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Protein

Cleft lip and palate transmembrane protein 1-like protein

Gene

Clptm1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enhances cisplatin-mediated apoptosis, when overexpressed.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cleft lip and palate transmembrane protein 1-like protein
Short name:
CLPTM1-like protein
Gene namesi
Name:Clptm1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2442892. Clptm1l.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Topological domaini32 – 285254ExtracellularSequence analysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence analysisAdd
BLAST
Topological domaini307 – 32519CytoplasmicSequence analysisAdd
BLAST
Transmembranei326 – 34217HelicalSequence analysisAdd
BLAST
Topological domaini343 – 40361ExtracellularSequence analysisAdd
BLAST
Transmembranei404 – 42421HelicalSequence analysisAdd
BLAST
Topological domaini425 – 4295CytoplasmicSequence analysis
Transmembranei430 – 45021HelicalSequence analysisAdd
BLAST
Topological domaini451 – 53989ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Cleft lip and palate transmembrane protein 1-like proteinPRO_0000331301Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8BXA5.
MaxQBiQ8BXA5.
PaxDbiQ8BXA5.
PRIDEiQ8BXA5.

PTM databases

PhosphoSiteiQ8BXA5.

Expressioni

Gene expression databases

BgeeiQ8BXA5.
GenevisibleiQ8BXA5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8BXA5. 1 interaction.
MINTiMINT-4118420.
STRINGi10090.ENSMUSP00000022102.

Family & Domainsi

Sequence similaritiesi

Belongs to the CLPTM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2489. Eukaryota.
ENOG410XPEV. LUCA.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiQ8BXA5.
OMAiFQFGTYS.
OrthoDBiEOG74N5GH.
PhylomeDBiQ8BXA5.
TreeFamiTF318501.

Family and domain databases

InterProiIPR008429. CLPTM1.
IPR030434. CLPTM1L.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PTHR21347:SF1. PTHR21347:SF1. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BXA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWSGRSSFTS LVVGVFLVYV VHTCWVMYGI VYTRPCSGDS NCIQPYLALR
60 70 80 90 100
PKLQLSVYTT TRSSLGAENN VDLILNVEDF DVDSKFERTV NVSVPKKTRN
110 120 130 140 150
NGTLYAYIFL HHAGILPWQD GKQVHVVSTL TTYMIPKPEE INLLTGESAT
160 170 180 190 200
QQQIEAEKKP SNALDEPVSH WRPRLTLNVM VDDFVFDGSS LPADVHRYMK
210 220 230 240 250
MIQLGKTVHY LPILFIDQLS NRVKDLMVIN RSTTELPLTV SYDKISLGRL
260 270 280 290 300
RFWIHMQDAV YSLQQFGFSE KDADELKGIF VDTNLYLLAL TFFVAAFHLL
310 320 330 340 350
FDFLAFKSDI SFWKKKKSMI GMSTKAVLWR CFSTVVIFLF LLDEQTSLLV
360 370 380 390 400
LIPAGVGAAI ELWKVKKALK ITVAWRGLRP VFQFGTHSES ERKTEKYDAQ
410 420 430 440 450
AMKYLSYLLY PLCVGGAVYS LLNIKYKSWY SWLINSFVNG VYAFGFLFML
460 470 480 490 500
PQLFVNYKMK SVAHLPWKAF TYKAFNTFID DVFAFIITMP TSHRLACFRD
510 520 530
DVVFLVYLYQ RWLYPVDKSR VNEFGESYEE QPKRKPHPD
Length:539
Mass (Da):62,183
Last modified:March 1, 2003 - v1
Checksum:iD08CF6B6E31B7AD9
GO

Sequence cautioni

The sequence AAH26562.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC27798.1 differs from that shown. Reason: Frameshift at position 335. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti212 – 2121P → L in BAE33624 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032295 mRNA. Translation: BAC27798.1. Frameshift.
AK048357 mRNA. Translation: BAC33311.1.
AK156203 mRNA. Translation: BAE33624.1.
BC026562 mRNA. Translation: AAH26562.1. Different initiation.
CCDSiCCDS56894.1.
RefSeqiNP_666159.2. NM_146047.2.
UniGeneiMm.30099.

Genome annotation databases

EnsembliENSMUST00000022102; ENSMUSP00000022102; ENSMUSG00000021610.
GeneIDi218335.
KEGGimmu:218335.
UCSCiuc007rdo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032295 mRNA. Translation: BAC27798.1. Frameshift.
AK048357 mRNA. Translation: BAC33311.1.
AK156203 mRNA. Translation: BAE33624.1.
BC026562 mRNA. Translation: AAH26562.1. Different initiation.
CCDSiCCDS56894.1.
RefSeqiNP_666159.2. NM_146047.2.
UniGeneiMm.30099.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BXA5. 1 interaction.
MINTiMINT-4118420.
STRINGi10090.ENSMUSP00000022102.

PTM databases

PhosphoSiteiQ8BXA5.

Proteomic databases

EPDiQ8BXA5.
MaxQBiQ8BXA5.
PaxDbiQ8BXA5.
PRIDEiQ8BXA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022102; ENSMUSP00000022102; ENSMUSG00000021610.
GeneIDi218335.
KEGGimmu:218335.
UCSCiuc007rdo.2. mouse.

Organism-specific databases

CTDi81037.
MGIiMGI:2442892. Clptm1l.

Phylogenomic databases

eggNOGiKOG2489. Eukaryota.
ENOG410XPEV. LUCA.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiQ8BXA5.
OMAiFQFGTYS.
OrthoDBiEOG74N5GH.
PhylomeDBiQ8BXA5.
TreeFamiTF318501.

Miscellaneous databases

ChiTaRSiClptm1l. mouse.
NextBioi376263.
PROiQ8BXA5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BXA5.
GenevisibleiQ8BXA5. MM.

Family and domain databases

InterProiIPR008429. CLPTM1.
IPR030434. CLPTM1L.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PTHR21347:SF1. PTHR21347:SF1. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryonic head, Olfactory bulb and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-539.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCLP1L_MOUSE
AccessioniPrimary (citable) accession number: Q8BXA5
Secondary accession number(s): Q3U176, Q8C053, Q8R0P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.