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Protein

Probable G-protein coupled receptor 21

Gene

Gpr21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating dopamine receptor signaling pathway Source: GO_Central
  • glucose homeostasis Source: MGI
  • learning Source: GO_Central
  • negative regulation of insulin receptor signaling pathway Source: MGI
  • phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
  • positive regulation of multicellular organism growth Source: MGI
  • synaptic transmission, dopaminergic Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 21
Gene namesi
Name:Gpr21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2441890. Gpr21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 53Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini54 – 75CytoplasmicSequence analysisAdd BLAST22
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 104ExtracellularSequence analysis8
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 147CytoplasmicSequence analysisAdd BLAST22
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 191ExtracellularSequence analysisAdd BLAST23
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 252CytoplasmicSequence analysisAdd BLAST40
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 283ExtracellularSequence analysis10
Transmembranei284 – 304Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini305 – 349CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003032341 – 349Probable G-protein coupled receptor 21Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BX79.
PRIDEiQ8BX79.

PTM databases

PhosphoSitePlusiQ8BX79.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053164.
CleanExiMM_GPR21.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066449.

Structurei

3D structure databases

ProteinModelPortaliQ8BX79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123085.
HOGENOMiHOG000261615.
HOVERGENiHBG051801.
InParanoidiQ8BX79.
KOiK04318.
OMAiTGHSNRF.
OrthoDBiEOG091G092Z.
PhylomeDBiQ8BX79.
TreeFamiTF332372.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BX79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTWDGNQS SHPFCLLALG YLETVRFCLL EVLIIVFLTV LIISGNIIVI
60 70 80 90 100
FVFHCAPLLN HHSTSYFIQT MAYADLLVGV SCLVPSLSLL YYPLPIEEAM
110 120 130 140 150
TCQVFGFVVS VLKSISMASL ACISIDRYIA ITKPLTYNTL VTPWRLRLCI
160 170 180 190 200
FLIWLYSTLV FLPSFFHWGK PGYHGDVFQW CAESWHTNSY FTLFIVMMLY
210 220 230 240 250
APAALIVCFT YFNIFRICQQ HTKEISERQA RFSSQNGETG EPQTCPDKRY
260 270 280 290 300
AMVLFRITSV FYVLWLPYII YFLLESSTGC SSRLASFLTT WLAISNSFCN
310 320 330 340
CIIYSLSNSV FQRGLKGLSG SLCTSCASHT TAKDPYTVRC KGPPNGSHI
Length:349
Mass (Da):39,509
Last modified:March 1, 2003 - v1
Checksum:i4D8B66348E60BB45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048682 mRNA. Translation: BAC33420.1.
AK141999 mRNA. Translation: BAE24908.1.
AL953890 Genomic DNA. Translation: CAM20745.1.
BC112377 mRNA. Translation: AAI12378.1.
AY255598 mRNA. Translation: AAO85110.1.
CCDSiCCDS16004.1.
RefSeqiNP_796357.1. NM_177383.4.
UniGeneiMm.445325.

Genome annotation databases

EnsembliENSMUST00000065441; ENSMUSP00000066449; ENSMUSG00000053164.
GeneIDi338346.
KEGGimmu:338346.
UCSCiuc008jna.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048682 mRNA. Translation: BAC33420.1.
AK141999 mRNA. Translation: BAE24908.1.
AL953890 Genomic DNA. Translation: CAM20745.1.
BC112377 mRNA. Translation: AAI12378.1.
AY255598 mRNA. Translation: AAO85110.1.
CCDSiCCDS16004.1.
RefSeqiNP_796357.1. NM_177383.4.
UniGeneiMm.445325.

3D structure databases

ProteinModelPortaliQ8BX79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066449.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8BX79.

Proteomic databases

PaxDbiQ8BX79.
PRIDEiQ8BX79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065441; ENSMUSP00000066449; ENSMUSG00000053164.
GeneIDi338346.
KEGGimmu:338346.
UCSCiuc008jna.1. mouse.

Organism-specific databases

CTDi2844.
MGIiMGI:2441890. Gpr21.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123085.
HOGENOMiHOG000261615.
HOVERGENiHBG051801.
InParanoidiQ8BX79.
KOiK04318.
OMAiTGHSNRF.
OrthoDBiEOG091G092Z.
PhylomeDBiQ8BX79.
TreeFamiTF332372.

Miscellaneous databases

PROiQ8BX79.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053164.
CleanExiMM_GPR21.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR21_MOUSE
AccessioniPrimary (citable) accession number: Q8BX79
Secondary accession number(s): Q80T46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.