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Protein

Solute carrier organic anion transporter family member 2B1

Gene

Slco2b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.By similarity

GO - Molecular functioni

  1. organic anion transmembrane transporter activity Source: MGI
  2. sodium-independent organic anion transmembrane transporter activity Source: MGI

GO - Biological processi

  1. organic anion transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_318911. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2B1
Alternative name(s):
Solute carrier family 21 member 9
Gene namesi
Name:Slco2b1
Synonyms:Oatp2b1, Slc21a9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1351872. Slco2b1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei42 – 6120Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini62 – 8019ExtracellularSequence AnalysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini102 – 1076CytoplasmicSequence Analysis
Transmembranei108 – 13225Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini133 – 17745ExtracellularSequence AnalysisAdd
BLAST
Transmembranei178 – 20730Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini208 – 22619CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini248 – 26518ExtracellularSequence AnalysisAdd
BLAST
Transmembranei266 – 29025Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini291 – 35565CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei356 – 37722Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini378 – 39720ExtracellularSequence AnalysisAdd
BLAST
Transmembranei398 – 42124Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini422 – 4254CytoplasmicSequence Analysis
Transmembranei426 – 44924Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini450 – 553104ExtracellularSequence AnalysisAdd
BLAST
Transmembranei554 – 57623Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini577 – 5859CytoplasmicSequence Analysis
Transmembranei586 – 61126Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini612 – 64433ExtracellularSequence AnalysisAdd
BLAST
Transmembranei645 – 66218Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini663 – 68321CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basal plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 683683Solute carrier organic anion transporter family member 2B1PRO_0000191062Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Phosphoserine1 Publication
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Modified residuei312 – 3121PhosphoserineBy similarity
Disulfide bondi478 ↔ 505PROSITE-ProRule annotation
Disulfide bondi482 ↔ 493PROSITE-ProRule annotation
Disulfide bondi484 ↔ 509PROSITE-ProRule annotation
Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BXB6.
PaxDbiQ8BXB6.
PRIDEiQ8BXB6.

PTM databases

PhosphoSiteiQ8BXB6.

Expressioni

Gene expression databases

BgeeiQ8BXB6.
ExpressionAtlasiQ8BXB6. baseline and differential.
GenevestigatoriQ8BXB6.

Structurei

3D structure databases

ProteinModelPortaliQ8BXB6.
SMRiQ8BXB6. Positions 481-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini472 – 53261Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320088.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ8BXB6.
KOiK14352.
OrthoDBiEOG7QG43R.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BXB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDRSTKTTM GTEDMHERKV SVEPQDSHQD AQPRGMFHNI KFFVLCHSLL
60 70 80 90 100
QLTQLMISGY LKSSISTVEK RFGLSSQISG LLAAFNEVGN VSLILFVSYF
110 120 130 140 150
GSRVHRPRMI GYGALLVATA GLLMALPHFI SEPYRYDHSS SDNRSLDFEA
160 170 180 190 200
SLCLPTTMAP ASALSNGSCS SHTETKHLTM VGIMFAAQTL LGIGGVPIQP
210 220 230 240 250
FGISYIDDFA HHSNSPLYIG ILFGITTMGP GLAYGLGSLM LRLYVDIDRM
260 270 280 290 300
PEGGINLTPK DPRWVGAWWL GFLISSGLVV LASSPYFFFP REMPKEKHEF
310 320 330 340 350
HFRRKVLASA ASTASKGEDL SSQHEPLKKQ AGLAQIAPDL TLVQFVKVFP
360 370 380 390 400
RVLLRNLRHP IFLLVVLSQV CTSSMVAGMA TFLPKFLERQ FSITASFANM
410 420 430 440 450
LLGCLTIPLV IVGIMMGGVL VKRLHLSPVQ CSALCLLGSL LCLLFSVPLF
460 470 480 490 500
FIGCSTHQIA GITQDLGAQP GPSLFPGCSE PCSCQSDDFN PVCDTSAYVE
510 520 530 540 550
YTTPCHAGCT GRVVQEALGK SQVFYTNCSC VAGNGTVPAG SCESACSRLV
560 570 580 590 600
LPFIVLFSLG AGLASITHTP SFMLILRGVK KEDKTLAVGM QFMLLRVLAW
610 620 630 640 650
MPSPVIHGSA IDTTCVHWAL TCGRRAVCRY YDHDLLRNRF IGLQFFFKSG
660 670 680
SLVCFTLVLA ILRQQSREAS TRTTVKSSEL QQL
Length:683
Mass (Da):74,531
Last modified:March 1, 2003 - v1
Checksum:i20D977BA1482688A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041144 mRNA. Translation: BAC30838.1.
AK048120 mRNA. Translation: BAC33248.1.
CCDSiCCDS21485.1.
RefSeqiNP_001239459.1. NM_001252530.1.
NP_001239460.1. NM_001252531.1.
NP_780525.1. NM_175316.3.
UniGeneiMm.11249.
Mm.442286.

Genome annotation databases

EnsembliENSMUST00000032985; ENSMUSP00000032985; ENSMUSG00000030737.
ENSMUST00000107086; ENSMUSP00000102701; ENSMUSG00000030737.
GeneIDi101488.
KEGGimmu:101488.
UCSCiuc009ilw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041144 mRNA. Translation: BAC30838.1.
AK048120 mRNA. Translation: BAC33248.1.
CCDSiCCDS21485.1.
RefSeqiNP_001239459.1. NM_001252530.1.
NP_001239460.1. NM_001252531.1.
NP_780525.1. NM_175316.3.
UniGeneiMm.11249.
Mm.442286.

3D structure databases

ProteinModelPortaliQ8BXB6.
SMRiQ8BXB6. Positions 481-509.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8BXB6.

Proteomic databases

MaxQBiQ8BXB6.
PaxDbiQ8BXB6.
PRIDEiQ8BXB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032985; ENSMUSP00000032985; ENSMUSG00000030737.
ENSMUST00000107086; ENSMUSP00000102701; ENSMUSG00000030737.
GeneIDi101488.
KEGGimmu:101488.
UCSCiuc009ilw.2. mouse.

Organism-specific databases

CTDi11309.
MGIiMGI:1351872. Slco2b1.

Phylogenomic databases

eggNOGiNOG320088.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ8BXB6.
KOiK14352.
OrthoDBiEOG7QG43R.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiREACT_318911. Transport of organic anions.

Miscellaneous databases

NextBioi354954.
PROiQ8BXB6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BXB6.
ExpressionAtlasiQ8BXB6. baseline and differential.
GenevestigatoriQ8BXB6.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta and Head.
  2. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSO2B1_MOUSE
AccessioniPrimary (citable) accession number: Q8BXB6
Secondary accession number(s): Q8BLV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2003
Last modified: April 1, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.