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Q8BX37 (PAPL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Iron/zinc purple acid phosphatase-like protein
EC=3.1.3.2
Gene names
Name:Papl
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

Sequence caution

The sequence AAH94908.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI32376.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC33559.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandIron
Metal-binding
Zinc
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacid phosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 438415Iron/zinc purple acid phosphatase-like protein
PRO_0000316825

Sites

Metal binding1411Iron By similarity
Metal binding1701Iron By similarity
Metal binding1701Zinc By similarity
Metal binding1731Iron By similarity
Metal binding2051Zinc By similarity
Metal binding2861Zinc By similarity
Metal binding3331Zinc By similarity
Metal binding3351Iron By similarity

Amino acid modifications

Glycosylation2111N-linked (GlcNAc...) Potential
Glycosylation3501N-linked (GlcNAc...) Potential
Glycosylation4041N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8BX37 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: A4DD79056E13C3B8

FASTA43850,663
        10         20         30         40         50         60 
MSPFLGGWLF FCMLLPFSPG VQGAQEYPHV TPEQIHLSYL GEPGTMTVTW TTWAPARSEV 

        70         80         90        100        110        120 
QFGSQLSGPL PFRAHGTARA FVDGGVLRRK LYIHRVTLRK LQPGAQYVYR CGSSQGWSRR 

       130        140        150        160        170        180 
FRFTALKNGV HWSPRLAVFG DMGADNPKAL PRLRRDTQQG MFDAVLHVGD FAYNMDQDNA 

       190        200        210        220        230        240 
RVGDRFMRLI EPVAASLPYM TCPGNHEQRY NFSNYKARFS MPGDNEGLWY SWDLGPAHII 

       250        260        270        280        290        300 
SFSTEVYFFL HYGRHLIEKQ FRWLENDLQK ANKNRVARPW IITMGHRPMY CSNADLDDCT 

       310        320        330        340        350        360 
RHESRVRKGL HGKLFGLEDL FHKYGVDLEF WAHEHSYERL WPIYNYQVFN GSLESPYTNP 

       370        380        390        400        410        420 
RGPVHIITGS AGCEELLTPF VRKPRPWSAV RVKEYGYTRM HILNGTHMHI QQVSDDQDGK 

       430 
IVDDVWVVRP LLGRMMYH

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK049131 mRNA. Translation: BAC33559.1. Different initiation.
BC094908 mRNA. Translation: AAH94908.1. Different initiation.
BC132375 mRNA. Translation: AAI32376.1. Different initiation.
IPIIPI00226445.
RefSeqNP_780528.1. NM_175319.4.
UniGeneMm.26022.

3D structure databases

ProteinModelPortalQ8BX37.
SMRQ8BX37. Positions 24-434.
ModBaseSearch...

Proteomic databases

PRIDEQ8BX37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101744.
KEGGmmu:101744.

Organism-specific databases

MGIMGI:2142121. C330005M16Rik.

Phylogenomic databases

eggNOGroNOG09139.
GeneTreeENSGT00390000015485.
HOVERGENHBG063988.
InParanoidQ8BX37.
OrthoDBEOG4NS3BK.

Gene expression databases

ArrayExpressQ8BX37.
BgeeQ8BX37.
CleanExMM_C330005M16RIK.
GenevestigatorQ8BX37.

Family and domain databases

InterProIPR004843. Metallo_PEstase_dom.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
[Graphical view]
Gene3DG3DSA:2.60.40.380. Purple_acid_Pase_N. 1 hit.
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMSSF49363. Purple_Pase_N. 1 hit.
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry namePAPL_MOUSE
AccessionPrimary (citable) accession number: Q8BX37
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 21, 2011
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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