SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8BXB6

- SO2B1_MOUSE

UniProt

Q8BXB6 - SO2B1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Solute carrier organic anion transporter family member 2B1

Gene
Slco2b1, Oatp2b1, Slc21a9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost By similarity.

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_210189. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2B1
Alternative name(s):
Solute carrier family 21 member 9
Gene namesi
Name:Slco2b1
Synonyms:Oatp2b1, Slc21a9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1351872. Slco2b1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei42 – 6120Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini62 – 8019Extracellular Reviewed predictionAdd
BLAST
Transmembranei81 – 10121Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini102 – 1076Cytoplasmic Reviewed prediction
Transmembranei108 – 13225Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini133 – 17745Extracellular Reviewed predictionAdd
BLAST
Transmembranei178 – 20730Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini208 – 22619Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei227 – 24721Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini248 – 26518Extracellular Reviewed predictionAdd
BLAST
Transmembranei266 – 29025Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini291 – 35565Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei356 – 37722Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini378 – 39720Extracellular Reviewed predictionAdd
BLAST
Transmembranei398 – 42124Helical; Name=8; Reviewed predictionAdd
BLAST
Topological domaini422 – 4254Cytoplasmic Reviewed prediction
Transmembranei426 – 44924Helical; Name=9; Reviewed predictionAdd
BLAST
Topological domaini450 – 553104Extracellular Reviewed predictionAdd
BLAST
Transmembranei554 – 57623Helical; Name=10; Reviewed predictionAdd
BLAST
Topological domaini577 – 5859Cytoplasmic Reviewed prediction
Transmembranei586 – 61126Helical; Name=11; Reviewed predictionAdd
BLAST
Topological domaini612 – 64433Extracellular Reviewed predictionAdd
BLAST
Transmembranei645 – 66218Helical; Name=12; Reviewed predictionAdd
BLAST
Topological domaini663 – 68321Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 683683Solute carrier organic anion transporter family member 2B1PRO_0000191062Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Phosphoserine1 Publication
Glycosylationi143 – 1431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi166 – 1661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi478 ↔ 505 By similarity
Disulfide bondi482 ↔ 493 By similarity
Disulfide bondi484 ↔ 509 By similarity
Glycosylationi527 – 5271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi534 – 5341N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BXB6.
PaxDbiQ8BXB6.
PRIDEiQ8BXB6.

PTM databases

PhosphoSiteiQ8BXB6.

Expressioni

Gene expression databases

ArrayExpressiQ8BXB6.
BgeeiQ8BXB6.
GenevestigatoriQ8BXB6.

Structurei

3D structure databases

ProteinModelPortaliQ8BXB6.
SMRiQ8BXB6. Positions 481-509.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini472 – 53261Kazal-likeAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320088.
GeneTreeiENSGT00740000114981.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ8BXB6.
KOiK14352.
OrthoDBiEOG7QG43R.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BXB6-1 [UniParc]FASTAAdd to Basket

« Hide

MPDRSTKTTM GTEDMHERKV SVEPQDSHQD AQPRGMFHNI KFFVLCHSLL    50
QLTQLMISGY LKSSISTVEK RFGLSSQISG LLAAFNEVGN VSLILFVSYF 100
GSRVHRPRMI GYGALLVATA GLLMALPHFI SEPYRYDHSS SDNRSLDFEA 150
SLCLPTTMAP ASALSNGSCS SHTETKHLTM VGIMFAAQTL LGIGGVPIQP 200
FGISYIDDFA HHSNSPLYIG ILFGITTMGP GLAYGLGSLM LRLYVDIDRM 250
PEGGINLTPK DPRWVGAWWL GFLISSGLVV LASSPYFFFP REMPKEKHEF 300
HFRRKVLASA ASTASKGEDL SSQHEPLKKQ AGLAQIAPDL TLVQFVKVFP 350
RVLLRNLRHP IFLLVVLSQV CTSSMVAGMA TFLPKFLERQ FSITASFANM 400
LLGCLTIPLV IVGIMMGGVL VKRLHLSPVQ CSALCLLGSL LCLLFSVPLF 450
FIGCSTHQIA GITQDLGAQP GPSLFPGCSE PCSCQSDDFN PVCDTSAYVE 500
YTTPCHAGCT GRVVQEALGK SQVFYTNCSC VAGNGTVPAG SCESACSRLV 550
LPFIVLFSLG AGLASITHTP SFMLILRGVK KEDKTLAVGM QFMLLRVLAW 600
MPSPVIHGSA IDTTCVHWAL TCGRRAVCRY YDHDLLRNRF IGLQFFFKSG 650
SLVCFTLVLA ILRQQSREAS TRTTVKSSEL QQL 683
Length:683
Mass (Da):74,531
Last modified:March 1, 2003 - v1
Checksum:i20D977BA1482688A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK041144 mRNA. Translation: BAC30838.1.
AK048120 mRNA. Translation: BAC33248.1.
CCDSiCCDS21485.1.
RefSeqiNP_001239459.1. NM_001252530.1.
NP_001239460.1. NM_001252531.1.
NP_780525.1. NM_175316.3.
UniGeneiMm.11249.
Mm.442286.

Genome annotation databases

EnsembliENSMUST00000032985; ENSMUSP00000032985; ENSMUSG00000030737.
ENSMUST00000107086; ENSMUSP00000102701; ENSMUSG00000030737.
GeneIDi101488.
KEGGimmu:101488.
UCSCiuc009ilw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK041144 mRNA. Translation: BAC30838.1 .
AK048120 mRNA. Translation: BAC33248.1 .
CCDSi CCDS21485.1.
RefSeqi NP_001239459.1. NM_001252530.1.
NP_001239460.1. NM_001252531.1.
NP_780525.1. NM_175316.3.
UniGenei Mm.11249.
Mm.442286.

3D structure databases

ProteinModelPortali Q8BXB6.
SMRi Q8BXB6. Positions 481-509.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BXB6.

Proteomic databases

MaxQBi Q8BXB6.
PaxDbi Q8BXB6.
PRIDEi Q8BXB6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032985 ; ENSMUSP00000032985 ; ENSMUSG00000030737 .
ENSMUST00000107086 ; ENSMUSP00000102701 ; ENSMUSG00000030737 .
GeneIDi 101488.
KEGGi mmu:101488.
UCSCi uc009ilw.2. mouse.

Organism-specific databases

CTDi 11309.
MGIi MGI:1351872. Slco2b1.

Phylogenomic databases

eggNOGi NOG320088.
GeneTreei ENSGT00740000114981.
HOGENOMi HOG000231269.
HOVERGENi HBG108345.
InParanoidi Q8BXB6.
KOi K14352.
OrthoDBi EOG7QG43R.
TreeFami TF317540.

Enzyme and pathway databases

Reactomei REACT_210189. Transport of organic anions.

Miscellaneous databases

NextBioi 354954.
PROi Q8BXB6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BXB6.
Bgeei Q8BXB6.
Genevestigatori Q8BXB6.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF03137. OATP. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 5 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta and Head.
  2. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSO2B1_MOUSE
AccessioniPrimary (citable) accession number: Q8BXB6
Secondary accession number(s): Q8BLV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi