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Q8BX07

- CTDS2_MOUSE

UniProt

Q8BX07 - CTDS2_MOUSE

Protein

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

Gene

Ctdsp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 1 magnesium ion per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei106 – 10614-aspartylphosphate intermediateBy similarity
    Metal bindingi106 – 1061MagnesiumBy similarity
    Active sitei108 – 1081Proton donorBy similarity
    Metal bindingi108 – 1081Magnesium; via carbonyl oxygenBy similarity
    Sitei162 – 1621Transition state stabilizerBy similarity
    Sitei200 – 2001Transition state stabilizerBy similarity
    Metal bindingi217 – 2171MagnesiumBy similarity

    GO - Molecular functioni

    1. CTD phosphatase activity Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of G1/S transition of mitotic cell cycle Source: MGI
    2. negative regulation of protein phosphorylation Source: MGI
    3. protein dephosphorylation Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_106572. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (EC:3.1.3.16)
    Alternative name(s):
    Small C-terminal domain phosphatase 2
    Small CTD phosphatase 2
    Short name:
    SCP2
    Gene namesi
    Name:Ctdsp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1098748. Ctdsp2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2PRO_0000212575Add
    BLAST

    Proteomic databases

    PRIDEiQ8BX07.

    PTM databases

    PhosphoSiteiQ8BX07.

    Expressioni

    Tissue specificityi

    Expression is restricted to non-neuronal tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ8BX07.
    BgeeiQ8BX07.
    GenevestigatoriQ8BX07.

    Interactioni

    Subunit structurei

    Monomer. Interacts with REST.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BX07.
    SMRiQ8BX07. Positions 89-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini96 – 254159FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5190.
    GeneTreeiENSGT00390000017194.
    HOVERGENiHBG053298.
    KOiK15731.
    OMAiPRGRSIF.
    OrthoDBiEOG71P2C3.
    PhylomeDBiQ8BX07.
    TreeFamiTF313556.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BX07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHGSIITQA RREDALVLTK QGLVSKSSPK KPRGRSIFKA LLCCFHTQHV    50
    VQSSSSTELT HKEEANTIAK SDLLQCLQYQ FYQIPGTCLL PEVTEQDQGR 100
    ICVVIDLDET LVHSSFKPIN NADFIVPVEI EGTTHQVYVL KRPYVDEFLR 150
    RMGELFECVL FTASLAKYAD PVTDLLDRCG VFRARLFREA CVFHQGCYVK 200
    DLSRLGRDLR KTVILDNSPA SYIFHPENAV PVQSWFDDMA DTELLNLIPV 250
    FEELSGTDDV YTSLGQLRAP 270
    Length:270
    Mass (Da):30,546
    Last modified:March 1, 2003 - v1
    Checksum:i0098B97E0AEC1B1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK049271 mRNA. Translation: BAC33649.1.
    BC085142 mRNA. Translation: AAH85142.1.
    CCDSiCCDS48711.1.
    RefSeqiNP_001106941.1. NM_001113470.1.
    NP_666124.1. NM_146012.2.
    UniGeneiMm.29490.

    Genome annotation databases

    EnsembliENSMUST00000105256; ENSMUSP00000100891; ENSMUSG00000078429.
    GeneIDi52468.
    KEGGimmu:52468.
    UCSCiuc007hhj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK049271 mRNA. Translation: BAC33649.1 .
    BC085142 mRNA. Translation: AAH85142.1 .
    CCDSi CCDS48711.1.
    RefSeqi NP_001106941.1. NM_001113470.1.
    NP_666124.1. NM_146012.2.
    UniGenei Mm.29490.

    3D structure databases

    ProteinModelPortali Q8BX07.
    SMRi Q8BX07. Positions 89-269.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BX07.

    Proteomic databases

    PRIDEi Q8BX07.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105256 ; ENSMUSP00000100891 ; ENSMUSG00000078429 .
    GeneIDi 52468.
    KEGGi mmu:52468.
    UCSCi uc007hhj.2. mouse.

    Organism-specific databases

    CTDi 10106.
    MGIi MGI:1098748. Ctdsp2.

    Phylogenomic databases

    eggNOGi COG5190.
    GeneTreei ENSGT00390000017194.
    HOVERGENi HBG053298.
    KOi K15731.
    OMAi PRGRSIF.
    OrthoDBi EOG71P2C3.
    PhylomeDBi Q8BX07.
    TreeFami TF313556.

    Enzyme and pathway databases

    Reactomei REACT_106572. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    NextBioi 309001.
    PROi Q8BX07.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BX07.
    Bgeei Q8BX07.
    Genevestigatori Q8BX07.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Small CTD phosphatases function in silencing neuronal gene expression."
      Yeo M., Lee S.-K., Lee B., Ruiz E.C., Pfaff S.L., Gill G.N.
      Science 307:596-600(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCTDS2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BX07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3