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Q8BX37

- PAPL_MOUSE

UniProt

Q8BX37 - PAPL_MOUSE

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Protein

Iron/zinc purple acid phosphatase-like protein

Gene

Papl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi141 – 1411IronBy similarity
Metal bindingi170 – 1701IronBy similarity
Metal bindingi170 – 1701ZincBy similarity
Metal bindingi173 – 1731IronBy similarity
Metal bindingi205 – 2051ZincBy similarity
Metal bindingi286 – 2861ZincBy similarity
Metal bindingi333 – 3331ZincBy similarity
Metal bindingi335 – 3351IronBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Iron/zinc purple acid phosphatase-like protein (EC:3.1.3.2)
Gene namesi
Name:Papl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2142121. Papl.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 438415Iron/zinc purple acid phosphatase-like proteinPRO_0000316825Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8BX37.

PTM databases

PhosphoSiteiQ8BX37.

Expressioni

Gene expression databases

BgeeiQ8BX37.
CleanExiMM_C330005M16RIK.
ExpressionAtlasiQ8BX37. baseline.
GenevestigatoriQ8BX37.

Structurei

3D structure databases

ProteinModelPortaliQ8BX37.
SMRiQ8BX37. Positions 32-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1409.
HOVERGENiHBG063988.
InParanoidiQ8BX37.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BX37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPFLGGWLF FCMLLPFSPG VQGAQEYPHV TPEQIHLSYL GEPGTMTVTW
60 70 80 90 100
TTWAPARSEV QFGSQLSGPL PFRAHGTARA FVDGGVLRRK LYIHRVTLRK
110 120 130 140 150
LQPGAQYVYR CGSSQGWSRR FRFTALKNGV HWSPRLAVFG DMGADNPKAL
160 170 180 190 200
PRLRRDTQQG MFDAVLHVGD FAYNMDQDNA RVGDRFMRLI EPVAASLPYM
210 220 230 240 250
TCPGNHEQRY NFSNYKARFS MPGDNEGLWY SWDLGPAHII SFSTEVYFFL
260 270 280 290 300
HYGRHLIEKQ FRWLENDLQK ANKNRVARPW IITMGHRPMY CSNADLDDCT
310 320 330 340 350
RHESRVRKGL HGKLFGLEDL FHKYGVDLEF WAHEHSYERL WPIYNYQVFN
360 370 380 390 400
GSLESPYTNP RGPVHIITGS AGCEELLTPF VRKPRPWSAV RVKEYGYTRM
410 420 430
HILNGTHMHI QQVSDDQDGK IVDDVWVVRP LLGRMMYH
Length:438
Mass (Da):50,663
Last modified:February 5, 2008 - v2
Checksum:iA4DD79056E13C3B8
GO

Sequence cautioni

The sequence AAH94908.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI32376.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC33559.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049131 mRNA. Translation: BAC33559.1. Different initiation.
BC094908 mRNA. Translation: AAH94908.1. Different initiation.
BC132375 mRNA. Translation: AAI32376.1. Different initiation.
RefSeqiNP_780528.1. NM_175319.4.
XP_006539510.1. XM_006539447.1.
XP_006539511.1. XM_006539448.1.
XP_006539512.1. XM_006539449.1.
XP_006539513.1. XM_006539450.1.
UniGeneiMm.26022.

Genome annotation databases

GeneIDi101744.
KEGGimmu:101744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049131 mRNA. Translation: BAC33559.1 . Different initiation.
BC094908 mRNA. Translation: AAH94908.1 . Different initiation.
BC132375 mRNA. Translation: AAI32376.1 . Different initiation.
RefSeqi NP_780528.1. NM_175319.4.
XP_006539510.1. XM_006539447.1.
XP_006539511.1. XM_006539448.1.
XP_006539512.1. XM_006539449.1.
XP_006539513.1. XM_006539450.1.
UniGenei Mm.26022.

3D structure databases

ProteinModelPortali Q8BX37.
SMRi Q8BX37. Positions 32-426.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BX37.

Proteomic databases

PRIDEi Q8BX37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101744.
KEGGi mmu:101744.

Organism-specific databases

CTDi 390928.
MGIi MGI:2142121. Papl.

Phylogenomic databases

eggNOGi COG1409.
HOVERGENi HBG063988.
InParanoidi Q8BX37.

Miscellaneous databases

NextBioi 355096.
PROi Q8BX37.
SOURCEi Search...

Gene expression databases

Bgeei Q8BX37.
CleanExi MM_C330005M16RIK.
ExpressionAtlasi Q8BX37. baseline.
Genevestigatori Q8BX37.

Family and domain databases

Gene3Di 2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view ]
SUPFAMi SSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPAPL_MOUSE
AccessioniPrimary (citable) accession number: Q8BX37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3