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Protein

Vacuolar protein sorting-associated protein 13C

Gene

Vps13c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PARK2-mediated mitophagy in response to mitochondrial depolarization.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 13C
Gene namesi
Name:Vps13cImported
Synonyms:Kiaa3021Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2444207. Vps13c.

Subcellular locationi

  • Mitochondrion outer membrane By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 37483748Vacuolar protein sorting-associated protein 13CPRO_0000262950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei132 – 1321PhosphoserineCombined sources
Modified residuei613 – 6131PhosphothreonineBy similarity
Modified residuei618 – 6181PhosphoserineBy similarity
Modified residuei623 – 6231PhosphothreonineBy similarity
Modified residuei736 – 7361PhosphoserineCombined sources
Modified residuei841 – 8411PhosphoserineBy similarity
Modified residuei871 – 8711PhosphoserineCombined sources
Modified residuei873 – 8731PhosphoserineCombined sources
Modified residuei1968 – 19681PhosphothreonineCombined sources
Modified residuei1974 – 19741PhosphoserineCombined sources
Cross-linki2352 – 2352Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei2442 – 24421PhosphoserineCombined sources
Modified residuei3533 – 35331N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8BX70.
MaxQBiQ8BX70.
PaxDbiQ8BX70.
PeptideAtlasiQ8BX70.
PRIDEiQ8BX70.

PTM databases

iPTMnetiQ8BX70.
PhosphoSiteiQ8BX70.
SwissPalmiQ8BX70.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035284.
CleanExiMM_VPS13C.
ExpressionAtlasiQ8BX70. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi236091. 2 interactions.
STRINGi10090.ENSMUSP00000077040.

Structurei

3D structure databases

ProteinModelPortaliQ8BX70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi145 – 17935Lys-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the VPS13 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG1809. Eukaryota.
COG5043. LUCA.
GeneTreeiENSGT00410000025397.
HOGENOMiHOG000218634.
HOVERGENiHBG079736.
InParanoidiQ8BX70.
KOiK19525.
OMAiTHIIETR.
OrthoDBiEOG091G001Z.
PhylomeDBiQ8BX70.
TreeFamiTF300316.

