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Protein

Protein CIP2A

Gene

Kiaa1524

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Promotes anchorage-independent cell growth and tumor formation.By similarity

GO - Biological processi

  • positive regulation of neural precursor cell proliferation Source: MGI
  • spermatogenesis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CIP2A
Alternative name(s):
Cancerous inhibitor of PP2A
p90 autoantigen homolog
Gene namesi
Name:Kiaa1524
Synonyms:Cip2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146335. C330027C09Rik.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei194 – 21421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 907907Protein CIP2APRO_0000287142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei906 – 9061PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BWY9.
MaxQBiQ8BWY9.
PaxDbiQ8BWY9.
PRIDEiQ8BWY9.

PTM databases

PhosphoSiteiQ8BWY9.

Expressioni

Tissue specificityi

Highly expressed in E17.5 and E18.5 liver but not pexpressed in adult liver. Expressed at moderate level in embryonic brain, muscle and epidermal layers.1 Publication

Gene expression databases

BgeeiQ8BWY9.
CleanExiMM_C330027C09RIK.
ExpressionAtlasiQ8BWY9. baseline and differential.
GenevisibleiQ8BWY9. MM.

Interactioni

Subunit structurei

Interacts with MYC.By similarity

Protein-protein interaction databases

BioGridi230256. 1 interaction.
IntActiQ8BWY9. 1 interaction.
STRINGi10090.ENSMUSP00000044714.

Structurei

3D structure databases

ProteinModelPortaliQ8BWY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili639 – 887249Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ1I. Eukaryota.
ENOG4110856. LUCA.
GeneTreeiENSGT00390000006861.
HOGENOMiHOG000007435.
HOVERGENiHBG107688.
InParanoidiQ8BWY9.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BWY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTACLKSL LLSISQYKAV KSEANATQLL RHLEVVSGQK LTRLFTSHQI
60 70 80 90 100
LPSECLSCLV ELLEDPNISA SLILSIISLL SQLAIDNETR DCLQNIYNLN
110 120 130 140 150
SVLSGVVCRS SACHNDSVFL QCIQLLQRLT YNAKFFHSGA HIDDLITFLI
160 170 180 190 200
GHVQSSEDEL TMPCLGLLAN LCRHNLSVQT QIKTLSNVKS FYRTLISFLA
210 220 230 240 250
HSSLTVVVFA LSILSSLTLN EEVGEKLFHA RNIHQTFQLI FNILINGDGT
260 270 280 290 300
LTRKYSVDLL MDLLKNPKIA DYLTRYEHFS SCLSQVLGLL NAKDPDSSSK
310 320 330 340 350
VLELLLAFCA VTQLRHVLSQ MMFEQSPSGN ILGSRPKSLE PTAALLRWLS
360 370 380 390 400
QPLDGAENCS VLALELFKEI FEDVIDTGNC SSTDHFVTLL LPTILDQLQF
410 420 430 440 450
KEQNLDETLV RNKCERMVKA IEVLLTLCGD DSLKMHVVKI LTTLKCTTLI
460 470 480 490 500
EQQFTYGKID LGFGTKVADS ELCKLAADVI LKTLTLMNKL KQLVPGMEVS
510 520 530 540 550
FYKILQDPRL ITPLAFALTS DNREQVQSGL GILLEASPLP DFPAFVLGES
560 570 580 590 600
IAANNVYRQQ ETEHLPRKMT FQPLNHGFST SAKCLTPPPS KDNAPALNIE
610 620 630 640 650
DLIEKLQAGV MVKDQISDIR ISDIMDVYEM KLSTLASKES RLQDLLEAKA
660 670 680 690 700
LALAQADRLI AQYRCQRTQA ETEARTLAGM LREVERKNEE LSVLLKSQQL
710 720 730 740 750
ESERAQNDIE HLFQHSKKLE SVAAEHEILT KSYMELVQRN EATEKKNTDL
760 770 780 790 800
QTTCESLNKH IETMKKLNEA LKQQNEKTIA QLIEKEEQRK EVQSQLADRE
810 820 830 840 850
CKLSNLHKIA KSQEEKLNVL QKEKEDKQET IDILRKELSR TEQIRKELSI
860 870 880 890 900
KASSLEMHKA QLEGRLEEKE SLLKLQQEEL NKHSHMIAMI HSLSGGKISP

ETVNLSI
Length:907
Mass (Da):102,043
Last modified:July 27, 2011 - v3
Checksum:iC4DA225F0492693B
GO

Sequence cautioni

The sequence BAC33705.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161S → R in BAC33705 (PubMed:16141072).Curated
Sequence conflicti413 – 4153KCE → EVI in AAH52662 (PubMed:15489334).Curated
Sequence conflicti699 – 6991Q → K in BAC33705 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049356 mRNA. Translation: BAC33705.1. Different initiation.
BC137719 mRNA. Translation: AAI37720.1.
BC052662 mRNA. Translation: AAH52662.1.
AK173190 mRNA. Translation: BAD32468.1.
CCDSiCCDS49867.1.
RefSeqiNP_766204.2. NM_172616.2.
UniGeneiMm.24491.

Genome annotation databases

EnsembliENSMUST00000048374; ENSMUSP00000044714; ENSMUSG00000033031.
GeneIDi224171.
KEGGimmu:224171.
UCSCiuc007zkb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049356 mRNA. Translation: BAC33705.1. Different initiation.
BC137719 mRNA. Translation: AAI37720.1.
BC052662 mRNA. Translation: AAH52662.1.
AK173190 mRNA. Translation: BAD32468.1.
CCDSiCCDS49867.1.
RefSeqiNP_766204.2. NM_172616.2.
UniGeneiMm.24491.

3D structure databases

ProteinModelPortaliQ8BWY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230256. 1 interaction.
IntActiQ8BWY9. 1 interaction.
STRINGi10090.ENSMUSP00000044714.

PTM databases

PhosphoSiteiQ8BWY9.

Proteomic databases

EPDiQ8BWY9.
MaxQBiQ8BWY9.
PaxDbiQ8BWY9.
PRIDEiQ8BWY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048374; ENSMUSP00000044714; ENSMUSG00000033031.
GeneIDi224171.
KEGGimmu:224171.
UCSCiuc007zkb.1. mouse.

Organism-specific databases

MGIiMGI:2146335. C330027C09Rik.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJ1I. Eukaryota.
ENOG4110856. LUCA.
GeneTreeiENSGT00390000006861.
HOGENOMiHOG000007435.
HOVERGENiHBG107688.
InParanoidiQ8BWY9.

Miscellaneous databases

NextBioi377125.
PROiQ8BWY9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BWY9.
CleanExiMM_C330027C09RIK.
ExpressionAtlasiQ8BWY9. baseline and differential.
GenevisibleiQ8BWY9. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg and Thymus.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 59-907.
    Tissue: Embryonic tail.
  4. "Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer."
    Soo Hoo L., Zhang J.Y., Chan E.K.L.
    Oncogene 21:5006-5015(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen and Testis.

Entry informationi

Entry nameiCIP2A_MOUSE
AccessioniPrimary (citable) accession number: Q8BWY9
Secondary accession number(s): B2RQ25, Q69ZH6, Q7TPZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 27, 2011
Last modified: March 16, 2016
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.