Reviewed, UniProtKB/Swiss-Prot Q8BX37 (PAPL_MOUSE)

Names and origin

Protein names

Recommended name:
    Iron/zinc purple acid phosphatase-like protein
    EC=3.1.3.2

Gene names

Name:

Papl

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acid phosphatase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 438	415	Iron/zinc purple acid phosphatase-like protein		PRO_0000316825
Sites
	Metal binding	141	1	Iron By similarity
	Metal binding	170	1	Iron By similarity
	Metal binding	170	1	Zinc By similarity
	Metal binding	173	1	Iron By similarity
	Metal binding	205	1	Zinc By similarity
	Metal binding	286	1	Zinc By similarity
	Metal binding	333	1	Zinc By similarity
	Metal binding	335	1	Iron By similarity
Amino acid modifications
	Glycosylation	211	1	N-linked (GlcNAc...) Potential
	Glycosylation	350	1	N-linked (GlcNAc...) Potential
	Glycosylation	404	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8BX37-1 [UniParc]. Last modified February 5, 2008. Version 2. Checksum: A4DD79056E13C3B8	FASTA	438	50,663
	10 20 30 40 50 60 MSPFLGGWLF FCMLLPFSPG VQGAQEYPHV TPEQIHLSYL GEPGTMTVTW TTWAPARSEV 70 80 90 100 110 120 QFGSQLSGPL PFRAHGTARA FVDGGVLRRK LYIHRVTLRK LQPGAQYVYR CGSSQGWSRR 130 140 150 160 170 180 FRFTALKNGV HWSPRLAVFG DMGADNPKAL PRLRRDTQQG MFDAVLHVGD FAYNMDQDNA 190 200 210 220 230 240 RVGDRFMRLI EPVAASLPYM TCPGNHEQRY NFSNYKARFS MPGDNEGLWY SWDLGPAHII 250 260 270 280 290 300 SFSTEVYFFL HYGRHLIEKQ FRWLENDLQK ANKNRVARPW IITMGHRPMY CSNADLDDCT 310 320 330 340 350 360 RHESRVRKGL HGKLFGLEDL FHKYGVDLEF WAHEHSYERL WPIYNYQVFN GSLESPYTNP 370 380 390 400 410 420 RGPVHIITGS AGCEELLTPF VRKPRPWSAV RVKEYGYTRM HILNGTHMHI QQVSDDQDGK 430 IVDDVWVVRP LLGRMMYH

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK049131 mRNA. Translation: BAC33559.1. Different initiation. BC094908 mRNA. Translation: AAH94908.1. Different initiation. BC132375 mRNA. Translation: AAI32376.1. Different initiation.
IPI	IPI00226445.
RefSeq	NP_780528.1.
UniGene	Mm.26022
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUST00000040112; ENSMUSP00000045437; ENSMUSG00000037469; Mus musculus. [Genome view]
GeneID	101744.
KEGG	mmu:101744.
UCSC	uc009fzi.1. mouse.
Organism-specific databases
MGI	MGI:2142121. C330005M16Rik.
Phylogenomic databases
HOGENOM	Q8BX37.
HOVERGEN	Q8BX37.
Enzyme and pathway databases
BRENDA	3.1.3.2. 244.
Gene expression databases
ArrayExpress	Q8BX37.
Bgee	Q8BX37.
CleanEx	MM_C330005M16RIK.
Genevestigator	Q8BX37.
Family and domain databases
InterPro	IPR004843. M-pesterase. IPR015914. Purple_acid_Pase_N. [Graphical view]
Gene3D	G3DSA:2.60.40.380. Purple_acid_Pase_N. 1 hit.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

PAPL_MOUSE

Accession

Primary (citable) accession number: Q8BX37

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	October 13, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)