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Q8BX94

- OSBL2_MOUSE

UniProt

Q8BX94 - OSBL2_MOUSE

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Protein

Oxysterol-binding protein-related protein 2

Gene
Osbpl2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate By similarity.

GO - Molecular functioni

  1. cholesterol binding Source: Ensembl

GO - Biological processi

  1. lipid transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 2
Short name:
ORP-2
Short name:
OSBP-related protein 2
Gene namesi
Name:Osbpl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2442832. Osbpl2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Oxysterol-binding protein-related protein 2PRO_0000100370Add
BLAST

Proteomic databases

MaxQBiQ8BX94.
PaxDbiQ8BX94.
PRIDEiQ8BX94.

PTM databases

PhosphoSiteiQ8BX94.

Expressioni

Gene expression databases

ArrayExpressiQ8BX94.
BgeeiQ8BX94.
CleanExiMM_OSBPL2.
GenevestigatoriQ8BX94.

Structurei

3D structure databases

ProteinModelPortaliQ8BX94.
SMRiQ8BX94. Positions 67-440.

Family & Domainsi

Sequence similaritiesi

Belongs to the OSBP family.

Phylogenomic databases

eggNOGiNOG281324.
GeneTreeiENSGT00710000106456.
HOGENOMiHOG000231233.
HOVERGENiHBG053374.
InParanoidiQ8BX94.
OMAiEWRTRWF.
OrthoDBiEOG7F24SJ.
PhylomeDBiQ8BX94.

Family and domain databases

InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 1 hit.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
PROSITEiPS01013. OSBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BX94-1 [UniParc]FASTAAdd to Basket

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MNGEEEFFDA VTGFDSDNSS IGEFSEANKI SGMIDLDTSK STRSGKNGEK    50
PQQENGIQKH RTALPAPMFT RSDFSVWSIL KKCIGLELSK ITMPIAFNEP 100
LSFLQRITEY MEHVYLIHKA SSQSQPLERM QSVAAFAVSA VASQWERTGK 150
PFNPLLGETY ELIREDLGFR FISEQVSHHP PISAFYSEGL NQDFRFHGSI 200
YPKLKFWGKS VEAEPRGTIT LELLKHNEAY TWTNPTCCVH NVILGQLWIE 250
QYGIVEIVNH RTGDKCILHF KPCGLFGKEL HRVEGYIQDK NRKKLFIMYG 300
KWTECLWGID PASYESFKKQ EKRGDQARKA KMDDGPEKAN SDVPGDVADD 350
VPVAQETVQV IPGSKLLWRI NSRPPNSAQM YNFTSFTVSL NELESGMEKT 400
LPPTDCRLRP DIRGMENGNM DLASQEKERL EEKQREARKE RAKEDAEWRT 450
RWFSPGNNPY TGAPDWLYAG HYFERNFSDC PDIY 484
Length:484
Mass (Da):55,384
Last modified:March 1, 2003 - v1
Checksum:iE67BCF2D0C413497
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211I → T in AAH26804. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK048537 mRNA. Translation: BAC33367.1.
AK170669 mRNA. Translation: BAE41948.1.
BC026804 mRNA. Translation: AAH26804.1.
CCDSiCCDS17170.1.
RefSeqiNP_653083.2. NM_144500.3.
UniGeneiMm.253578.

Genome annotation databases

EnsembliENSMUST00000040668; ENSMUSP00000046538; ENSMUSG00000039050.
GeneIDi228983.
KEGGimmu:228983.
UCSCiuc008oik.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK048537 mRNA. Translation: BAC33367.1 .
AK170669 mRNA. Translation: BAE41948.1 .
BC026804 mRNA. Translation: AAH26804.1 .
CCDSi CCDS17170.1.
RefSeqi NP_653083.2. NM_144500.3.
UniGenei Mm.253578.

3D structure databases

ProteinModelPortali Q8BX94.
SMRi Q8BX94. Positions 67-440.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BX94.

Proteomic databases

MaxQBi Q8BX94.
PaxDbi Q8BX94.
PRIDEi Q8BX94.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040668 ; ENSMUSP00000046538 ; ENSMUSG00000039050 .
GeneIDi 228983.
KEGGi mmu:228983.
UCSCi uc008oik.1. mouse.

Organism-specific databases

CTDi 9885.
MGIi MGI:2442832. Osbpl2.

Phylogenomic databases

eggNOGi NOG281324.
GeneTreei ENSGT00710000106456.
HOGENOMi HOG000231233.
HOVERGENi HBG053374.
InParanoidi Q8BX94.
OMAi EWRTRWF.
OrthoDBi EOG7F24SJ.
PhylomeDBi Q8BX94.

Miscellaneous databases

NextBioi 379285.
PROi Q8BX94.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BX94.
Bgeei Q8BX94.
CleanExi MM_OSBPL2.
Genevestigatori Q8BX94.

Family and domain databases

InterProi IPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
[Graphical view ]
PANTHERi PTHR10972. PTHR10972. 1 hit.
Pfami PF01237. Oxysterol_BP. 1 hit.
[Graphical view ]
PROSITEi PS01013. OSBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiOSBL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BX94
Secondary accession number(s): Q3TCK8, Q8R0H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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