Family and domain databases

InterProiIPR015412. Autophagy-rel_C.
IPR009543. SHR-BD.
IPR026847. VPS13.
IPR031645. VPS13_C.
IPR031642. VPS13_mid_rpt.
IPR026854. VPS13_N.
IPR031646. VPS13_N2.
[Graphical view]
PANTHERiPTHR16166. PTHR16166. 3 hits.
PfamiPF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
PF06650. SHR-BD. 1 hit.
PF16908. VPS13. 1 hit.
PF16909. VPS13_C. 1 hit.
PF16910. VPS13_mid_rpt. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BX70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLESVVADL LNRFLGDYVE NLNKSQLKLG IWGGNVALDN LQIKENALSE
60 70 80 90 100
LDVPFKVKAG QIDKLTLKIP WKNLYGEAVV ATLEGLYLLV VPGASIKYDA
110 120 130 140 150
EKEEKSLQDI KQKELCRIEE ALQKAAEKGA HSGEFMYGLE NLLYKDVKPG
160 170 180 190 200
RKRKKHKKHF KKRFKGLDRS KDKPKEAKKD TFLEKLATQV IKNVQVKITD
210 220 230 240 250
IHIKYEDDIT DPERPLSFGV TLREFSLLTT NEHWTPCILN EAEKIIYKLV
260 270 280 290 300
KLDSLSAYWN VGCCMSYRGS REHILEQLKR EILTSTNIPP DHQYIFQPIS
310 320 330 340 350
ASAKLYMNPG AESELKTPKL DGNVEVQNIA IELTKPQYLS MIDFLESLDY
360 370 380 390 400
MVRNAPYRKY KPCLPLHTNC RQWWKYAIDS VLEVHIRRYT QPWSWSNIKN
410 420 430 440 450
HRQLLKSYKM AYKTKLTQAK VSEEIQKQIQ DLEKSLDVFN IILVRQQAQV
460 470 480 490 500
EVIHSGQKLR KKSAEAGEKR GWFSGFWGKK ESKKRDEESS VPETIDDLMT
510 520 530 540 550
PEEKDKLFTA IGYSENAYNL ALPKQYVAHI LTLKLVSTSI IIRENRNVPE
560 570 580 590 600
ILRVQIIGLG TQVSQRPGAQ ALKIEAKLEH WYVTGLRQQD IVPSLVASIG
610 620 630 640 650
DTTSSLLKIE FETNPENSPA DQTLIVQSQP VEVIYDAKTI NAVVEFFQSN
660 670 680 690 700
KGLDLEQITS ATLMKLEEIK ERTATGLTHI IETRKVLDLR INLKPSYLII
710 720 730 740 750
PQTGFHHEKS NLLILDFGTF QLNSKDQGAQ KTANASLEEI IDKAYDKFDV
760 770 780 790 800
EIRSVQLLFA KAEENWKKCR FQHPSTMHIL QPMDIHVELA KAMVEKDVRM
810 820 830 840 850
AKFKVSGGLP LMHVRISDQK IKDALCLINS IPLPQKSSTP SPERQVASIP
860 870 880 890 900
VLSGGTKALL GTSLLLDGVE SESDEEFFDA EDGDSQAART VKASELKKAA
910 920 930 940 950
EVPNEELVSL LLKFEIKEVV LELTKQQKEE ETILVFNVTQ LGTEATMRTF
960 970 980 990 1000
DLTAVSYLRK ISLDYHDIKG SRKKPIHLIS SSDRPGLDLL KVEYIKVDRN
1010 1020 1030 1040 1050
GPSFQTTFEK TEQTVKVAFS SLNLLLQTQA LLSSLNYLTT VIPSDSQNTG
1060 1070 1080 1090 1100
VAKEVQAMPE KQKNSPLQKV MVPSRDSDVI GFRLFAKLNA FCVTVCDEKS
1110 1120 1130 1140 1150
NIAEIKIQGL DSSLSLQSKK QSLFARLENI IVTDVDPKTI HKKAVSIVGN
