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Q8BX07

- CTDS2_MOUSE

UniProt

Q8BX07 - CTDS2_MOUSE

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Protein

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

Gene

Ctdsp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 10614-aspartylphosphate intermediateBy similarity
Metal bindingi106 – 1061MagnesiumBy similarity
Active sitei108 – 1081Proton donorBy similarity
Metal bindingi108 – 1081Magnesium; via carbonyl oxygenBy similarity
Sitei162 – 1621Transition state stabilizerBy similarity
Sitei200 – 2001Transition state stabilizerBy similarity
Metal bindingi217 – 2171MagnesiumBy similarity

GO - Molecular functioni

  1. CTD phosphatase activity Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of G1/S transition of mitotic cell cycle Source: MGI
  2. negative regulation of protein phosphorylation Source: MGI
  3. protein dephosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_106572. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (EC:3.1.3.16)
Alternative name(s):
Small C-terminal domain phosphatase 2
Small CTD phosphatase 2
Short name:
SCP2
Gene namesi
Name:Ctdsp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1098748. Ctdsp2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2PRO_0000212575Add
BLAST

Proteomic databases

MaxQBiQ8BX07.
PRIDEiQ8BX07.

PTM databases

PhosphoSiteiQ8BX07.

Expressioni

Tissue specificityi

Expression is restricted to non-neuronal tissues.1 Publication

Gene expression databases

BgeeiQ8BX07.
ExpressionAtlasiQ8BX07. baseline and differential.
GenevestigatoriQ8BX07.

Interactioni

Subunit structurei

Monomer. Interacts with REST.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BX07.
SMRiQ8BX07. Positions 89-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 254159FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5190.
GeneTreeiENSGT00390000017194.
HOVERGENiHBG053298.
InParanoidiQ8BX07.
KOiK15731.
OMAiPRGRSIF.
OrthoDBiEOG71P2C3.
PhylomeDBiQ8BX07.
TreeFamiTF313556.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BX07-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEHGSIITQA RREDALVLTK QGLVSKSSPK KPRGRSIFKA LLCCFHTQHV
60 70 80 90 100
VQSSSSTELT HKEEANTIAK SDLLQCLQYQ FYQIPGTCLL PEVTEQDQGR
110 120 130 140 150
ICVVIDLDET LVHSSFKPIN NADFIVPVEI EGTTHQVYVL KRPYVDEFLR
160 170 180 190 200
RMGELFECVL FTASLAKYAD PVTDLLDRCG VFRARLFREA CVFHQGCYVK
210 220 230 240 250
DLSRLGRDLR KTVILDNSPA SYIFHPENAV PVQSWFDDMA DTELLNLIPV
260 270
FEELSGTDDV YTSLGQLRAP
Length:270
Mass (Da):30,546
Last modified:March 1, 2003 - v1
Checksum:i0098B97E0AEC1B1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049271 mRNA. Translation: BAC33649.1.
BC085142 mRNA. Translation: AAH85142.1.
CCDSiCCDS48711.1.
RefSeqiNP_001106941.1. NM_001113470.1.
NP_666124.1. NM_146012.2.
UniGeneiMm.29490.

Genome annotation databases

EnsembliENSMUST00000105256; ENSMUSP00000100891; ENSMUSG00000078429.
GeneIDi52468.
KEGGimmu:52468.
UCSCiuc007hhj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049271 mRNA. Translation: BAC33649.1 .
BC085142 mRNA. Translation: AAH85142.1 .
CCDSi CCDS48711.1.
RefSeqi NP_001106941.1. NM_001113470.1.
NP_666124.1. NM_146012.2.
UniGenei Mm.29490.

3D structure databases

ProteinModelPortali Q8BX07.
SMRi Q8BX07. Positions 89-269.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BX07.

Proteomic databases

MaxQBi Q8BX07.
PRIDEi Q8BX07.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000105256 ; ENSMUSP00000100891 ; ENSMUSG00000078429 .
GeneIDi 52468.
KEGGi mmu:52468.
UCSCi uc007hhj.2. mouse.

Organism-specific databases

CTDi 10106.
MGIi MGI:1098748. Ctdsp2.

Phylogenomic databases

eggNOGi COG5190.
GeneTreei ENSGT00390000017194.
HOVERGENi HBG053298.
InParanoidi Q8BX07.
KOi K15731.
OMAi PRGRSIF.
OrthoDBi EOG71P2C3.
PhylomeDBi Q8BX07.
TreeFami TF313556.

Enzyme and pathway databases

Reactomei REACT_106572. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSi Ctdsp2. mouse.
NextBioi 309001.
PROi Q8BX07.
SOURCEi Search...

Gene expression databases

Bgeei Q8BX07.
ExpressionAtlasi Q8BX07. baseline and differential.
Genevestigatori Q8BX07.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
[Graphical view ]
SMARTi SM00577. CPDc. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
PROSITEi PS50969. FCP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Small CTD phosphatases function in silencing neuronal gene expression."
    Yeo M., Lee S.-K., Lee B., Ruiz E.C., Pfaff S.L., Gill G.N.
    Science 307:596-600(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCTDS2_MOUSE
AccessioniPrimary (citable) accession number: Q8BX07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3