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Protein

Intermediate filament family orphan 1

Gene

Iffo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate filament family orphan 1
Gene namesi
Name:Iffo1
Synonyms:Iffo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2444516. Iffo1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Intermediate filament family orphan 1PRO_0000316795Add
BLAST

Proteomic databases

MaxQBiQ8BXL9.
PaxDbiQ8BXL9.
PRIDEiQ8BXL9.

PTM databases

iPTMnetiQ8BXL9.
PhosphoSiteiQ8BXL9.

Expressioni

Gene expression databases

BgeeiQ8BXL9.
ExpressionAtlasiQ8BXL9. baseline and differential.
GenevisibleiQ8BXL9. MM.

Interactioni

Protein-protein interaction databases

BioGridi236208. 8 interactions.
STRINGi10090.ENSMUSP00000056373.

Structurei

3D structure databases

ProteinModelPortaliQ8BXL9.
SMRiQ8BXL9. Positions 456-522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili85 – 11733Sequence analysisAdd
BLAST
Coiled coili237 – 30165Sequence analysisAdd
BLAST
Coiled coili458 – 50447Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi541 – 5455Poly-Pro

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE4D. Eukaryota.
ENOG410ZMWF. LUCA.
GeneTreeiENSGT00510000046803.
HOGENOMiHOG000049269.
HOVERGENiHBG100545.
InParanoidiQ8BXL9.
OMAiVQTGFIS.
OrthoDBiEOG79CXZD.
PhylomeDBiQ8BXL9.
TreeFamiTF331217.

Family and domain databases

InterProiIPR001664. IF.
[Graphical view]
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BXL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPLFGPNLF LLQQEQQGLA GPLGDPLGGD HFAGGGDLAS APLASAGPSA
60 70 80 90 100
YSPPGPGPAP PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL
110 120 130 140 150
LEKQLQQALE EGKQGRRGLA RRDQAVQTGF ISPIRPLGLP LSSRPAAVCP
160 170 180 190 200
PSARVLGSPS RSPAGPLASS AACHTSSSTS TSTAFSSSTR FMPGTIWSFS
210 220 230 240 250
HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA LYNVLAKVKR
260 270 280 290 300
ERDEYKRRWE EEYTVRIQLQ ERVTELQEEA QEADACQEEL AMKVEQLKAE
310 320 330 340 350
LVVFKGLMSN NLTELDTKIQ EKAMKVDMDI CRRIDITAKL CDLAQQRNCE
360 370 380 390 400
DMIQMFQKKL VPSMGGRKRE RKAAVEEDTS LSESDGPRQP EGAEEESTAL
410 420 430 440 450
SINEEMQRML SQLREYDFED DCDSLTWEET EETLLLWEDF SGYAMAAAEA
460 470 480 490 500
QGEQEDSLEK VIKDTESLFK TREKEYQETI DQIELELATA KNDMNRHLHE
510 520 530 540 550
YMEMCSMKRG LDVQMETCRR LITQSGDRKS PAFTAVPLSD PPPPPSETED
560
SDRDVSSDSS MR
Note: No experimental confirmation available.
Length:562
Mass (Da):62,415
Last modified:March 1, 2003 - v1
Checksum:i4310CC2DEAC8B604
GO
Isoform 2 (identifier: Q8BXL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-562: Missing.

Note: No experimental confirmation available.
Show »
Length:258
Mass (Da):27,392
Checksum:i7C396D0FD5E49A07
GO
Isoform 3 (identifier: Q8BXL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-191: Missing.
     358-360: Missing.

Note: No experimental confirmation available.
Show »
Length:368
Mass (Da):42,220
Checksum:i9DEEBBFFAB4A28A0
GO
Isoform 4 (identifier: Q8BXL9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-191: Missing.
     358-358: Missing.

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):42,462
Checksum:iE52E51B3A55E2DF2
GO
Isoform 5 (identifier: Q8BXL9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-360: Missing.

Note: No experimental confirmation available.
Show »
Length:559
Mass (Da):62,046
Checksum:i88632EE1128C3F86
GO
Isoform 6 (identifier: Q8BXL9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-358: Missing.

