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Q8BX37

- PAPL_MOUSE

UniProt

Q8BX37 - PAPL_MOUSE

Protein

Iron/zinc purple acid phosphatase-like protein

Gene

Papl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Cofactori

    Binds 1 iron ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi141 – 1411IronBy similarity
    Metal bindingi170 – 1701IronBy similarity
    Metal bindingi170 – 1701ZincBy similarity
    Metal bindingi173 – 1731IronBy similarity
    Metal bindingi205 – 2051ZincBy similarity
    Metal bindingi286 – 2861ZincBy similarity
    Metal bindingi333 – 3331ZincBy similarity
    Metal bindingi335 – 3351IronBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Iron, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iron/zinc purple acid phosphatase-like protein (EC:3.1.3.2)
    Gene namesi
    Name:Papl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2142121. Papl.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 438415Iron/zinc purple acid phosphatase-like proteinPRO_0000316825Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8BX37.

    PTM databases

    PhosphoSiteiQ8BX37.

    Expressioni

    Gene expression databases

    BgeeiQ8BX37.
    CleanExiMM_C330005M16RIK.
    GenevestigatoriQ8BX37.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BX37.
    SMRiQ8BX37. Positions 3-431.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1409.
    HOVERGENiHBG063988.
    InParanoidiQ8BX37.

    Family and domain databases

    Gene3Di2.60.40.380. 1 hit.
    3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR008963. Purple_acid_Pase-like_N.
    IPR015914. Purple_acid_Pase_N.
    IPR025733. Purple_acid_PPase_C_dom.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    PF14008. Metallophos_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF49363. SSF49363. 1 hit.
    SSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BX37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPFLGGWLF FCMLLPFSPG VQGAQEYPHV TPEQIHLSYL GEPGTMTVTW    50
    TTWAPARSEV QFGSQLSGPL PFRAHGTARA FVDGGVLRRK LYIHRVTLRK 100
    LQPGAQYVYR CGSSQGWSRR FRFTALKNGV HWSPRLAVFG DMGADNPKAL 150
    PRLRRDTQQG MFDAVLHVGD FAYNMDQDNA RVGDRFMRLI EPVAASLPYM 200
    TCPGNHEQRY NFSNYKARFS MPGDNEGLWY SWDLGPAHII SFSTEVYFFL 250
    HYGRHLIEKQ FRWLENDLQK ANKNRVARPW IITMGHRPMY CSNADLDDCT 300
    RHESRVRKGL HGKLFGLEDL FHKYGVDLEF WAHEHSYERL WPIYNYQVFN 350
    GSLESPYTNP RGPVHIITGS AGCEELLTPF VRKPRPWSAV RVKEYGYTRM 400
    HILNGTHMHI QQVSDDQDGK IVDDVWVVRP LLGRMMYH 438
    Length:438
    Mass (Da):50,663
    Last modified:February 5, 2008 - v2
    Checksum:iA4DD79056E13C3B8
    GO

    Sequence cautioni

    The sequence AAH94908.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI32376.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC33559.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK049131 mRNA. Translation: BAC33559.1. Different initiation.
    BC094908 mRNA. Translation: AAH94908.1. Different initiation.
    BC132375 mRNA. Translation: AAI32376.1. Different initiation.
    RefSeqiNP_780528.1. NM_175319.4.
    XP_006539510.1. XM_006539447.1.
    XP_006539511.1. XM_006539448.1.
    XP_006539512.1. XM_006539449.1.
    XP_006539513.1. XM_006539450.1.
    UniGeneiMm.26022.

    Genome annotation databases

    GeneIDi101744.
    KEGGimmu:101744.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK049131 mRNA. Translation: BAC33559.1 . Different initiation.
    BC094908 mRNA. Translation: AAH94908.1 . Different initiation.
    BC132375 mRNA. Translation: AAI32376.1 . Different initiation.
    RefSeqi NP_780528.1. NM_175319.4.
    XP_006539510.1. XM_006539447.1.
    XP_006539511.1. XM_006539448.1.
    XP_006539512.1. XM_006539449.1.
    XP_006539513.1. XM_006539450.1.
    UniGenei Mm.26022.

    3D structure databases

    ProteinModelPortali Q8BX37.
    SMRi Q8BX37. Positions 3-431.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BX37.

    Proteomic databases

    PRIDEi Q8BX37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101744.
    KEGGi mmu:101744.

    Organism-specific databases

    CTDi 390928.
    MGIi MGI:2142121. Papl.

    Phylogenomic databases

    eggNOGi COG1409.
    HOVERGENi HBG063988.
    InParanoidi Q8BX37.

    Miscellaneous databases

    NextBioi 355096.
    PROi Q8BX37.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BX37.
    CleanExi MM_C330005M16RIK.
    Genevestigatori Q8BX37.

    Family and domain databases

    Gene3Di 2.60.40.380. 1 hit.
    3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR008963. Purple_acid_Pase-like_N.
    IPR015914. Purple_acid_Pase_N.
    IPR025733. Purple_acid_PPase_C_dom.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    PF14008. Metallophos_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49363. SSF49363. 1 hit.
    SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPAPL_MOUSE
    AccessioniPrimary (citable) accession number: Q8BX37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3