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Protein

Protein phosphatase 1K, mitochondrial

Gene

Ppm1k

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi127MagnesiumBy similarity1
Metal bindingi128Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi337MagnesiumBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-70895. Branched-chain amino acid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1K, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform kappa
Short name:
PP2C-kappa
Gene namesi
Name:Ppm1k
Synonyms:Pp2cm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2442111. Ppm1k.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionAdd BLAST29
ChainiPRO_000027820930 – 372Protein phosphatase 1K, mitochondrialAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BXN7.
PRIDEiQ8BXN7.

PTM databases

iPTMnetiQ8BXN7.
PhosphoSitePlusiQ8BXN7.

Expressioni

Tissue specificityi

Highly expressed in the heart, kidney, brain and liver and to a lesser extent in testis, lung, spleen and adipose tissue. Very low amount in muscle (at protein level). Also expressed in the thymus (at protein level) and the diaphragm. Significantly reduced in hypertrophied hearts.2 Publications

Gene expression databases

BgeeiENSMUSG00000037826.
CleanExiMM_PPM1K.
ExpressionAtlasiQ8BXN7. baseline and differential.
GenevisibleiQ8BXN7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041395.

Structurei

3D structure databases

ProteinModelPortaliQ8BXN7.
SMRiQ8BXN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 346PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST253

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00840000129732.
HOGENOMiHOG000059620.
HOVERGENiHBG096199.
InParanoidiQ8BXN7.
KOiK17505.
OMAiIKLYHAD.
OrthoDBiEOG091G0A0V.
PhylomeDBiQ8BXN7.
TreeFamiTF354344.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BXN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAAFITLL RSGGNQVKKR VLLSSILLQD HRQATPACYF STSEARCSRF
60 70 80 90 100
DPDGSGQPAT WDNFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCASL
110 120 130 140 150
IGKRKENEDR FGFAQLTEEV LYFAVYDGHG GPAAADFCHT HMEKCVMDLL
160 170 180 190 200
PREKDLETVL TLAFLEIDKA FASYAHLSAD ASLLTSGTTA TVALLRDGVE
210 220 230 240 250
LVVASVGDSR ALLCRKGKPM KLTTDHTPER KDEKERIKKF GGFVAWNSLG
260 270 280 290 300
QPHVNGRLAM TRSIGDLDLK ASGVIAEPET TRIKLYHADD SFLVLTTDGI
310 320 330 340 350
NFMVNSQEIC DFVNQCHDPK EAAHSVTEQA IQYGTEDNST AVVVPFGAWG
360 370
KYKNSEITFS FSRSFASSGR WA
Length:372
Mass (Da):40,918
Last modified:March 1, 2003 - v1
Checksum:i3749BEB94F211E7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044610 mRNA. Translation: BAC32001.1.
BC092238 mRNA. Translation: AAH92238.1.
CCDSiCCDS20183.1.
RefSeqiNP_780732.1. NM_175523.4.
UniGeneiMm.396893.
Mm.491373.

Genome annotation databases

EnsembliENSMUST00000042766; ENSMUSP00000041395; ENSMUSG00000037826.
GeneIDi243382.
KEGGimmu:243382.
UCSCiuc009cch.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044610 mRNA. Translation: BAC32001.1.
BC092238 mRNA. Translation: AAH92238.1.
CCDSiCCDS20183.1.
RefSeqiNP_780732.1. NM_175523.4.
UniGeneiMm.396893.
Mm.491373.

3D structure databases

ProteinModelPortaliQ8BXN7.
SMRiQ8BXN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041395.

PTM databases

iPTMnetiQ8BXN7.
PhosphoSitePlusiQ8BXN7.

Proteomic databases

PaxDbiQ8BXN7.
PRIDEiQ8BXN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042766; ENSMUSP00000041395; ENSMUSG00000037826.
GeneIDi243382.
KEGGimmu:243382.
UCSCiuc009cch.1. mouse.

Organism-specific databases

CTDi152926.
MGIiMGI:2442111. Ppm1k.

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00840000129732.
HOGENOMiHOG000059620.
HOVERGENiHBG096199.
InParanoidiQ8BXN7.
KOiK17505.
OMAiIKLYHAD.
OrthoDBiEOG091G0A0V.
PhylomeDBiQ8BXN7.
TreeFamiTF354344.

Enzyme and pathway databases

ReactomeiR-MMU-70895. Branched-chain amino acid catabolism.

Miscellaneous databases

PROiQ8BXN7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037826.
CleanExiMM_PPM1K.
ExpressionAtlasiQ8BXN7. baseline and differential.
GenevisibleiQ8BXN7. MM.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPM1K_MOUSE
AccessioniPrimary (citable) accession number: Q8BXN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.