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Protein

Protein CIP2A

Gene

Cip2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes anchorage-independent cell growth and tumor formation.By similarity

GO - Molecular functioni

GO - Biological processi

  • positive regulation of neural precursor cell proliferation Source: MGI
  • spermatogenesis Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CIP2A
Alternative name(s):
Cancerous inhibitor of PP2A
p90 autoantigen homolog
Gene namesi
Name:Cip2a
Synonyms:Kiaa1524
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2146335 C330027C09Rik

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871421 – 907Protein CIP2AAdd BLAST907

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei906PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8BWY9
MaxQBiQ8BWY9
PaxDbiQ8BWY9
PRIDEiQ8BWY9

PTM databases

iPTMnetiQ8BWY9
PhosphoSitePlusiQ8BWY9

Expressioni

Tissue specificityi

Highly expressed in E17.5 and E18.5 liver but not pexpressed in adult liver. Expressed at moderate level in embryonic brain, muscle and epidermal layers.1 Publication

Gene expression databases

BgeeiENSMUSG00000033031
CleanExiMM_C330027C09RIK
ExpressionAtlasiQ8BWY9 baseline and differential
GenevisibleiQ8BWY9 MM

Interactioni

Subunit structurei

Homodimer. Interacts with MYC. Interacts with PPP2R5C; this interaction stabilizes CIP2A. Interacts with PPP2R1A; this interaction stabilizes CIP2A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230256, 1 interactor
IntActiQ8BWY9, 1 interactor
STRINGi10090.ENSMUSP00000044714

Structurei

3D structure databases

ProteinModelPortaliQ8BWY9
SMRiQ8BWY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 247Required for interaction with PPP2R5CBy similarityAdd BLAST87
Regioni389 – 559Required for homodimerizationBy similarityAdd BLAST171

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili639 – 887Sequence analysisAdd BLAST249

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ1I Eukaryota
ENOG4110856 LUCA
GeneTreeiENSGT00390000006861
HOGENOMiHOG000007435
HOVERGENiHBG107688
InParanoidiQ8BWY9
OrthoDBiEOG091G01PK

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BWY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTACLKSL LLSISQYKAV KSEANATQLL RHLEVVSGQK LTRLFTSHQI
60 70 80 90 100
LPSECLSCLV ELLEDPNISA SLILSIISLL SQLAIDNETR DCLQNIYNLN
110 120 130 140 150
SVLSGVVCRS SACHNDSVFL QCIQLLQRLT YNAKFFHSGA HIDDLITFLI
160 170 180 190 200
GHVQSSEDEL TMPCLGLLAN LCRHNLSVQT QIKTLSNVKS FYRTLISFLA
210 220 230 240 250
HSSLTVVVFA LSILSSLTLN EEVGEKLFHA RNIHQTFQLI FNILINGDGT
260 270 280 290 300
LTRKYSVDLL MDLLKNPKIA DYLTRYEHFS SCLSQVLGLL NAKDPDSSSK
310 320 330 340 350
VLELLLAFCA VTQLRHVLSQ MMFEQSPSGN ILGSRPKSLE PTAALLRWLS
360 370 380 390 400
QPLDGAENCS VLALELFKEI FEDVIDTGNC SSTDHFVTLL LPTILDQLQF
410 420 430 440 450
KEQNLDETLV RNKCERMVKA IEVLLTLCGD DSLKMHVVKI LTTLKCTTLI
460 470 480 490 500
EQQFTYGKID LGFGTKVADS ELCKLAADVI LKTLTLMNKL KQLVPGMEVS
510 520 530 540 550
FYKILQDPRL ITPLAFALTS DNREQVQSGL GILLEASPLP DFPAFVLGES
560 570 580 590 600
IAANNVYRQQ ETEHLPRKMT FQPLNHGFST SAKCLTPPPS KDNAPALNIE
610 620 630 640 650
DLIEKLQAGV MVKDQISDIR ISDIMDVYEM KLSTLASKES RLQDLLEAKA
660 670 680 690 700
LALAQADRLI AQYRCQRTQA ETEARTLAGM LREVERKNEE LSVLLKSQQL
710 720 730 740 750
ESERAQNDIE HLFQHSKKLE SVAAEHEILT KSYMELVQRN EATEKKNTDL
760 770 780 790 800
QTTCESLNKH IETMKKLNEA LKQQNEKTIA QLIEKEEQRK EVQSQLADRE
810 820 830 840 850
CKLSNLHKIA KSQEEKLNVL QKEKEDKQET IDILRKELSR TEQIRKELSI
860 870 880 890 900
KASSLEMHKA QLEGRLEEKE SLLKLQQEEL NKHSHMIAMI HSLSGGKISP

ETVNLSI
Length:907
Mass (Da):102,043
Last modified:July 27, 2011 - v3
Checksum:iC4DA225F0492693B
GO

Sequence cautioni

The sequence BAC33705 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216S → R in BAC33705 (PubMed:16141072).Curated1
Sequence conflicti413 – 415KCE → EVI in AAH52662 (PubMed:15489334).Curated3
Sequence conflicti699Q → K in BAC33705 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049356 mRNA Translation: BAC33705.1 Different initiation.
BC137719 mRNA Translation: AAI37720.1
BC052662 mRNA Translation: AAH52662.1
AK173190 mRNA Translation: BAD32468.1
CCDSiCCDS49867.1
RefSeqiNP_766204.2, NM_172616.2
UniGeneiMm.24491

Genome annotation databases

EnsembliENSMUST00000048374; ENSMUSP00000044714; ENSMUSG00000033031
GeneIDi224171
KEGGimmu:224171
UCSCiuc007zkb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCIP2A_MOUSE
AccessioniPrimary (citable) accession number: Q8BWY9
Secondary accession number(s): B2RQ25, Q69ZH6, Q7TPZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health