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Protein

C-type lectin domain family 1 member A

Gene

Clec1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 1 member A
Gene namesi
Name:Clec1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2444151. Clec1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 72Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini73 – 269ExtracellularSequence analysisAdd BLAST197

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466101 – 269C-type lectin domain family 1 member AAdd BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi164 ↔ 256PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Glycosylationi202N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi235 ↔ 248PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BWY2.
PaxDbiQ8BWY2.
PRIDEiQ8BWY2.

PTM databases

iPTMnetiQ8BWY2.
PhosphoSitePlusiQ8BWY2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033082.
CleanExiMM_CLEC1A.
ExpressionAtlasiQ8BWY2. baseline and differential.
GenevisibleiQ8BWY2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047065.

Structurei

3D structure databases

ProteinModelPortaliQ8BWY2.
SMRiQ8BWY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 257C-type lectinPROSITE-ProRule annotationAdd BLAST115

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000111777.
HOVERGENiHBG103475.
InParanoidiQ8BWY2.
KOiK10069.
OMAiFQFYQLS.
OrthoDBiEOG091G0K57.
PhylomeDBiQ8BWY2.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BWY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAKYSSTRD MLDDDDTTIS LYSGTSTVTR RAEPRHSENG TPSSVWRPVA
60 70 80 90 100
LTLLTLCLVL LVGLAALGLV FFQFYQLSNI QQDSITEKDE KLGNMSRQLQ
110 120 130 140 150
SLQAQNRKLI ETLQQVAVKL CRELYNKSGG HRCSPCPEKW KWYGDKCYQF
160 170 180 190 200
YKESKNWQSC EYFCLADNAT MLKISTQEEL DFAMPQSYSE FFYSYWTGLS
210 220 230 240 250
RNGSGKAWLW TDGTPYSFEL FEIIIDPTNL RNRDCMTIFN GKAYSKDCKE
260
LRRCACERIA GRVVPGELQ
Length:269
Mass (Da):30,958
Last modified:March 1, 2003 - v1
Checksum:iDEC53DB093451ED0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6S → G in AAH52840 (PubMed:15489334).Curated1
Sequence conflicti222E → Q in BAC27264 (PubMed:16141072).Curated1
Sequence conflicti228T → N in BAC27264 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031121 mRNA. Translation: BAC27264.1.
AK049608 mRNA. Translation: BAC33840.1.
BC052840 mRNA. Translation: AAH52840.1.
CCDSiCCDS20587.1.
RefSeqiNP_780735.2. NM_175526.3.
UniGeneiMm.131289.

Genome annotation databases

EnsembliENSMUST00000037481; ENSMUSP00000047065; ENSMUSG00000033082.
GeneIDi243653.
KEGGimmu:243653.
UCSCiuc009eft.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031121 mRNA. Translation: BAC27264.1.
AK049608 mRNA. Translation: BAC33840.1.
BC052840 mRNA. Translation: AAH52840.1.
CCDSiCCDS20587.1.
RefSeqiNP_780735.2. NM_175526.3.
UniGeneiMm.131289.

3D structure databases

ProteinModelPortaliQ8BWY2.
SMRiQ8BWY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047065.

PTM databases

iPTMnetiQ8BWY2.
PhosphoSitePlusiQ8BWY2.

Proteomic databases

MaxQBiQ8BWY2.
PaxDbiQ8BWY2.
PRIDEiQ8BWY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037481; ENSMUSP00000047065; ENSMUSG00000033082.
GeneIDi243653.
KEGGimmu:243653.
UCSCiuc009eft.2. mouse.

Organism-specific databases

CTDi51267.
MGIiMGI:2444151. Clec1a.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000111777.
HOVERGENiHBG103475.
InParanoidiQ8BWY2.
KOiK10069.
OMAiFQFYQLS.
OrthoDBiEOG091G0K57.
PhylomeDBiQ8BWY2.
TreeFamiTF336674.

Miscellaneous databases

PROiQ8BWY2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033082.
CleanExiMM_CLEC1A.
ExpressionAtlasiQ8BWY2. baseline and differential.
GenevisibleiQ8BWY2. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC1A_MOUSE
AccessioniPrimary (citable) accession number: Q8BWY2
Secondary accession number(s): Q7TPX7, Q8BMH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.