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Q8BXB6 (SO2B1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 2B1
Alternative name(s):
Solute carrier family 21 member 9
Gene names
Name:Slco2b1
Synonyms:Oatp2b1, Slc21a9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length683 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 683683Solute carrier organic anion transporter family member 2B1
PRO_0000191062

Regions

Topological domain1 – 4141Cytoplasmic Potential
Transmembrane42 – 6120Helical; Name=1; Potential
Topological domain62 – 8019Extracellular Potential
Transmembrane81 – 10121Helical; Name=2; Potential
Topological domain102 – 1076Cytoplasmic Potential
Transmembrane108 – 13225Helical; Name=3; Potential
Topological domain133 – 17745Extracellular Potential
Transmembrane178 – 20730Helical; Name=4; Potential
Topological domain208 – 22619Cytoplasmic Potential
Transmembrane227 – 24721Helical; Name=5; Potential
Topological domain248 – 26518Extracellular Potential
Transmembrane266 – 29025Helical; Name=6; Potential
Topological domain291 – 35565Cytoplasmic Potential
Transmembrane356 – 37722Helical; Name=7; Potential
Topological domain378 – 39720Extracellular Potential
Transmembrane398 – 42124Helical; Name=8; Potential
Topological domain422 – 4254Cytoplasmic Potential
Transmembrane426 – 44924Helical; Name=9; Potential
Topological domain450 – 553104Extracellular Potential
Transmembrane554 – 57623Helical; Name=10; Potential
Topological domain577 – 5859Cytoplasmic Potential
Transmembrane586 – 61126Helical; Name=11; Potential
Topological domain612 – 64433Extracellular Potential
Transmembrane645 – 66218Helical; Name=12; Potential
Topological domain663 – 68321Cytoplasmic Potential
Domain472 – 53261Kazal-like

Amino acid modifications

Modified residue211Phosphoserine Ref.2
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation1661N-linked (GlcNAc...) Potential
Glycosylation5271N-linked (GlcNAc...) Potential
Glycosylation5341N-linked (GlcNAc...) Potential
Disulfide bond478 ↔ 505 By similarity
Disulfide bond482 ↔ 493 By similarity
Disulfide bond484 ↔ 509 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8BXB6 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 20D977BA1482688A

FASTA68374,531
        10         20         30         40         50         60 
MPDRSTKTTM GTEDMHERKV SVEPQDSHQD AQPRGMFHNI KFFVLCHSLL QLTQLMISGY 

        70         80         90        100        110        120 
LKSSISTVEK RFGLSSQISG LLAAFNEVGN VSLILFVSYF GSRVHRPRMI GYGALLVATA 

       130        140        150        160        170        180 
GLLMALPHFI SEPYRYDHSS SDNRSLDFEA SLCLPTTMAP ASALSNGSCS SHTETKHLTM 

       190        200        210        220        230        240 
VGIMFAAQTL LGIGGVPIQP FGISYIDDFA HHSNSPLYIG ILFGITTMGP GLAYGLGSLM 

       250        260        270        280        290        300 
LRLYVDIDRM PEGGINLTPK DPRWVGAWWL GFLISSGLVV LASSPYFFFP REMPKEKHEF 

       310        320        330        340        350        360 
HFRRKVLASA ASTASKGEDL SSQHEPLKKQ AGLAQIAPDL TLVQFVKVFP RVLLRNLRHP 

       370        380        390        400        410        420 
IFLLVVLSQV CTSSMVAGMA TFLPKFLERQ FSITASFANM LLGCLTIPLV IVGIMMGGVL 

       430        440        450        460        470        480 
VKRLHLSPVQ CSALCLLGSL LCLLFSVPLF FIGCSTHQIA GITQDLGAQP GPSLFPGCSE 

       490        500        510        520        530        540 
PCSCQSDDFN PVCDTSAYVE YTTPCHAGCT GRVVQEALGK SQVFYTNCSC VAGNGTVPAG 

       550        560        570        580        590        600 
SCESACSRLV LPFIVLFSLG AGLASITHTP SFMLILRGVK KEDKTLAVGM QFMLLRVLAW 

       610        620        630        640        650        660 
MPSPVIHGSA IDTTCVHWAL TCGRRAVCRY YDHDLLRNRF IGLQFFFKSG SLVCFTLVLA 

       670        680 
ILRQQSREAS TRTTVKSSEL QQL 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Aorta and Head.
[2]"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK041144 mRNA. Translation: BAC30838.1.
AK048120 mRNA. Translation: BAC33248.1.
CCDSCCDS21485.1.
RefSeqNP_001239459.1. NM_001252530.1.
NP_001239460.1. NM_001252531.1.
NP_780525.1. NM_175316.3.
UniGeneMm.11249.
Mm.442286.

3D structure databases

ProteinModelPortalQ8BXB6.
SMRQ8BXB6. Positions 481-509.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BXB6.

Proteomic databases

MaxQBQ8BXB6.
PaxDbQ8BXB6.
PRIDEQ8BXB6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032985; ENSMUSP00000032985; ENSMUSG00000030737.
ENSMUST00000107086; ENSMUSP00000102701; ENSMUSG00000030737.
GeneID101488.
KEGGmmu:101488.
UCSCuc009ilw.2. mouse.

Organism-specific databases

CTD11309.
MGIMGI:1351872. Slco2b1.

Phylogenomic databases

eggNOGNOG320088.
GeneTreeENSGT00740000114981.
HOGENOMHOG000231269.
HOVERGENHBG108345.
InParanoidQ8BXB6.
KOK14352.
OrthoDBEOG7QG43R.
TreeFamTF317540.

Gene expression databases

ArrayExpressQ8BXB6.
BgeeQ8BXB6.
GenevestigatorQ8BXB6.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 5 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio354954.
PROQ8BXB6.
SOURCESearch...

Entry information

Entry nameSO2B1_MOUSE
AccessionPrimary (citable) accession number: Q8BXB6
Secondary accession number(s): Q8BLV8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot