Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zeta-sarcoglycan

Gene

Sgcz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Zeta-sarcoglycan
Short name:
Zeta-SG
Alternative name(s):
ZSG1
Gene namesi
Name:Sgcz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2388820. Sgcz.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50CytoplasmicSequence analysisAdd BLAST50
Transmembranei51 – 71Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini72 – 311ExtracellularSequence analysisAdd BLAST240

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
  • sarcoglycan complex Source: MGI
  • sarcolemma Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000316791 – 311Zeta-sarcoglycanAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi285 ↔ 301Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BX51.
PRIDEiQ8BX51.

PTM databases

PhosphoSitePlusiQ8BX51.

Expressioni

Tissue specificityi

Expressed in the heart, skeletal muscle and arterial vascular smooth muscle.

Gene expression databases

BgeeiENSMUSG00000039539.
CleanExiMM_SGCZ.
ExpressionAtlasiQ8BX51. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi232651. 2 interactors.
STRINGi10090.ENSMUSP00000113912.

Structurei

3D structure databases

ProteinModelPortaliQ8BX51.
SMRiQ8BX51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3950. Eukaryota.
ENOG4111GCH. LUCA.
GeneTreeiENSGT00390000017950.
HOGENOMiHOG000007853.
HOVERGENiHBG008669.
InParanoidiQ8BX51.
OMAiNSRQTVY.
OrthoDBiEOG091G11VY.
PhylomeDBiQ8BX51.
TreeFamiTF313538.

Family and domain databases

InterProiIPR006875. Sarcoglycan.
IPR027662. Sgcz.
[Graphical view]
PANTHERiPTHR12939:SF5. PTHR12939:SF5. 1 hit.
PfamiPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q8BX51-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRSTDLDIQ ELKMTREQYI LATQQNNLPR PENAQLYPVG IYGWRKRCLY
60 70 80 90 100
FFVLLLLVTM IVNLAMTIWI LKVMNFTVDG MGNLRVTKKG IRLEGISEFL
110 120 130 140 150
LPLYVKEIHS RKDSPLVLQS DRNVTVNARN HMGQLTGQLT VGAEAVEAQC
160 170 180 190 200
KRFEVRASED GRVLFSADED EITIGAEKLK VTGTEGAVFG HSVETPHIRA
210 220 230 240 250
EPSQDLRLES PTRSLKMEAP RGVQVSAAAG DFKATCRKEL HLQSTEGEIF
260 270 280 290 300
LNADSIRLGN LPIGSFSSST SSSNSRQTVY ELCVCPNGKL YLSPAGVGST
310
CQSSSSICLW N
Length:311
Mass (Da):34,461
Last modified:March 1, 2003 - v1
Checksum:i1F85C0B347810E2B
GO
Isoform 2 (identifier: Q8BX51-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:298
Mass (Da):32,916
Checksum:i22E72618F0472BB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti274N → D in AAM23275 (PubMed:12189167).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188851 – 13Missing in isoform 2. 3 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY095374 mRNA. Translation: AAM23275.1.
AY250713 mRNA. Translation: AAP76378.1.
AK048960 mRNA. Translation: BAC33500.1.
AK136779 mRNA. Translation: BAE23127.1.
CCDSiCCDS22251.2. [Q8BX51-1]
RefSeqiNP_665840.2. NM_145841.2. [Q8BX51-1]
XP_006509183.1. XM_006509120.3. [Q8BX51-1]
XP_011240440.1. XM_011242138.1. [Q8BX51-2]
UniGeneiMm.210388.

Genome annotation databases

EnsembliENSMUST00000118896; ENSMUSP00000113912; ENSMUSG00000039539. [Q8BX51-1]
GeneIDi244431.
KEGGimmu:244431.
UCSCiuc009lme.2. mouse. [Q8BX51-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY095374 mRNA. Translation: AAM23275.1.
AY250713 mRNA. Translation: AAP76378.1.
AK048960 mRNA. Translation: BAC33500.1.
AK136779 mRNA. Translation: BAE23127.1.
CCDSiCCDS22251.2. [Q8BX51-1]
RefSeqiNP_665840.2. NM_145841.2. [Q8BX51-1]
XP_006509183.1. XM_006509120.3. [Q8BX51-1]
XP_011240440.1. XM_011242138.1. [Q8BX51-2]
UniGeneiMm.210388.

3D structure databases

ProteinModelPortaliQ8BX51.
SMRiQ8BX51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232651. 2 interactors.
STRINGi10090.ENSMUSP00000113912.

PTM databases

PhosphoSitePlusiQ8BX51.

Proteomic databases

PaxDbiQ8BX51.
PRIDEiQ8BX51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118896; ENSMUSP00000113912; ENSMUSG00000039539. [Q8BX51-1]
GeneIDi244431.
KEGGimmu:244431.
UCSCiuc009lme.2. mouse. [Q8BX51-1]

Organism-specific databases

CTDi137868.
MGIiMGI:2388820. Sgcz.

Phylogenomic databases

eggNOGiKOG3950. Eukaryota.
ENOG4111GCH. LUCA.
GeneTreeiENSGT00390000017950.
HOGENOMiHOG000007853.
HOVERGENiHBG008669.
InParanoidiQ8BX51.
OMAiNSRQTVY.
OrthoDBiEOG091G11VY.
PhylomeDBiQ8BX51.
TreeFamiTF313538.

Miscellaneous databases

ChiTaRSiSgcz. mouse.
PROiQ8BX51.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039539.
CleanExiMM_SGCZ.
ExpressionAtlasiQ8BX51. baseline and differential.

Family and domain databases

InterProiIPR006875. Sarcoglycan.
IPR027662. Sgcz.
[Graphical view]
PANTHERiPTHR12939:SF5. PTHR12939:SF5. 1 hit.
PfamiPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGCZ_MOUSE
AccessioniPrimary (citable) accession number: Q8BX51
Secondary accession number(s): Q3UVZ2, Q8K1E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.