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Protein

Acid phosphatase type 7

Gene

Acp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi141IronBy similarity1
Metal bindingi170IronBy similarity1
Metal bindingi170ZincBy similarity1
Metal bindingi173IronBy similarity1
Metal bindingi205ZincBy similarity1
Metal bindingi286ZincBy similarity1
Metal bindingi333ZincBy similarity1
Metal bindingi335IronBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase type 7Curated (EC:3.1.3.2)
Alternative name(s):
Purple acid phosphatase long form1 Publication
Gene namesi
Name:Acp7By similarity
Synonyms:Papl1 Publication, Papl11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2142121. Acp7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000031682524 – 438Acid phosphatase type 7Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi404N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BX37.
PRIDEiQ8BX37.

PTM databases

iPTMnetiQ8BX37.
PhosphoSitePlusiQ8BX37.

Expressioni

Gene expression databases

CleanExiMM_C330005M16RIK.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045437.

Structurei

3D structure databases

ProteinModelPortaliQ8BX37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1378. Eukaryota.
COG1409. LUCA.
HOVERGENiHBG063988.
InParanoidiQ8BX37.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
PF16656. Pur_ac_phosph_N. 1 hit.
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BX37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPFLGGWLF FCMLLPFSPG VQGAQEYPHV TPEQIHLSYL GEPGTMTVTW
60 70 80 90 100
TTWAPARSEV QFGSQLSGPL PFRAHGTARA FVDGGVLRRK LYIHRVTLRK
110 120 130 140 150
LQPGAQYVYR CGSSQGWSRR FRFTALKNGV HWSPRLAVFG DMGADNPKAL
160 170 180 190 200
PRLRRDTQQG MFDAVLHVGD FAYNMDQDNA RVGDRFMRLI EPVAASLPYM
210 220 230 240 250
TCPGNHEQRY NFSNYKARFS MPGDNEGLWY SWDLGPAHII SFSTEVYFFL
260 270 280 290 300
HYGRHLIEKQ FRWLENDLQK ANKNRVARPW IITMGHRPMY CSNADLDDCT
310 320 330 340 350
RHESRVRKGL HGKLFGLEDL FHKYGVDLEF WAHEHSYERL WPIYNYQVFN
360 370 380 390 400
GSLESPYTNP RGPVHIITGS AGCEELLTPF VRKPRPWSAV RVKEYGYTRM
410 420 430
HILNGTHMHI QQVSDDQDGK IVDDVWVVRP LLGRMMYH
Length:438
Mass (Da):50,663
Last modified:February 5, 2008 - v2
Checksum:iA4DD79056E13C3B8
GO

Sequence cautioni

The sequence AAH94908 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI32376 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC33559 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049131 mRNA. Translation: BAC33559.1. Different initiation.
BC094908 mRNA. Translation: AAH94908.1. Different initiation.
BC132375 mRNA. Translation: AAI32376.1. Different initiation.
RefSeqiNP_780528.1. NM_175319.4.
XP_006539510.1. XM_006539447.3.
XP_006539512.1. XM_006539449.3.
XP_006539513.1. XM_006539450.1.
UniGeneiMm.26022.

Genome annotation databases

GeneIDi101744.
KEGGimmu:101744.

Similar proteinsi

Entry informationi

Entry nameiACP7_MOUSE
AccessioniPrimary (citable) accession number: Q8BX37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 25, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families