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Protein

Acid phosphatase type 7

Gene

Acp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi141IronBy similarity1
Metal bindingi170IronBy similarity1
Metal bindingi170ZincBy similarity1
Metal bindingi173IronBy similarity1
Metal bindingi205ZincBy similarity1
Metal bindingi286ZincBy similarity1
Metal bindingi333ZincBy similarity1
Metal bindingi335IronBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase type 7Curated (EC:3.1.3.2)
Alternative name(s):
Purple acid phosphatase long form1 Publication
Gene namesi
Name:Acp7By similarity
Synonyms:Papl1 Publication, Papl11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2142121. Acp7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000031682524 – 438Acid phosphatase type 7Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1
Glycosylationi404N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BX37.
PRIDEiQ8BX37.

PTM databases

iPTMnetiQ8BX37.
PhosphoSitePlusiQ8BX37.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037469.
CleanExiMM_C330005M16RIK.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045437.

Structurei

3D structure databases

ProteinModelPortaliQ8BX37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1378. Eukaryota.
COG1409. LUCA.
HOVERGENiHBG063988.
InParanoidiQ8BX37.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
PF16656. Pur_ac_phosph_N. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BX37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPFLGGWLF FCMLLPFSPG VQGAQEYPHV TPEQIHLSYL GEPGTMTVTW
60 70 80 90 100
TTWAPARSEV QFGSQLSGPL PFRAHGTARA FVDGGVLRRK LYIHRVTLRK
110 120 130 140 150
LQPGAQYVYR CGSSQGWSRR FRFTALKNGV HWSPRLAVFG DMGADNPKAL
160 170 180 190 200
PRLRRDTQQG MFDAVLHVGD FAYNMDQDNA RVGDRFMRLI EPVAASLPYM
210 220 230 240 250
TCPGNHEQRY NFSNYKARFS MPGDNEGLWY SWDLGPAHII SFSTEVYFFL
260 270 280 290 300
HYGRHLIEKQ FRWLENDLQK ANKNRVARPW IITMGHRPMY CSNADLDDCT
310 320 330 340 350
RHESRVRKGL HGKLFGLEDL FHKYGVDLEF WAHEHSYERL WPIYNYQVFN
360 370 380 390 400
GSLESPYTNP RGPVHIITGS AGCEELLTPF VRKPRPWSAV RVKEYGYTRM
410 420 430
HILNGTHMHI QQVSDDQDGK IVDDVWVVRP LLGRMMYH
Length:438
Mass (Da):50,663
Last modified:February 5, 2008 - v2
Checksum:iA4DD79056E13C3B8
GO

Sequence cautioni

The sequence AAH94908 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI32376 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC33559 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049131 mRNA. Translation: BAC33559.1. Different initiation.
BC094908 mRNA. Translation: AAH94908.1. Different initiation.
BC132375 mRNA. Translation: AAI32376.1. Different initiation.
RefSeqiNP_780528.1. NM_175319.4.
XP_006539510.1. XM_006539447.3.
XP_006539512.1. XM_006539449.3.
XP_006539513.1. XM_006539450.1.
UniGeneiMm.26022.

Genome annotation databases

GeneIDi101744.
KEGGimmu:101744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049131 mRNA. Translation: BAC33559.1. Different initiation.
BC094908 mRNA. Translation: AAH94908.1. Different initiation.
BC132375 mRNA. Translation: AAI32376.1. Different initiation.
RefSeqiNP_780528.1. NM_175319.4.
XP_006539510.1. XM_006539447.3.
XP_006539512.1. XM_006539449.3.
XP_006539513.1. XM_006539450.1.
UniGeneiMm.26022.

3D structure databases

ProteinModelPortaliQ8BX37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045437.

PTM databases

iPTMnetiQ8BX37.
PhosphoSitePlusiQ8BX37.

Proteomic databases

PaxDbiQ8BX37.
PRIDEiQ8BX37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101744.
KEGGimmu:101744.

Organism-specific databases

CTDi390928.
MGIiMGI:2142121. Acp7.

Phylogenomic databases

eggNOGiKOG1378. Eukaryota.
COG1409. LUCA.
HOVERGENiHBG063988.
InParanoidiQ8BX37.

Miscellaneous databases

PROiQ8BX37.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037469.
CleanExiMM_C330005M16RIK.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
PF16656. Pur_ac_phosph_N. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACP7_MOUSE
AccessioniPrimary (citable) accession number: Q8BX37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.