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Protein

Oxysterol-binding protein-related protein 2

Gene

Osbpl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds 25-hydroxycholesterol.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 2
Short name:
ORP-2
Short name:
OSBP-related protein 2
Gene namesi
Name:Osbpl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442832. Osbpl2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Oxysterol-binding protein-related protein 2PRO_0000100370Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191PhosphoserineBy similarity
Modified residuei20 – 201PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BX94.
PaxDbiQ8BX94.
PRIDEiQ8BX94.

PTM databases

PhosphoSiteiQ8BX94.

Expressioni

Gene expression databases

BgeeiQ8BX94.
CleanExiMM_OSBPL2.
ExpressionAtlasiQ8BX94. baseline and differential.
GenevisibleiQ8BX94. MM.

Interactioni

Subunit structurei

Interacts with DIAPH1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046538.

Structurei

3D structure databases

ProteinModelPortaliQ8BX94.
SMRiQ8BX94. Positions 67-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OSBP family.Curated

Phylogenomic databases

eggNOGiNOG281324.
GeneTreeiENSGT00760000119155.
HOGENOMiHOG000231233.
HOVERGENiHBG053374.
InParanoidiQ8BX94.
OMAiYAGGYFE.
OrthoDBiEOG7F24SJ.
PhylomeDBiQ8BX94.

Family and domain databases

InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 1 hit.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
PROSITEiPS01013. OSBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BX94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGEEEFFDA VTGFDSDNSS IGEFSEANKI SGMIDLDTSK STRSGKNGEK
60 70 80 90 100
PQQENGIQKH RTALPAPMFT RSDFSVWSIL KKCIGLELSK ITMPIAFNEP
110 120 130 140 150
LSFLQRITEY MEHVYLIHKA SSQSQPLERM QSVAAFAVSA VASQWERTGK
160 170 180 190 200
PFNPLLGETY ELIREDLGFR FISEQVSHHP PISAFYSEGL NQDFRFHGSI
210 220 230 240 250
YPKLKFWGKS VEAEPRGTIT LELLKHNEAY TWTNPTCCVH NVILGQLWIE
260 270 280 290 300
QYGIVEIVNH RTGDKCILHF KPCGLFGKEL HRVEGYIQDK NRKKLFIMYG
310 320 330 340 350
KWTECLWGID PASYESFKKQ EKRGDQARKA KMDDGPEKAN SDVPGDVADD
360 370 380 390 400
VPVAQETVQV IPGSKLLWRI NSRPPNSAQM YNFTSFTVSL NELESGMEKT
410 420 430 440 450
LPPTDCRLRP DIRGMENGNM DLASQEKERL EEKQREARKE RAKEDAEWRT
460 470 480
RWFSPGNNPY TGAPDWLYAG HYFERNFSDC PDIY
Length:484
Mass (Da):55,384
Last modified:March 1, 2003 - v1
Checksum:iE67BCF2D0C413497
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211I → T in AAH26804 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048537 mRNA. Translation: BAC33367.1.
AK170669 mRNA. Translation: BAE41948.1.
BC026804 mRNA. Translation: AAH26804.1.
CCDSiCCDS17170.1.
RefSeqiNP_653083.2. NM_144500.3.
UniGeneiMm.253578.

Genome annotation databases

EnsembliENSMUST00000040668; ENSMUSP00000046538; ENSMUSG00000039050.
GeneIDi228983.
KEGGimmu:228983.
UCSCiuc008oik.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048537 mRNA. Translation: BAC33367.1.
AK170669 mRNA. Translation: BAE41948.1.
BC026804 mRNA. Translation: AAH26804.1.
CCDSiCCDS17170.1.
RefSeqiNP_653083.2. NM_144500.3.
UniGeneiMm.253578.

3D structure databases

ProteinModelPortaliQ8BX94.
SMRiQ8BX94. Positions 67-440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046538.

PTM databases

PhosphoSiteiQ8BX94.

Proteomic databases

MaxQBiQ8BX94.
PaxDbiQ8BX94.
PRIDEiQ8BX94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040668; ENSMUSP00000046538; ENSMUSG00000039050.
GeneIDi228983.
KEGGimmu:228983.
UCSCiuc008oik.1. mouse.

Organism-specific databases

CTDi9885.
MGIiMGI:2442832. Osbpl2.

Phylogenomic databases

eggNOGiNOG281324.
GeneTreeiENSGT00760000119155.
HOGENOMiHOG000231233.
HOVERGENiHBG053374.
InParanoidiQ8BX94.
OMAiYAGGYFE.
OrthoDBiEOG7F24SJ.
PhylomeDBiQ8BX94.

Miscellaneous databases

NextBioi379285.
PROiQ8BX94.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BX94.
CleanExiMM_OSBPL2.
ExpressionAtlasiQ8BX94. baseline and differential.
GenevisibleiQ8BX94. MM.

Family and domain databases

InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 1 hit.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
PROSITEiPS01013. OSBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiOSBL2_MOUSE
AccessioniPrimary (citable) accession number: Q8BX94
Secondary accession number(s): Q3TCK8, Q8R0H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.