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Q8BX51

- SGCZ_MOUSE

UniProt

Q8BX51 - SGCZ_MOUSE

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Protein

Zeta-sarcoglycan

Gene
Sgcz
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. membrane organization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Zeta-sarcoglycan
Short name:
Zeta-SG
Alternative name(s):
ZSG1
Gene namesi
Name:Sgcz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2388820. Sgcz.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei51 – 7121Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini72 – 311240Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: MGI
  5. sarcoglycan complex Source: MGI
  6. sarcolemma Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Zeta-sarcoglycanPRO_0000031679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi123 – 1231N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi285 ↔ 301 Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8BX51.

PTM databases

PhosphoSiteiQ8BX51.

Expressioni

Tissue specificityi

Expressed in the heart, skeletal muscle and arterial vascular smooth muscle.

Gene expression databases

BgeeiQ8BX51.
CleanExiMM_SGCZ.
GenevestigatoriQ8BX51.

Interactioni

Protein-protein interaction databases

BioGridi232651. 2 interactions.
STRINGi10090.ENSMUSP00000113912.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG318936.
GeneTreeiENSGT00390000017950.
HOGENOMiHOG000007853.
HOVERGENiHBG008669.
InParanoidiQ8BX51.
OMAiCLYFFIL.
PhylomeDBiQ8BX51.
TreeFamiTF313538.

Family and domain databases

InterProiIPR006875. Sarcoglycan.
IPR027662. Sgcz.
[Graphical view]
PANTHERiPTHR12939:SF5. PTHR12939:SF5. 1 hit.
PfamiPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform 1 (identifier: Q8BX51-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDRSTDLDIQ ELKMTREQYI LATQQNNLPR PENAQLYPVG IYGWRKRCLY    50
FFVLLLLVTM IVNLAMTIWI LKVMNFTVDG MGNLRVTKKG IRLEGISEFL 100
LPLYVKEIHS RKDSPLVLQS DRNVTVNARN HMGQLTGQLT VGAEAVEAQC 150
KRFEVRASED GRVLFSADED EITIGAEKLK VTGTEGAVFG HSVETPHIRA 200
EPSQDLRLES PTRSLKMEAP RGVQVSAAAG DFKATCRKEL HLQSTEGEIF 250
LNADSIRLGN LPIGSFSSST SSSNSRQTVY ELCVCPNGKL YLSPAGVGST 300
CQSSSSICLW N 311
Length:311
Mass (Da):34,461
Last modified:March 1, 2003 - v1
Checksum:i1F85C0B347810E2B
GO
Isoform 2 (identifier: Q8BX51-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:298
Mass (Da):32,916
Checksum:i22E72618F0472BB3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313Missing in isoform 2. VSP_018885Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti274 – 2741N → D in AAM23275. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY095374 mRNA. Translation: AAM23275.1.
AY250713 mRNA. Translation: AAP76378.1.
AK048960 mRNA. Translation: BAC33500.1.
AK136779 mRNA. Translation: BAE23127.1.
CCDSiCCDS22251.2. [Q8BX51-1]
RefSeqiNP_665840.2. NM_145841.2. [Q8BX51-1]
XP_006509183.1. XM_006509120.1. [Q8BX51-1]
XP_006509184.1. XM_006509121.1. [Q8BX51-2]
UniGeneiMm.210388.

Genome annotation databases

EnsembliENSMUST00000118896; ENSMUSP00000113912; ENSMUSG00000039539. [Q8BX51-1]
GeneIDi244431.
KEGGimmu:244431.
UCSCiuc009lme.2. mouse. [Q8BX51-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY095374 mRNA. Translation: AAM23275.1 .
AY250713 mRNA. Translation: AAP76378.1 .
AK048960 mRNA. Translation: BAC33500.1 .
AK136779 mRNA. Translation: BAE23127.1 .
CCDSi CCDS22251.2. [Q8BX51-1 ]
RefSeqi NP_665840.2. NM_145841.2. [Q8BX51-1 ]
XP_006509183.1. XM_006509120.1. [Q8BX51-1 ]
XP_006509184.1. XM_006509121.1. [Q8BX51-2 ]
UniGenei Mm.210388.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 232651. 2 interactions.
STRINGi 10090.ENSMUSP00000113912.

PTM databases

PhosphoSitei Q8BX51.

Proteomic databases

PRIDEi Q8BX51.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000118896 ; ENSMUSP00000113912 ; ENSMUSG00000039539 . [Q8BX51-1 ]
GeneIDi 244431.
KEGGi mmu:244431.
UCSCi uc009lme.2. mouse. [Q8BX51-1 ]

Organism-specific databases

CTDi 137868.
MGIi MGI:2388820. Sgcz.

Phylogenomic databases

eggNOGi NOG318936.
GeneTreei ENSGT00390000017950.
HOGENOMi HOG000007853.
HOVERGENi HBG008669.
InParanoidi Q8BX51.
OMAi CLYFFIL.
PhylomeDBi Q8BX51.
TreeFami TF313538.

Miscellaneous databases

ChiTaRSi SGCZ. mouse.
NextBioi 386281.
PROi Q8BX51.
SOURCEi Search...

Gene expression databases

Bgeei Q8BX51.
CleanExi MM_SGCZ.
Genevestigatori Q8BX51.

Family and domain databases

InterProi IPR006875. Sarcoglycan.
IPR027662. Sgcz.
[Graphical view ]
PANTHERi PTHR12939:SF5. PTHR12939:SF5. 1 hit.
Pfami PF04790. Sarcoglycan_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy."
    Wheeler M.T., Zarnegar S., McNally E.M.
    Hum. Mol. Genet. 11:2147-2154(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE INITIATION.
    Strain: C57BL/6.
    Tissue: Heart and Skeletal muscle.
  2. "Cloning and characterization of zeta-sarcoglycan: new insights into the structure of the sarcoglycan complex."
    Svensson R.U., Groh S.C., Campbell K.P.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Diencephalon.

Entry informationi

Entry nameiSGCZ_MOUSE
AccessioniPrimary (citable) accession number: Q8BX51
Secondary accession number(s): Q3UVZ2, Q8K1E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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