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Q8BX51

- SGCZ_MOUSE

UniProt

Q8BX51 - SGCZ_MOUSE

Protein

Zeta-sarcoglycan

Gene

Sgcz

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability.

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. membrane organization Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zeta-sarcoglycan
    Short name:
    Zeta-SG
    Alternative name(s):
    ZSG1
    Gene namesi
    Name:Sgcz
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2388820. Sgcz.

    Subcellular locationi

    Cell membranesarcolemma By similarity; Single-pass type II membrane protein By similarity. Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: MGI
    5. sarcoglycan complex Source: MGI
    6. sarcolemma Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Zeta-sarcoglycanPRO_0000031679Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi285 ↔ 301Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8BX51.

    PTM databases

    PhosphoSiteiQ8BX51.

    Expressioni

    Tissue specificityi

    Expressed in the heart, skeletal muscle and arterial vascular smooth muscle.

    Gene expression databases

    BgeeiQ8BX51.
    CleanExiMM_SGCZ.
    GenevestigatoriQ8BX51.

    Interactioni

    Protein-protein interaction databases

    BioGridi232651. 2 interactions.
    STRINGi10090.ENSMUSP00000113912.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5050CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini72 – 311240ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei51 – 7121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG318936.
    GeneTreeiENSGT00390000017950.
    HOGENOMiHOG000007853.
    HOVERGENiHBG008669.
    InParanoidiQ8BX51.
    OMAiCLYFFIL.
    PhylomeDBiQ8BX51.
    TreeFamiTF313538.

    Family and domain databases

    InterProiIPR006875. Sarcoglycan.
    IPR027662. Sgcz.
    [Graphical view]
    PANTHERiPTHR12939:SF5. PTHR12939:SF5. 1 hit.
    PfamiPF04790. Sarcoglycan_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform 1 (identifier: Q8BX51-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDRSTDLDIQ ELKMTREQYI LATQQNNLPR PENAQLYPVG IYGWRKRCLY    50
    FFVLLLLVTM IVNLAMTIWI LKVMNFTVDG MGNLRVTKKG IRLEGISEFL 100
    LPLYVKEIHS RKDSPLVLQS DRNVTVNARN HMGQLTGQLT VGAEAVEAQC 150
    KRFEVRASED GRVLFSADED EITIGAEKLK VTGTEGAVFG HSVETPHIRA 200
    EPSQDLRLES PTRSLKMEAP RGVQVSAAAG DFKATCRKEL HLQSTEGEIF 250
    LNADSIRLGN LPIGSFSSST SSSNSRQTVY ELCVCPNGKL YLSPAGVGST 300
    CQSSSSICLW N 311
    Length:311
    Mass (Da):34,461
    Last modified:March 1, 2003 - v1
    Checksum:i1F85C0B347810E2B
    GO
    Isoform 2 (identifier: Q8BX51-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: Missing.

    Show »
    Length:298
    Mass (Da):32,916
    Checksum:i22E72618F0472BB3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti274 – 2741N → D in AAM23275. (PubMed:12189167)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1313Missing in isoform 2. 3 PublicationsVSP_018885Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY095374 mRNA. Translation: AAM23275.1.
    AY250713 mRNA. Translation: AAP76378.1.
    AK048960 mRNA. Translation: BAC33500.1.
    AK136779 mRNA. Translation: BAE23127.1.
    CCDSiCCDS22251.2. [Q8BX51-1]
    RefSeqiNP_665840.2. NM_145841.2. [Q8BX51-1]
    XP_006509183.1. XM_006509120.1. [Q8BX51-1]
    XP_006509184.1. XM_006509121.1. [Q8BX51-2]
    UniGeneiMm.210388.

    Genome annotation databases

    EnsembliENSMUST00000118896; ENSMUSP00000113912; ENSMUSG00000039539. [Q8BX51-1]
    GeneIDi244431.
    KEGGimmu:244431.
    UCSCiuc009lme.2. mouse. [Q8BX51-1]

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY095374 mRNA. Translation: AAM23275.1 .
    AY250713 mRNA. Translation: AAP76378.1 .
    AK048960 mRNA. Translation: BAC33500.1 .
    AK136779 mRNA. Translation: BAE23127.1 .
    CCDSi CCDS22251.2. [Q8BX51-1 ]
    RefSeqi NP_665840.2. NM_145841.2. [Q8BX51-1 ]
    XP_006509183.1. XM_006509120.1. [Q8BX51-1 ]
    XP_006509184.1. XM_006509121.1. [Q8BX51-2 ]
    UniGenei Mm.210388.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 232651. 2 interactions.
    STRINGi 10090.ENSMUSP00000113912.

    PTM databases

    PhosphoSitei Q8BX51.

    Proteomic databases

    PRIDEi Q8BX51.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000118896 ; ENSMUSP00000113912 ; ENSMUSG00000039539 . [Q8BX51-1 ]
    GeneIDi 244431.
    KEGGi mmu:244431.
    UCSCi uc009lme.2. mouse. [Q8BX51-1 ]

    Organism-specific databases

    CTDi 137868.
    MGIi MGI:2388820. Sgcz.

    Phylogenomic databases

    eggNOGi NOG318936.
    GeneTreei ENSGT00390000017950.
    HOGENOMi HOG000007853.
    HOVERGENi HBG008669.
    InParanoidi Q8BX51.
    OMAi CLYFFIL.
    PhylomeDBi Q8BX51.
    TreeFami TF313538.

    Miscellaneous databases

    ChiTaRSi SGCZ. mouse.
    NextBioi 386281.
    PROi Q8BX51.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BX51.
    CleanExi MM_SGCZ.
    Genevestigatori Q8BX51.

    Family and domain databases

    InterProi IPR006875. Sarcoglycan.
    IPR027662. Sgcz.
    [Graphical view ]
    PANTHERi PTHR12939:SF5. PTHR12939:SF5. 1 hit.
    Pfami PF04790. Sarcoglycan_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy."
      Wheeler M.T., Zarnegar S., McNally E.M.
      Hum. Mol. Genet. 11:2147-2154(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE INITIATION.
      Strain: C57BL/6.
      Tissue: Heart and Skeletal muscle.
    2. "Cloning and characterization of zeta-sarcoglycan: new insights into the structure of the sarcoglycan complex."
      Svensson R.U., Groh S.C., Campbell K.P.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Cerebellum and Diencephalon.

    Entry informationi

    Entry nameiSGCZ_MOUSE
    AccessioniPrimary (citable) accession number: Q8BX51
    Secondary accession number(s): Q3UVZ2, Q8K1E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3