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Q8BXB6

- SO2B1_MOUSE

UniProt

Q8BXB6 - SO2B1_MOUSE

Protein

Solute carrier organic anion transporter family member 2B1

Gene

Slco2b1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.By similarity

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_210189. Transport of organic anions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 2B1
    Alternative name(s):
    Solute carrier family 21 member 9
    Gene namesi
    Name:Slco2b1
    Synonyms:Oatp2b1, Slc21a9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1351872. Slco2b1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 683683Solute carrier organic anion transporter family member 2B1PRO_0000191062Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 211Phosphoserine1 Publication
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi478 ↔ 505PROSITE-ProRule annotation
    Disulfide bondi482 ↔ 493PROSITE-ProRule annotation
    Disulfide bondi484 ↔ 509PROSITE-ProRule annotation
    Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ8BXB6.
    PaxDbiQ8BXB6.
    PRIDEiQ8BXB6.

    PTM databases

    PhosphoSiteiQ8BXB6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BXB6.
    BgeeiQ8BXB6.
    GenevestigatoriQ8BXB6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BXB6.
    SMRiQ8BXB6. Positions 481-509.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini62 – 8019ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini102 – 1076CytoplasmicSequence Analysis
    Topological domaini133 – 17745ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 22619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini291 – 35565CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini378 – 39720ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini422 – 4254CytoplasmicSequence Analysis
    Topological domaini450 – 553104ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini577 – 5859CytoplasmicSequence Analysis
    Topological domaini612 – 64433ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini663 – 68321CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6120Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 13225Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei178 – 20730Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei266 – 29025Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei356 – 37722Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei398 – 42124Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei426 – 44924Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei554 – 57623Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei586 – 61126Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei645 – 66218Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini472 – 53261Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320088.
    GeneTreeiENSGT00740000114981.
    HOGENOMiHOG000231269.
    HOVERGENiHBG108345.
    InParanoidiQ8BXB6.
    KOiK14352.
    OrthoDBiEOG7QG43R.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF03137. OATP. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 5 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BXB6-1 [UniParc]FASTAAdd to Basket

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    MPDRSTKTTM GTEDMHERKV SVEPQDSHQD AQPRGMFHNI KFFVLCHSLL    50
    QLTQLMISGY LKSSISTVEK RFGLSSQISG LLAAFNEVGN VSLILFVSYF 100
    GSRVHRPRMI GYGALLVATA GLLMALPHFI SEPYRYDHSS SDNRSLDFEA 150
    SLCLPTTMAP ASALSNGSCS SHTETKHLTM VGIMFAAQTL LGIGGVPIQP 200
    FGISYIDDFA HHSNSPLYIG ILFGITTMGP GLAYGLGSLM LRLYVDIDRM 250
    PEGGINLTPK DPRWVGAWWL GFLISSGLVV LASSPYFFFP REMPKEKHEF 300
    HFRRKVLASA ASTASKGEDL SSQHEPLKKQ AGLAQIAPDL TLVQFVKVFP 350
    RVLLRNLRHP IFLLVVLSQV CTSSMVAGMA TFLPKFLERQ FSITASFANM 400
    LLGCLTIPLV IVGIMMGGVL VKRLHLSPVQ CSALCLLGSL LCLLFSVPLF 450
    FIGCSTHQIA GITQDLGAQP GPSLFPGCSE PCSCQSDDFN PVCDTSAYVE 500
    YTTPCHAGCT GRVVQEALGK SQVFYTNCSC VAGNGTVPAG SCESACSRLV 550
    LPFIVLFSLG AGLASITHTP SFMLILRGVK KEDKTLAVGM QFMLLRVLAW 600
    MPSPVIHGSA IDTTCVHWAL TCGRRAVCRY YDHDLLRNRF IGLQFFFKSG 650
    SLVCFTLVLA ILRQQSREAS TRTTVKSSEL QQL 683
    Length:683
    Mass (Da):74,531
    Last modified:March 1, 2003 - v1
    Checksum:i20D977BA1482688A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK041144 mRNA. Translation: BAC30838.1.
    AK048120 mRNA. Translation: BAC33248.1.
    CCDSiCCDS21485.1.
    RefSeqiNP_001239459.1. NM_001252530.1.
    NP_001239460.1. NM_001252531.1.
    NP_780525.1. NM_175316.3.
    UniGeneiMm.11249.
    Mm.442286.

    Genome annotation databases

    EnsembliENSMUST00000032985; ENSMUSP00000032985; ENSMUSG00000030737.
    ENSMUST00000107086; ENSMUSP00000102701; ENSMUSG00000030737.
    GeneIDi101488.
    KEGGimmu:101488.
    UCSCiuc009ilw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK041144 mRNA. Translation: BAC30838.1 .
    AK048120 mRNA. Translation: BAC33248.1 .
    CCDSi CCDS21485.1.
    RefSeqi NP_001239459.1. NM_001252530.1.
    NP_001239460.1. NM_001252531.1.
    NP_780525.1. NM_175316.3.
    UniGenei Mm.11249.
    Mm.442286.

    3D structure databases

    ProteinModelPortali Q8BXB6.
    SMRi Q8BXB6. Positions 481-509.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BXB6.

    Proteomic databases

    MaxQBi Q8BXB6.
    PaxDbi Q8BXB6.
    PRIDEi Q8BXB6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032985 ; ENSMUSP00000032985 ; ENSMUSG00000030737 .
    ENSMUST00000107086 ; ENSMUSP00000102701 ; ENSMUSG00000030737 .
    GeneIDi 101488.
    KEGGi mmu:101488.
    UCSCi uc009ilw.2. mouse.

    Organism-specific databases

    CTDi 11309.
    MGIi MGI:1351872. Slco2b1.

    Phylogenomic databases

    eggNOGi NOG320088.
    GeneTreei ENSGT00740000114981.
    HOGENOMi HOG000231269.
    HOVERGENi HBG108345.
    InParanoidi Q8BXB6.
    KOi K14352.
    OrthoDBi EOG7QG43R.
    TreeFami TF317540.

    Enzyme and pathway databases

    Reactomei REACT_210189. Transport of organic anions.

    Miscellaneous databases

    NextBioi 354954.
    PROi Q8BXB6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BXB6.
    Bgeei Q8BXB6.
    Genevestigatori Q8BXB6.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF03137. OATP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 5 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Aorta and Head.
    2. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiSO2B1_MOUSE
    AccessioniPrimary (citable) accession number: Q8BXB6
    Secondary accession number(s): Q8BLV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3