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Protein

COMM domain-containing protein 2

Gene

Commd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B.By similarity

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 2
Gene namesi
Name:Commd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1098806 Commd2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000773871 – 199COMM domain-containing protein 2Add BLAST199

Proteomic databases

EPDiQ8BXC6
MaxQBiQ8BXC6
PaxDbiQ8BXC6
PRIDEiQ8BXC6

PTM databases

iPTMnetiQ8BXC6
PhosphoSitePlusiQ8BXC6

Expressioni

Gene expression databases

BgeeiENSMUSG00000036513
CleanExiMM_COMMD2
ExpressionAtlasiQ8BXC6 baseline and differential
GenevisibleiQ8BXC6 MM

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4B, CUL5, CUL7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124819

Structurei

3D structure databases

ProteinModelPortaliQ8BXC6
SMRiQ8BXC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 190COMMPROSITE-ProRule annotationAdd BLAST68

Phylogenomic databases

eggNOGiENOG410IKFK Eukaryota
ENOG410XTIB LUCA
GeneTreeiENSGT00390000008489
HOVERGENiHBG060564
InParanoidiQ8BXC6
OMAiQEDERLH
OrthoDBiEOG091G0UUT
PhylomeDBiQ8BXC6
TreeFamiTF323519

Family and domain databases

CDDicd04750 Commd2, 1 hit
InterProiView protein in InterPro
IPR017920 COMM
IPR037354 Commd2
PANTHERiPTHR15857 PTHR15857, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BXC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLDLSEEHK EHLAFLPQVD TAVVAEFGRI AVEFLRRGSN PKIYEGAARK
60 70 80 90 100
LNVSSDTIQH GVEGLTYLLT ESSKLMISEL DFQDSVFVLG FSEELNKLLL
110 120 130 140 150
QLYLDNRKEI RTILNELAPR LPSYHSLEWR LDVQLASRSL RQQIKPAVTI
160 170 180 190
KLHLDQNGDH STHFLQTDPA TLLHLVQQLE QALEEMKTNH CRRVVRSIK
Length:199
Mass (Da):22,848
Last modified:March 1, 2003 - v1
Checksum:iF569762574608B05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17P → A in BAC39018 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047941 mRNA Translation: BAC33194.1
AK083784 mRNA Translation: BAC39018.1
CCDSiCCDS17362.1
RefSeqiNP_780304.2, NM_175095.4
UniGeneiMm.21901

Genome annotation databases

EnsembliENSMUST00000160959; ENSMUSP00000124819; ENSMUSG00000036513
GeneIDi52245
KEGGimmu:52245
UCSCiuc008phd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCOMD2_MOUSE
AccessioniPrimary (citable) accession number: Q8BXC6
Secondary accession number(s): Q8BJI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health