ID   PAPL_MOUSE              Reviewed;         438 AA.
AC   Q8BX37;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   16-JUN-2009, entry version 48.
DE   RecName: Full=Iron/zinc purple acid phosphatase-like protein;
DE            EC=3.1.3.2;
DE   Flags: Precursor;
GN   Name=Papl;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol +
CC       phosphate.
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC       Purple acid phosphatase family.
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DR   EMBL; AK049131; BAC33559.1; ALT_INIT; mRNA.
DR   EMBL; BC094908; AAH94908.1; ALT_INIT; mRNA.
DR   EMBL; BC132375; AAI32376.1; ALT_INIT; mRNA.
DR   IPI; IPI00226445; -.
DR   UniGene; Mm.26022; -.
DR   PhosphoSite; Q8BX37; -.
DR   Ensembl; ENSMUSG00000037469; Mus musculus.
DR   MGI; MGI:2142121; C330005M16Rik.
DR   HOGENOM; Q8BX37; -.
DR   HOVERGEN; Q8BX37; -.
DR   BRENDA; 3.1.3.2; 244.
DR   ArrayExpress; Q8BX37; -.
DR   Bgee; Q8BX37; -.
DR   CleanEx; MM_C330005M16RIK; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003993; F:acid phosphatase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004843; M-pesterase.
DR   InterPro; IPR015914; Purple_acid_Pase_N.
DR   Gene3D; G3DSA:2.60.40.380; Purple_acid_Pase_N; 1.
DR   Pfam; PF00149; Metallophos; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Hydrolase; Iron; Metal-binding; Secreted; Signal; Zinc.
FT   SIGNAL        1     23       Potential.
FT   CHAIN        24    438       Iron/zinc purple acid phosphatase-like
FT                                protein.
FT                                /FTId=PRO_0000316825.
FT   METAL       141    141       Iron (By similarity).
FT   METAL       170    170       Iron (By similarity).
FT   METAL       170    170       Zinc (By similarity).
FT   METAL       173    173       Iron (By similarity).
FT   METAL       205    205       Zinc (By similarity).
FT   METAL       286    286       Zinc (By similarity).
FT   METAL       333    333       Zinc (By similarity).
FT   METAL       335    335       Iron (By similarity).
FT   CARBOHYD    211    211       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    350    350       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    404    404       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   438 AA;  50663 MW;  A4DD79056E13C3B8 CRC64;
     MSPFLGGWLF FCMLLPFSPG VQGAQEYPHV TPEQIHLSYL GEPGTMTVTW TTWAPARSEV
     QFGSQLSGPL PFRAHGTARA FVDGGVLRRK LYIHRVTLRK LQPGAQYVYR CGSSQGWSRR
     FRFTALKNGV HWSPRLAVFG DMGADNPKAL PRLRRDTQQG MFDAVLHVGD FAYNMDQDNA
     RVGDRFMRLI EPVAASLPYM TCPGNHEQRY NFSNYKARFS MPGDNEGLWY SWDLGPAHII
     SFSTEVYFFL HYGRHLIEKQ FRWLENDLQK ANKNRVARPW IITMGHRPMY CSNADLDDCT
     RHESRVRKGL HGKLFGLEDL FHKYGVDLEF WAHEHSYERL WPIYNYQVFN GSLESPYTNP
     RGPVHIITGS AGCEELLTPF VRKPRPWSAV RVKEYGYTRM HILNGTHMHI QQVSDDQDGK
     IVDDVWVVRP LLGRMMYH
//