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Protein

Tumor necrosis factor receptor superfamily member 27

Gene

Eda2r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 27
Alternative name(s):
X-linked ectodysplasin-A2 receptor
Short name:
EDA-A2 receptor
Gene namesi
Name:Eda2r
Synonyms:Tnfrsf27, Xedar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2442860. Eda2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 138138ExtracellularSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini160 – 297138CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Tumor necrosis factor receptor superfamily member 27PRO_0000058939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi3 ↔ 15PROSITE-ProRule annotation
Disulfide bondi18 ↔ 31PROSITE-ProRule annotation
Disulfide bondi21 ↔ 41PROSITE-ProRule annotation
Disulfide bondi44 ↔ 58PROSITE-ProRule annotation
Disulfide bondi61 ↔ 75PROSITE-ProRule annotation
Disulfide bondi64 ↔ 83PROSITE-ProRule annotation
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi86 ↔ 104PROSITE-ProRule annotation
Disulfide bondi107 ↔ 118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BX35.
PaxDbiQ8BX35.
PRIDEiQ8BX35.

PTM databases

PhosphoSiteiQ8BX35.

Expressioni

Gene expression databases

BgeeiQ8BX35.
CleanExiMM_EDA2R.
ExpressionAtlasiQ8BX35. baseline and differential.
GenevisibleiQ8BX35. MM.

Interactioni

Subunit structurei

Associates with TRAF1, TRAF3 and TRAF6.By similarity

Protein-protein interaction databases

BioGridi232789. 2 interactions.
IntActiQ8BX35. 1 interaction.
STRINGi10090.ENSMUSP00000041210.

Structurei

3D structure databases

ProteinModelPortaliQ8BX35.
SMRiQ8BX35. Positions 5-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 4140TNFR-Cys 1Add
BLAST
Repeati43 – 8341TNFR-Cys 2Add
BLAST
Repeati85 – 11834TNFR-Cys 3Add
BLAST

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IETX. Eukaryota.
ENOG41104RU. LUCA.
GeneTreeiENSGT00730000110978.
HOGENOMiHOG000132464.
HOVERGENiHBG059312.
InParanoidiQ8BX35.
KOiK05163.
OMAiLPRFYRK.
OrthoDBiEOG7Z3F4G.
PhylomeDBiQ8BX35.
TreeFamiTF331385.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022319. TNFR_27.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01973. TNFACTORR27.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BX35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCQENEYRD QWGRCVTCQQ CGPGQELSKD CGYGEGGDAH CIVCPPRKYK
60 70 80 90 100
STWGHHRCQT CITCAVINRV QKANCTNTSN AICGDCLPRF YRKTRIGGLQ
110 120 130 140 150
DQECIPCTKQ TPSSEVQCTF QLSLVKVDAH TVPPREATLV ALVGSLLVVF
160 170 180 190 200
ALAFLGLFFL YCKQIFNRHC QCRDSLQYEA EKTVEEDSLF PVPPGQETSP
210 220 230 240 250
EFPANEGILE IKPLNSILDD DCSSTRGFPT QESFTMASCA SESHSQWVHT
260 270 280 290
PIECTELDLQ KFSSSIPSTG PETLRENTAE HSGDRLELYV PFEVPSL
Length:297
Mass (Da):33,066
Last modified:March 1, 2003 - v1
Checksum:i46FEFDDC51D739BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701V → A in BAC28879 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034909 mRNA. Translation: BAC28879.1.
AK049134 mRNA. Translation: BAC33562.1.
CCDSiCCDS30293.1.
RefSeqiNP_001154904.1. NM_001161432.1.
NP_001154905.1. NM_001161433.1.
NP_780749.3. NM_175540.5.
XP_006528088.1. XM_006528025.2.
XP_006528089.1. XM_006528026.2.
UniGeneiMm.189270.

Genome annotation databases

EnsembliENSMUST00000037353; ENSMUSP00000041210; ENSMUSG00000034457.
ENSMUST00000113832; ENSMUSP00000109463; ENSMUSG00000034457.
GeneIDi245527.
KEGGimmu:245527.
UCSCiuc009tus.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034909 mRNA. Translation: BAC28879.1.
AK049134 mRNA. Translation: BAC33562.1.
CCDSiCCDS30293.1.
RefSeqiNP_001154904.1. NM_001161432.1.
NP_001154905.1. NM_001161433.1.
NP_780749.3. NM_175540.5.
XP_006528088.1. XM_006528025.2.
XP_006528089.1. XM_006528026.2.
UniGeneiMm.189270.

3D structure databases

ProteinModelPortaliQ8BX35.
SMRiQ8BX35. Positions 5-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232789. 2 interactions.
IntActiQ8BX35. 1 interaction.
STRINGi10090.ENSMUSP00000041210.

PTM databases

PhosphoSiteiQ8BX35.

Proteomic databases

MaxQBiQ8BX35.
PaxDbiQ8BX35.
PRIDEiQ8BX35.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037353; ENSMUSP00000041210; ENSMUSG00000034457.
ENSMUST00000113832; ENSMUSP00000109463; ENSMUSG00000034457.
GeneIDi245527.
KEGGimmu:245527.
UCSCiuc009tus.2. mouse.

Organism-specific databases

CTDi60401.
MGIiMGI:2442860. Eda2r.

Phylogenomic databases

eggNOGiENOG410IETX. Eukaryota.
ENOG41104RU. LUCA.
GeneTreeiENSGT00730000110978.
HOGENOMiHOG000132464.
HOVERGENiHBG059312.
InParanoidiQ8BX35.
KOiK05163.
OMAiLPRFYRK.
OrthoDBiEOG7Z3F4G.
PhylomeDBiQ8BX35.
TreeFamiTF331385.

Enzyme and pathway databases

ReactomeiR-MMU-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

PROiQ8BX35.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BX35.
CleanExiMM_EDA2R.
ExpressionAtlasiQ8BX35. baseline and differential.
GenevisibleiQ8BX35. MM.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022319. TNFR_27.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01973. TNFACTORR27.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiTNR27_MOUSE
AccessioniPrimary (citable) accession number: Q8BX35
Secondary accession number(s): Q8BM50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.