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Q8BX94

- OSBL2_MOUSE

UniProt

Q8BX94 - OSBL2_MOUSE

Protein

Oxysterol-binding protein-related protein 2

Gene

Osbpl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate.By similarity

    GO - Molecular functioni

    1. cholesterol binding Source: Ensembl

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxysterol-binding protein-related protein 2
    Short name:
    ORP-2
    Short name:
    OSBP-related protein 2
    Gene namesi
    Name:Osbpl2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2442832. Osbpl2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Oxysterol-binding protein-related protein 2PRO_0000100370Add
    BLAST

    Proteomic databases

    MaxQBiQ8BX94.
    PaxDbiQ8BX94.
    PRIDEiQ8BX94.

    PTM databases

    PhosphoSiteiQ8BX94.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BX94.
    BgeeiQ8BX94.
    CleanExiMM_OSBPL2.
    GenevestigatoriQ8BX94.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BX94.
    SMRiQ8BX94. Positions 67-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OSBP family.Curated

    Phylogenomic databases

    eggNOGiNOG281324.
    GeneTreeiENSGT00710000106456.
    HOGENOMiHOG000231233.
    HOVERGENiHBG053374.
    InParanoidiQ8BX94.
    OMAiEWRTRWF.
    OrthoDBiEOG7F24SJ.
    PhylomeDBiQ8BX94.

    Family and domain databases

    InterProiIPR000648. Oxysterol-bd.
    IPR018494. Oxysterol-bd_CS.
    [Graphical view]
    PANTHERiPTHR10972. PTHR10972. 1 hit.
    PfamiPF01237. Oxysterol_BP. 1 hit.
    [Graphical view]
    PROSITEiPS01013. OSBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BX94-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGEEEFFDA VTGFDSDNSS IGEFSEANKI SGMIDLDTSK STRSGKNGEK    50
    PQQENGIQKH RTALPAPMFT RSDFSVWSIL KKCIGLELSK ITMPIAFNEP 100
    LSFLQRITEY MEHVYLIHKA SSQSQPLERM QSVAAFAVSA VASQWERTGK 150
    PFNPLLGETY ELIREDLGFR FISEQVSHHP PISAFYSEGL NQDFRFHGSI 200
    YPKLKFWGKS VEAEPRGTIT LELLKHNEAY TWTNPTCCVH NVILGQLWIE 250
    QYGIVEIVNH RTGDKCILHF KPCGLFGKEL HRVEGYIQDK NRKKLFIMYG 300
    KWTECLWGID PASYESFKKQ EKRGDQARKA KMDDGPEKAN SDVPGDVADD 350
    VPVAQETVQV IPGSKLLWRI NSRPPNSAQM YNFTSFTVSL NELESGMEKT 400
    LPPTDCRLRP DIRGMENGNM DLASQEKERL EEKQREARKE RAKEDAEWRT 450
    RWFSPGNNPY TGAPDWLYAG HYFERNFSDC PDIY 484
    Length:484
    Mass (Da):55,384
    Last modified:March 1, 2003 - v1
    Checksum:iE67BCF2D0C413497
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211I → T in AAH26804. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK048537 mRNA. Translation: BAC33367.1.
    AK170669 mRNA. Translation: BAE41948.1.
    BC026804 mRNA. Translation: AAH26804.1.
    CCDSiCCDS17170.1.
    RefSeqiNP_653083.2. NM_144500.3.
    UniGeneiMm.253578.

    Genome annotation databases

    EnsembliENSMUST00000040668; ENSMUSP00000046538; ENSMUSG00000039050.
    GeneIDi228983.
    KEGGimmu:228983.
    UCSCiuc008oik.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK048537 mRNA. Translation: BAC33367.1 .
    AK170669 mRNA. Translation: BAE41948.1 .
    BC026804 mRNA. Translation: AAH26804.1 .
    CCDSi CCDS17170.1.
    RefSeqi NP_653083.2. NM_144500.3.
    UniGenei Mm.253578.

    3D structure databases

    ProteinModelPortali Q8BX94.
    SMRi Q8BX94. Positions 67-440.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BX94.

    Proteomic databases

    MaxQBi Q8BX94.
    PaxDbi Q8BX94.
    PRIDEi Q8BX94.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040668 ; ENSMUSP00000046538 ; ENSMUSG00000039050 .
    GeneIDi 228983.
    KEGGi mmu:228983.
    UCSCi uc008oik.1. mouse.

    Organism-specific databases

    CTDi 9885.
    MGIi MGI:2442832. Osbpl2.

    Phylogenomic databases

    eggNOGi NOG281324.
    GeneTreei ENSGT00710000106456.
    HOGENOMi HOG000231233.
    HOVERGENi HBG053374.
    InParanoidi Q8BX94.
    OMAi EWRTRWF.
    OrthoDBi EOG7F24SJ.
    PhylomeDBi Q8BX94.

    Miscellaneous databases

    NextBioi 379285.
    PROi Q8BX94.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BX94.
    Bgeei Q8BX94.
    CleanExi MM_OSBPL2.
    Genevestigatori Q8BX94.

    Family and domain databases

    InterProi IPR000648. Oxysterol-bd.
    IPR018494. Oxysterol-bd_CS.
    [Graphical view ]
    PANTHERi PTHR10972. PTHR10972. 1 hit.
    Pfami PF01237. Oxysterol_BP. 1 hit.
    [Graphical view ]
    PROSITEi PS01013. OSBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Head.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiOSBL2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BX94
    Secondary accession number(s): Q3TCK8, Q8R0H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3