1160 1170 1180 1190 1200
EVFRFNLDLY PDATEGDSYT DMSTVDGVVA LHVGCIQIVY LHKFLMSLLS
1210 1220 1230 1240 1250
FLNNFQVAKE ALSAATAQAA EKAATSVKDL AQRSFRVSVD IDLKAPVIVI
1260 1270 1280 1290 1300
PQSSLSTNAV VVDLGLIRVH NRFSLVSGED TANPPVIDKM EVQLTKLKLS
1310 1320 1330 1340 1350
RTAIQPGTSH PDIQLLHPIN LEFFVSRNLA ANWYHKVPVV EIKGRLDSMN
1360 1370 1380 1390 1400
VSLNQEDLNL LFRILAENLG EATEDLDKGK PRIQERGETK ACREVSTPQD
1410 1420 1430 1440 1450
VHTTQGVPAA RVEETRPVDI INVLLNFEIK EVVVTLMKKA ERKGSPFHEL
1460 1470 1480 1490 1500
KILHLGMEAK VKAHDMTAAA YLRNISMRCF HFPDSKGEPL RIVNTSDVSD
1510 1520 1530 1540 1550
GILLKLLFIK ADSDGPDFKT IHDNTKQKLK VSFSSLDLVL HLEALLSLMD
1560 1570 1580 1590 1600
FLSSAIPSSD SSSSEKEPEL KPLVGESRSL AIRAVPSSYE GDAFDLKITA
1610 1620 1630 1640 1650
ELNAFNIFIC DQKSNIAEIK IHGMDASISV KPKQTDVFAR LKNIIVMNVD
1660 1670 1680 1690 1700
SLSIHKKAVS ILGDEVFRFQ MSLYPDATEG ENYGDMSKVD GRLSLKVGCI
1710 1720 1730 1740 1750
QIVYVHKFFM SLLSFLNNFQ AAKEALSTAT VQAAERAASS VKDLAQKSFR
1760 1770 1780 1790 1800
LLMDIDLKAP VITIPQSSVS PNVVIADLGL IRVENKFSLV SVEQLALPPV
1810 1820 1830 1840 1850
ADEMSIQLTQ LKLARTVLQA DSPQHDVEIL KPVNMLLCIQ RNLSAAWYTQ
1860 1870 1880 1890 1900
IPGMEIKGEL KPMQVALSQD DLTVLMKILL ENLGEASSQP SPTQYAQEAA
1910 1920 1930 1940 1950
RVKRDTRSGP DYLKEQELAD PKPPGDQTVT LQFDFHFDSL SIILYNSDSS
1960 1970 1980 1990 2000
QEPRLSFHND SFRLGELTLH LMASAGKMFK DGSMNVSLKL KTCTLDDLRE
2010 2020 2030 2040 2050
GIERATSRMI DKKNDQDNNS SMIDISYSQD KNGSQVDAVL DKLYVCASVE
2060 2070 2080 2090 2100
FLMTVADFFI KAMPQSPENI AKEIQIPSRQ TAAGRVKMEK DDSVRPNMTL
2110 2120 2130 2140 2150
KAMITDPEVV FVASLTKADA PALTASFQCN LSLSTSKLEQ MMEASVRDLK
2160 2170 2180 2190 2200
VLACPFLRER RGKSITTVLQ PCSLFMEKCT WASGKQNINI VVKEFVIKIS
2210 2220 2230 2240 2250
PIILNTVMTI MAAMSPKTKE DEWKDTPKET DNLWAVKSIT DYNSWFLGVD
2260 2270 2280 2290 2300
MATEVTENFR DSEHPSIEEN CVVAVESVQV TLECGLGHRT VPLLLAESKF
2310 2320 2330 2340 2350
SGNIKNWTSL MAAAADMTLE VHYYNETHAV WEPLIERVEG NKPWSLKLNV
2360 2370 2380 2390 2400
KKNPIQDKSL MPGDDFIPEP QTAVHISSGA TMNITISKSC LNVFSNLAKG
2410 2420 2430 2440 2450
FSEGAASTFD YSLKDRAPFT VKNALGVPMK VQPNRNLKVM GSPEKSDIYD
2460 2470 2480 2490 2500
VGAGQHLELD YASLEPSRQG KLSILSRQES SLFTLTFVPY GYTEVASVPV
2510 2520 2530 2540 2550
