Q8BX51 (SGCZ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zeta-sarcoglycan
Short name=Zeta-SG

Alternative name(s):
ZSG1

Gene names

Name:

Sgcz

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability.
Subcellular location	Cell membrane › sarcolemma; Single-pass type II membrane protein By similarity. Cytoplasm › cytoskeleton By similarity.
Tissue specificity	Expressed in the heart, skeletal muscle and arterial vascular smooth muscle.
Sequence similarities	Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane
Coding sequence diversity	Alternative initiation
Domain	Signal-anchor Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular membrane organization Traceable author statement Ref.1. Source: MGI cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW sarcoglycan complex Inferred from direct assay Ref.1. Source: MGI sarcolemma Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]

Isoform 1 (identifier: Q8BX51-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8BX51-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Zeta-sarcoglycan		PRO_0000031679
Regions
	Topological domain	1 – 50	50	Cytoplasmic Potential
	Transmembrane	51 – 71	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	72 – 311	240	Extracellular Potential
Amino acid modifications
	Glycosylation	75	1	N-linked (GlcNAc...) Potential
	Glycosylation	123	1	N-linked (GlcNAc...) Potential
	Disulfide bond	285 ↔ 301		Potential
Natural variations
	Alternative sequence	1 – 13	13	Missing in isoform 2.		VSP_018885
Experimental info
	Sequence conflict	274	1	N → D in AAM23275. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 1F85C0B347810E2B	FASTA	311	34,461
	10 20 30 40 50 60 MDRSTDLDIQ ELKMTREQYI LATQQNNLPR PENAQLYPVG IYGWRKRCLY FFVLLLLVTM 70 80 90 100 110 120 IVNLAMTIWI LKVMNFTVDG MGNLRVTKKG IRLEGISEFL LPLYVKEIHS RKDSPLVLQS 130 140 150 160 170 180 DRNVTVNARN HMGQLTGQLT VGAEAVEAQC KRFEVRASED GRVLFSADED EITIGAEKLK 190 200 210 220 230 240 VTGTEGAVFG HSVETPHIRA EPSQDLRLES PTRSLKMEAP RGVQVSAAAG DFKATCRKEL 250 260 270 280 290 300 HLQSTEGEIF LNADSIRLGN LPIGSFSSST SSSNSRQTVY ELCVCPNGKL YLSPAGVGST 310 CQSSSSICLW N
	Isoform 2 [UniParc]. Checksum: 22E72618F0472BB3	FASTA	298	32,916
	10 20 30 40 50 60 MTREQYILAT QQNNLPRPEN AQLYPVGIYG WRKRCLYFFV LLLLVTMIVN LAMTIWILKV 70 80 90 100 110 120 MNFTVDGMGN LRVTKKGIRL EGISEFLLPL YVKEIHSRKD SPLVLQSDRN VTVNARNHMG 130 140 150 160 170 180 QLTGQLTVGA EAVEAQCKRF EVRASEDGRV LFSADEDEIT IGAEKLKVTG TEGAVFGHSV 190 200 210 220 230 240 ETPHIRAEPS QDLRLESPTR SLKMEAPRGV QVSAAAGDFK ATCRKELHLQ STEGEIFLNA 250 260 270 280 290 DSIRLGNLPI GSFSSSTSSS NSRQTVYELC VCPNGKLYLS PAGVGSTCQS SSSICLWN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy." Wheeler M.T., Zarnegar S., McNally E.M. Hum. Mol. Genet. 11:2147-2154(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE INITIATION. Strain: C57BL/6. Tissue: Heart and Skeletal muscle.
[2]	"Cloning and characterization of zeta-sarcoglycan: new insights into the structure of the sarcoglycan complex." Svensson R.U., Groh S.C., Campbell K.P. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Strain: C57BL/6. Tissue: Brain.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J. Tissue: Cerebellum and Diencephalon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY095374 mRNA. Translation: AAM23275.1. AY250713 mRNA. Translation: AAP76378.1. AK048960 mRNA. Translation: BAC33500.1. AK136779 mRNA. Translation: BAE23127.1.
IPI	IPI00226479. IPI00759995.
RefSeq	NP_665840.2. NM_145841.2.
UniGene	Mm.210388.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000113912.
PTM databases
PhosphoSite	Q8BX51.
Proteomic databases
PRIDE	Q8BX51.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000118896; ENSMUSP00000113912; ENSMUSG00000039539.
GeneID	244431.
KEGG	mmu:244431.
UCSC	uc009lme.2. mouse.
Organism-specific databases
CTD	137868.
MGI	MGI:2388820. Sgcz.
Phylogenomic databases
eggNOG	NOG318936.
GeneTree	ENSGT00390000017950.
HOGENOM	HOG000007853.
HOVERGEN	HBG008669.
InParanoid	Q8BX51.
OMA	NSRQTVY.
Gene expression databases
ArrayExpress	Q8BX51.
Bgee	Q8BX51.
CleanEx	MM_SGCZ.
Genevestigator	Q8BX51.
Family and domain databases
InterPro	IPR006875. Sarcoglycan. [Graphical view]
Pfam	PF04790. Sarcoglycan_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SGCZ. mouse.
NextBio	386281.
SOURCE	Search...

Entry information

Entry name

SGCZ_MOUSE

Accession

Primary (citable) accession number: Q8BX51
Secondary accession number(s): Q3UVZ2, Q8K1E7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program