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Protein

Solute carrier organic anion transporter family member 2B1

Gene

Slco2b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-879518. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2B1
Alternative name(s):
Solute carrier family 21 member 9
Gene namesi
Name:Slco2b1
Synonyms:Oatp2b1, Slc21a9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1351872. Slco2b1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 61Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini62 – 80ExtracellularSequence analysisAdd BLAST19
Transmembranei81 – 101Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini102 – 107CytoplasmicSequence analysis6
Transmembranei108 – 132Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini133 – 177ExtracellularSequence analysisAdd BLAST45
Transmembranei178 – 207Helical; Name=4Sequence analysisAdd BLAST30
Topological domaini208 – 226CytoplasmicSequence analysisAdd BLAST19
Transmembranei227 – 247Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini248 – 265ExtracellularSequence analysisAdd BLAST18
Transmembranei266 – 290Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini291 – 355CytoplasmicSequence analysisAdd BLAST65
Transmembranei356 – 377Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini378 – 397ExtracellularSequence analysisAdd BLAST20
Transmembranei398 – 421Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini422 – 425CytoplasmicSequence analysis4
Transmembranei426 – 449Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini450 – 553ExtracellularSequence analysisAdd BLAST104
Transmembranei554 – 576Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini577 – 585CytoplasmicSequence analysis9
Transmembranei586 – 611Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini612 – 644ExtracellularSequence analysisAdd BLAST33
Transmembranei645 – 662Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini663 – 683CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910621 – 683Solute carrier organic anion transporter family member 2B1Add BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Modified residuei312PhosphoserineBy similarity1
Modified residuei315PhosphoserineBy similarity1
Disulfide bondi478 ↔ 505PROSITE-ProRule annotation
Disulfide bondi482 ↔ 493PROSITE-ProRule annotation
Disulfide bondi484 ↔ 509PROSITE-ProRule annotation
Glycosylationi527N-linked (GlcNAc...)Sequence analysis1
Glycosylationi534N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BXB6.
PaxDbiQ8BXB6.
PRIDEiQ8BXB6.

PTM databases

iPTMnetiQ8BXB6.
PhosphoSitePlusiQ8BXB6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030737.
ExpressionAtlasiQ8BXB6. baseline and differential.
GenevisibleiQ8BXB6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102703.

Structurei

3D structure databases

ProteinModelPortaliQ8BXB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini472 – 532Kazal-likePROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ8BXB6.
KOiK14352.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BXB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDRSTKTTM GTEDMHERKV SVEPQDSHQD AQPRGMFHNI KFFVLCHSLL
60 70 80 90 100
QLTQLMISGY LKSSISTVEK RFGLSSQISG LLAAFNEVGN VSLILFVSYF
110 120 130 140 150
GSRVHRPRMI GYGALLVATA GLLMALPHFI SEPYRYDHSS SDNRSLDFEA
160 170 180 190 200
SLCLPTTMAP ASALSNGSCS SHTETKHLTM VGIMFAAQTL LGIGGVPIQP
210 220 230 240 250
FGISYIDDFA HHSNSPLYIG ILFGITTMGP GLAYGLGSLM LRLYVDIDRM
260 270 280 290 300
PEGGINLTPK DPRWVGAWWL GFLISSGLVV LASSPYFFFP REMPKEKHEF
310 320 330 340 350
HFRRKVLASA ASTASKGEDL SSQHEPLKKQ AGLAQIAPDL TLVQFVKVFP
360 370 380 390 400
RVLLRNLRHP IFLLVVLSQV CTSSMVAGMA TFLPKFLERQ FSITASFANM
410 420 430 440 450
LLGCLTIPLV IVGIMMGGVL VKRLHLSPVQ CSALCLLGSL LCLLFSVPLF
460 470 480 490 500
FIGCSTHQIA GITQDLGAQP GPSLFPGCSE PCSCQSDDFN PVCDTSAYVE
510 520 530 540 550
YTTPCHAGCT GRVVQEALGK SQVFYTNCSC VAGNGTVPAG SCESACSRLV
560 570 580 590 600
LPFIVLFSLG AGLASITHTP SFMLILRGVK KEDKTLAVGM QFMLLRVLAW
610 620 630 640 650
MPSPVIHGSA IDTTCVHWAL TCGRRAVCRY YDHDLLRNRF IGLQFFFKSG
660 670 680
SLVCFTLVLA ILRQQSREAS TRTTVKSSEL QQL
Length:683
Mass (Da):74,531
Last modified:March 1, 2003 - v1
Checksum:i20D977BA1482688A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041144 mRNA. Translation: BAC30838.1.
AK048120 mRNA. Translation: BAC33248.1.
CCDSiCCDS21485.1.
RefSeqiNP_001239459.1. NM_001252530.1.
NP_001239460.1. NM_001252531.1.
NP_780525.1. NM_175316.3.
XP_011239942.1. XM_011241640.2.
XP_011239943.1. XM_011241641.2.
UniGeneiMm.11249.
Mm.442286.

Genome annotation databases

EnsembliENSMUST00000032985; ENSMUSP00000032985; ENSMUSG00000030737.
ENSMUST00000107086; ENSMUSP00000102701; ENSMUSG00000030737.
GeneIDi101488.
KEGGimmu:101488.
UCSCiuc009ilw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041144 mRNA. Translation: BAC30838.1.
AK048120 mRNA. Translation: BAC33248.1.
CCDSiCCDS21485.1.
RefSeqiNP_001239459.1. NM_001252530.1.
NP_001239460.1. NM_001252531.1.
NP_780525.1. NM_175316.3.
XP_011239942.1. XM_011241640.2.
XP_011239943.1. XM_011241641.2.
UniGeneiMm.11249.
Mm.442286.

3D structure databases

ProteinModelPortaliQ8BXB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102703.

PTM databases

iPTMnetiQ8BXB6.
PhosphoSitePlusiQ8BXB6.

Proteomic databases

MaxQBiQ8BXB6.
PaxDbiQ8BXB6.
PRIDEiQ8BXB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032985; ENSMUSP00000032985; ENSMUSG00000030737.
ENSMUST00000107086; ENSMUSP00000102701; ENSMUSG00000030737.
GeneIDi101488.
KEGGimmu:101488.
UCSCiuc009ilw.2. mouse.

Organism-specific databases

CTDi11309.
MGIiMGI:1351872. Slco2b1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ8BXB6.
KOiK14352.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiR-MMU-879518. Transport of organic anions.

Miscellaneous databases

PROiQ8BXB6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030737.
ExpressionAtlasiQ8BXB6. baseline and differential.
GenevisibleiQ8BXB6. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO2B1_MOUSE
AccessioniPrimary (citable) accession number: Q8BXB6
Secondary accession number(s): Q8BLV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.