ARPGRRLYNV RNPSASHSDS VLVQIDATEG NKVVTLRSPL QIKNHFSIAF
2560 2570 2580 2590 2600
IIYKFVKNVK LLERIGIARP EEEFHVPLDS YRCQLYVQPA GGLEQQYTHS
2610 2620 2630 2640 2650
STYISWKEEL HRSREVRCML QCPAVEVSFL PLIVNTVALP DELSYIGAHG
2660 2670 2680 2690 2700
EDWDPAYVIH LYPPLTLRNL LPYSLRYLLE GTAETHELAE GSSADVLHSR
2710 2720 2730 2740 2750
ISGEIIELVL VKYLGKNWNG HFRICDTLPE FFLVCFSSDT AEVMTVDLSV
2760 2770 2780 2790 2800
HVRRIGCRME LSVFSPYWLI NKTSRVLQYR SEEIHVKHPA DFRDIILFSF
2810 2820 2830 2840 2850
KKKNIFSKNK VQLKISTSAW SNGFSLDTVG SYGCVKCPAT NMEYLVGVSI
2860 2870 2880 2890 2900
KMSSFNLSRV VTLTPFCTVA NKSSLDLEVG EIASDGSIPT NKWHYVASSE
2910 2920 2930 2940 2950
CIPFWPENLS GKLCVRVVGY EGSSKPFFYN RQDNGTLLSL EDLNGGILVD
2960 2970 2980 2990 3000
INTAEHSTVI TFSDYHEGSA PALIMNHTQW DVLTYKQSGS QEELVLLPGE
3010 3020 3030 3040 3050
TRLFAWADPT GIRKLTWNYA ANFGEHDLLK DECGQFPYDA NIQIHWVSFL
3060 3070 3080 3090 3100
DGRQRVLLFT DDVALVSKAL QAEEMEQADH EVALSLHSLG LSLVNNENKQ
3110 3120 3130 3140 3150
EVSYVGITSS GVVWEMKPKQ KWKPFSQKQI MSLEQAYSKR LASQDRGWVK
3160 3170 3180 3190 3200
LDSNFEVNFD KVPMEMRLPI RCPIKRDFLS GIQVEFKQSP HQRSLRARLY
3210 3220 3230 3240 3250
WLQVDNQLPG TMFPVVFHPV APPKSIALDS EPKPFIDVSV ITRFNEYSKV
3260 3270 3280 3290 3300
LQFKYFMVLI QEMALKVDQG FLGAVISLFT PTTDPEAERK RTKLIQQDID
3310 3320 3330 3340 3350
ALNTELMESS MTDMSILSFF EHFHISPVKL HLSLSLGSGG EESDKEKQEM
3360 3370 3380 3390 3400
IAIHSVNLLL KSIGATLTDV DDLIFKLAYY EIRYQFYKRD QLMWSVVRHY
3410 3420 3430 3440 3450
SEQFLKQMYV LVLGLDVLGN PFGLIRGLSE GVEALFYEPF QGAVQGPEEF
3460 3470 3480 3490 3500
AEGLVIGVRS LVGHTVGGAA GVVSRITGSV GKGLAAITMD KEYQQKRREE
3510 3520 3530 3540 3550
MGRQPKDFGD SLARGGKGFL RGVVGGVTGI ITKPVEGAKK EGAAGFFKGI
3560 3570 3580 3590 3600
GKGLVGAVAR PTGGIIDMAS STFQGIQRVA ESTEEVSSLR PPRLIHEDGI
3610 3620 3630 3640 3650
IRPYDRQESE GSDLLENHIK KLEGEAYQFH CAVPGNKRAV LMITNRRALF
3660 3670 3680 3690 3700
IKEVEILGHM SVDWQCLFED FVCPPEVSEN LLKISVKEQG LFHKKDSANI
3710 3720 3730 3740
GHLRKIYLKD PITAKRAFDA IESAQSARQQ QKLMRQSSVK LLRPQGPS
Length:3,748
Mass (Da):420,089
Last modified:November 28, 2006 - v2
Checksum:i57F0943B89B7A087
GO
Isoform 21 Publication (identifier: Q8BX70-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3617-3623: NHIKKLE → QEMGTQE
     3624-3748: Missing.

