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Protein

SKI family transcriptional corepressor 1

Gene

Skor1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1.By similarity1 Publication

GO - Molecular functioni

  • transcription corepressor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SKI family transcriptional corepressor 1
Alternative name(s):
Fussel-15 homolog
Ladybird homeobox corepressor 1
Lbx1 corepressor 1
Transcriptional corepressor Corl1
Gene namesi
Name:Skor1
Synonyms:Corl1Imported, Lbxcor1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2443473. Skor1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • dendrite Source: Ensembl
  • neuronal cell body Source: Ensembl
  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 964964SKI family transcriptional corepressor 1PRO_0000129391Add
BLAST

Proteomic databases

MaxQBiQ8BX46.
PaxDbiQ8BX46.
PRIDEiQ8BX46.

PTM databases

PhosphoSiteiQ8BX46.

Expressioni

Tissue specificityi

Expressed in brain with higher levels in embryo than adult. Expressed by migratory precursors of Purkinje cells in the postnatal brain. Also expressed in adult testis.2 Publications

Developmental stagei

Expressed in the developing cerebellum, pons, medulla oblongata and spinal cord. In embryonic brain, expressed in a subset of postmitotic neurons generated posterior to the midbrain-hindbrain border. In the developing spinal cord, selectively expressed in dorsal horn interneurons.2 Publications

Gene expression databases

BgeeiQ8BX46.
ExpressionAtlasiQ8BX46. baseline and differential.
GenevisibleiQ8BX46. MM.

Interactioni

Subunit structurei

Interacts with SMAD1, SMAD2 and SMAD3 (By similarity). Interacts with LBX1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Lbx1P529552EBI-604451,EBI-604594

Protein-protein interaction databases

BioGridi228910. 5 interactions.
IntActiQ8BX46. 5 interactions.
STRINGi10090.ENSMUSP00000055037.

Structurei

3D structure databases

ProteinModelPortaliQ8BX46.
SMRiQ8BX46. Positions 79-167, 183-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili853 – 92169Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SKI family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEFD. Eukaryota.
ENOG410XPY0. LUCA.
GeneTreeiENSGT00530000063040.
HOVERGENiHBG081893.
InParanoidiQ8BX46.
OMAiNRFPDEE.
OrthoDBiEOG7R56SW.
PhylomeDBiQ8BX46.
TreeFamiTF324133.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028762. SKOR1.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 3 hits.
PTHR10005:SF8. PTHR10005:SF8. 3 hits.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1Curated (identifier: Q8BX46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLCGLGQV TLRLWVPLPF QSENRIGFLA AGAFLRSGGM EALTTQLGPG
60 70 80 90 100
REGSSSPNSK QELQPYSGSS ALKPNQVGET SLYGVPIVSL VIDGQERLCL
110 120 130 140 150
AQISNTLLKN YSYNEIHNRR VALGITCVQC TPVQLEILRR AGAMPISSRR
160 170 180 190 200
CGMITKREAE RLCKSFLGEH KPPKLPENFA FDVVHECAWG SRGSFIPARY
210 220 230 240 250
NSSRAKCIKC GYCSMYFSPN KFIFHSHRTP DAKYTQPDAA NFNSWRRHLK
260 270 280 290 300
LSDKSATDEL SHAWEDVKAM FNGGTRKRTF SLQGGGGGGA NSGSGGAGKG
310 320 330 340 350
GAGGGGGPGC GSEMAPGPPP HKSLRCGEDE AAGPPGPPPP HPQRALGLAA
360 370 380 390 400
AASGPAGPGG PGGSAGVRSY PVIPVPSKGF GLLQKLPPPL FPHPYGFPTA
410 420 430 440 450
FGLCPKKDDP VLVAGEPKGG PGTGSSGGAG TAAGAGGPGA GHLPPGAGPG
460 470 480 490 500
PGGGTMFWGH QPSGAAKDAA AVAAAAAAAT VYPTFPMFWP AAGSLPVPPY
510 520 530 540 550
PAAQSQAKAV AAAVAAAAAA AAAAAGGGGP ESLDGAEPAK EGSLGTEERC
560 570 580 590 600
PSALSRGPLD EDGADEALPP SLGPLPPPPP PPARKSSYVS AFRPVVKDAE
610 620 630 640 650
SIAKLYGSAR EAYGSGPARG PVPGTGTGGG YVSPDFLSEG SSSYHSASPD
660 670 680 690 700
VDTADEPEVD VESNRFPDEE GAQDDTEPRA PSTGGGPDGD QPAGPPSVTS
710 720 730 740 750
SGADGPTDSA DGDSPRPRRR LGPPPAIRSA FGDLVADDVV RRTERSPPSG
760 770 780 790 800
GYELREPCGP LGGPGAAKVY APERDEHVKS TAVAAALGPA ASYLCTPETH
810 820 830 840 850
EPDKEDNHST TADDLETRKS FSDQRSVSQP SPANTDRGED GLTLDVTGTQ
860 870 880 890 900
LVEKDIENLA REELQKLLLE QMELRKKLER EFQSLKDNFQ DQMKRELAYR
910 920 930 940 950
EEMVQQLQIV RDTLCNELDQ ERKARYAIQQ KLKEAHDALH HFSCKMLTPR
960
HCTGNCSFKP PLLP
Note: No experimental confirmation available.Curated
Length:964
Mass (Da):100,245
Last modified:June 13, 2006 - v2
Checksum:iB1ECDB458D789E2C
GO
Isoform 21 Publication (identifier: Q8BX46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-36: Missing.

Show »
Length:936
Mass (Da):97,062
Checksum:i32431031D6A6A22D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti934 – 9341Missing in BAE22308 (PubMed:16141072).Curated
Sequence conflicti961 – 9611P → Q in BAC33520 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei9 – 3628Missing in isoform 2. 3 PublicationsVSP_014179Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB185113 mRNA. Translation: BAD69568.1.
AK049035 mRNA. Translation: BAC33520.1.
AK134840 mRNA. Translation: BAE22308.1.
BC138063 mRNA. Translation: AAI38064.1.
CCDSiCCDS23268.1. [Q8BX46-1]
CCDS52829.1. [Q8BX46-2]
RefSeqiNP_001157227.1. NM_001163755.1. [Q8BX46-2]
NP_001157229.1. NM_001163757.1.
NP_766034.2. NM_172446.3. [Q8BX46-1]
UniGeneiMm.36349.
Mm.447200.

Genome annotation databases

EnsembliENSMUST00000055281; ENSMUSP00000055037; ENSMUSG00000022245. [Q8BX46-1]
ENSMUST00000119146; ENSMUSP00000113924; ENSMUSG00000022245. [Q8BX46-2]
GeneIDi207667.
KEGGimmu:207667.
UCSCiuc009qat.2. mouse. [Q8BX46-1]
uc009qau.2. mouse. [Q8BX46-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB185113 mRNA. Translation: BAD69568.1.
AK049035 mRNA. Translation: BAC33520.1.
AK134840 mRNA. Translation: BAE22308.1.
BC138063 mRNA. Translation: AAI38064.1.
CCDSiCCDS23268.1. [Q8BX46-1]
CCDS52829.1. [Q8BX46-2]
RefSeqiNP_001157227.1. NM_001163755.1. [Q8BX46-2]
NP_001157229.1. NM_001163757.1.
NP_766034.2. NM_172446.3. [Q8BX46-1]
UniGeneiMm.36349.
Mm.447200.

3D structure databases

ProteinModelPortaliQ8BX46.
SMRiQ8BX46. Positions 79-167, 183-272.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228910. 5 interactions.
IntActiQ8BX46. 5 interactions.
STRINGi10090.ENSMUSP00000055037.

PTM databases

PhosphoSiteiQ8BX46.

Proteomic databases

MaxQBiQ8BX46.
PaxDbiQ8BX46.
PRIDEiQ8BX46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055281; ENSMUSP00000055037; ENSMUSG00000022245. [Q8BX46-1]
ENSMUST00000119146; ENSMUSP00000113924; ENSMUSG00000022245. [Q8BX46-2]
GeneIDi207667.
KEGGimmu:207667.
UCSCiuc009qat.2. mouse. [Q8BX46-1]
uc009qau.2. mouse. [Q8BX46-2]

Organism-specific databases

CTDi390598.
MGIiMGI:2443473. Skor1.

Phylogenomic databases

eggNOGiENOG410IEFD. Eukaryota.
ENOG410XPY0. LUCA.
GeneTreeiENSGT00530000063040.
HOVERGENiHBG081893.
InParanoidiQ8BX46.
OMAiNRFPDEE.
OrthoDBiEOG7R56SW.
PhylomeDBiQ8BX46.
TreeFamiTF324133.

Miscellaneous databases

NextBioi371991.
PROiQ8BX46.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BX46.
ExpressionAtlasiQ8BX46. baseline and differential.
GenevisibleiQ8BX46. MM.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028762. SKOR1.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 3 hits.
PTHR10005:SF8. PTHR10005:SF8. 3 hits.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1."
    Mizuhara E., Nakatani T., Minaki Y., Sakamoto Y., Ono Y.
    J. Biol. Chem. 280:3645-3655(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH LBX1.
    Tissue: Embryonic brain1 Publication.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Medulla oblongata.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling."
    Arndt S., Poser I., Moser M., Bosserhoff A.-K.
    Mol. Cell. Neurosci. 34:603-611(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSKOR1_MOUSE
AccessioniPrimary (citable) accession number: Q8BX46
Secondary accession number(s): B2RQS8
, Q3UYA4, Q5W8I2, Q8C0T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 13, 2006
Last modified: May 11, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.