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Q8BXN7

- PPM1K_MOUSE

UniProt

Q8BXN7 - PPM1K_MOUSE

Protein

Protein phosphatase 1K, mitochondrial

Gene

Ppm1k

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi127 – 1271MagnesiumBy similarity
    Metal bindingi128 – 1281Magnesium; via carbonyl oxygenBy similarity
    Metal bindingi337 – 3371MagnesiumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1K, mitochondrial (EC:3.1.3.16)
    Alternative name(s):
    Protein phosphatase 2C isoform kappa
    Short name:
    PP2C-kappa
    Gene namesi
    Name:Ppm1k
    Synonyms:Pp2cm
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2442111. Ppm1k.

    Subcellular locationi

    Mitochondrion matrix 1 Publication

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionAdd
    BLAST
    Chaini30 – 372343Protein phosphatase 1K, mitochondrialPRO_0000278209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei248 – 2481Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8BXN7.
    PRIDEiQ8BXN7.

    PTM databases

    PhosphoSiteiQ8BXN7.

    Expressioni

    Tissue specificityi

    Highly expressed in the heart, kidney, brain and liver and to a lesser extent in testis, lung, spleen and adipose tissue. Very low amount in muscle (at protein level). Also expressed in the thymus (at protein level) and the diaphragm. Significantly reduced in hypertrophied hearts.2 Publications

    Gene expression databases

    ArrayExpressiQ8BXN7.
    BgeeiQ8BXN7.
    CleanExiMM_PPM1K.
    GenevestigatoriQ8BXN7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BXN7.
    SMRiQ8BXN7. Positions 90-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini93 – 346254PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00740000114971.
    HOGENOMiHOG000059620.
    HOVERGENiHBG096199.
    InParanoidiQ8BXN7.
    KOiK17505.
    OMAiIVPFGAW.
    OrthoDBiEOG7992QN.
    PhylomeDBiQ8BXN7.
    TreeFamiTF354344.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BXN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSAAFITLL RSGGNQVKKR VLLSSILLQD HRQATPACYF STSEARCSRF    50
    DPDGSGQPAT WDNFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCASL 100
    IGKRKENEDR FGFAQLTEEV LYFAVYDGHG GPAAADFCHT HMEKCVMDLL 150
    PREKDLETVL TLAFLEIDKA FASYAHLSAD ASLLTSGTTA TVALLRDGVE 200
    LVVASVGDSR ALLCRKGKPM KLTTDHTPER KDEKERIKKF GGFVAWNSLG 250
    QPHVNGRLAM TRSIGDLDLK ASGVIAEPET TRIKLYHADD SFLVLTTDGI 300
    NFMVNSQEIC DFVNQCHDPK EAAHSVTEQA IQYGTEDNST AVVVPFGAWG 350
    KYKNSEITFS FSRSFASSGR WA 372
    Length:372
    Mass (Da):40,918
    Last modified:March 1, 2003 - v1
    Checksum:i3749BEB94F211E7A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK044610 mRNA. Translation: BAC32001.1.
    BC092238 mRNA. Translation: AAH92238.1.
    CCDSiCCDS20183.1.
    RefSeqiNP_780732.1. NM_175523.4.
    UniGeneiMm.396893.
    Mm.491373.

    Genome annotation databases

    EnsembliENSMUST00000042766; ENSMUSP00000041395; ENSMUSG00000037826.
    GeneIDi243382.
    KEGGimmu:243382.
    UCSCiuc009cch.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK044610 mRNA. Translation: BAC32001.1 .
    BC092238 mRNA. Translation: AAH92238.1 .
    CCDSi CCDS20183.1.
    RefSeqi NP_780732.1. NM_175523.4.
    UniGenei Mm.396893.
    Mm.491373.

    3D structure databases

    ProteinModelPortali Q8BXN7.
    SMRi Q8BXN7. Positions 90-349.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BXN7.

    Proteomic databases

    PaxDbi Q8BXN7.
    PRIDEi Q8BXN7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042766 ; ENSMUSP00000041395 ; ENSMUSG00000037826 .
    GeneIDi 243382.
    KEGGi mmu:243382.
    UCSCi uc009cch.1. mouse.

    Organism-specific databases

    CTDi 152926.
    MGIi MGI:2442111. Ppm1k.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00740000114971.
    HOGENOMi HOG000059620.
    HOVERGENi HBG096199.
    InParanoidi Q8BXN7.
    KOi K17505.
    OMAi IVPFGAW.
    OrthoDBi EOG7992QN.
    PhylomeDBi Q8BXN7.
    TreeFami TF354344.

    Miscellaneous databases

    NextBioi 385765.
    PROi Q8BXN7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BXN7.
    Bgeei Q8BXN7.
    CleanExi MM_PPM1K.
    Genevestigatori Q8BXN7.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development."
      Lu G., Ren S., Korge P., Choi J., Dong Y., Weiss J., Koehler C., Chen J.-N., Wang Y.
      Genes Dev. 21:784-796(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Retina.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Head.
    4. "Identification of a novel PP2C-type mitochondrial phosphatase."
      Joshi M.A., Jeoung N.H., Popov K.M., Harris R.A.
      Biochem. Biophys. Res. Commun. 356:38-44(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiPPM1K_MOUSE
    AccessioniPrimary (citable) accession number: Q8BXN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3