Show »
Length:3,623
Mass (Da):405,827
Checksum:i1111D28941C7116A
GO
Isoform 31 Publication (identifier: Q8BX70-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     763-802: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:3,708
Mass (Da):415,300
Checksum:i4916DC5EAF3BAE31
GO

Sequence cautioni

The sequence BAC33451 differs from that shown. Reason: Frameshift at position 763. Curated
The sequence BAC33809 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE20465 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1759 – 17591A → S in BAC33809 (PubMed:16141072).Curated
Sequence conflicti2868 – 28681T → P in BAC98296 (PubMed:14621295).Curated
Sequence conflicti2916 – 29161R → G in BAC98296 (PubMed:14621295).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei763 – 80240Missing in isoform 3. 1 PublicationVSP_052246Add
BLAST
Alternative sequencei3617 – 36237NHIKKLE → QEMGTQE in isoform 2. 1 PublicationVSP_052247
Alternative sequencei3624 – 3748125Missing in isoform 2. 1 PublicationVSP_052248Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156799 Genomic DNA. No translation available.
AK030931 mRNA. Translation: BAE20465.1. Different initiation.
AK045749 mRNA. Translation: BAC32479.2.
AK048766 mRNA. Translation: BAC33451.1. Frameshift.
AK049557 mRNA. Translation: BAC33809.1. Different initiation.
AK129486 mRNA. Translation: BAC98296.1.
CCDSiCCDS40676.1. [Q8BX70-1]
RefSeqiNP_796158.2. NM_177184.3. [Q8BX70-1]
XP_006511289.1. XM_006511226.1. [Q8BX70-2]
UniGeneiMm.241454.

Genome annotation databases

EnsembliENSMUST00000077879; ENSMUSP00000077040; ENSMUSG00000035284. [Q8BX70-1]
GeneIDi320528.
KEGGimmu:320528.
UCSCiuc009qms.1. mouse. [Q8BX70-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156799 Genomic DNA. No translation available.
AK030931 mRNA. Translation: BAE20465.1. Different initiation.
AK045749 mRNA. Translation: BAC32479.2.
AK048766 mRNA. Translation: BAC33451.1. Frameshift.
AK049557 mRNA. Translation: BAC33809.1. Different initiation.
AK129486 mRNA. Translation: BAC98296.1.
CCDSiCCDS40676.1. [Q8BX70-1]
RefSeqiNP_796158.2. NM_177184.3. [Q8BX70-1]
XP_006511289.1. XM_006511226.1. [Q8BX70-2]
UniGeneiMm.241454.

3D structure databases

ProteinModelPortaliQ8BX70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236091. 2 interactions.
STRINGi10090.ENSMUSP00000077040.

PTM databases

iPTMnetiQ8BX70.
PhosphoSiteiQ8BX70.
SwissPalmiQ8BX70.

Proteomic databases

EPDiQ8BX70.
MaxQBiQ8BX70.
PaxDbiQ8BX70.
PeptideAtlasiQ8BX70.
PRIDEiQ8BX70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077879; ENSMUSP00000077040; ENSMUSG00000035284. [Q8BX70-1]
GeneIDi320528.
KEGGimmu:320528.
UCSCiuc009qms.1. mouse. [Q8BX70-1]

Organism-specific databases

CTDi54832.
MGIiMGI:2444207. Vps13c.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1809. Eukaryota.
COG5043. LUCA.
GeneTreeiENSGT00410000025397.
HOGENOMiHOG000218634.
HOVERGENiHBG079736.
InParanoidiQ8BX70.
KOiK19525.
OMAiTHIIETR.
OrthoDBiEOG091G001Z.
PhylomeDBiQ8BX70.
TreeFamiTF300316.

Miscellaneous databases

ChiTaRSiVps13c. mouse.
PROiQ8BX70.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035284.
CleanExiMM_VPS13C.
ExpressionAtlasiQ8BX70. baseline and differential.

Family and domain databases

InterProiIPR015412. Autophagy-rel_C.
IPR009543. SHR-BD.
IPR026847. VPS13.
IPR031645. VPS13_C.
IPR031642. VPS13_mid_rpt.
IPR026854. VPS13_N.
IPR031646. VPS13_N2.
[Graphical view]
PANTHERiPTHR16166. PTHR16166. 3 hits.
PfamiPF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
PF06650. SHR-BD. 1 hit.
PF16908. VPS13. 1 hit.
PF16909. VPS13_C. 1 hit.
PF16910. VPS13_mid_rpt. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVP13C_MOUSE
AccessioniPrimary (citable) accession number: Q8BX70
Secondary accession number(s): Q3V3W5
, Q6ZPE1, Q8BLB1, Q8BQI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.