Note: No experimental confirmation available.
Show »
Length:561
Mass (Da):62,287
Checksum:iFA0DE43E30409434
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti291 – 2911A → P in BAC25852 (PubMed:16141072).Curated
Sequence conflicti331 – 3311C → W in BAC25852 (PubMed:16141072).Curated
Sequence conflicti345 – 3451Q → H in BAC25852 (PubMed:16141072).Curated
Sequence conflicti454 – 4541Q → QQ in BAC25852 (PubMed:16141072).Curated
Sequence conflicti454 – 4541Q → QQ in AAH57601 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 191191Missing in isoform 3 and isoform 4. 2 PublicationsVSP_030785Add
BLAST
Alternative sequencei259 – 562304Missing in isoform 2. 1 PublicationVSP_030786Add
BLAST
Alternative sequencei358 – 3603Missing in isoform 3 and isoform 5. 1 PublicationVSP_030787
Alternative sequencei358 – 3581Missing in isoform 4 and isoform 6. 2 PublicationsVSP_030788

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028273 mRNA. Translation: BAC25852.1.
AK044382 mRNA. Translation: BAC31894.1.
AK044728 mRNA. Translation: BAC32053.1.
AK163571 mRNA. Translation: BAE37401.1.
BC057601 mRNA. Translation: AAH57601.2.
CCDSiCCDS39634.1. [Q8BXL9-1]
CCDS39635.1. [Q8BXL9-5]
RefSeqiNP_001034758.1. NM_001039669.3. [Q8BXL9-1]
NP_001289707.1. NM_001302778.1.
NP_001289708.1. NM_001302779.1.
NP_848902.4. NM_178787.6. [Q8BXL9-5]
UniGeneiMm.129415.

Genome annotation databases

EnsembliENSMUST00000117675; ENSMUSP00000113088; ENSMUSG00000038271. [Q8BXL9-1]
ENSMUST00000119527; ENSMUSP00000113376; ENSMUSG00000038271. [Q8BXL9-5]
GeneIDi320678.
KEGGimmu:320678.
UCSCiuc009dto.2. mouse. [Q8BXL9-1]
uc009dtp.2. mouse. [Q8BXL9-5]
uc009dtq.2. mouse. [Q8BXL9-6]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028273 mRNA. Translation: BAC25852.1.
AK044382 mRNA. Translation: BAC31894.1.
AK044728 mRNA. Translation: BAC32053.1.
AK163571 mRNA. Translation: BAE37401.1.
BC057601 mRNA. Translation: AAH57601.2.
CCDSiCCDS39634.1. [Q8BXL9-1]
CCDS39635.1. [Q8BXL9-5]
RefSeqiNP_001034758.1. NM_001039669.3. [Q8BXL9-1]
NP_001289707.1. NM_001302778.1.
NP_001289708.1. NM_001302779.1.
NP_848902.4. NM_178787.6. [Q8BXL9-5]
UniGeneiMm.129415.

3D structure databases

ProteinModelPortaliQ8BXL9.
SMRiQ8BXL9. Positions 456-522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236208. 8 interactions.
STRINGi10090.ENSMUSP00000056373.

PTM databases

iPTMnetiQ8BXL9.
PhosphoSiteiQ8BXL9.

Proteomic databases

MaxQBiQ8BXL9.
PaxDbiQ8BXL9.
PRIDEiQ8BXL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117675; ENSMUSP00000113088; ENSMUSG00000038271. [Q8BXL9-1]
ENSMUST00000119527; ENSMUSP00000113376; ENSMUSG00000038271. [Q8BXL9-5]
GeneIDi320678.
KEGGimmu:320678.
UCSCiuc009dto.2. mouse. [Q8BXL9-1]
uc009dtp.2. mouse. [Q8BXL9-5]
uc009dtq.2. mouse. [Q8BXL9-6]

Organism-specific databases

CTDi25900.
MGIiMGI:2444516. Iffo1.

Phylogenomic databases

eggNOGiENOG410IE4D. Eukaryota.
ENOG410ZMWF. LUCA.
GeneTreeiENSGT00510000046803.
HOGENOMiHOG000049269.
HOVERGENiHBG100545.
InParanoidiQ8BXL9.
OMAiVQTGFIS.
OrthoDBiEOG79CXZD.
PhylomeDBiQ8BXL9.
TreeFamiTF331217.

Miscellaneous databases

ChiTaRSiIffo1. mouse.
PROiQ8BXL9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BXL9.
ExpressionAtlasiQ8BXL9. baseline and differential.
GenevisibleiQ8BXL9. MM.

Family and domain databases

InterProiIPR001664. IF.
[Graphical view]
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 6).
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina, Head and Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiIFFO1_MOUSE
AccessioniPrimary (citable) accession number: Q8BXL9
Secondary accession number(s): Q3TQI1
, Q6PFE6, Q8BXS3, Q8C1D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.