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Q8BX51 (SGCZ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zeta-sarcoglycan

Short name=Zeta-SG
Alternative name(s):
ZSG1
Gene names
Name:Sgcz
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability.

Subcellular location

Cell membranesarcolemma; Single-pass type II membrane protein By similarity. Cytoplasmcytoskeleton By similarity.

Tissue specificity

Expressed in the heart, skeletal muscle and arterial vascular smooth muscle.

Sequence similarities

Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform 1 (identifier: Q8BX51-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8BX51-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Zeta-sarcoglycan
PRO_0000031679

Regions

Topological domain1 – 5050Cytoplasmic Potential
Transmembrane51 – 7121Helical; Signal-anchor for type II membrane protein; Potential
Topological domain72 – 311240Extracellular Potential

Amino acid modifications

Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation1231N-linked (GlcNAc...) Potential
Disulfide bond285 ↔ 301 Potential

Natural variations

Alternative sequence1 – 1313Missing in isoform 2.
VSP_018885

Experimental info

Sequence conflict2741N → D in AAM23275. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 1F85C0B347810E2B

FASTA31134,461
        10         20         30         40         50         60 
MDRSTDLDIQ ELKMTREQYI LATQQNNLPR PENAQLYPVG IYGWRKRCLY FFVLLLLVTM 

        70         80         90        100        110        120 
IVNLAMTIWI LKVMNFTVDG MGNLRVTKKG IRLEGISEFL LPLYVKEIHS RKDSPLVLQS 

       130        140        150        160        170        180 
DRNVTVNARN HMGQLTGQLT VGAEAVEAQC KRFEVRASED GRVLFSADED EITIGAEKLK 

       190        200        210        220        230        240 
VTGTEGAVFG HSVETPHIRA EPSQDLRLES PTRSLKMEAP RGVQVSAAAG DFKATCRKEL 

       250        260        270        280        290        300 
HLQSTEGEIF LNADSIRLGN LPIGSFSSST SSSNSRQTVY ELCVCPNGKL YLSPAGVGST 

       310 
CQSSSSICLW N 

« Hide

Isoform 2 [UniParc].

Checksum: 22E72618F0472BB3
Show »

FASTA29832,916

References

« Hide 'large scale' references
[1]"Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy."
Wheeler M.T., Zarnegar S., McNally E.M.
Hum. Mol. Genet. 11:2147-2154(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE INITIATION.
Strain: C57BL/6.
Tissue: Heart and Skeletal muscle.
[2]"Cloning and characterization of zeta-sarcoglycan: new insights into the structure of the sarcoglycan complex."
Svensson R.U., Groh S.C., Campbell K.P.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: C57BL/6.
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Cerebellum and Diencephalon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY095374 mRNA. Translation: AAM23275.1.
AY250713 mRNA. Translation: AAP76378.1.
AK048960 mRNA. Translation: BAC33500.1.
AK136779 mRNA. Translation: BAE23127.1.
CCDSCCDS22251.2. [Q8BX51-1]
RefSeqNP_665840.2. NM_145841.2. [Q8BX51-1]
XP_006509183.1. XM_006509120.1. [Q8BX51-1]
XP_006509184.1. XM_006509121.1. [Q8BX51-2]
UniGeneMm.210388.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid232651. 2 interactions.
STRING10090.ENSMUSP00000113912.

PTM databases

PhosphoSiteQ8BX51.

Proteomic databases

PRIDEQ8BX51.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000118896; ENSMUSP00000113912; ENSMUSG00000039539. [Q8BX51-1]
GeneID244431.
KEGGmmu:244431.
UCSCuc009lme.2. mouse. [Q8BX51-1]

Organism-specific databases

CTD137868.
MGIMGI:2388820. Sgcz.

Phylogenomic databases

eggNOGNOG318936.
GeneTreeENSGT00390000017950.
HOGENOMHOG000007853.
HOVERGENHBG008669.
InParanoidQ8BX51.
OMACLYFFIL.
PhylomeDBQ8BX51.
TreeFamTF313538.

Gene expression databases

BgeeQ8BX51.
CleanExMM_SGCZ.
GenevestigatorQ8BX51.

Family and domain databases

InterProIPR006875. Sarcoglycan.
IPR027662. Sgcz.
[Graphical view]
PANTHERPTHR12939:SF5. PTHR12939:SF5. 1 hit.
PfamPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSGCZ. mouse.
NextBio386281.
PROQ8BX51.
SOURCESearch...

Entry information

Entry nameSGCZ_MOUSE
AccessionPrimary (citable) accession number: Q8BX51
Secondary accession number(s): Q3UVZ2, Q8K1E7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot