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Protein

Tumor necrosis factor receptor superfamily member 19L

Gene

Relt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates activation of NF-kappa-B. May play a role in T-cell activation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 19L
Gene namesi
Name:Relt
Synonyms:Tnfrsf19l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2443373. Relt.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 169ExtracellularSequence analysisAdd BLAST138
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 436CytoplasmicSequence analysisAdd BLAST246

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000003460132 – 436Tumor necrosis factor receptor superfamily member 19LAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 72By similarity
Disulfide bondi78 ↔ 97By similarity
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Modified residuei230PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8BX43.
PRIDEiQ8BX43.

PTM databases

iPTMnetiQ8BX43.
PhosphoSitePlusiQ8BX43.

Expressioni

Gene expression databases

BgeeiENSMUSG00000008318.
CleanExiMM_RELT.
ExpressionAtlasiQ8BX43. baseline and differential.
GenevisibleiQ8BX43. MM.

Interactioni

Subunit structurei

Associates with TRAF1. Interacts with RELL1, RELL2 and OXSR1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008462.

Structurei

3D structure databases

ProteinModelPortaliQ8BX43.
SMRiQ8BX43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 97TNFR-CysAdd BLAST41

Sequence similaritiesi

Belongs to the RELT family.Curated
Contains 1 TNFR-Cys repeat.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJV. Eukaryota.
ENOG410YDMP. LUCA.
GeneTreeiENSGT00530000063385.
HOGENOMiHOG000134238.
HOVERGENiHBG062274.
InParanoidiQ8BX43.
KOiK05156.
OMAiLCRSCPP.
OrthoDBiEOG091G0ADI.
TreeFamiTF332339.

Family and domain databases

InterProiIPR022248. TNF_rcpt_RELT.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022333. TNFR_19-like.
[Graphical view]
PfamiPF12606. RELT. 1 hit.
PF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01970. TNFACTORR19L.
SMARTiSM00208. TNFR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BX43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQGLMMKR TLLCWPLSCL FVLLPWPLAT PTPITPWLCP PGKEPDPDPG
60 70 80 90 100
QGTLCRTCPP GTFSASWNSY PCQPHYRCSL QKRLEAQAGT ATHDTMCGDC
110 120 130 140 150
QHGWFGPQGV PHVPCQPCSK APPSTGGCDE SGRRGRRGVE VAAGTSSNGE
160 170 180 190 200
PRQPGNGTRA GGPEETAAQY AVIAIVPVFC LMGLLGILVC NLLKRKGYHC
210 220 230 240 250
TAQKEVGPSP GGGGSGINPA YRTEDANEDT IGVLVRLITE KKENAAALEE
260 270 280 290 300
LLKEYHSKQL VQTSHRPVPR LLPASPSIPH ICPHHHHLHT VQGLASLSGP
310 320 330 340 350
CCSRCSQKWP EVLLSPEAAA ATTPAPTLLP TASRAPKASA KPGRQGEITI
360 370 380 390 400
LSVGRFRVAR IPEQRTSSLL SEVKTITEAG PSEGDLPDSP QPGLPPEQRA
410 420 430
LLGSGGSHTK WLKPPAENKA EENRYVVRLS ESNLVI
Length:436
Mass (Da):46,518
Last modified:July 27, 2011 - v2
Checksum:iE61304480DBA0815
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39C → G in BAC33534 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049073 mRNA. Translation: BAC33534.1.
AK088621 mRNA. Translation: BAC40459.1.
BC100310 mRNA. Translation: AAI00311.1.
BC131929 mRNA. Translation: AAI31930.1.
BC131931 mRNA. Translation: AAI31932.1.
BC145200 mRNA. Translation: AAI45201.1.
CCDSiCCDS21506.1.
RefSeqiNP_796047.2. NM_177073.6.
XP_006507994.1. XM_006507931.3.
XP_006507995.1. XM_006507932.3.
XP_006507996.1. XM_006507933.2.
XP_006507997.1. XM_006507934.3.
XP_006507998.1. XM_006507935.3.
XP_006507999.1. XM_006507936.3.
UniGeneiMm.40336.

Genome annotation databases

EnsembliENSMUST00000008462; ENSMUSP00000008462; ENSMUSG00000008318.
GeneIDi320100.
KEGGimmu:320100.
UCSCiuc009int.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049073 mRNA. Translation: BAC33534.1.
AK088621 mRNA. Translation: BAC40459.1.
BC100310 mRNA. Translation: AAI00311.1.
BC131929 mRNA. Translation: AAI31930.1.
BC131931 mRNA. Translation: AAI31932.1.
BC145200 mRNA. Translation: AAI45201.1.
CCDSiCCDS21506.1.
RefSeqiNP_796047.2. NM_177073.6.
XP_006507994.1. XM_006507931.3.
XP_006507995.1. XM_006507932.3.
XP_006507996.1. XM_006507933.2.
XP_006507997.1. XM_006507934.3.
XP_006507998.1. XM_006507935.3.
XP_006507999.1. XM_006507936.3.
UniGeneiMm.40336.

3D structure databases

ProteinModelPortaliQ8BX43.
SMRiQ8BX43.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000008462.

PTM databases

iPTMnetiQ8BX43.
PhosphoSitePlusiQ8BX43.

Proteomic databases

PaxDbiQ8BX43.
PRIDEiQ8BX43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008462; ENSMUSP00000008462; ENSMUSG00000008318.
GeneIDi320100.
KEGGimmu:320100.
UCSCiuc009int.2. mouse.

Organism-specific databases

CTDi84957.
MGIiMGI:2443373. Relt.

Phylogenomic databases

eggNOGiENOG410IKJV. Eukaryota.
ENOG410YDMP. LUCA.
GeneTreeiENSGT00530000063385.
HOGENOMiHOG000134238.
HOVERGENiHBG062274.
InParanoidiQ8BX43.
KOiK05156.
OMAiLCRSCPP.
OrthoDBiEOG091G0ADI.
TreeFamiTF332339.

Miscellaneous databases

PROiQ8BX43.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008318.
CleanExiMM_RELT.
ExpressionAtlasiQ8BX43. baseline and differential.
GenevisibleiQ8BX43. MM.

Family and domain databases

InterProiIPR022248. TNF_rcpt_RELT.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022333. TNFR_19-like.
[Graphical view]
PfamiPF12606. RELT. 1 hit.
PF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01970. TNFACTORR19L.
SMARTiSM00208. TNFR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTR19L_MOUSE
AccessioniPrimary (citable) accession number: Q8BX43
Secondary accession number(s): Q497Z8, Q8BTV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.