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Protein

COMM domain-containing protein 2

Gene

Commd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 2
Gene namesi
Name:Commd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1098806. Commd2.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199COMM domain-containing protein 2PRO_0000077387Add
BLAST

Proteomic databases

EPDiQ8BXC6.
MaxQBiQ8BXC6.
PaxDbiQ8BXC6.
PRIDEiQ8BXC6.

PTM databases

iPTMnetiQ8BXC6.
PhosphoSiteiQ8BXC6.

Expressioni

Gene expression databases

BgeeiQ8BXC6.
CleanExiMM_COMMD2.
ExpressionAtlasiQ8BXC6. baseline and differential.
GenevisibleiQ8BXC6. MM.

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4B, CUL5, CUL7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124819.

Structurei

3D structure databases

ProteinModelPortaliQ8BXC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 19068COMMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 COMM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKFK. Eukaryota.
ENOG410XTIB. LUCA.
GeneTreeiENSGT00390000008489.
HOVERGENiHBG060564.
InParanoidiQ8BXC6.
OMAiTESSKHM.
OrthoDBiEOG790G0Q.
PhylomeDBiQ8BXC6.
TreeFamiTF323519.

Family and domain databases

InterProiIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BXC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLDLSEEHK EHLAFLPQVD TAVVAEFGRI AVEFLRRGSN PKIYEGAARK
60 70 80 90 100
LNVSSDTIQH GVEGLTYLLT ESSKLMISEL DFQDSVFVLG FSEELNKLLL
110 120 130 140 150
QLYLDNRKEI RTILNELAPR LPSYHSLEWR LDVQLASRSL RQQIKPAVTI
160 170 180 190
KLHLDQNGDH STHFLQTDPA TLLHLVQQLE QALEEMKTNH CRRVVRSIK
Length:199
Mass (Da):22,848
Last modified:March 1, 2003 - v1
Checksum:iF569762574608B05
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171P → A in BAC39018 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047941 mRNA. Translation: BAC33194.1.
AK083784 mRNA. Translation: BAC39018.1.
CCDSiCCDS17362.1.
RefSeqiNP_780304.2. NM_175095.4.
UniGeneiMm.21901.

Genome annotation databases

EnsembliENSMUST00000160959; ENSMUSP00000124819; ENSMUSG00000036513.
GeneIDi52245.
KEGGimmu:52245.
UCSCiuc008phd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047941 mRNA. Translation: BAC33194.1.
AK083784 mRNA. Translation: BAC39018.1.
CCDSiCCDS17362.1.
RefSeqiNP_780304.2. NM_175095.4.
UniGeneiMm.21901.

3D structure databases

ProteinModelPortaliQ8BXC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124819.

PTM databases

iPTMnetiQ8BXC6.
PhosphoSiteiQ8BXC6.

Proteomic databases

EPDiQ8BXC6.
MaxQBiQ8BXC6.
PaxDbiQ8BXC6.
PRIDEiQ8BXC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160959; ENSMUSP00000124819; ENSMUSG00000036513.
GeneIDi52245.
KEGGimmu:52245.
UCSCiuc008phd.1. mouse.

Organism-specific databases

CTDi51122.
MGIiMGI:1098806. Commd2.

Phylogenomic databases

eggNOGiENOG410IKFK. Eukaryota.
ENOG410XTIB. LUCA.
GeneTreeiENSGT00390000008489.
HOVERGENiHBG060564.
InParanoidiQ8BXC6.
OMAiTESSKHM.
OrthoDBiEOG790G0Q.
PhylomeDBiQ8BXC6.
TreeFamiTF323519.

Miscellaneous databases

NextBioi308700.
PROiQ8BXC6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BXC6.
CleanExiMM_COMMD2.
ExpressionAtlasiQ8BXC6. baseline and differential.
GenevisibleiQ8BXC6. MM.

Family and domain databases

InterProiIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Spinal ganglion.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 38-50, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCOMD2_MOUSE
AccessioniPrimary (citable) accession number: Q8BXC6
Secondary accession number(s): Q8BJI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.