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Q8BX94 (OSBL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxysterol-binding protein-related protein 2

Short name=ORP-2
Short name=OSBP-related protein 2
Gene names
Name:Osbpl2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate By similarity.

Sequence similarities

Belongs to the OSBP family.

Ontologies

Keywords
   Biological processLipid transport
Transport
   LigandLipid-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncholesterol binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484Oxysterol-binding protein-related protein 2
PRO_0000100370

Experimental info

Sequence conflict211I → T in AAH26804. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8BX94 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: E67BCF2D0C413497

FASTA48455,384
        10         20         30         40         50         60 
MNGEEEFFDA VTGFDSDNSS IGEFSEANKI SGMIDLDTSK STRSGKNGEK PQQENGIQKH 

        70         80         90        100        110        120 
RTALPAPMFT RSDFSVWSIL KKCIGLELSK ITMPIAFNEP LSFLQRITEY MEHVYLIHKA 

       130        140        150        160        170        180 
SSQSQPLERM QSVAAFAVSA VASQWERTGK PFNPLLGETY ELIREDLGFR FISEQVSHHP 

       190        200        210        220        230        240 
PISAFYSEGL NQDFRFHGSI YPKLKFWGKS VEAEPRGTIT LELLKHNEAY TWTNPTCCVH 

       250        260        270        280        290        300 
NVILGQLWIE QYGIVEIVNH RTGDKCILHF KPCGLFGKEL HRVEGYIQDK NRKKLFIMYG 

       310        320        330        340        350        360 
KWTECLWGID PASYESFKKQ EKRGDQARKA KMDDGPEKAN SDVPGDVADD VPVAQETVQV 

       370        380        390        400        410        420 
IPGSKLLWRI NSRPPNSAQM YNFTSFTVSL NELESGMEKT LPPTDCRLRP DIRGMENGNM 

       430        440        450        460        470        480 
DLASQEKERL EEKQREARKE RAKEDAEWRT RWFSPGNNPY TGAPDWLYAG HYFERNFSDC 


PDIY 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Head.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK048537 mRNA. Translation: BAC33367.1.
AK170669 mRNA. Translation: BAE41948.1.
BC026804 mRNA. Translation: AAH26804.1.
CCDSCCDS17170.1.
RefSeqNP_653083.2. NM_144500.3.
UniGeneMm.253578.

3D structure databases

ProteinModelPortalQ8BX94.
SMRQ8BX94. Positions 67-440.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BX94.

Proteomic databases

MaxQBQ8BX94.
PaxDbQ8BX94.
PRIDEQ8BX94.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040668; ENSMUSP00000046538; ENSMUSG00000039050.
GeneID228983.
KEGGmmu:228983.
UCSCuc008oik.1. mouse.

Organism-specific databases

CTD9885.
MGIMGI:2442832. Osbpl2.

Phylogenomic databases

eggNOGNOG281324.
GeneTreeENSGT00710000106456.
HOGENOMHOG000231233.
HOVERGENHBG053374.
InParanoidQ8BX94.
OMAEWRTRWF.
OrthoDBEOG7F24SJ.
PhylomeDBQ8BX94.

Gene expression databases

ArrayExpressQ8BX94.
BgeeQ8BX94.
CleanExMM_OSBPL2.
GenevestigatorQ8BX94.

Family and domain databases

InterProIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
[Graphical view]
PANTHERPTHR10972. PTHR10972. 1 hit.
PfamPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
PROSITEPS01013. OSBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio379285.
PROQ8BX94.
SOURCESearch...

Entry information

Entry nameOSBL2_MOUSE
AccessionPrimary (citable) accession number: Q8BX94
Secondary accession number(s): Q3TCK8, Q8R0H8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot