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Protein

Probable G-protein coupled receptor 21

Gene

Gpr21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating dopamine receptor signaling pathway Source: GO_Central
  • glucose homeostasis Source: MGI
  • learning Source: GO_Central
  • negative regulation of insulin receptor signaling pathway Source: MGI
  • phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
  • positive regulation of multicellular organism growth Source: MGI
  • synaptic transmission, dopaminergic Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 21
Gene namesi
Name:Gpr21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2441890. Gpr21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence analysisAdd
BLAST
Transmembranei33 – 5321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini54 – 7522CytoplasmicSequence analysisAdd
BLAST
Transmembranei76 – 9621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini97 – 1048ExtracellularSequence analysis
Transmembranei105 – 12521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini126 – 14722CytoplasmicSequence analysisAdd
BLAST
Transmembranei148 – 16821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini169 – 19123ExtracellularSequence analysisAdd
BLAST
Transmembranei192 – 21221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini213 – 25240CytoplasmicSequence analysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini274 – 28310ExtracellularSequence analysis
Transmembranei284 – 30421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini305 – 34945CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Probable G-protein coupled receptor 21PRO_0000303234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BX79.
PRIDEiQ8BX79.

PTM databases

PhosphoSiteiQ8BX79.

Expressioni

Gene expression databases

BgeeiQ8BX79.
CleanExiMM_GPR21.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066449.

Structurei

3D structure databases

ProteinModelPortaliQ8BX79.
SMRiQ8BX79. Positions 38-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123085.
HOGENOMiHOG000261615.
HOVERGENiHBG051801.
InParanoidiQ8BX79.
KOiK04318.
OMAiTGHSNRF.
OrthoDBiEOG7B05D5.
PhylomeDBiQ8BX79.
TreeFamiTF332372.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BX79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTWDGNQS SHPFCLLALG YLETVRFCLL EVLIIVFLTV LIISGNIIVI
60 70 80 90 100
FVFHCAPLLN HHSTSYFIQT MAYADLLVGV SCLVPSLSLL YYPLPIEEAM
110 120 130 140 150
TCQVFGFVVS VLKSISMASL ACISIDRYIA ITKPLTYNTL VTPWRLRLCI
160 170 180 190 200
FLIWLYSTLV FLPSFFHWGK PGYHGDVFQW CAESWHTNSY FTLFIVMMLY
210 220 230 240 250
APAALIVCFT YFNIFRICQQ HTKEISERQA RFSSQNGETG EPQTCPDKRY
260 270 280 290 300
AMVLFRITSV FYVLWLPYII YFLLESSTGC SSRLASFLTT WLAISNSFCN
310 320 330 340
CIIYSLSNSV FQRGLKGLSG SLCTSCASHT TAKDPYTVRC KGPPNGSHI
Length:349
Mass (Da):39,509
Last modified:March 1, 2003 - v1
Checksum:i4D8B66348E60BB45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048682 mRNA. Translation: BAC33420.1.
AK141999 mRNA. Translation: BAE24908.1.
AL953890 Genomic DNA. Translation: CAM20745.1.
BC112377 mRNA. Translation: AAI12378.1.
AY255598 mRNA. Translation: AAO85110.1.
CCDSiCCDS16004.1.
RefSeqiNP_796357.1. NM_177383.4.
UniGeneiMm.445325.

Genome annotation databases

EnsembliENSMUST00000065441; ENSMUSP00000066449; ENSMUSG00000053164.
GeneIDi338346.
KEGGimmu:338346.
UCSCiuc008jna.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048682 mRNA. Translation: BAC33420.1.
AK141999 mRNA. Translation: BAE24908.1.
AL953890 Genomic DNA. Translation: CAM20745.1.
BC112377 mRNA. Translation: AAI12378.1.
AY255598 mRNA. Translation: AAO85110.1.
CCDSiCCDS16004.1.
RefSeqiNP_796357.1. NM_177383.4.
UniGeneiMm.445325.

3D structure databases

ProteinModelPortaliQ8BX79.
SMRiQ8BX79. Positions 38-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066449.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8BX79.

Proteomic databases

PaxDbiQ8BX79.
PRIDEiQ8BX79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065441; ENSMUSP00000066449; ENSMUSG00000053164.
GeneIDi338346.
KEGGimmu:338346.
UCSCiuc008jna.1. mouse.

Organism-specific databases

CTDi2844.
MGIiMGI:2441890. Gpr21.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123085.
HOGENOMiHOG000261615.
HOVERGENiHBG051801.
InParanoidiQ8BX79.
KOiK04318.
OMAiTGHSNRF.
OrthoDBiEOG7B05D5.
PhylomeDBiQ8BX79.
TreeFamiTF332372.

Miscellaneous databases

PROiQ8BX79.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BX79.
CleanExiMM_GPR21.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Spinal ganglion.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-219.

Entry informationi

Entry nameiGPR21_MOUSE
AccessioniPrimary (citable) accession number: Q8BX79
Secondary accession number(s): Q80T46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.