRELLEA MPKVRLVLLK DNPWICDCHL
210 220 230 240 250
LGLKLWLERF TFQGGETDGA ICRLPEPWQG KALLSIPHEL YQPCSLPSQD
260 270 280 290 300
LAPSLVQQPG SAPQDAQKSH ENSSGQQDPL ECEAKPKPKP TNLRHAVATV
310 320 330 340 350
VITGVVCGIV CLMMLAAAIY GCTYAAITAQ YQGRPLASAR KSEKMGSKEL

MDSSSA
Length:356
Mass (Da):38,542
Last modified:March 1, 2003 - v1
Checksum:i463D93C7CCF96B5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044492 mRNA. Translation: BAC31949.1.
AK138618 mRNA. Translation: BAE23722.1.
BC099587 mRNA. Translation: AAH99587.1.
BC132594 mRNA. Translation: AAI32595.1.
CCDSiCCDS26889.1.
RefSeqiNP_795894.1. NM_176920.4.
UniGeneiMm.95780.

Genome annotation databases

EnsembliENSMUST00000055662; ENSMUSP00000061828; ENSMUSG00000045776.
GeneIDi319476.
KEGGimmu:319476.
UCSCiuc007suj.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiLRTM1_MOUSE
AccessioniPrimary (citable) accession number: Q8BXQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot