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Protein

Protein phosphatase 1K, mitochondrial

Gene

Ppm1k

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi127MagnesiumBy similarity1
Metal bindingi128Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi337MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-70895 Branched-chain amino acid catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1K, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform kappa
Short name:
PP2C-kappa
Gene namesi
Name:Ppm1k
Synonyms:Pp2cm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2442111 Ppm1k

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionAdd BLAST29
ChainiPRO_000027820930 – 372Protein phosphatase 1K, mitochondrialAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BXN7
PaxDbiQ8BXN7
PRIDEiQ8BXN7

PTM databases

iPTMnetiQ8BXN7
PhosphoSitePlusiQ8BXN7

Expressioni

Tissue specificityi

Highly expressed in the heart, kidney, brain and liver and to a lesser extent in testis, lung, spleen and adipose tissue. Very low amount in muscle (at protein level). Also expressed in the thymus (at protein level) and the diaphragm. Significantly reduced in hypertrophied hearts.2 Publications

Gene expression databases

BgeeiENSMUSG00000037826
CleanExiMM_PPM1K
ExpressionAtlasiQ8BXN7 baseline and differential
GenevisibleiQ8BXN7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041395

Structurei

3D structure databases

ProteinModelPortaliQ8BXN7
SMRiQ8BXN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 346PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST253

Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00900000140907
HOGENOMiHOG000059620
HOVERGENiHBG096199
InParanoidiQ8BXN7
KOiK17505
OMAiNVGCASH
OrthoDBiEOG091G0A0V
PhylomeDBiQ8BXN7
TreeFamiTF354344

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BXN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAAFITLL RSGGNQVKKR VLLSSILLQD HRQATPACYF STSEARCSRF
60 70 80 90 100
DPDGSGQPAT WDNFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCASL
110 120 130 140 150
IGKRKENEDR FGFAQLTEEV LYFAVYDGHG GPAAADFCHT HMEKCVMDLL
160 170 180 190 200
PREKDLETVL TLAFLEIDKA FASYAHLSAD ASLLTSGTTA TVALLRDGVE
210 220 230 240 250
LVVASVGDSR ALLCRKGKPM KLTTDHTPER KDEKERIKKF GGFVAWNSLG
260 270 280 290 300
QPHVNGRLAM TRSIGDLDLK ASGVIAEPET TRIKLYHADD SFLVLTTDGI
310 320 330 340 350
NFMVNSQEIC DFVNQCHDPK EAAHSVTEQA IQYGTEDNST AVVVPFGAWG
360 370
KYKNSEITFS FSRSFASSGR WA
Length:372
Mass (Da):40,918
Last modified:March 1, 2003 - v1
Checksum:i3749BEB94F211E7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044610 mRNA Translation: BAC32001.1
BC092238 mRNA Translation: AAH92238.1
CCDSiCCDS20183.1
RefSeqiNP_780732.1, NM_175523.4
UniGeneiMm.396893
Mm.491373

Genome annotation databases

EnsembliENSMUST00000042766; ENSMUSP00000041395; ENSMUSG00000037826
GeneIDi243382
KEGGimmu:243382
UCSCiuc009cch.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPPM1K_MOUSE
AccessioniPrimary (citable) accession number: Q8BXN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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