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Q8BXL7

- ARFRP_MOUSE

UniProt

Q8BXL7 - ARFRP_MOUSE

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Protein

ADP-ribosylation factor-related protein 1

Gene

Arfrp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Possibly involved in plasma membrane-related signaling events.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTPBy similarity
Nucleotide bindingi75 – 795GTPBy similarity
Nucleotide bindingi134 – 1374GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: MGI
  2. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. gastrulation Source: MGI
  2. Golgi to plasma membrane protein transport Source: Ensembl
  3. GTP catabolic process Source: GOC
  4. protein localization to Golgi apparatus Source: Ensembl
  5. retrograde transport, endosome to Golgi Source: Ensembl
  6. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-related protein 1
Short name:
ARF-related protein 1
Gene namesi
Name:Arfrp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1923938. Arfrp1.

Subcellular locationi

Golgi apparatus By similarity

GO - Cellular componenti

  1. membrane Source: MGI
  2. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201ADP-ribosylation factor-related protein 1PRO_0000207488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8BXL7.
PaxDbiQ8BXL7.
PRIDEiQ8BXL7.

PTM databases

PhosphoSiteiQ8BXL7.

Expressioni

Gene expression databases

BgeeiQ8BXL7.
CleanExiMM_ARFRP1.
ExpressionAtlasiQ8BXL7. baseline and differential.
GenevestigatoriQ8BXL7.

Interactioni

Subunit structurei

Interacts with SYS1.By similarity

Protein-protein interaction databases

BioGridi218262. 1 interaction.
STRINGi10090.ENSMUSP00000104436.

Structurei

3D structure databases

ProteinModelPortaliQ8BXL7.
SMRiQ8BXL7. Positions 17-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00550000074639.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ8BXL7.
KOiK07952.
OMAiSKNYKGM.
OrthoDBiEOG76473Q.
PhylomeDBiQ8BXL7.
TreeFamiTF105788.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00177. ARF. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BXL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYTLLSGLYK YMFQKDEYCI LILGLDNAGK TTFLEQSKTR FNKNYKGMSL
60 70 80 90 100
SKITTTVGLN IGTVDVGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI
110 120 130 140 150
DSTDEERLSE SKEAFEKVVS SEALDGVPIL VLANKQDVET CLSIPDIKTA
160 170 180 190 200
FSDCTCKIGR RDCLTQACSA LTGKGVREGI EWMVKCVVRN VHRPPRQRDI

T
Length:201
Mass (Da):22,659
Last modified:May 10, 2004 - v2
Checksum:i7BB6D213946F597E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411F → L in BAC32069. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ413952 Genomic DNA. Translation: CAC88691.1.
AJ413953 mRNA. Translation: CAC88692.1.
AK005174 mRNA. Translation: BAB23861.1.
AK044759 mRNA. Translation: BAC32069.1.
BC010713 mRNA. Translation: AAH10713.1.
CCDSiCCDS17209.1.
RefSeqiNP_001159463.1. NM_001165991.1.
NP_001159464.1. NM_001165992.1.
NP_083978.3. NM_029702.4.
UniGeneiMm.87720.

Genome annotation databases

EnsembliENSMUST00000108808; ENSMUSP00000104436; ENSMUSG00000038671.
ENSMUST00000127988; ENSMUSP00000122066; ENSMUSG00000038671.
GeneIDi76688.
KEGGimmu:76688.
UCSCiuc008oly.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ413952 Genomic DNA. Translation: CAC88691.1 .
AJ413953 mRNA. Translation: CAC88692.1 .
AK005174 mRNA. Translation: BAB23861.1 .
AK044759 mRNA. Translation: BAC32069.1 .
BC010713 mRNA. Translation: AAH10713.1 .
CCDSi CCDS17209.1.
RefSeqi NP_001159463.1. NM_001165991.1.
NP_001159464.1. NM_001165992.1.
NP_083978.3. NM_029702.4.
UniGenei Mm.87720.

3D structure databases

ProteinModelPortali Q8BXL7.
SMRi Q8BXL7. Positions 17-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 218262. 1 interaction.
STRINGi 10090.ENSMUSP00000104436.

PTM databases

PhosphoSitei Q8BXL7.

Proteomic databases

MaxQBi Q8BXL7.
PaxDbi Q8BXL7.
PRIDEi Q8BXL7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108808 ; ENSMUSP00000104436 ; ENSMUSG00000038671 .
ENSMUST00000127988 ; ENSMUSP00000122066 ; ENSMUSG00000038671 .
GeneIDi 76688.
KEGGi mmu:76688.
UCSCi uc008oly.2. mouse.

Organism-specific databases

CTDi 10139.
MGIi MGI:1923938. Arfrp1.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00550000074639.
HOGENOMi HOG000163691.
HOVERGENi HBG002073.
InParanoidi Q8BXL7.
KOi K07952.
OMAi SKNYKGM.
OrthoDBi EOG76473Q.
PhylomeDBi Q8BXL7.
TreeFami TF105788.

Miscellaneous databases

NextBioi 345635.
PROi Q8BXL7.
SOURCEi Search...

Gene expression databases

Bgeei Q8BXL7.
CleanExi MM_ARFRP1.
ExpressionAtlasi Q8BXL7. baseline and differential.
Genevestigatori Q8BXL7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view ]
Pfami PF00025. Arf. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00177. ARF. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51417. ARF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Embryonic lethality caused by apoptosis during gastrulation in mice lacking the gene of the ADP-ribosylation factor-related protein 1."
    Mueller A.G., Moser M., Kluge R., Leder S., Blum M., Buttner R., Joost H.-G., Schurmann A.
    Mol. Cell. Biol. 22:1488-1494(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Retina.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiARFRP_MOUSE
AccessioniPrimary (citable) accession number: Q8BXL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3